Medicinal parts of mulberry (leaf, twig, root bark, and fruit) and compounds thereof are excellent traditional Chinese medicines and foods for diabetes mellitus

Corchorus olitorius extract exhibit anti-hyperglycemic and anti-inflammatory properties in rodent models of obesity and diabetes mellitus

(2023) Kabelo Mokgalaboni et al.   Frontiers in Nutrition

Morus alba leaves ethanol extract protects pancreatic islet cells against dysfunction and death by inducing autophagy in type 2 diabetes

(2021) Shuai Ji et al.   PHYTOMEDICINE

Defining type 2 diabetes remission: KISS goodbye to confusion?

(2021) Shahrad Taheri   Lancet Diabetes & Endocrinology

IRS1/PI3K/AKT pathway signal involved in the regulation of glycolipid metabolic abnormalities by Mulberry (Morus alba L.) leaf extracts in 3T3-L1 adipocytes

(2020) Qinghai Meng et al.   Chinese Medicine

Extended Intake of Mulberry Leaf Extract Delayed Metformin Elimination via Inhibiting the Organic Cation Transporter 2

(2020) Hyun Wook Huh et al.   Pharmaceutics

Mulberry Fruit Prevents Diabetes and Diabetic Dementia by Regulation of Blood Glucose through Upregulation of Antioxidative Activities and CREB/BDNF Pathway in Alloxan-Induced Diabetic Mice

(2020) A Young Min et al.   Oxidative Medicine and Cellular Longevity

The Protective Effects of Cryptochlorogenic Acid on β-Cells Function in Diabetes in vivo and vitro via Inhibition of Ferroptosis

(2020) Yi Zhou   Diabetes Metabolic Syndrome and Obesity-Targets and Therapy

Inhibition of PTP1B by farnesylated 2-arylbenzofurans isolated from Morus alba root bark: unraveling the mechanism of inhibition based on in vitro and in silico studies

(2020) Manh Tuan Ha et al.   ARCHIVES OF PHARMACAL RESEARCH

2. Classification and Diagnosis of Diabetes: Standards of Medical Care in Diabetes—2021

(2020)   DIABETES CARE

Hypoglycaemia, cardiovascular disease, and mortality in diabetes: epidemiology, pathogenesis, and management

(2019) Stephanie A Amiel et al.   Lancet Diabetes & Endocrinology

Effects of unaltered and bioconverted mulberry leaf extracts on cellular glucose uptake and antidiabetic action in animals

(2019) Sang-Hyuk Jung et al.   BMC Complementary and Alternative Medicine

Mulberry leaf active components alleviate type 2 diabetes and its liver and kidney injury in db/db mice through insulin receptor and TGF-β/Smads signaling pathway

(2019) Liwen Zhang et al.   BIOMEDICINE & PHARMACOTHERAPY

IRS-1 targets TAZ to inhibit adipogenesis of rat bone marrow mesenchymal stem cells through PI3K-Akt and MEK-ERK pathways

(2019) Na Wang et al.   EUROPEAN JOURNAL OF PHARMACOLOGY

Investigation on the Enzymatic Profile of Mulberry Alkaloids by Enzymatic Study and Molecular Docking

(2019) Zhihua Liu et al.   MOLECULES

Hypoglycemia in diabetes: The dark side of diabetes treatment. A patient‐centered review

(2019) Brianna Johnson‐Rabbett et al.   Journal of Diabetes

Mortality and Cardiovascular Disease in Type 1 and Type 2 Diabetes

(2019) Thwe Htay et al.   Current Cardiology Reports

Antidiabetic Potential of Flavonoids from Traditional Chinese Medicine: A Review

(2019) Lan Bai et al.   AMERICAN JOURNAL OF CHINESE MEDICINE

Effect of 1-Deoxynojirimycin Isolated from Mulberry Leaves on Glucose Metabolism and Gut Microbiota in a Streptozotocin-Induced Diabetic Mouse Model

(2019) Teng-Gen Hu et al.   JOURNAL OF NATURAL PRODUCTS

Insight into the PTP1B Inhibitory Activity of Arylbenzofurans: An In Vitro and In Silico Study

(2019) Srijan Shrestha et al.   MOLECULES

Mulberry leaf reduces inflammation and insulin resistance in type 2 diabetic mice by TLRs and insulin Signalling pathway

(2019) Simin Tian et al.   BMC Complementary and Alternative Medicine

1-Deoxynojirimycin modulates glucose homeostasis by regulating the combination of IR-GlUT4 and ADIPO-GLUT4 pathways in 3T3-L1 adipocytes

(2019) Qian Li et al.   MOLECULAR BIOLOGY REPORTS

Flavonoids extracted from mulberry (Morus alba L.) leaf improve skeletal muscle mitochondrial function by activating AMPK in type 2 diabetes

(2019) Qinghai Meng et al.   JOURNAL OF ETHNOPHARMACOLOGY

Evaluating Traditional Chinese Medicine and Herbal Products for the Treatment of Gestational Diabetes Mellitus

(2019) Yang Xin Zi Xu et al.   Journal of Diabetes Research

Diabetes, cardiovascular disease and the microcirculation

(2018) W. David Strain et al.   Cardiovascular Diabetology

Protein Tyrosine Phosphatase 1B Inhibition and Glucose Uptake Potentials of Mulberrofuran G, Albanol B, and Kuwanon G from Root Bark of Morus alba L. in Insulin-Resistant HepG2 Cells: An In Vitro and In Silico Study

(2018) Pradeep Paudel et al.   INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES

Quadruple high-resolution α-glucosidase/α-amylase/PTP1B/radical scavenging profiling combined with high-performance liquid chromatography–high-resolution mass spectrometry–solid-phase extraction–nuclear magnetic resonance spectroscopy for identification of antidiabetic constituents in crude root bark of Morus alba L.

(2018) Yong Zhao et al.   JOURNAL OF CHROMATOGRAPHY A

Ferroptosis-inducing agents compromise in vitro human islet viability and function

(2018) Antonio Bruni et al.   Cell Death & Disease

Modulation of gut microbiota by mulberry fruit polysaccharide treatment of obese diabetic db/db mice

(2018) Chun Chen et al.   Food & Function

Meta-Analysis of Sulfonylurea Therapy on Long-Term Risk of Mortality and Cardiovascular Events Compared to Other Oral Glucose-Lowering Treatments

(2018) W. Ryan Powell et al.   Diabetes Therapy

Meta-Analysis of Sulfonylurea Therapy on Long-Term Risk of Mortality and Cardiovascular Events Compared to Other Oral Glucose-Lowering Treatments

(2018) W. Ryan Powell et al.   Diabetes Therapy

Chalcone derivatives from the root bark of Morus alba L. act as inhibitors of PTP1B and α-glucosidase

(2018) Manh Tuan Ha et al.   PHYTOCHEMISTRY

Dietary compounds and traditional Chinese medicine ameliorate type 2 diabetes by modulating gut microbiota

(2018) Qixing Nie et al.   CRITICAL REVIEWS IN FOOD SCIENCE AND NUTRITION

Protective effect of mulberry fruit anthocyanin on human hepatocyte cells (LO2) and Caenorhabditis elegans under hyperglycemic conditions

(2017) Fujie Yan et al.   FOOD RESEARCH INTERNATIONAL

Anti-diabetic effects of mulberry (Morus alba L.) branches and oxyresveratrol in streptozotocin-induced diabetic mice

(2017) Eunyeong Ahn et al.   FOOD SCIENCE AND BIOTECHNOLOGY

Scientific evidence on the links between periodontal diseases and diabetes: Consensus report and guidelines of the joint workshop on periodontal diseases and diabetes by the International Diabetes Federation and the European Federation of Periodontology

(2017) Mariano Sanz et al.   JOURNAL OF CLINICAL PERIODONTOLOGY

Antidiabetic effects of Morus alba fruit polysaccharides on high-fat diet- and streptozotocin-induced type 2 diabetes in rats

(2017) Yukun Jiao et al.   JOURNAL OF ETHNOPHARMACOLOGY

Anthocyanin-rich mulberry fruit improves insulin resistance and protects hepatocytes against oxidative stress during hyperglycemia by regulating AMPK/ACC/mTOR pathway

(2017) Fujie Yan et al.   Journal of Functional Foods

Hypoglycemic effects of a Fructus Mori polysaccharide in vitro and in vivo

(2017) Chun Chen et al.   Food & Function

Mulberry branch bark powder significantly improves hyperglycemia and regulates insulin secretion in type II diabetic mice

(2017) Xiao-Lu Yin et al.   Food & Nutrition Research

Mulberry leaf alleviates streptozotocin-induced diabetic rats by attenuating NEFA signaling and modulating intestinal microflora

(2017) Yao Sheng et al.   Scientific Reports

Mulberry (Morus alba L.) Fruit Extract Containing Anthocyanins Improves Glycemic Control and Insulin Sensitivity via Activation of AMP-Activated Protein Kinase in Diabetic C57BL/Ksj-db/db Mice

(2016) Kyung Ha Choi et al.   JOURNAL OF MEDICINAL FOOD

Mulberry anthocyanin extract ameliorates insulin resistance by regulating PI3K/AKT pathway in HepG2 cells and db/db mice

(2016) Fujie Yan et al.   JOURNAL OF NUTRITIONAL BIOCHEMISTRY

Effect of mulberry leaf (Folium Mori) on insulin resistance via IRS-1/PI3K/Glut-4 signalling pathway in type 2 diabetes mellitus rats

(2016) Shengyu Cai et al.   PHARMACEUTICAL BIOLOGY

Anti-diabetic effect mediated by Ramulus mori polysaccharides

(2015) Lingyuan Xu et al.   CARBOHYDRATE POLYMERS

A polysaccharide extract of mulberry leaf ameliorates hepatic glucose metabolism and insulin signaling in rats with type 2 diabetes induced by high fat-diet and streptozotocin

(2015) Chunjiu Ren et al.   INTERNATIONAL JOURNAL OF BIOLOGICAL MACROMOLECULES

Multiple Comparisons of Glucokinase Activation Mechanisms of Five Mulberry Bioactive Ingredients in Hepatocyte

(2015) Hao He et al.   JOURNAL OF AGRICULTURAL AND FOOD CHEMISTRY

1-Deoxynojirimycin Alleviates Insulin Resistance via Activation of Insulin Signaling PI3K/AKT Pathway in Skeletal Muscle of db/db Mice

(2015) Qingpu Liu et al.   MOLECULES

Diabetes, oxidative stress and therapeutic strategies

(2014) Luc Rochette et al.   BIOCHIMICA ET BIOPHYSICA ACTA-GENERAL SUBJECTS

Cyanidin-3-glucoside isolated from mulberry fruit protects pancreatic β-cells against oxidative stress-induced apoptosis

(2014) JONG SEOK LEE et al.   INTERNATIONAL JOURNAL OF MOLECULAR MEDICINE

Cyanidin-3-glucoside isolated from mulberry fruits protects pancreatic β-cells against glucotoxicity-induced apoptosis

(2014) JONG SEOK LEE et al.   Molecular Medicine Reports

The adipokine/ceramide axis: Key aspects of insulin sensitization

(2013) Jonathan Y. Xia et al.   BIOCHIMIE

Diabetes Mellitus and Inflammation

(2013) Eric Lontchi-Yimagou et al.   Current Diabetes Reports

Anti-diabetic effect of ramulus mori polysaccharides, isolated from Morus alba L., on STZ-diabetic mice through blocking inflammatory response and attenuating oxidative stress

(2013) Chao Guo et al.   INTERNATIONAL IMMUNOPHARMACOLOGY

Comparison of Inhibitory Activities and Mechanisms of Five Mulberry Plant Bioactive Components against α-Glucosidase

(2013) Hao He et al.   JOURNAL OF AGRICULTURAL AND FOOD CHEMISTRY

Antidiabetic and Antioxidant Effects and Phytochemicals of Mulberry Fruit (Morus alba L.) Polyphenol Enhanced Extract

(2013) Yihai Wang et al.   PLoS One

Rapid screening and identification ofα-glucosidase inhibitors from mulberry leaves using enzyme-immobilized magnetic beads coupled with HPLC/MS and NMR

(2012) Yi Tao et al.   BIOMEDICAL CHROMATOGRAPHY

Chlorogenic Acid and Rutin Play a Major Role in the In Vivo Anti-Diabetic Activity of Morus alba Leaf Extract on Type II Diabetic Rats

(2012) Attila Hunyadi et al.   PLoS One

Repeated ingestion of the leaf extract from Morus alba reduces insulin resistance in KK-Ay mice

(2011) Kenichi Tanabe et al.   NUTRITION RESEARCH

Carbonyl reductase 1 protects pancreatic β-cells against oxidative stress-induced apoptosis in glucotoxicity and glucolipotoxicity

(2010) M.A. Rashid et al.   FREE RADICAL BIOLOGY AND MEDICINE

In vivo hypoglycemic effects of phenolics from the root bark of Morus alba

(2009) Mi Zhang et al.   FITOTERAPIA

Mulberry leaf extract restores arterial pressure in streptozotocin-induced chronic diabetic rats

(2009) Jarinyaporn Naowaboot et al.   NUTRITION RESEARCH

Quali-quantitative Analyses of Flavonoids of Morus nigra L. and Morus alba L. (Moraceae) Fruits

(2008) Agata Maria Pawlowska et al.   JOURNAL OF AGRICULTURAL AND FOOD CHEMISTRY

Molecular and metabolic mechanisms of insulin resistance and β-cell failure in type 2 diabetes

(2008) Deborah M. Muoio et al.   NATURE REVIEWS MOLECULAR CELL BIOLOGY