Selinexor, a novel selective inhibitor of nuclear export, reduces SARS-CoV-2 infection and protects the respiratory system in vivo

Detection of 2019 novel coronavirus (2019-nCoV) by real-time RT-PCR

(2020) Victor M Corman et al.   Eurosurveillance

Severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) and coronavirus disease-2019 (COVID-19): The epidemic and the challenges

(2020) Chih-Cheng Lai et al.   INTERNATIONAL JOURNAL OF ANTIMICROBIAL AGENTS

The pivotal link between ACE2 deficiency and SARS-CoV-2 infection

(2020) Paolo Verdecchia et al.   European Journal of Internal Medicine

COVID-19: consider cytokine storm syndromes and immunosuppression

(2020) Puja Mehta et al.   LANCET

Mild or Moderate Covid-19

(2020) Rajesh T. Gandhi et al.   NEW ENGLAND JOURNAL OF MEDICINE

Immunomodulation in COVID-19

(2020) Nicholas E Ingraham et al.   Lancet Respiratory Medicine

Network-based drug repurposing for novel coronavirus 2019-nCoV/SARS-CoV-2

(2020) Yadi Zhou et al.   Cell Discovery

SARS-CoV-2 Orf9b suppresses type I interferon responses by targeting TOM70

(2020) He-wei Jiang et al.   Cellular & Molecular Immunology

Organ-specific manifestations of COVID-19 infection

(2020) Maria Gavriatopoulou et al.   CLINICAL AND EXPERIMENTAL MEDICINE

Exportin 1 inhibition as antiviral therapy

(2020) Md. Hafiz Uddin et al.   DRUG DISCOVERY TODAY

Selinexor in patients with relapsed or refractory diffuse large B-cell lymphoma (SADAL): a single-arm, multinational, multicentre, open-label, phase 2 trial

(2020) Nagesh Kalakonda et al.   Lancet Haematology

COVID-19 infection: Origin, transmission, and characteristics of human coronaviruses

(2020) Muhammad Adnan Shereen et al.   Journal of Advanced Research

The ORF6, ORF8 and nucleocapsid proteins of SARS-CoV-2 inhibit type I interferon signaling pathway

(2020) Jin-Yan Li et al.   VIRUS RESEARCH

SARS-CoV-2 ORF3b Is a Potent Interferon Antagonist Whose Activity Is Increased by a Naturally Occurring Elongation Variant

(2020) Yoriyuki Konno et al.   Cell Reports

ACE2 in the Era of SARS-CoV-2: Controversies and Novel Perspectives

(2020) Federica Saponaro et al.   Frontiers in Molecular Biosciences

pCRM1exportome: database of predicted CRM1-dependent Nuclear Export Signal (NES) motifs in cancer-related genes

(2019) Yoonji Lee et al.   BIOINFORMATICS

A comprehensive proteomics analysis of JC virus Agnoprotein-interacting proteins: Agnoprotein primarily targets the host proteins with coiled-coil motifs

(2019) A. Sami Saribas et al.   VIROLOGY

KPT-330, a potent and selective CRM1 inhibitor, exhibits anti-inflammation effects and protection against sepsis

(2018) Ming Wu et al.   BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS

In vitro toxicity and efficacy of verdinexor, an exportin 1 inhibitor, on opportunistic viruses affecting immunocompromised individuals

(2018) Douglas G. Widman et al.   PLoS One

Verdinexor (KPT-335), a selective inhibitor of nuclear export, reduces RSV replication in vitro

(2018) Patricia A. Jorquera et al.   JOURNAL OF VIROLOGY

A Nuclear Attack on Traumatic Brain Injury: Sequestration of Cell Death in the Nucleus

(2016) Naoki Tajiri et al.   CNS Neuroscience & Therapeutics

First-in-Class, First-in-Human Phase I Study of Selinexor, a Selective Inhibitor of Nuclear Export, in Patients With Advanced Solid Tumors

(2016) Albiruni R. Abdul Razak et al.   JOURNAL OF CLINICAL ONCOLOGY

Antiviral Efficacy of Verdinexor In Vivo in Two Animal Models of Influenza A Virus Infection

(2016) Olivia Perwitasari et al.   PLoS One

Mitochondrial Translocation of High Mobility Group Box 1 Facilitates LIM Kinase 2-Mediated Programmed Necrotic Neuronal Death

(2016) Hye-Won Hyun et al.   Frontiers in Cellular Neuroscience

Selinexor, a Selective Inhibitor of Nuclear Export (SINE) compound, acts through NF-κB deactivation and combines with proteasome inhibitors to synergistically induce tumor cell death

(2016) Trinayan Kashyap et al.   Oncotarget

T cell-mediated immune response to respiratory coronaviruses

(2014) Rudragouda Channappanavar et al.   IMMUNOLOGIC RESEARCH

SARS-Coronavirus Open Reading Frame-9b Suppresses Innate Immunity by Targeting Mitochondria and the MAVS/TRAF3/TRAF6 Signalosome

(2014) Chong-Shan Shi et al.   JOURNAL OF IMMUNOLOGY

Verdinexor, a Novel Selective Inhibitor of Nuclear Export, Reduces Influenza A Virus Replication In Vitro and In Vivo

(2014) O. Perwitasari et al.   JOURNAL OF VIROLOGY

TMPRSS2 and ADAM17 Cleave ACE2 Differentially and Only Proteolysis by TMPRSS2 Augments Entry Driven by the Severe Acute Respiratory Syndrome Coronavirus Spike Protein

(2013) A. Heurich et al.   JOURNAL OF VIROLOGY

Nuclear export inhibition through covalent conjugation and hydrolysis of Leptomycin B by CRM1

(2013) Qingxiang Sun et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Ligand-dependent nucleo-cytoplasmic shuttling of peroxisome proliferator-activated receptors, PPARα and PPARγ

(2012) Tomoe Umemoto et al.   GENES TO CELLS

SARS-CoV 9b Protein Diffuses into Nucleus, Undergoes Active Crm1 Mediated Nucleocytoplasmic Export and Triggers Apoptosis When Retained in the Nucleus

(2011) Kulbhushan Sharma et al.   PLoS One

Cessation of HIV-1 Transcription by Inhibiting Regulatory Protein Rev- Mediated RNA Transport

(2009) Yuan Cao et al.   CURRENT HIV RESEARCH

Molecular Determinants for Subcellular Localization of the Severe Acute Respiratory Syndrome Coronavirus Open Reading Frame 3b Protein

(2009) E. C. Freundt et al.   JOURNAL OF VIROLOGY

Nuclear-Cytosolic Transport of COMMD1 Regulates NF-κB and HIF-1 Activity

(2009) Patricia A. J. Muller et al.   TRAFFIC