Journal
CARBOHYDRATE POLYMERS
Volume 117, Issue -, Pages 63-69Publisher
ELSEVIER SCI LTD
DOI: 10.1016/j.carbpol.2014.09.052
Keywords
Ramulus mori polysaccharides; Hyperglycemia; Apoptosis; Metabolism
Categories
Funding
- Foundation of Traditional Chinese Medicine Department of Guangxi Province, China [GZKZ1157, GZZC1042]
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Diabetes mellitus is a complicated metabolic disease, whose pathogenesis is related to apoptosis within pancreatic tissue. In this study, the potential therapeutic benefits of Ramulus mori polysaccharides (RMP) on streptozotocin (STZ)-induced diabetic mice were evaluated. Our experiments indicated that RMP lowered hyperglycemia and increased insulin levels in diabetic mice. Histopathological examination revealed that RMP contributed to the reduction of STZ-lesioned pancreatic cells. In addition, the serum level of HbAl c was decreased. RMP treatment also showed increased Bcl-2 expression and reduced Bax protein level in pancreatic tissue. Furthermore, intrapancreatic expressions of p-JNK, p-p38 and cleavedcaspase-3 were down-regulated by RMP treatment. Collectively, the findings demonstrate that RMP exerts the pronounced hypoglycemic effect via regulation of the intrapancreatic JNK/p38 pathway to protect against STZ-induced apoptosis in pancreatic tissue, eventually ameliorating metabolic function in the pancreas. (C) 2014 Elsevier Ltd. All rights reserved.
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