Article
Oncology
Ruihui Xie, Liang Cheng, Ming Huang, Lin Huang, Ziyue Chen, Qiang Zhang, Hong Li, Junlin Lu, Hongjin Wang, Qianghua Zhou, Jian Huang, Xu Chen, Tianxin Lin
Summary: This study identified that the ac4C modification mediated by NAT10 is induced by cisplatin treatment and correlates with chemoresistance in bladder cancer. NAT10 promotes cisplatin chemoresistance by enhancing DNA damage repair (DDR) in bladder cancer cells. Mechanistically, NAT10 binds and stabilizes AHNAK mRNA by protecting it from exonucleases, and AHNAK-mediated DDR is crucial for cisplatin resistance in bladder cancer.
Article
Biochemistry & Molecular Biology
Feng Xu, Tian Xia, Qi-Tong Xu, Xu Zhang, Yu-Zhou Huang, Xi Sun, Liang Shi, Xu-Jie Zhou, Ji-Fu Wei, Qiang Ding
Summary: Chemoresistance, which is closely associated with therapeutic outcomes and prognosis in breast cancer patients, has been shown to be influenced by RNA binding proteins (RBPs) such as RBMS2. In this study, the researchers found that upregulation of RBMS2 enhanced sensitivity to doxorubicin and induced apoptosis in breast cancer cells. Furthermore, the chemosensitizing effect of RBMS2 was found to be mediated by the regulation of the Bcl-2 modifying factor (BMF). These findings suggest that RBMS2 may serve as a potential therapeutic target for drug-resistant breast cancer.
INTERNATIONAL JOURNAL OF BIOLOGICAL SCIENCES
(2022)
Article
Biochemistry & Molecular Biology
Mei-Yi Lin, Wan-Ting Cheng, Hui-Ching Cheng, Wan-Ching Chou, Hsiu- Chen, Hsiu-Chung Ou, Kun-Ling Tsai
Summary: Baicalin can enhance chemosensitivity to doxorubicin in breast cancer cells through inducing apoptosis via increasing intracellular ROS and Ca2+ concentrations. Pretreatment with ROS inhibitor or Ca2+ chelator can reduce this chemosensitivity.
Article
Biotechnology & Applied Microbiology
Quanyuan Wan, Zihua Zeng, Jianjun Qi, Zhenghu Chen, Xiaohui Liu, Youli Zu
Summary: The study demonstrates the effectiveness of targeted chemotherapy for triple-negative breast cancer using a DNA nanoparticle to deliver doxorubicin to cancer cells, showing promising results in vitro and in animal experiments while potentially reducing side effects for patients.
Article
Polymer Science
Hamideh Gharnas-Ghamesh, Mojtaba Masoumi, Vahid Erfani-Moghadam
Summary: This study synthesized a nanocarrier for the chemotherapy drug doxorubicin (DOX) to enhance its anticancer efficacy while reducing side effects. The nanocarrier, made of PBMA-b-POEGMA diblock copolymer, demonstrated good physicochemical and biological properties. It efficiently encapsulated DOX and released the drug using the Korsmeyer-Peppas model. The DOX-loaded micelles showed high cellular uptake and induced apoptosis in cancer cells.
JOURNAL OF APPLIED POLYMER SCIENCE
(2022)
Article
Oncology
Jieqing Li
Summary: This study aimed to confirm the possibility of using CHI combined with DOX to prevent chemotherapeutic BC resistance. The results showed that CHI could inhibit cell proliferation, tumor growth, and cell invasion in BC. It also promoted apoptosis and autophagy, and increased cell sensitivity to DOX, leading to decreased tumor growth.
Article
Biochemistry & Molecular Biology
Mona Safari Sharafshadeh, Farzaneh Tafvizi, Parvin Khodarahmi, Somayeh Ehtesham
Summary: In this study, alginate-coated niosomal nanocarriers were prepared for the co-delivery of doxorubicin (Dox) and cisplatin (Cis) in the treatment of breast and ovarian cancers. The coated nanocarriers showed improved physicochemical characteristics compared to uncoated niosomes. In vitro experiments demonstrated that the co-delivery system effectively induced apoptosis and cell cycle arrest, showing potential for the treatment of ovarian and breast cancer.
INTERNATIONAL JOURNAL OF BIOLOGICAL MACROMOLECULES
(2023)
Article
Multidisciplinary Sciences
Muhammad H. Sultan, Sivakumar S. Moni, Osama A. Madkhali, Mohammed Ali Bakkari, Saeed Alshahrani, Saad S. Alqahtani, Nabil A. Alhakamy, Syam Mohan, Mohammed Ghazwani, Haitham A. Bukhary, Yosif Almoshari, Ahmad Salawi, Meshal Alshamrani
Summary: This study developed cisplatin-loaded chitosan nanoparticles (CCNP) and cisplatin-loaded chitosan nanoparticle surface linked to rituximab (mAbCCNP) as targeted delivery formulations. The formulations showed significant physicochemical properties. The release of cisplatin from the nanoparticles followed zero order kinetics. CCNP exhibited good cytotoxicity against breast cancer cells.
SCIENTIFIC REPORTS
(2022)
Article
Biochemistry & Molecular Biology
Shifaa M. Abdin, Mai F. Tolba, Dana M. Zaher, Hany A. Omar
Summary: The inhibition of NF-kappa B activity can enhance the sensitivity of breast cancer cells to chemotherapy, particularly doxorubicin, by modulating multidrug resistance. Combined treatment with NF-kappa B inhibitors can sensitize resistant breast cancer cells to doxorubicin, by suppressing NF-kappa B activation and downregulating MDR efflux transporters.
CHEMICO-BIOLOGICAL INTERACTIONS
(2021)
Article
Biochemistry & Molecular Biology
Elnaz Aghaei, Hossein Soltanzadeh, Leila Kohan, Mohammad Heiat
Summary: Our study demonstrated that the combination of apatinib and doxorubicin significantly decreased proliferation, migration, and invasion of MDA-MB-231 breast cancer cells, while increasing apoptosis percentage. The anticancer potential of the combination therapy was significantly higher than apatinib or doxorubicin alone, suggesting a promising approach in breast cancer treatment.
MOLECULAR BIOLOGY REPORTS
(2023)
Article
Chemistry, Multidisciplinary
Yu Gao, Jiahui Wang, Hao Han, Huaxin Xiao, Wei-kui Jin, Siyu Wang, Shengpei Shao, Zhixuan Wang, Wenjing Yang, Lianhui Wang, Lixing Weng
Summary: The use of implantable drug-containing polymeric scaffolds shows promise in delivering chemotherapy directly to post-resection sites and inhibiting local recurrence of residual tumors. This strategy offers a potential alternative to systemic chemotherapy with lower side effects and may be useful in combating post-resection breast cancer recurrence in clinics.
Article
Medicine, Research & Experimental
Norma Cesilia Arellano-Rodriguez, Oscar Alberto Alvarez-Quezada, Pablo Zapata Benavides, Gerardo Vargas-Alanis, Moises Franco-Molina, Diana Zamora-Avila, Mariela Arellano-Rodriguez, Santiago Saavedra-Alonso, Juan Manuel Izaguirre-Alvarez, Cristina Rodriguez-Padilla
Summary: The study demonstrates that curcumin can induce the expression of soluble PAR4 and enhance its release in mice. Mice treated with a combination of curcumin and cisplatin exhibit greater tumor shrinkage compared to the control group.
Article
Chemistry, Multidisciplinary
Nafees Muhammad, Tan Cai-Ping, Sadia Nasreen, Zong-Wan Mao
Summary: A mitochondria targeting dual-action platinum(IV) prodrug shows high anticancer activity in triple negative breast cancer cells by intervening in various cellular processes, ultimately killing cancer cells through DNA damage, perturbation of mitochondrial bioenergetics, and induction of necrosis.
CHEMISTRY-AN ASIAN JOURNAL
(2021)
Article
Biochemistry & Molecular Biology
Andria M. Yaourtis, Aviva Levina, Peter A. Lay
Summary: Tumour cell heterogeneity affects the cytotoxicity of cisplatin but not doxorubicin in two phenotypes of the triple-negative breast cancer cell line, MDA-MB-231. The mesenchymal phenotype showed three times less sensitivity to cisplatin compared to the epithelial-type phenotype, which has significant implications for the efficacy of TNBC chemotherapies.
JOURNAL OF INORGANIC BIOCHEMISTRY
(2023)
Review
Food Science & Technology
Na-Yoen Kwon, Soo-Hyun Sung, Hyun-Kyung Sung, Jang-Kyung Park
Summary: Bee venom and its components have been found to have anticancer effects on breast cancer cells by reducing cell numbers and improving survival rates. The various mechanisms of action suggest the potential for reducing side effects and the future prevention and treatment of breast cancer.
Article
Physiology
L. Yahaghi, Parichehreh Yaghmaei, N. Hayati-Roodbari, S. Irani, A. Ebrahim-Habibi
PHYSIOLOGY INTERNATIONAL
(2020)
Article
Cell Biology
Maryam Hosseinmardi, Fatemeh Siadat, Mohsen Sharafi, Nasim Hayati Roodbari, Maryam Hezavehei
Summary: CeO(2)NPs at a concentration of 0.1 mu g/mL significantly improved motility, viability, membrane functionality, DNA integrity, and protamination of human sperm after thawing, while also reducing MDA levels. Different concentrations of CeO(2)NPs did not significantly affect sperm morphology and mitochondria activity.
BIOPRESERVATION AND BIOBANKING
(2022)
Article
Endocrinology & Metabolism
Alicia Requena-Jimenez, Mohammad Nabiuni, Jaleel A. Miyan
Summary: A proteomics study was conducted on hydrocephalic and normal rat CSF, revealing a transformation in the proteome across embryonic days 17-20. Predictions were made on the top molecular regulators that control the shift in CSF metabolic signature, along with potential key biomarkers for early detection of these changes.
JOURNAL OF CEREBRAL BLOOD FLOW AND METABOLISM
(2021)
Article
Oncology
Zabih Mir Hassani, Mohammad Nabiuni, Kazem Parivar, Somayeh Abdirad, Latifeh Karimzadeh
Summary: Melittin effectively inhibits HIF-1 alpha signaling pathway in breast adenocarcinoma cell line MDA-MB-231, leading to decreased expression of VEGFA and LDHA. Additionally, Melittin inhibits cell growth through activation of apoptotic pathways in MDA-MB-231 cell line.
Article
Obstetrics & Gynecology
J. Shakerzadeh, M. Movahedin, A. Eidi, N. Hayati Roodbari, K. Parivar
Summary: Forced suppression of mmu-let-7a-5p through successful transfection of Anti-miR leads to upregulation of downstream genes, Igf1, Itgb3 and Tgfb1, which directly involved in the trophoblast-endometrium attachment and improve the implantation rate.
REPRODUCTIVE SCIENCES
(2022)
Article
Biochemistry & Molecular Biology
Latifeh Karimzadeh Bardeei, Ehsan Seyedjafari, Ghamartaj Hossein, Mohammad Nabiuni, Mohammad Hosein Majles Ara, Jochen Salber
Summary: The study demonstrated that the PCL/npW composite scaffolds showed significantly enhanced cytocompatibility and osteogenic activity in SAON lesions, providing a new design concept for early treatment of osteonecrosis defects.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2021)
Article
Engineering, Biomedical
Somayeh Tofighi Nasab, Nasim Hayati Roodbari, Vahabodin Goodarzi, Hossein Ali Khonakdar, Mohammad Reza Nourani
Summary: The study revealed that the PU/C/NBG conduit is significantly more suitable for nerve regeneration compared to PU and PU/C conduits, while all three groups of conduits had the potential for nerve regeneration.
JOURNAL OF BIOMEDICAL MATERIALS RESEARCH PART B-APPLIED BIOMATERIALS
(2022)
Article
Biochemistry & Molecular Biology
Hanieh Jalali, Hasti Golchin, Zahra Sadri, Latifeh Karimzadeh Bardei, Mohammad Nabiuni
Summary: The study demonstrated that Na2SeO3 promoted neural differentiation of BMSCs by increasing the expression of Map-2 and ChAT proteins, as well as significantly upregulating miR-9, miR-124, and miR-29a. This suggests that selenium may mediate neural differentiation through neuron-specific microRNAs, highlighting the importance of selenium supplementation in preventing neuronal diseases.
JOURNAL OF TRACE ELEMENTS IN MEDICINE AND BIOLOGY
(2022)
Article
Anatomy & Morphology
Ghazal Ghajari, Mohammad Nabiuni, Elaheh Amini
Summary: The experiment demonstrated that Ganoderma lucidum extract can prevent lithium carbonate-induced testicular toxicity and related lesions by inhibiting oxidative stress and repairing damages, thus protecting the health of the male reproductive system.
Article
Pharmacology & Pharmacy
Farima Rahimi Mansour, Mohammad Nabiuni, Elaheh Amini
Summary: Aluminum, a widely used metal, can affect the ovaries and granulosa cells by up-regulating steroidogenic and proliferative genes. Additionally, aluminum may induce issues such as apoptosis and autophagy.
Article
Public, Environmental & Occupational Health
Mohaddeseh Mohammadi-Sardoo, Ali Mandegary, Seyed Noureddin Nematollahi-Mahani, Mahshid Moballegh Nasery, Mohammad Nabiuni, Bagher Amirheidari
Summary: The study revealed toxic effects of Mancozeb (MZB) on co-culture of mouse Sertoli-germ cells, indicating a potential role of redox imbalance and activation of p38 and JNK signaling pathways in MZB-induced apoptosis in the male reproductive system.
TOXICOLOGY AND INDUSTRIAL HEALTH
(2021)
Article
Biochemistry & Molecular Biology
Ali Ebrahimi, Kazem Parivar, Nasim Hayati-e Roodbari, Akram Eidi
Summary: This study investigated the effects of quercetin on the expression of the Nrf2 gene and the proliferation and differentiation of NPSCs derived from the brain of adult rats. The results showed that quercetin increased the expression of Nrf2 and had a dose-dependent effect on the proliferation and differentiation of NPSCs. These findings suggest that quercetin may be an effective compound for treating degenerative CNS disorders.
MOLECULAR BIOLOGY REPORTS
(2023)
Meeting Abstract
Cell & Tissue Engineering
Latifeh Karimzadeh, Jochen Salber, Ehsan Seyedjafari, Ghamartaj Hosein, Mohammad Nabiuni, Mohammadhosein Majlesara
TISSUE ENGINEERING PART A
(2022)
Article
Cell Biology
Fatemeh Salimian, Mohammad Nabiuni, Ensieh Salehghamari
Summary: This study investigated the effects of melittin on the migration and metastasis of EGF-induced MDA-MB-231 cells, and found that melittin can reduce cell migration and invasion by suppressing the SDF-1 alpha/CXCR4 signaling pathway.
Article
Pharmacology & Pharmacy
Shirin Ahmadi, Mohammad Nabiuni, Mohammad Tahmaseb, Elaheh Amini
Summary: The study revealed that Lithium and Crocin can enhance the expression of neurotrophic factors BDNF and GDNF in EPI-NCSCs, supporting their neuroprotective/neurogenesis effects. This suggests a potential for using these substances in cell therapy and combination therapy for neurodegenerative diseases.
IRANIAN JOURNAL OF PHARMACEUTICAL RESEARCH
(2021)