Article
Integrative & Complementary Medicine
Maher Obeidat, Ihab F. F. Al-khraisat, Da'san M. M. Jaradat, Bayan Y. Y. Ghanim, Qasem M. M. Abdallah, Duaa Abu Arqoub, Duaa Sabbah, Ola M. M. Al-Sanabra, Tawfiq Arafat, Nidal A. A. Qinna
Summary: This study collected Jordanian crude bee venom (JCBV) during different seasons and investigated its in vitro antitumor effects. It was found that JCBV collected during springtime had the highest content of melittin (MEL), which showed apoptotic and cell cycle arrest effects on K562 leukemia cells. The study concludes that the application of bee venom in chemotherapy needs further research and should carefully consider the correlation between bee genotype, collection time, and MEL concentration in JCBV.
BMC COMPLEMENTARY MEDICINE AND THERAPIES
(2023)
Review
Toxicology
Aysegul Varol, Serap Sezen, Dilhan Evcimen, Atefeh Zarepour, Gonul Ulus, Ali Zarrabi, Gamal Badr, Sevgi Durna Dastan, Asya Gulistan Orbayoglu, Zeliha Selamoglu, Mehmet Varol
Summary: Bee venom therapy is a traditional approach to curing various medical conditions and also shows promising potential for treating multiple types of cancers. Researchers focus on understanding the molecular activity mechanisms and cellular targets of bee venom, as well as utilizing cutting-edge nanotechnological advances to overcome challenges and exploring its anticancer application in clinical settings.
Review
Food Science & Technology
Jasmin Katrin Badawi
Summary: Prostate cancer is one of the most common cancers in men, with challenges in disease progression and resistance of cancer cells to available therapeutic agents. Further therapeutic agents are needed, and bee venom components have shown promising anticancer effects, particularly melittin.
Article
Pharmacology & Pharmacy
Diana Duarte, Soraia Falcao, Iouraouine El Mehdi, Miguel Vilas-Boas, Nuno Vale
Summary: The study evaluated the anti-cancer efficacy of honeybee venom in combination with chemotherapeutic or CNS drugs in colon and breast cancer cells. The results showed that the combination of honeybee venom with these drugs can improve their anti-cancer activity, especially at lower concentrations.
Review
Oncology
Tenzin Tender, Rakesh Ravishankar Rahangdale, Sridevi Balireddy, Madhavan Nampoothiri, K. Krishna Sharma, Hariharapura Raghu Chandrashekar
Summary: CIPN is a common neurological complication of cancer treatment with limited treatment options and severe adverse effects. Current medications offer only symptomatic relief for short term, and there is a lack of standard treatment protocol for the condition.
Article
Food Science & Technology
Pelin Erkoc, Bjoern Marcus von Reumont, Tim Lueddecke, Marina Henke, Thomas Ulshoefer, Andreas Vilcinskas, Robert Fuerst, Susanne Schiffmann
Summary: The venom of honeybees, specifically melittin peptides, has shown potential therapeutic effects on inflammation and cancer. This study explores the pharmacological activities of known and newly discovered melittin variants from honeybees and older solitary bees in the context of cancer and inflammation. The findings suggest that some ancestral variants from solitary bees have promising therapeutic potential in modulating inflammatory processes and inhibiting cancer cell viability/proliferation, including aggressive breast cancers.
Review
Food Science & Technology
Na-Yoen Kwon, Soo-Hyun Sung, Hyun-Kyung Sung, Jang-Kyung Park
Summary: Bee venom and its components have been found to have anticancer effects on breast cancer cells by reducing cell numbers and improving survival rates. The various mechanisms of action suggest the potential for reducing side effects and the future prevention and treatment of breast cancer.
Review
Pharmacology & Pharmacy
Arijit Mondal, Amit Kumar Nayak, Prithviraj Chakraborty, Sabyasachi Banerjee, Bankim Chandra Nandy
Summary: Cancer is a common and deadly disease, and nanomedicine has emerged as a potential substitute for cancer treatment. The combination of natural bioactive compounds and nanotechnology has shown promise in improving chemotherapy effectiveness. Nanotechnology allows for targeted delivery of drugs, while natural bioactive compounds enhance the therapeutic outcomes.
Article
Infectious Diseases
Jakkrawut Maitip, Wannapha Mookhploy, Supharerk Khorndork, Panuwan Chantawannakul
Summary: This study investigated the antimicrobial activities of bee venom and synthetic melittin derived from four different honey bee species in Thailand. Results showed stronger antibacterial activities against Gram-positive bacteria, with A. cerana venom extract exhibiting the highest activity.
Article
Pharmacology & Pharmacy
Diana Harfmann, Adrian Florea
Summary: Bee stings are a public health concern, but the mechanisms of bee venom toxicity are still not fully understood. In this study, the reactions of adrenocortical cells to two components of honeybee venom, melittin and phospholipase A2, were investigated. The results showed that both melittin and phospholipase A2 had toxic effects on cellular structures, particularly the mitochondria.
Review
Biochemistry & Molecular Biology
Marta Burzynska, Dorota Piasecka-Kwiatkowska
Summary: Honeybee venom contains allergenic proteins that can cause severe allergic reactions, with potential therapeutic value.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2021)
Article
Polymer Science
Zulfiya Cernochova, Volodymyr Lobaz, Lucie Ctverackova, Peter Cernoch, Miroslav Slouf, Marcela Filipova, Martin Hruby, Jiri Panek
Summary: This paper presents an efficient platform for forming polypeptide complexes from cationic amphiphilic animal venoms, such as melittin. The platform utilizes supramolecular charge compensation between melittin and nanoparticles composed of hydrophobic glassy polystyrene core and hydrophilic poly(meth)acrylic acid corona. The study demonstrates the successful complexation of melittin with nanoparticles at low concentrations and discusses the influence of nanoparticle structures on their potency.
EUROPEAN POLYMER JOURNAL
(2023)
Article
Multidisciplinary Sciences
Samuel D. Robinson, Lucas Kambanis, Daniel Clayton, Hannes Hinneburg, Leo Corcilius, Alexander Mueller, Andrew A. Walker, Angelo Keramidas, Sameer S. Kulkarni, Alun Jones, Irina Vetter, Morten Thaysen-Andersen, Richard J. Payne, Glenn F. King, Eivind A. B. Undheim
Summary: Ants are common inhabitants in terrestrial environments, and their venom chemistry, particularly the glycopeptide Mg7a, has been discovered and characterized. Mg7a exhibits paralytic and lethal effects on insects, as well as inducing pain and inflammation in mammals through a membrane-targeting mechanism. The presence of O-glycans plays a crucial role in the solubility of Mg7a in aqueous solutions.
Review
Oncology
Agata Malek, Maciej Strzemski, Joanna Kurzepa, Jacek Kurzepa
Summary: This paper presents the current state of knowledge regarding the mechanisms of anticancer activity of bee venom, showing its strong potential in inducing apoptosis and inhibiting the cell cycle of tumor cells without affecting normal cells significantly. Animal studies also support the safety of venom doses effective in vitro. This information is valuable for planning future clinical trials.
Article
Chemistry, Multidisciplinary
Dingkang Liu, Ye Chen, Qun Wang, Yue Ji, Lichen Bao, Wenbing Yao, Xiangdong Gao, Jun Yin
Summary: In this study, a multifunctional fusion protein-DNA conjugate was developed as a co-delivery vehicle for anticancer peptides and chemotherapeutic drugs. The tailored nanostructure showed enhanced stability, tumor targeting, and controlled-release properties, allowing selective entry into tumor cells and synergistic antitumor activity with no significant adverse effects.
JOURNAL OF CONTROLLED RELEASE
(2022)
Review
Neurosciences
Harsh Goel, Keshav Goyal, Avanish Kumar Pandey, Mercilena Benjamin, Fahad Khan, Pratibha Pandey, Sandeep Mittan, Danish Iqbal, Mohammed Alsaweed, Wael Alturaiki, Yahya Madkhali, Mohammad Amjad Kamal, Pranay Tanwar, Tarun Kumar Upadhyay
Summary: Due to environmental contamination, humans are exposed to physical and chemical mutagens, which cause a variety of neurological disorders through neuroinflammation, genetic instability, oxidative stress, and mitochondrial damage. This review summarizes the molecular mechanisms and effects of mutagens in the environment on neurological disorders.
CNS & NEUROLOGICAL DISORDERS-DRUG TARGETS
(2023)
Review
Biochemistry & Molecular Biology
Pratibha Pandey, Fahad Khan, Tarun Kumar Upadhyay, Amit Baran Sharangi
Summary: Cancer is characterized by abnormal cell cycle regulation and CDK stimulation, and suppressing CDKs is an intriguing approach for anticancer drug development. CDK inhibitors can block CDK4/6 and control the cell cycle, thus inducing apoptosis and cell cycle arrest. Recent studies have shown that CDK4/6 inhibitors not only inhibit cell growth but also modulate the tumor microenvironment and enhance antitumor immunity by affecting the interaction between tumor cells and the host immune system. This article discusses the biological significance of CDK4/6 inhibitors in cancer therapeutics and their impact on immune cells.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2023)
Review
Biochemistry & Molecular Biology
Pratibha Pandey, Fahad Khan, Tarun Kumar Upadhyay, Ramish Maqsood
Summary: Immune checkpoint inhibitors have revolutionized cancer treatment, leading to prolonged survival and expanded therapeutic indications. However, some patients still experience treatment failure or develop immunotherapy resistance, highlighting the need for a better understanding of tumor progression and metabolic regulation in the tumor microenvironment. This review discusses the significance of the tumor microenvironment, immunological checkpoints, and metabolic pathways in tumor immunity, providing insights for potential metabolism-based treatment approaches in cancer research.
Review
Medicine, Research & Experimental
Harsh Goel, Rahul Kumar, Pranay Tanwar, Tarun Kumar Upadhyay, Fahad Khan, Pratibha Pandey, Sojin Kang, Myunghan Moon, Jinwon Choi, Min Choi, Moon Nyeo Park, Bonglee Kim, Mohd Saeed
Summary: Leukemia is a heterogeneous group of hematological malignancies characterized by differentiation blockage and uncontrolled proliferation of myeloid or lymphoid progenitor cells. Traditional treatments such as chemotherapy and stem cell transplantation have severe side effects and drug resistance. Therefore, it is essential to develop novel therapeutic approaches using natural products, which have diverse bioactive compounds and have been proven to destroy leukemia cells through various mechanisms of action.
BIOMEDICINE & PHARMACOTHERAPY
(2023)
Review
Medicine, Research & Experimental
Pratibha Pandey, Fahad Khan, Tarun Kumar Upadhyay, Moon Seungjoon, Moon Nyeo Park, Bonglee Kim
Summary: The PDGF/PDGFR pathway plays a crucial role in the growth and spread of several cancers. Targeting this pathway is a viable therapeutic approach for treating cancer.
BIOMEDICINE & PHARMACOTHERAPY
(2023)
Review
Biochemistry & Molecular Biology
Pratibha Pandey, Fahad Khan, Tarun Kumar Upadhyay
Summary: Cancer, a complex malignancy controlled by various pathways, has prompted growing interest in natural extracts for cancer treatment due to their reduced side effects. Apigenin, a flavonoid derived from plants, has shown potential as an anticancer agent in experimental and biological studies. It can induce cell growth arrest and apoptosis in a wide range of human tumors. This review focuses on summarizing the modulation of oncogenic pathways by apigenin, which could lead to the development of alternative therapies for various cancers.
CHEMICAL BIOLOGY & DRUG DESIGN
(2023)
Review
Biochemistry & Molecular Biology
Pratibha Pandey, Fahad Khan, Tarun Kumar Upadhyay, Pavan Prakash Giri
Summary: Currently, there is great interest in using phytochemicals for treating human ailments. Despite advancements in cancer medicine, there are still obstacles such as severe side effects and drug resistance linked to chemotherapy. Phytochemically derived compounds, like caffeic acid phenethyl ester (CAPE) found in propolis, show promise as a potent therapeutic molecule for cancer treatment. Research has shown that CAPE has various therapeutic effects and can specifically target genes involved in cell death, cell cycle regulation, angiogenesis, and metastasis, limiting the proliferation of human cancer cells.
CHEMICAL BIOLOGY & DRUG DESIGN
(2023)
Article
Polymer Science
Vijay Patel, Unnati Joshi, Anand Joshi, Tarun Kumar Upadhyay, Lamya Ahmed Al-Keridis, Mohd Saeed
Summary: In this research, a unique three-dimensional mixing technique was used to incorporate MWCNTs into PMMA. The cytotoxicity, apoptosis detection, and cell viability of the composite were analyzed using the KB cell line. The results showed that the CNT increased lymphocyte-mediated cytotoxicity against KB cell lines and could potentially be used to treat certain types of cancer.
Review
Pharmacology & Pharmacy
Pratibha Pandey, Fahad Khan, Nawaf Alshammari, Amir Saeed, Farrukh Aqil, Mohd Saeed
Summary: Garlic has various pharmacological effects, including antibacterial, antiarthritic, antithrombotic, anticancer, hypoglycemic, and hypolipidemic effects. Its anticancer action is well researched and provides significant protection against the risk of developing cancer. Active compounds in garlic, such as diallyl trisulfide, allicin, and diallyl sulphide, have been found to have anticancer properties against different types of cancer.
FRONTIERS IN PHARMACOLOGY
(2023)
Review
Endocrinology & Metabolism
Pratibha Pandey, Fahad Khan, Ramish Maqsood, Tarun Kumar Upadhyay
Summary: Breast cancer is a common and deadly disease worldwide, and there is a need for better treatment approaches. Nanotechnology has emerged as a promising method for targeted drug delivery in breast cancer treatment. Optimized nanoparticles can enhance the effectiveness of conventional drugs by improving circulation time and targeting cancer cells. This review summarizes the drug delivery approaches and nanoparticle-based targeting strategies that can potentially overcome the limitations of traditional therapies.
ENDOCRINE METABOLIC & IMMUNE DISORDERS-DRUG TARGETS
(2023)
Review
Medicine, Research & Experimental
Pratibha Pandey, Fahad Khan, Min Choi, Sujeet Kumar Singh, Han Na Kang, Moon Nyeo Park, Seong-Gyu Ko, Sanjeev Kumar Sahu, Rupa Mazumder, Bonglee Kim
Summary: Natural products have been an unmatched source of anticancer medications in the current drug development period. They modify the cancer microenvironment and various signaling pathways, playing a significant role in cancer treatment. These substances are effective against multiple signaling pathways, particularly in cell death and embryonic developmental pathways. More research is needed to fully understand their function in cancer treatments and their potential as therapeutic agents.
BIOMEDICINE & PHARMACOTHERAPY
(2023)
Review
Chemistry, Applied
Fahad Khan, Pratibha Pandey, Ramish Maqsood, Tarun Kumar Upadhyay
Summary: Carvacrol is an active compound with enormous anticancer potential, showing antiproliferative and apoptotic effects in various cancers by targeting multiple signaling pathways. Although in vitro experiments demonstrate the potent phytoactivity of Carvacrol against several cancers, further in vivo research is needed to determine safe dosage, toxicity, and mode of action.
BIOINTERFACE RESEARCH IN APPLIED CHEMISTRY
(2023)
