Viral Subversion of the Chromosome Region Maintenance 1 Export Pathway and Its Consequences for the Cell Host

Karyopherin-mediated nucleocytoplasmic transport

(2022) Casey E. Wing et al.   NATURE REVIEWS MOLECULAR CELL BIOLOGY

Nuclear Exportin 1 (XPO1) Binds to the Nuclear Localization/Export Signal of the Turnip Mosaic Virus NIb to Promote Viral Infection

(2022) Mingzhen Zhang et al.   Frontiers in Microbiology

Selinexor combined with ibrutinib demonstrates tolerability and safety in advanced B-cell malignancies: A phase I study

(2022) Deborah M. Stephens et al.   CLINICAL CANCER RESEARCH

Staufen‐2 functions as a cofactor for enhanced Rev‐mediated nucleocytoplasmic trafficking of HIV‐1 genomic RNA via the CRM1 pathway

(2022) Kannan Balakrishnan et al.   FEBS Journal

Nup98 Is Subverted from Annulate Lamellae by Hepatitis C Virus Core Protein to Foster Viral Assembly

(2022) Bertrand Boson et al.   mBio

CRM1-spike-mediated nuclear export of hepatitis B virus encapsidated viral RNA

(2022) Ching-Chun Yang et al.   Cell Reports

The XPO1 Inhibitor KPT-8602 Ameliorates Parkinson’s Disease by Inhibiting the NF-κB/NLRP3 Pathway

(2022) Shuhan Liu et al.   Frontiers in Pharmacology

Architecture of the cytoplasmic face of the nuclear pore

(2022) Christopher J. Bley et al.   SCIENCE

Nucleo-Cytoplasmic Transport of ZIKV Non-Structural 3 Protein Is Mediated by Importin-α/β and Exportin CRM-1

(2022) Luis Adrián De Jesús-González et al.   JOURNAL OF VIROLOGY

Recurrent XPO1 mutations alter pathogenesis of chronic lymphocytic leukemia

(2021) Janek S. Walker et al.   Journal of Hematology & Oncology

Characterization of SARS-CoV-2 proteins reveals Orf6 pathogenicity, subcellular localization, host interactions and attenuation by Selinexor

(2021) Jin-Gu Lee et al.   Cell and Bioscience

Selinexor, a novel selective inhibitor of nuclear export, reduces SARS-CoV-2 infection and protects the respiratory system in vivo

(2021) Trinayan Kashyap et al.   ANTIVIRAL RESEARCH

Nuclear exportin 1 facilitates turnip mosaic virus infection by exporting the sumoylated viral replicase and by repressing plant immunity

(2021) Mingzhen Zhang et al.   NEW PHYTOLOGIST

Nucleocytoplasmic Trafficking Perturbation Induced by Picornaviruses

(2021) Belén Lizcano-Perret et al.   Viruses-Basel

A Phase II Study of the Efficacy and Safety of Oral Selinexor in Recurrent Glioblastoma

(2021) Andrew B. Lassman et al.   CLINICAL CANCER RESEARCH

CRM1 Promotes Capsid Disassembly and Nuclear Envelope Translocation of Adenovirus Independently of Its Export Function

(2021) Floriane Lagadec et al.   JOURNAL OF VIROLOGY

HIV-1 hypermethylated guanosine cap licenses specialized translation unaffected by mTOR

(2021) Gatikrushna Singh et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

NXF1 and CRM1 nuclear export pathways orchestrate nuclear export, translation and packaging of murine leukaemia retrovirus unspliced RNA

(2020) M. Mougel et al.   RNA Biology

4E-T-bound mRNAs are stored in a silenced and deadenylated form

(2020) Felix Räsch et al.   GENES & DEVELOPMENT

A SARS-CoV-2 protein interaction map reveals targets for drug repurposing

(2020) David E. Gordon et al.   NATURE

Small Molecule Inhibitors of CRM1

(2020) Bibiana I. Ferreira et al.   Frontiers in Pharmacology

Exportin 1 inhibition as antiviral therapy

(2020) Md. Hafiz Uddin et al.   DRUG DISCOVERY TODAY

XPO1-dependent nuclear export as a target for cancer therapy

(2020) Nancy G. Azizian et al.   Journal of Hematology & Oncology

Characterization of Inhibition Reveals Distinctive Properties for Human and Saccharomyces cerevisiae CRM1

(2020) Alaa Shaikhqasem et al.   JOURNAL OF MEDICINAL CHEMISTRY

Recognition of nuclear export signals by CRM1 carrying the oncogenic E571K mutation

(2020) Jordan M. Baumhardt et al.   MOLECULAR BIOLOGY OF THE CELL

Selinexor in patients with relapsed or refractory diffuse large B-cell lymphoma (SADAL): a single-arm, multinational, multicentre, open-label, phase 2 trial

(2020) Nagesh Kalakonda et al.   Lancet Haematology

Features of Nuclear Export Signals of NS2 Protein of Influenza D Virus

(2020) Lingcai Zhao et al.   Viruses-Basel

XPO1E571K Mutation Modifies Exportin 1 Localisation and Interactome in B-Cell Lymphoma

(2020) Hadjer Miloudi et al.   Cancers

Identification of nuclear localization signal and nuclear export signal of VP1 from the chicken anemia virus and effects on VP2 shuttling in cells

(2019) Jai-Hong Cheng et al.   Virology Journal

Enhanced nuclear protein export in premature aging and rescue of the progeria phenotype by modulation of CRM1 activity

(2019) Ian García‐Aguirre et al.   AGING CELL

Altered nuclear export signal recognition as a driver of oncogenesis

(2019) Justin Taylor et al.   Cancer Discovery

Structural prerequisites for CRM1-dependent nuclear export signaling peptides: accessibility, adapting conformation, and the stability at the binding site

(2019) Yoonji Lee et al.   Scientific Reports

A Heterochromatin-Specific RNA Export Pathway Facilitates piRNA Production

(2019) Mostafa F. ElMaghraby et al.   CELL

STK 38 kinase acts as XPO 1 gatekeeper regulating the nuclear export of autophagy proteins and other cargoes

(2019) Alexandre PJ Martin et al.   EMBO REPORTS

Lessons from studying the AU-rich elements in chronic inflammation and autoimmunity

(2019) Niki Lourou et al.   JOURNAL OF AUTOIMMUNITY

ANP32A and ANP32B are key factors in the Rev-dependent CRM1 pathway for nuclear export of HIV-1 unspliced mRNA

(2019) Yujie Wang et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

XPO1 is a critical player for bortezomib resistance in multiple myeloma: A quantitative proteomic approach

(2019) Venkatesh Chanukuppa et al.   Journal of Proteomics

Oncoviruses Can Drive Cancer by Rewiring Signaling Pathways Through Interface Mimicry

(2019) Emine Guven-Maiorov et al.   Frontiers in Oncology

Evidence for lysosomal biogenesis proteome defect and impaired autophagy in preeclampsia

(2019) Akitoshi Nakashima et al.   Autophagy

Correlation of CRM1-NES affinity with nuclear export activity

(2018) Szu-Chin Fu et al.   MOLECULAR BIOLOGY OF THE CELL

Regulation of inflammatory responses by dynamic subcellular localization of RNA-binding protein Arid5a

(2018) Mitsuru Higa et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Verdinexor Targeting of CRM1 is a Promising Therapeutic Approach against RSV and Influenza Viruses

(2018) et al.   Viruses-Basel

KPT-330, a potent and selective CRM1 inhibitor, exhibits anti-inflammation effects and protection against sepsis

(2018) Ming Wu et al.   BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS

Verdinexor (KPT-335), a selective inhibitor of nuclear export, reduces RSV replication in vitro

(2018) Patricia A. Jorquera et al.   JOURNAL OF VIROLOGY

Nucleocytoplasmic shuttling of the human parainfluenza virus type 2 phosphoprotein

(2018) Junpei Ohtsuka et al.   VIROLOGY

Nuclear export factor 3 regulates localization of small nucleolar RNAs

(2017) Melissa W. Li et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Nuclear export receptor CRM1 recognizes diverse conformations in nuclear export signals

(2017) Ho Yee Joyce Fung et al.   eLife

CRM1 Inhibitors for Antiviral Therapy

(2017) Cynthia Mathew et al.   Frontiers in Microbiology

A Nuclear Attack on Traumatic Brain Injury: Sequestration of Cell Death in the Nucleus

(2016) Naoki Tajiri et al.   CNS Neuroscience & Therapeutics

Manipulation of the N-terminal sequence of the Borna disease virus X protein improves its mitochondrial targeting and neuroprotective potential

(2016) Cécile A. Ferré et al.   FASEB JOURNAL

Antiviral Efficacy of Verdinexor In Vivo in Two Animal Models of Influenza A Virus Infection

(2016) Olivia Perwitasari et al.   PLoS One

Cardiovirus Leader proteins bind exportins: Implications for virus replication and nucleocytoplasmic trafficking inhibition

(2016) Jessica J. Ciomperlik et al.   VIROLOGY

HTLV-1 Rex Tunes the Cellular Environment Favorable for Viral Replication

(2016) Kazumi Nakano et al.   Viruses-Basel

The RanBP2/RanGAP1*SUMO1/Ubc9 SUMO E3 ligase is a disassembly machine for Crm1-dependent nuclear export complexes

(2016) Tobias Ritterhoff et al.   Nature Communications

Selinexor, a Selective Inhibitor of Nuclear Export (SINE) compound, acts through NF-κB deactivation and combines with proteasome inhibitors to synergistically induce tumor cell death

(2016) Trinayan Kashyap et al.   Oncotarget

XPO1 inhibitor combination therapy with bortezomib or carfilzomib induces nuclear localization of IκBα and overcomes acquired proteasome inhibitor resistance in human multiple myeloma

(2016) Joel G. Turner et al.   Oncotarget

Nuclear transport factors: global regulation of mitosis

(2015) Douglass J Forbes et al.   CURRENT OPINION IN CELL BIOLOGY

HBx interacted with Smad4 to deprive activin a growth inhibition function in hepatocyte HL7702 on CRM1 manner

(2015) Ying Shi et al.   TUMOR BIOLOGY

Nuclear export of cutaneous HPV8 E7 oncoprotein is mediated by a leucine-rich nuclear export signal via a CRM1 pathway

(2015) Zeynep Onder et al.   VIROLOGY

Novel reversible selective inhibitor of CRM1 for targeted therapy in ovarian cancer

(2015) Xuejiao Liu et al.   Journal of Ovarian Research

A deep proteomics perspective on CRM1-mediated nuclear export and nucleocytoplasmic partitioning

(2015) Koray Kırlı et al.   eLife

RNA Export through the NPC in Eukaryotes

(2015) Masumi Okamura et al.   Genes

Human Exportin-1 is a Target for Combined Therapy of HIV and AIDS Related Lymphoma

(2015) Eline Boons et al.   EBioMedicine

Interferon-Stimulated Genes: A Complex Web of Host Defenses

(2014) William M. Schneider et al.   Annual Review of Immunology

Components and regulation of nuclear transport processes

(2014) Bastien Cautain et al.   FEBS Journal

The eukaryotic translation initiation factor eIF4E in the nucleus: taking the road less traveled

(2014) Michael J. Osborne et al.   IMMUNOLOGICAL REVIEWS

Nucleo-cytoplasmic transport as a therapeutic target of cancer

(2014) Giovanni Luca Gravina et al.   Journal of Hematology & Oncology

Verdinexor, a Novel Selective Inhibitor of Nuclear Export, Reduces Influenza A Virus Replication In Vitro and In Vivo

(2014) O. Perwitasari et al.   JOURNAL OF VIROLOGY

Causes and consequences of centrosome abnormalities in cancer

(2014) S. A. Godinho et al.   PHILOSOPHICAL TRANSACTIONS OF THE ROYAL SOCIETY B-BIOLOGICAL SCIENCES

Solution structures of Mengovirus Leader protein, its phosphorylated derivatives, and in complex with nuclear transport regulatory protein, RanGTPase

(2014) V. R. Bacot-Davis et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Human protein Staufen-2 promotes HIV-1 proliferation by positively regulating RNA export activity of viral protein Rev

(2014) Atoshi Banerjee et al.   Retrovirology

Atomic basis of CRM1-cargo recognition, release and inhibition

(2014) Ho Yee Joyce Fung et al.   SEMINARS IN CANCER BIOLOGY

DDX3 RNA helicase is required for HIV-1 Tat function

(2013) Mariko Yasuda-Inoue et al.   BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS

UPF1 Is Crucial for the Infectivity of Human Immunodeficiency Virus Type 1 Progeny Virions

(2013) A. K. P. Serquina et al.   JOURNAL OF VIROLOGY

HTLV-1 HBZ positively regulates the mTOR signaling pathway via inhibition of GADD34 activity in the cytoplasm

(2013) R Mukai et al.   ONCOGENE

HBx-Induced NF-κB Signaling in Liver Cells Is Potentially Mediated by the Ternary Complex of HBx with p22-FLIP and NEMO

(2013) Keo-Heun Lim et al.   PLoS One

DDX5 Facilitates HIV-1 Replication as a Cellular Co-Factor of Rev

(2013) Xiuxia Zhou et al.   PLoS One

Structural basis for cooperativity of CRM1 export complex formation

(2013) T. Monecke et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Nuclear export inhibition through covalent conjugation and hydrolysis of Leptomycin B by CRM1

(2013) Qingxiang Sun et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Structure of a Truncation Mutant of the Nuclear Export Factor CRM1 Provides Insights into the Auto-Inhibitory Role of Its C-Terminal Helix

(2013) Cyril Dian et al.   STRUCTURE

Regulation of nuclear factor-κB in autoimmunity

(2013) Shao-Cong Sun et al.   TRENDS IN IMMUNOLOGY

Characterization of the transport signals that mediate the nucleocytoplasmic traffic of low risk HPV11 E7

(2013) Courtney H. McKee et al.   VIROLOGY

Chikungunya virus capsid protein contains nuclear import and export signals

(2013) Saijo Thomas et al.   Virology Journal

A Nuclear Export Signal in the Matrix Protein of Influenza A Virus Is Required for Efficient Virus Replication

(2012) S. Cao et al.   JOURNAL OF VIROLOGY

A Second CRM1-Dependent Nuclear Export Signal in the Influenza A Virus NS2 Protein Contributes to the Nuclear Export of Viral Ribonucleoproteins

(2012) S. Huang et al.   JOURNAL OF VIROLOGY

The HIV-1 Rev response element

(2012) Jason Fernandes et al.   RNA Biology

Human cytomegalovirus UL94 is a nucleocytoplasmic shuttling protein containing two NLSs and one NES

(2012) Yalan Liu et al.   VIRUS RESEARCH

CRM1 plays a nuclear role in transporting snoRNPs to nucleoli in higher eukaryotes

(2012) Celine Verheggen et al.   Nucleus

CRM1 controls the composition of nucleoplasmic pre-snoRNA complexes to licence them for nucleolar transport

(2011) Bérengère Pradet-Balade et al.   EMBO JOURNAL

Ran-dependent nuclear export mediators: a structural perspective

(2011) Thomas Güttler et al.   EMBO JOURNAL

Single-Molecule Studies Reveal that DEAD Box Protein DDX1 Promotes Oligomerization of HIV-1 Rev on the Rev Response Element

(2011) Rae M. Robertson-Anderson et al.   JOURNAL OF MOLECULAR BIOLOGY

DDX1 Is an RNA-Dependent ATPase Involved in HIV-1 Rev Function and Virus Replication

(2011) Stephen P. Edgcomb et al.   JOURNAL OF MOLECULAR BIOLOGY

The E3 Ubiquitin Ligase Activity Associated with the Adenoviral E1B-55K-E4orf6 Complex Does Not Require CRM1-Dependent Export

(2011) M. Schmid et al.   JOURNAL OF VIROLOGY

Requirements for Mouse Mammary Tumor Virus Rem Signal Peptide Processing and Function

(2011) H. Byun et al.   JOURNAL OF VIROLOGY

CRM1-Dependent Transport Supports Cytoplasmic Accumulation of Adenoviral Early Transcripts

(2011) M. Schmid et al.   JOURNAL OF VIROLOGY

Whole-genome sequencing identifies recurrent mutations in chronic lymphocytic leukaemia

(2011) Xose S. Puente et al.   NATURE

Viral-mediated stabilization of AU-rich element containing mRNA contributes to cell transformation

(2011) T Kuroshima et al.   ONCOGENE

Insights into the Function of the CRM1 Cofactor RanBP3 from the Structure of Its Ran-Binding Domain

(2011) Karla Langer et al.   PLoS One

SARS-CoV 9b Protein Diffuses into Nucleus, Undergoes Active Crm1 Mediated Nucleocytoplasmic Export and Triggers Apoptosis When Retained in the Nucleus

(2011) Kulbhushan Sharma et al.   PLoS One

Identification of a Functional, CRM-1-Dependent Nuclear Export Signal in Hepatitis C Virus Core Protein

(2011) Andrea Cerutti et al.   PLoS One

mRNA export and cancer

(2011) Nadeem Siddiqui et al.   Wiley Interdisciplinary Reviews-RNA

Modification of the major tegument protein pp65 of human cytomegalovirus inhibits virus growth and leads to the enhancement of a protein complex with pUL69 and pUL97 in infected cells

(2010) S. Becke et al.   JOURNAL OF GENERAL VIROLOGY

Foamy Virus Nuclear RNA Export Is Distinct from That of Other Retroviruses

(2010) J. Bodem et al.   JOURNAL OF VIROLOGY

Export of Adenoviral Late mRNA from the Nucleus Requires the Nxf1/Tap Export Receptor

(2010) G. Yatherajam et al.   JOURNAL OF VIROLOGY

Venezuelan Equine Encephalitis Virus Capsid Protein Forms a Tetrameric Complex with CRM1 and Importin  /  That Obstructs Nuclear Pore Complex Function

(2010) S. Atasheva et al.   JOURNAL OF VIROLOGY

Nuclear Export of Human Papillomavirus Type 31 E1 Is Regulated by Cdk2 Phosphorylation and Required for Viral Genome Maintenance

(2010) A. Fradet-Turcotte et al.   JOURNAL OF VIROLOGY

Novel cis-active structures in the coding region mediate CRM1-dependent nuclear export of IFN-α 1 mRNA

(2010) Tominori Kimura et al.   Medical Molecular Morphology

The role of pattern-recognition receptors in innate immunity: update on Toll-like receptors

(2010) Taro Kawai et al.   NATURE IMMUNOLOGY

NES consensus redefined by structures of PKI-type and Rev-type nuclear export signals bound to CRM1

(2010) Thomas Güttler et al.   NATURE STRUCTURAL & MOLECULAR BIOLOGY

Trimethylguanosine capping selectively promotes expression of Rev-dependent HIV-1 RNAs

(2010) V. S. R. K. Yedavalli et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Characterization of the nuclear import and export mechanisms of bovine herpesvirus-1 infected cell protein 27

(2010) Qiong Ding et al.   VIRUS RESEARCH

CRM1-mediated Nuclear Export of Dengue Virus RNA Polymerase NS5 Modulates Interleukin-8 Induction and Virus Production

(2009) Stephen M. Rawlinson et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

The Cellular RNA Export Receptor TAP/NXF1 Is Required for ICP27-Mediated Export of Herpes Simplex Virus 1 RNA, but the TREX Complex Adaptor Protein Aly/REF Appears To Be Dispensable

(2009) L. A. Johnson et al.   JOURNAL OF VIROLOGY

Mengovirus-Induced Rearrangement of the Nuclear Pore Complex: Hijacking Cellular Phosphorylation Machinery

(2009) M. V. Bardina et al.   JOURNAL OF VIROLOGY

The Respiratory Syncytial Virus Matrix Protein Possesses a Crm1-Mediated Nuclear Export Mechanism

(2009) R. Ghildyal et al.   JOURNAL OF VIROLOGY

Molecular Determinants for Subcellular Localization of the Severe Acute Respiratory Syndrome Coronavirus Open Reading Frame 3b Protein

(2009) E. C. Freundt et al.   JOURNAL OF VIROLOGY

Structural basis for leucine-rich nuclear export signal recognition by CRM1

(2009) Xiuhua Dong et al.   NATURE

Rev and Rex proteins of human complex retroviruses function with the MMTV Rem-responsive element

(2009) Jennifer A Mertz et al.   Retrovirology

Crystal Structure of the Nuclear Export Receptor CRM1 in Complex with Snurportin1 and RanGTP

(2009) T. Monecke et al.   SCIENCE

Identification of the Nuclear Export and Adjacent Nuclear Localization Signals for ORF45 of Kaposi's Sarcoma-Associated Herpesvirus

(2008) X. Li et al.   JOURNAL OF VIROLOGY

Characterization of a CRM1-Dependent Nuclear Export Signal in the C Terminus of Herpes Simplex Virus Type 1 Tegument Protein UL47

(2008) P. Williams et al.   JOURNAL OF VIROLOGY

Mutually exclusive interactions drive handover of mRNA from export adaptors to TAP

(2008) Guillaume M. Hautbergue et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Protein structure and oligomerization are important for the formation of export-competent HIV-1 Rev-RRE complexes

(2008) Stephen P. Edgcomb et al.   PROTEIN SCIENCE

Identification of the nuclear localization and export signals of high risk HPV16 E7 oncoprotein

(2008) Alixandra A. Knapp et al.   VIROLOGY

Purα as a cellular co-factor of Rev/RRE-mediated expression of HIV-1 intron-containing mRNA

(2007) Rafal Kaminski et al.   JOURNAL OF CELLULAR BIOCHEMISTRY