Enhanced nuclear protein export in premature aging and rescue of the progeria phenotype by modulation of CRM1 activity

Control of nuclear β-dystroglycan content is crucial for the maintenance of nuclear envelope integrity and function

(2018) Griselda Vélez-Aguilera et al.   BIOCHIMICA ET BIOPHYSICA ACTA-MOLECULAR CELL RESEARCH

Nuclear Export Inhibition Enhances HLH-30/TFEB Activity, Autophagy, and Lifespan

(2018) Melissa J. Silvestrini et al.   Cell Reports

An overview of treatment strategies for Hutchinson-Gilford Progeria syndrome

(2018) Karim Harhouri et al.   Nucleus

An overview of treatment strategies for Hutchinson-Gilford Progeria syndrome

(2018) Karim Harhouri et al.   Nucleus

Consequences of Lamin B1 and Lamin B Receptor Downregulation in Senescence

(2018) Emilie Lukášová et al.   Cells

A nuclear lamina-chromatin-Ran GTPase axis modulates nuclear import and DNA damage signaling

(2018) Natalia Dworak et al.   AGING CELL

Shared molecular and cellular mechanisms of premature ageing and ageing-associated diseases

(2017) Nard Kubben et al.   NATURE REVIEWS MOLECULAR CELL BIOLOGY

Nucleolar expansion and elevated protein translation in premature aging

(2017) Abigail Buchwalter et al.   Nature Communications

Formation of a nucleoplasmic reticulum requires de novo assembly of nascent phospholipids and shows preferential incorporation of nascent lamins

(2017) Marek M. Drozdz et al.   Scientific Reports

Prelamin A impairs 53BP1 nuclear entry by mislocalizing NUP153 and disrupting the Ran gradient

(2016) Andrew M. Cobb et al.   AGING CELL

Interruption of progerin–lamin A/C binding ameliorates Hutchinson-Gilford progeria syndrome phenotype

(2016) Su-Jin Lee et al.   JOURNAL OF CLINICAL INVESTIGATION

Structural Biology and Regulation of Protein Import into the Nucleus

(2016) Mary Christie et al.   JOURNAL OF MOLECULAR BIOLOGY

Importins and exportins as therapeutic targets in cancer

(2016) Amit Mahipal et al.   PHARMACOLOGY & THERAPEUTICS

Methylene blue alleviates nuclear and mitochondrial abnormalities in progeria

(2015) Zheng-Mei Xiong et al.   AGING CELL

Nuclear localization of the dystrophin-associated protein α-dystrobrevin through importin α2/β1 is critical for interaction with the nuclear lamina/maintenance of nuclear integrity

(2015) Areli Aguilar et al.   FASEB JOURNAL

Expression, function, and targeting of the nuclear exporter chromosome region maintenance 1 (CRM1) protein

(2015) Jo Ishizawa et al.   PHARMACOLOGY & THERAPEUTICS

A deep proteomics perspective on CRM1-mediated nuclear export and nucleocytoplasmic partitioning

(2015) Koray Kırlı et al.   eLife

Loss of lamin B1 results in prolongation of S phase and decondensation of chromosome territories

(2014) Jordi Camps et al.   FASEB JOURNAL

A pathway linking oxidative stress and the Ran GTPase system in progeria

(2014) Sutirtha Datta et al.   MOLECULAR BIOLOGY OF THE CELL

Defective nuclear import of Tpr in Progeria reflects the Ran sensitivity of large cargo transport

(2013) Chelsi J. Snow et al.   JOURNAL OF CELL BIOLOGY

The contrasting roles of lamin B1 in cellular aging and human disease

(2013) Oliver Dreesen et al.   Nucleus

Lamin B1 loss is a senescence-associated biomarker

(2012) Adam Freund et al.   MOLECULAR BIOLOGY OF THE CELL

The nuclear exporter, Crm1, is regulated by NFY and Sp1 in cancer cells and repressed by p53 in response to DNA damage

(2011) Pauline J. van der Watt et al.   Biochimica et Biophysica Acta-Gene Regulatory Mechanisms

The role of nuclear lamin B1 in cell proliferation and senescence

(2011) T. Shimi et al.   GENES & DEVELOPMENT

Rapamycin Reverses Cellular Phenotypes and Enhances Mutant Protein Clearance in Hutchinson-Gilford Progeria Syndrome Cells

(2011) K. Cao et al.   Science Translational Medicine

Induction of dystrophin Dp71 expression during neuronal differentiation: opposite roles of Sp1 and AP2α in Dp71 promoter activity

(2009) Sara Luz Morales-Lázaro et al.   JOURNAL OF NEUROCHEMISTRY