Article
Pharmacology & Pharmacy
Martial Caillaud, Danielle Thompson, Wisam Toma, Alyssa White, Jared Mann, Jane L. Roberts, John W. Bigbee, David A. Gewirtz, M. Imad Damaj
Summary: This study demonstrates the preventive effect of curcumin and its lecithin formulation Meriva on paclitaxel-induced peripheral neuropathy. It also confirms the anti-inflammatory effects of curcumin through the activation of alpha 7 nAChRs receptors.
Review
Medicine, General & Internal
Cindy Tofthagen, Mary Tanay, Adam Perlman, Jason Starr, Pooja Advani, Katharine Sheffield, Tara Brigham
Summary: This study evaluated the relationship between laboratory measures of nutrition and chemotherapy induced peripheral neuropathy (CIPN). It found that hemoglobin/hematocrit, vitamin D, albumin, and magnesium were associated with CIPN. Further research is needed to confirm these associations.
JOURNAL OF CLINICAL MEDICINE
(2022)
Review
Oncology
Manaal Siddiqui, Basma Abdellatif, Kevin Zhai, Alena Liskova, Peter Kubatka, Dietrich Busselberg
Summary: Flavonoids show promising potential in treating CIPN by reducing oxidative stress, inflammation, and neuronal damage. Further research is needed to evaluate the efficacy and side effects of flavonoids in human models before clinical benefits can be realized.
Review
Nutrition & Dietetics
Megan Crichton, Patsy M. Yates, Oluwaseyifunmi Andi Agbejule, Amy Spooner, Raymond J. Chan, Nicolas H. Hart
Summary: This study reviewed the effects of non-pharmacological self-management interventions on chemotherapy-induced peripheral neurotherapy in people with advanced cancer. The study found that physical exercise had a certain effect in reducing the severity of peripheral neurotherapy and improving physical function, while the evidence for other interventions was limited. More well-designed studies are needed to explore the effects of these interventions.
Article
Oncology
Lauren Thomaier, Burcu F. Darst, Patricia Jewett, Cody Hoffmann, Katherine Brown, Aditi Makaram, Anne Blaes, Peter Argenta, Deanna Teoh, Rachel Vogel
Summary: The study identified genetic variants associated with chemotherapy-induced peripheral neuropathy symptoms among gynecologic cancer survivors. Two SNPs were significantly linked to high CIPN symptomatology. Combining these SNPs with clinical characteristics improved predictive power for CIPN symptoms compared to using clinical factors alone.
GYNECOLOGIC ONCOLOGY
(2021)
Review
Biochemistry & Molecular Biology
Fumiko Sekiguchi, Atsufumi Kawabata
Summary: Chemotherapy-induced peripheral neuropathy (CIPN) is resistant to most existing medicines and is one of the major dose-limiting side effects of chemotherapeutic agents. HMGB1 plays a key role in the development of CIPN, while TMα is effective in preventing CIPN in both animal models and patients.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2021)
Article
Immunology
Martial Caillaud, Nipa H. Patel, Alyssa White, Mackinsey Wood, Katherine M. Contreras, Wisam Toma, Yasmin Alkhlaif, Jane L. Roberts, Tammy H. Tran, Asti B. Jackson, Justin Poklis, David A. Gewirtz, M. Imad Damaj
Summary: The study demonstrated the therapeutic potential of fibrates, specifically fenofibrate and choline fenofibrate, in reversing and preventing pain sensitivity in peripheral neuropathies associated with paclitaxel treatment. Additionally, these fibrates did not diminish the antitumoral effects of paclitaxel, suggesting a potential for their pharmacological repurposing in PIPN.
BRAIN BEHAVIOR AND IMMUNITY
(2021)
Review
Biochemistry & Molecular Biology
Scarlett Acklin, Fen Xia
Summary: Platinum-based chemotherapy-induced peripheral neuropathy (CIPN) is a common and debilitating complication in cancer treatment, with dorsal root ganglia sensory neurons playing a key role in symptom development. Nucleotide excision repair is crucial for repairing platinum adducts and may serve as potential targets for future therapeutics.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2021)
Review
Medicine, Research & Experimental
Allison D. Desforges, Chance M. Hebert, Allyson L. Spence, Bailey Reid, Hemangini A. Dhaibar, Diana Cruz-Topete, Elyse M. Cornett, Alan David Kaye, Ivan Urits, Omar Viswanath
Summary: Chemotherapy-induced peripheral neuropathy (CIPN) is a complex condition that affects sensory functions. Currently, there are no approved preventive agents, but Duloxetine is an effective treatment. Developing prevention and treatment strategies for CIPN is crucial in improving patients' quality of life.
BIOMEDICINE & PHARMACOTHERAPY
(2022)
Article
Oncology
Sebastian W. Nielsen, Simone Dyring Hasselsteen, Helena Sylow Heilmann Dominiak, Dejan Labudovic, Lars Reiter, Susanne Oksbjerg Dalton, Jorn Herrstedt
Summary: This study aimed to assess the safety, dosing, and preventive effects of cannabidiol (CBD) on chemotherapy-induced peripheral neuropathy (CIPN). The results showed that CBD attenuated early symptoms of CIPN with no major safety concerns. Further confirmation is needed in larger randomized studies.
SUPPORTIVE CARE IN CANCER
(2022)
Review
Biochemistry & Molecular Biology
Maryam Omran, Elizabeth K. Belcher, Nimish A. Mohile, Shelli R. Kesler, Michelle C. Janelsins, Andrea G. Hohmann, Ian R. Kleckner
Summary: This review investigates the role of the brain in chemotherapy-induced peripheral neuropathy (CIPN) and identifies brain hyperactivity, reduced GABAergic inhibition, neuroinflammation, and overactivation of GPCR/MAPK pathways as contributing factors to CIPN. Leveraging this knowledge may guide future research and treatment strategies for CIPN.
FRONTIERS IN MOLECULAR BIOSCIENCES
(2021)
Article
Nutrition & Dietetics
Katarzyna Szklener, Sebastian Szklener, Adam Michalski, Klaudia Zak, Weronika Kurylo, Konrad Rejdak, Slawomir Mandziuk
Summary: Chemotherapy-induced peripheral neuropathy (CIPN) is a major side effect of chemotherapy, significantly impacting patients' quality of life and treatment process. However, managing CIPN is challenging, and prevention options are currently limited. Therefore, it is important to explore alternative treatments, including repurposing existing medications.
Article
Medicine, General & Internal
Sebastian W. Nielsen, Sanne Lindberg, Christina Halgaard Bruvik Ruhlmann, Lise Eckhoff, Jorn Herrstedt
Summary: The study evaluated the correlation between multi-frequency vibrometry and chemotherapy-induced peripheral neuropathy measurements, and found that low-frequency vibration perception thresholds (8 and 32 Hz) were more correlated with CIPN18 scores.
JOURNAL OF CLINICAL MEDICINE
(2022)
Review
Clinical Neurology
Guido Cavaletti, Paola Marmiroli, Cynthia L. Renn, Susan G. Dorsey, Maria Pina Serra, Marina Quartu, Cristina Meregalli
Summary: Chemotherapy-induced peripheral neurotoxicity (CIPN) is a common side effect of antineoplastic treatment without effective prevention options, but modulation of the endocannabinoid system may be a promising therapeutic approach. Clinical trials are underway to investigate changes in endocannabinoid levels induced by systemic chemotherapy and the potential role of endocannabinoid system modulation in relieving CIPN symptoms.
Review
Health Care Sciences & Services
Roser Velasco, Montserrat Alemany, Macarena Villagran, Andreas A. Argyriou
Summary: Oxaliplatin is a platinum compound used in gastrointestinal cancer treatment, but its major toxicity is peripheral neurotoxicity. There is currently no effective strategy to reverse or treat this neurotoxicity, so early prediction of whether patients will develop neurotoxicity is crucial. Several biomarkers for predicting neurotoxicity have been described in recent years, which may assist clinicians in making better treatment decisions.
JOURNAL OF PERSONALIZED MEDICINE
(2021)
Review
Pharmacology & Pharmacy
Bharath Singh Padya, Abhijeet Pandey, Muralidhar Pisay, K. B. Koteshwara, Raghu Chandrashekhar Hariharapura, Kuruveri Udaya Bhat, Swati Biswas, Srinivas Mutalik
Summary: Interdisciplinary applications of nanopharmaceutical sciences show great potential in enhancing pharmacokinetics, efficacy, and safety of cancer therapy. Different nanotechnological approaches, including polymeric, lipidic and inorganic nanoplatforms, have been experimented for the treatment of skin cancer. Stimuli-responsive nanoplatforms, surface engineering, conjugation with drugs, and multimodal effects are discussed as strategies for potentiating nanoparticles application for cancer therapy.
EUROPEAN JOURNAL OF PHARMACOLOGY
(2021)
Article
Multidisciplinary Sciences
Ananthamurthy Koteshwara, Nancy Philip, Jesil Mathew Aranjani, Raghu Chandrashekhar Hariharapura, Subrahmanyam Volety Mallikarjuna
Summary: Ammonium sulfate precipitation is a crucial step in protein extraction, and this study developed a simple method for directly analyzing the precipitates. By using laminarin-infused agarose plate and a fluorescent optical brightener Tinopal CBS-X, accurate results can be obtained even in the presence of ammonium sulfate.
SCIENTIFIC REPORTS
(2021)
Review
Neurosciences
S. Gayathri, Chandrashekar H. Raghu, S. M. Fayaz
Summary: Alzheimer's disease is increasing worldwide, but current approved drugs have limited effectiveness. Traditional medicinal systems like Ayurveda use multimodal herbs to treat the disease holistically. High-throughput technologies have advanced research in Ayurveda, specifically in identifying plants with anti-Alzheimer's disease properties. However, clinical trials of herbal medicines are limited. This review summarizes Indian plants and Ayurvedic medicines against Alzheimer's disease and proposes a framework for the development of herbal medicine.
CNS & NEUROLOGICAL DISORDERS-DRUG TARGETS
(2022)
Review
Biochemistry & Molecular Biology
Rakesh Ravishankar Rahangdale, Tenzin Tender, Sridevi Balireddy, Mukesh Pasupuleti, Raghu Chandrashekar Hariharapura
Summary: The occurrence of herpes zoster co-infection in COVID-19 patients may be linked to increased psychological and immunological stress, leading to virus reactivation.
CANADIAN JOURNAL OF MICROBIOLOGY
(2022)
Review
Biochemistry & Molecular Biology
Archana Mahadev Rao, Sridevi Balireddy, Fayaz Shaik Mohammad, Divyashree M. Somashekara, Raghu Chandrashekar Hariharapura
Summary: This article discusses the life cycle of Herpes simplex virus and the potential role of the terminase complex in nuclear egress and secondary envelopment.
CURRENT PROTEIN & PEPTIDE SCIENCE
(2022)
Article
Biochemistry & Molecular Biology
Neerada Meenakshi Warrier, Ramesh Kumar Krishnan, Vijendra Prabhu, Raghu Chandrashekhar Hariharapura, Prasoon Agarwal, Praveen Kumar
Summary: This study identifies survivin as a significant biomarker for glioblastoma multiforme cancer stem cells (GSCs) and demonstrates its importance in stemness, cancer progression, and therapy resistance.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2022)
Review
Infectious Diseases
Ruby Benson, Mazhuvancherry Kesavan Unnikrishnan, Shilia Jacob Kurian, Saleena Ummer Velladath, Gabriel Sunil Rodrigues, Raghu Chandrashekar Hariharapura, Anju Muraleedharan, Dinesh Bangalore Venkateshiah, Barnini Banerjee, Chiranjay Mukhopadhyay, Aieshel Serafin Johnson, Murali Munisamy, Mahadev Rao, Benson Mathai Kochikuzhyil, Sonal Sekhar Miraj
Summary: Infections are becoming more difficult to treat due to microbes producing biofilms. Vitamin D deficiency is associated with decreased antimicrobial peptides, increased inflammatory cytokines, and biofilm formation, making deficient individuals more susceptible to infection. Adjuvant therapy with vitamin D can help manage infections caused by biofilm-producing microbes due to its immunomodulatory role in inducing antimicrobial peptides and reducing proinflammatory cytokines.
EXPERT REVIEW OF ANTI-INFECTIVE THERAPY
(2023)
Review
Chemistry, Medicinal
Akshatha Handattu Shankaranarayana, Bhagyalalitha Meduri, Gurubasavaraj Veeranna Pujar, Raghu Chandrashekar Hariharapura, Arun Kumar Sethu, Manisha Singh, Durgesh Bidye
Summary: This review discusses the significance of overexpressed p53 binding partner mortalin in cancer and explores the challenges and strategies for discovering drugs to suppress mortalin-p53 sequestration.
FUTURE MEDICINAL CHEMISTRY
(2023)
Review
Biotechnology & Applied Microbiology
Rakesh Rahangdale, Tenzin Tender, Sridevi Balireddy, Kamini Goswami, Mukesh Pasupuleti, Raghu Chandrashekar Hariharapura
Summary: The health of the human population is constantly challenged by viral infections, including the herpes simplex virus (HSV). Current anti-HSV therapies have limitations, and protein therapeutics are being explored as a potential alternative due to their specificity and low toxicity. This review emphasizes the importance of HSV viral glycoproteins and host receptors in the pathogenesis of HSV infection, and discusses the possibility of using proteins or peptides derived from these glycoproteins and receptors to inhibit HSV attachment, entry, or fusion.
MICROBIAL BIOTECHNOLOGY
(2023)
Article
Biochemistry & Molecular Biology
Tenzin Tender, Rakesh Ravishankar Rahangdale, Fayaz Shaik Mohammad, Madhavan Nampoothiri, Krishna Sharma, Raghu Chandrashekar Hariharapura
Summary: A chaperone peptide called MAC derived from eye lens alpha A-crystallin was found to inhibit the toxic effects of melittin, the main component of honey bee venom, on human blood cells and lymphocytes. Experimental and computational studies showed that MAC can prevent cell lysis and death caused by melittin, which could be beneficial for treating severe honeybee stings.
INTERNATIONAL JOURNAL OF PEPTIDE RESEARCH AND THERAPEUTICS
(2023)
Review
Biochemistry & Molecular Biology
Nainika Prashant Kotian, Anusha Prabhu, Tenzin Tender, Hariharapura Raghu Chandrashekar
Summary: Therapeutic proteins, although highly effective, face challenges such as high costs, limited stability, and chaperone issues. Methylglyoxal (MGO), a compound that affects protein structure and stability, has been studied for its impact on proteins. The research aims to understand the potential solutions to the stability and chaperone problems faced by proteins, particularly alpha-crystallin.