A Nuclear Attack on Traumatic Brain Injury: Sequestration of Cell Death in the Nucleus

Cytotoxicity of novel, small molecule, CRM1-selective inhibitors of nuclear export (SINE) in colorectal cancer (CRC) cells.

(2017) G. F. Draetta et al.   JOURNAL OF CLINICAL ONCOLOGY

Kainic Acid-Induced Golgi Complex Fragmentation/Dispersal Shifts the Proteolysis of Reelin in Primary Rat Neuronal Cells: An In Vitro Model of Early Stage Epilepsy

(2015) Yuji Kaneko et al.   MOLECULAR NEUROBIOLOGY

Nuclear export inhibitors avert progression in preclinical models of inflammatory demyelination

(2015) Jeffery D Haines et al.   NATURE NEUROSCIENCE

Selective inhibitors of nuclear export (SINE) as novel therapeutics for prostate cancer

(2015) Janet Mendonca et al.   Oncotarget

Suppressed cytokine expression immediatey following traumatic brain injury in neonatal rats indicates an expeditious endogenous anti-inflammatory response

(2014) Naoki Tajiri et al.   BRAIN RESEARCH

Traumatic white matter injury and glial activation: From basic science to clinics

(2014) Zhifeng Kou et al.   GLIA

Hydrogen sulfide-releasing cyclooxygenase inhibitor ATB-346 enhances motor function and reduces cortical lesion volume following traumatic brain injury in mice

(2014) Michela Campolo et al.   Journal of Neuroinflammation

Intravenous Transplants of Human Adipose-Derived Stem Cell Protect the Brain from Traumatic Brain Injury-Induced Neurodegeneration and Motor and Cognitive Impairments: Cell Graft Biodistribution and Soluble Factors in Young and Aged Rats

(2014) N. Tajiri et al.   JOURNAL OF NEUROSCIENCE

Verdinexor, a Novel Selective Inhibitor of Nuclear Export, Reduces Influenza A Virus Replication In Vitro and In Vivo

(2014) O. Perwitasari et al.   JOURNAL OF VIROLOGY

XPO1 (CRM1) Inhibition Represses STAT3 Activation to Drive a Survivin-Dependent Oncogenic Switch in Triple-Negative Breast Cancer

(2014) Y. Cheng et al.   MOLECULAR CANCER THERAPEUTICS

Preclinical Evaluation of the Novel, Orally Bioavailable Selective Inhibitor of Nuclear Export (SINE) KPT-335 in Spontaneous Canine Cancer: Results of a Phase I Study

(2014) Cheryl A. London et al.   PLoS One

Prognostic impact and targeting of CRM1 in acute myeloid leukemia

(2013) K. Kojima et al.   BLOOD

KPT-330 inhibitor of CRM1 (XPO1)-mediated nuclear export has selective anti-leukaemic activity in preclinical models of T-cell acute lymphoblastic leukaemia and acute myeloid leukaemia

(2013) Julia Etchin et al.   BRITISH JOURNAL OF HAEMATOLOGY

Oxygen-Glucose-Deprived Rat Primary Neural Cells Exhibit DJ-1 Translocation into Healthy Mitochondria: A Potent Stroke Therapeutic Target

(2013) Yuji Kaneko et al.   CNS Neuroscience & Therapeutics

Upregulation of CRM1 Relates to Neuronal Apoptosis after Traumatic Brain Injury in Adult Rats

(2013) Aihong Li et al.   JOURNAL OF MOLECULAR NEUROSCIENCE

CRM1 inhibition induces tumor cell cytotoxicity and impairs osteoclastogenesis in multiple myeloma: molecular mechanisms and therapeutic implications

(2013) Y-T Tai et al.   LEUKEMIA

Long-Term Upregulation of Inflammation and Suppression of Cell Proliferation in the Brain of Adult Rats Exposed to Traumatic Brain Injury Using the Controlled Cortical Impact Model

(2013) Sandra A. Acosta et al.   PLoS One

Selective Inhibition of Matrix Metalloproteinase-9 Attenuates Secondary Damage Resulting from Severe Traumatic Brain Injury

(2013) Orr Hadass et al.   PLoS One

Influence of Post-Traumatic Stress Disorder on Neuroinflammation and Cell Proliferation in a Rat Model of Traumatic Brain Injury

(2013) Sandra A. Acosta et al.   PLoS One

Axon Degeneration and Regeneration: Insights from Drosophila Models of Nerve Injury

(2012) Yanshan Fang et al.   Annual Review of Cell and Developmental Biology

Selective inhibitors of nuclear export show that CRM1/XPO1 is a target in chronic lymphocytic leukemia

(2012) R. Lapalombella et al.   BLOOD

Preclinical activity of a novel CRM1 inhibitor in acute myeloid leukemia

(2012) P. Ranganathan et al.   BLOOD

Abstract 3775: Pharmacokinetic (PK) / pharmacodynamic (PD) and efficacy relationship of selective inhibitors of nuclear export (KPT-SINE)

(2012) Yosef Landesman et al.   CANCER RESEARCH

Novel selective inhibitors of nuclear export CRM1 antagonists for therapy in mantle cell lymphoma

(2012) Kejie Zhang et al.   EXPERIMENTAL HEMATOLOGY

Selective Inhibitors of Nuclear Export Block Pancreatic Cancer Cell Proliferation and Reduce Tumor Growth in Mice

(2012) Asfar S. Azmi et al.   GASTROENTEROLOGY

Sulfonylurea Receptor 1 in Central Nervous System Injury: A Focused Review

(2012) J Marc Simard et al.   JOURNAL OF CEREBRAL BLOOD FLOW AND METABOLISM

Estrone Is Neuroprotective in Rats after Traumatic Brain Injury

(2012) Joshua W. Gatson et al.   JOURNAL OF NEUROTRAUMA

Causes and Trends in Traumatic Brain Injury for United States Adolescents

(2012) Anthony O. Asemota et al.   JOURNAL OF NEUROTRAUMA

dSarm/Sarm1 Is Required for Activation of an Injury-Induced Axon Death Pathway

(2012) J. M. Osterloh et al.   SCIENCE

Nuclear export of proteins and drug resistance in cancer

(2011) Joel G. Turner et al.   BIOCHEMICAL PHARMACOLOGY

Ran-dependent nuclear export mediators: a structural perspective

(2011) Thomas Güttler et al.   EMBO JOURNAL

Lateral fluid percussion injury of the brain induces CCL20 inflammatory chemokine expression in rats

(2011) Mahasweta Das et al.   Journal of Neuroinflammation

Recognition of nuclear targeting signals by Karyopherin-β proteins

(2010) Darui Xu et al.   CURRENT OPINION IN STRUCTURAL BIOLOGY

Genetic and histologic evidence implicates role of inflammation in traumatic brain injury-induced apoptosis in the rat cerebral cortex following moderate fluid percussion injury

(2010) H. Shojo et al.   NEUROSCIENCE

Spirulina Promotes Stem Cell Genesis and Protects against LPS Induced Declines in Neural Stem Cell Proliferation

(2010) Adam D. Bachstetter et al.   PLoS One

Identification of Nuclear Export Inhibitors with Potent Anticancer Activity In vivo

(2009) S. C. Mutka et al.   CANCER RESEARCH

HDAC1 nuclear export induced by pathological conditions is essential for the onset of axonal damage

(2009) Jin Young Kim et al.   NATURE NEUROSCIENCE

Embryonic neural stem cells transplanted in middle cerebral artery occlusion model of rats demonstrated potent therapeutic effects, compared to adult neural stem cells

(2008) Kazuya Takahashi et al.   BRAIN RESEARCH

CRM1-Mediated Nuclear Export of Proteins and Drug Resistance in Cancer

(2008) Joel Turner et al.   CURRENT MEDICINAL CHEMISTRY

Minimal Traumatic Brain Injury Induce Apoptotic Cell Death in Mice

(2008) V. Tashlykov et al.   JOURNAL OF MOLECULAR NEUROSCIENCE

A new penumbra: transitioning from injury into repair after stroke

(2008) Eng H Lo   NATURE MEDICINE