XPO1E571K Mutation Modifies Exportin 1 Localisation and Interactome in B-Cell Lymphoma

XPO1-dependent nuclear export as a target for cancer therapy

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Targeting nuclear import and export in hematological malignancies

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Recognition of nuclear export signals by CRM1 carrying the oncogenic E571K mutation

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Histamine releasing factor and elongation factor 1 alpha secreted via malaria parasites extracellular vesicles promote immune evasion by inhibiting specific T cell responses

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Altered nuclear export signal recognition as a driver of oncogenesis

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STAT6 is a cargo of exportin 1: Biological relevance in primary mediastinal B-cell lymphoma

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New generation sequencing of targeted genes in the classical and the variant form of hairy cell leukemia highlights mutations in epigenetic regulation genes

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XPO1 in B cell hematological malignancies: from recurrent somatic mutations to targeted therapy

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Gain in the short arm of chromosome 2 (2p+) induces gene overexpression and drug resistance in chronic lymphocytic leukemia: analysis of the central role of XPO1

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RelA NF-κB subunit activation as a therapeutic target in diffuse large B-cell lymphoma

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Recurrent mutations of the exportin 1 gene (XPO1) and their impact on selective inhibitor of nuclear export compounds sensitivity in primary mediastinal B-cell lymphoma

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Nucleophosmin-anaplastic lymphoma kinase: the ultimate oncogene and therapeutic target

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A cellular reporter to evaluate CRM1 nuclear export activity: functional analysis of the cancer-related mutant E571K

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Next-Generation Sequencing in Diffuse Large B-Cell Lymphoma Highlights Molecular Divergence and Therapeutic Opportunities: a LYSA Study

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Detection and prognostic value of recurrent exportin 1 mutations in tumor and cell-free circulating DNA of patients with classical Hodgkin lymphoma

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Structural Biology and Regulation of Protein Import into the Nucleus

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CRISPR-Barcoding for Intratumor Genetic Heterogeneity Modeling and Functional Analysis of Oncogenic Driver Mutations

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The RanBP2/RanGAP1*SUMO1/Ubc9 SUMO E3 ligase is a disassembly machine for Crm1-dependent nuclear export complexes

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Ran GTPase promotes cancer progression via Met receptor-mediated downstream signaling

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Detection and prognostic value of recurrent exportin 1 mutations in tumor and cell-free circulating DNA of patients with classical Hodgkin lymphoma

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A Human Interactome in Three Quantitative Dimensions Organized by Stoichiometries and Abundances

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Importin β1 mediates nuclear factor-κB signal transduction into the nuclei of myeloma cells and affects their proliferation and apoptosis

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Identifying Drug-Target Selectivity of Small-Molecule CRM1/XPO1 Inhibitors by CRISPR/Cas9 Genome Editing

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Upregulation of nuclear transporter, Kpnβ1, contributes to accelerated cell proliferation- and cell adhesion-mediated drug resistance (CAM-DR) in diffuse large B-cell lymphoma

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Identification and characterization of essential genes in the human genome

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Structural and Functional Characterization of CRM1-Nup214 Interactions Reveals Multiple FG-Binding Sites Involved in Nuclear Export

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A deep proteomics perspective on CRM1-mediated nuclear export and nucleocytoplasmic partitioning

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Genomic Landscape of Primary Mediastinal B-Cell Lymphoma Cell Lines

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Importazole, a Small Molecule Inhibitor of the Transport Receptor Importin-β

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Ran Is a Potential Therapeutic Target for Cancer Cells with Molecular Changes Associated with Activation of the PI3K/Akt/mTORC1 and Ras/MEK/ERK Pathways

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Global enhancement of nuclear localization-dependent nuclear transport in transformed cells

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Ran-dependent docking of importin-β to RanBP2/Nup358 filaments is essential for protein import and cell viability

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Whole-genome sequencing identifies recurrent mutations in chronic lymphocytic leukaemia

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Oncogenic Activation of NF- B

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Recurrent mutations of the STAT6 DNA binding domain in primary mediastinal B-cell lymphoma

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Structural basis for leucine-rich nuclear export signal recognition by CRM1

(2009) Xiuhua Dong et al.   NATURE

Crystal Structure of the Nuclear Export Receptor CRM1 in Complex with Snurportin1 and RanGTP

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