Article
Multidisciplinary Sciences
Jingjing Shang, Zhentang Yu, Chengwei Xiong, Junjie Zhang, Jinhong Gong, Changlin Yu, Yong Huang, Xindie Zhou
Summary: Osteogenic differentiation of bone marrow mesenchymal stem cells (BMSCs) plays a crucial role in bone defect regeneration. Resistin, an adipose tissue-specific secretory factor, has diverse functions including metabolism, inflammation, cancer, and bone remodeling. However, the effects and mechanisms of resistin on BMSCs' osteogenic differentiation are still unclear.
Article
Plant Sciences
Chengjian Li, Ying Wang, Chenxi Wu, Jin Zhou, Yanqing Zhou, Yang Jiao, Yamei Li, Liang Zhao
Summary: The study investigated the antitumor activity of Ebracteolatain A (EA) in breast cancer and revealed its mechanism of action. EA inhibited the proliferation and clone formation of breast cancer cells, and arrested cells in the G(0)/G(1) phase. In vivo experiments showed that EA significantly suppressed tumor weight and volume in xenograft nude mice. Furthermore, EA was found to regulate breast cancer by suppressing PKD1 in the MEK/ERK and PI3K/AKT signaling pathways, indicating its potential as a breast cancer drug candidate.
Article
Chemistry, Medicinal
Xin Yang, Long Wang, Jing Zeng, Anguo Wu, Mi Qin, Min Wen, Ting Zhang, Wang Chen, Qibing Mei, Dalian Qin, Jing Yang, Yu Jiang, Jianming Wu
Summary: This study demonstrates that CPM may be a promising thrombopoietic agent for treating chemotherapy and radiation-induced thrombocytopenia.
Article
Biochemistry & Molecular Biology
Ziling Wang, Lu Wang, Rong Jiang, Chang Li, Xiongbin Chen, Hanxianzhi Xiao, Jiying Hou, Ling Hu, Caihong Huang, Yaping Wang
Summary: The study revealed that ginsenoside Rg1 can prevent MSCs from entering senescence state by activating the NRF2 and AKT pathways, enhancing cell antioxidant capacity. This discovery provides new therapeutic targets for preventing cell senescence.
FREE RADICAL BIOLOGY AND MEDICINE
(2021)
Article
Hematology
Hiroyuki Muranushi, Takero Shindo, Toyofumi F. Chen-Yoshikawa, Akihiko Yoshizawa, Huong Thi Ngo, Fumiaki Gochi, Hiroshi Date, Akifumi Takaori-Kondo
Summary: Bronchiolitis and perivascular inflammation are the main features of pGVHD. Cobimetinib, a MEK inhibitor, improves survival rates and suppresses B-cell and monocyte activation. Dual inhibition of the MEK/ERK and PI3K/AKT pathways shows better efficacy in suppressing B-cell activation and improving survival rates in a mouse model. The MEK/ERK and PI3K/AKT pathways play a crucial role in the pathogenesis of pGVHD and may represent a potential therapeutic target.
Article
Cell Biology
Lina Wei, Xiaohong Ma, Yixin Hou, Tianyi Zhao, Rui Sun, Chunping Qiu, Yao Liu, Ziyi Qiu, Zhiming Liu, Jie Jiang
Summary: Progestin resistance is a problem for patients with endometrial carcinoma (EC) who require conservative treatment with progestin, and the underlying mechanisms are unclear. This study found that YAP/TAZ, downstream transcription coactivators of Hippo pathway, were upregulated in progestin resistant tissues and played a role in promoting progestin resistance by regulating the PI3K-Akt pathway.
CELL DEATH DISCOVERY
(2023)
Article
Environmental Sciences
Huiling Chen, Jiangbin Li, Yanchao Zhang, Wei Zhang, Xing Li, Huanwen Tang, Yungang Liu, Tianlan Li, Haoqi He, Bohai Du, Li Li, Ming Shi
Summary: This study aimed to explore the effects of BPF on glucose metabolism and insulin sensitivity. The results showed that BPF treatment altered the expression of adipokines, impaired the insulin signaling pathway, and reduced insulin-stimulated glucose metabolism.
ECOTOXICOLOGY AND ENVIRONMENTAL SAFETY
(2022)
Article
Biochemistry & Molecular Biology
Wang Chen, Linjie Zhu, Long Wang, Jing Zeng, Min Wen, Xiyan Xu, LiLe Zou, Feihong Huang, Qianqian Huang, Dalian Qin, Qibing Mei, Jing Yang, Qiaozhi Wang, Jianming Wu
Summary: This study found that the aqueous extracts of Cibotii rhizoma (AECRs) can promote megakaryopoiesis and thrombopoiesis through activating the PI3K/AKT, MEK/ERK, and JAK2/STAT3 signaling pathways, which has the potential to treat radiation-induced thrombocytopenia.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2022)
Article
Cell Biology
Xuping Niu, Qixin Han, Xinhua Li, Juan Li, Yanmin Liu, Yan Li, Yan Wu, Kaiming Zhang
Summary: This study investigated the association between DMSCs-derived EDIL3 and psoriasis-associated angiogenesis. It was found that DMSCs-derived EDIL3 and the αvβ3-FAK/MEK/ERK signal pathway play important roles in the pathogenesis of psoriasis.
JOURNAL OF CELLULAR AND MOLECULAR MEDICINE
(2022)
Article
Plant Sciences
Yuan Zhao, Ying Xu, Hongxia Zheng, Na Lin
Summary: This study showed that QingYan Formula has a definite anti-bone loss effect and potential effect on postmenopausal osteoporosis. The mechanism involves the activation of estrogen receptor (ER)-dependent MEK/ERK and PI3K/Akt signal pathways in osteoblast, and down-regulation of ER-dependent p-ERK and ER-independent p-Akt in osteoclast.
JOURNAL OF ETHNOPHARMACOLOGY
(2021)
Article
Cell Biology
Shuyan Han, Zhihua Tian, Huifang Tian, Haibo Han, Jun Zhao, Yanna Jiao, Chunli Wang, Huifeng Hao, Shan Wang, Jialei Fu, Dong Xue, Hong Sun, Pingping Li
Summary: This study examined the role of hepatoma-derived growth factor (HDGF) in gefitinib resistance in non-small cell lung cancer (NSCLC) and identified the underlying mechanisms. The results showed that HDGF overexpression aggravated the malignant phenotype of NSCLC cells, while HDGF knockdown reversed these effects. The overexpression of HDGF also led to gefitinib resistance, while knockdown enhanced gefitinib sensitivity. Higher levels of HDGF in plasma or tumor tissue were associated with gefitinib resistance. HDGF activated the Akt and ERK signaling pathways, independent of EGFR phosphorylation, contributing to gefitinib resistance.
CELL DEATH DISCOVERY
(2023)
Article
Chemistry, Multidisciplinary
Yan-yan Zhao, Jing Jia, Jing-jing Zhang, Yan-ping Xun, Shu-jun Xie, Jia-feng Liang, Hong-gang Guo, Jia-zhen Zhu, Sheng-lin Ma, Shi-rong Zhang
Summary: Recent evidence suggests that the expression levels of histamine receptor H3 (Hrh3) are upregulated in various cancers, including non-small cell lung cancer (NSCLC). High levels of Hrh3 are associated with poor overall survival in NSCLC patients. Inhibition of Hrh3 has shown to inhibit cell growth, induce apoptosis, and suppress migration and invasion of NSCLC cells through signaling pathways such as PI3K/Akt/mTOR and MEK/ERK. Furthermore, in animal studies, Hrh3 antagonist CPX was able to significantly inhibit tumor growth and modulate expression of EMT markers in NSCLC xenograft models.
ACTA PHARMACOLOGICA SINICA
(2021)
Article
Biochemistry & Molecular Biology
Shao-Yue Du, Liang Hu, Bing-He Zhou, Ze Zhang, Ming-Chao Li, Dong Chang, Cong-Jian Xu, Xin Dou
Summary: The commitment of mesenchymal stem cells (MSCs) to preadipocytes and the termination of differentiation into adipocytes are critical for maintaining energy homeostasis, but the molecular mechanisms involved are still not well understood. In this study, we investigated the role of Sox6, a transcription factor, in regulating adipocyte differentiation and discovered its potential as a therapeutic target for obesity and metabolic disorders.
BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS
(2023)
Article
Cell Biology
Ying Zhao, Haokun Liu, Mingzhen Fan, Yuyang Miao, Xiaoe Zhao, Qing Wei, Baohua Ma
Summary: Estrogen regulates the proliferation of goat mammary epithelial cells through the GPR30, MEK/ERK, and PI3K/AKT signaling pathways, providing a theoretical basis for researching estrogen sustained-release drugs promoting breast development and improving lactation performance.
Article
Medicine, Research & Experimental
Chikondi Jassi, Wei-Wen Kuo, Yu-Chun Chang, Tso-Fu Wang, Chi-Cheng Li, Tsung-Jung Ho, Dennis Jine-Yuan Hsieh, Chia-Hua Kuo, Ming-Cheng Chen, Chih-Yang Huang
Summary: The combination of Aloin and CPT-11 has been found to have an enhanced anti-tumor effect in colorectal cancer. This combination reduces cell viability and induces apoptosis, while regulating the expression of miRNA-133b, IGF1R, and their downstream pathways. CPT-11 and Aloin show potential as combination treatment partners against colorectal cancer, with miRNA-133b possibly serving as a co-therapeutic target with IGF1R.
BIOMEDICINE & PHARMACOTHERAPY
(2023)
