Biomechanical Aspects in Bone Tumour Engineering

Targeted therapy for osteosarcoma: a review

(2023) Shizhe Li et al.   JOURNAL OF CANCER RESEARCH AND CLINICAL ONCOLOGY

Surgical Advances in Osteosarcoma

(2021) Marcus J. Brookes et al.   Cancers

Osteosarcoma: a review of current and future therapeutic approaches

(2021) Xin Zhao et al.   Biomedical Engineering Online

Potential Antimetastatic Effect of Timosaponin AIII against Human Osteosarcoma Cells through Regulating the Integrin/FAK/Cofilin Axis

(2021) Yi-Hsien Hsieh et al.   Pharmaceuticals

Bioengineering a humanized 3D tri-culture osteosarcoma model to assess tumor invasiveness and therapy response

(2021) Cátia F. Monteiro et al.   Acta Biomaterialia

The Effect of Fluid Flow Shear Stress and Substrate Stiffness on Yes-Associated Protein (YAP) Activity and Osteogenesis in Murine Osteosarcoma Cells

(2021) Thomas R. Coughlin et al.   Cancers

Osteosarcoma mechanobiology and therapeutic targets

(2021) Zunaira Shoaib et al.   BRITISH JOURNAL OF PHARMACOLOGY

In vitro three-dimensional cell cultures for bone sarcomas

(2021) Javier Munoz-Garcia et al.   Journal of Bone Oncology

Re-epithelialization and immune cell behaviour in an ex vivo human skin model

(2020) Ana Rakita et al.   Scientific Reports

Human Platelet Lysates‐Based Hydrogels: A Novel Personalized 3D Platform for Spheroid Invasion Assessment

(2020) Cátia F. Monteiro et al.   Advanced Science

Correlative Monitoring of Immune Activation and Tissue Damage in Malignant Melanoma—An Algorithm for Identification of Tolerance Breakage During Immune Checkpoint Inhibitor Therapy of Cancer

(2020) Renate U. Wahl et al.   INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES

Concepts of extracellular matrix remodelling in tumour progression and metastasis

(2020) Juliane Winkler et al.   Nature Communications

Tissue engineered platforms for studying primary and metastatic neoplasm behavior in bone

(2020) Victoria L. Thai et al.   JOURNAL OF BIOMECHANICS

Three-Dimensional Spheroids as In Vitro Preclinical Models for Cancer Research

(2020) Bárbara Pinto et al.   Pharmaceutics

In vitro bone metastasis dwelling in a 3D bioengineered niche

(2020) Weijing Han et al.   BIOMATERIALS

The relationship between metastatic potential and in vitro mechanical properties of osteosarcoma cells

(2019) Claude N. Holenstein et al.   MOLECULAR BIOLOGY OF THE CELL

Multiscale modeling of solid stress and tumor cell invasion in response to dynamic mechanical microenvironment

(2019) H. Chen et al.   Biomechanics and Modeling in Mechanobiology

The tumour microenvironment as an integrated framework to understand cancer biology

(2019) Rebeca Burgos-Panadero et al.   CANCER LETTERS

Co-Culture of Osteoblasts and Endothelial Cells on a Microfiber Scaffold to Construct Bone-Like Tissue with Vascular Networks

(2019) Kouki Inomata et al.   Materials

ROCK2 deprivation leads to the inhibition of tumor growth and metastatic potential in osteosarcoma cells through the modulation of YAP activity

(2019) Cinzia Zucchini et al.   JOURNAL OF EXPERIMENTAL & CLINICAL CANCER RESEARCH

Pazopanib in the Treatment of Bone Sarcomas: Clinical Experience

(2019) Ninna Aggerholm-Pedersen et al.   Translational Oncology

Bone Mechanical Properties in Healthy and Diseased States

(2018) Elise F. Morgan et al.   Annual Review of Biomedical Engineering

Biomechanical regulation of drug sensitivity in an engineered model of human tumor

(2018) A. Marturano-Kruik et al.   BIOMATERIALS

Investigating Low-Velocity Fluid Flow in Tumors with Convection-MRI

(2018) Simon Walker-Samuel et al.   CANCER RESEARCH

Quantifying solid stress and elastic energy from excised or in situ tumors

(2018) Hadi T Nia et al.   Nature Protocols

Cellular Mechanotransduction: From Tension to Function

(2018) Fabiana Martino et al.   Frontiers in Physiology

The Solid Mechanics of Cancer and Strategies for Improved Therapy

(2017) Triantafyllos Stylianopoulos   JOURNAL OF BIOMECHANICAL ENGINEERING-TRANSACTIONS OF THE ASME

Effects of Shear Stress Gradients on Ewing Sarcoma Cells Using 3D Printed Scaffolds and Flow Perfusion

(2017) Jordan E. Trachtenberg et al.   ACS Biomaterials-Science & Engineering

Effects of Shear Stress Gradients on Ewing Sarcoma Cells Using 3D Printed Scaffolds and Flow Perfusion

(2017) Jordan E. Trachtenberg et al.   ACS Biomaterials Science & Engineering

Ezrin Inhibition Up-regulates Stress Response Gene Expression

(2016) Haydar Çelik et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Recent Advances in Mechanobiology of Osteosarcoma

(2016) Christos Adamopoulos et al.   JOURNAL OF CELLULAR BIOCHEMISTRY

Zoledronate in combination with chemotherapy and surgery to treat osteosarcoma (OS2006): a randomised, multicentre, open-label, phase 3 trial

(2016) Sophie Piperno-Neumann et al.   LANCET ONCOLOGY

Simvastatin-Induced Apoptosis in Osteosarcoma Cells: A Key Role of RhoA-AMPK/p38 MAPK Signaling in Antitumor Activity

(2016) Walied A. Kamel et al.   MOLECULAR CANCER THERAPEUTICS

Mechanics of intact bone marrow

(2015) Lauren E. Jansen et al.   Journal of the Mechanical Behavior of Biomedical Materials

Flow perfusion effects on three-dimensional culture and drug sensitivity of Ewing sarcoma

(2015) Marco Santoro et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Stem cell mechanobiology: diverse lessons from bone marrow

(2015) Irena L. Ivanovska et al.   TRENDS IN CELL BIOLOGY

Optimum 3D Matrix Stiffness for Maintenance of Cancer Stem Cells Is Dependent on Tissue Origin of Cancer Cells

(2015) Esmaiel Jabbari et al.   PLoS One

Biomechanical forces in the skeleton and their relevance to bone metastasis: Biology and engineering considerations

(2014) Maureen E. Lynch et al.   ADVANCED DRUG DELIVERY REVIEWS

The Role of Mechanical Forces in Tumor Growth and Therapy

(2014) Rakesh K. Jain et al.   Annual Review of Biomedical Engineering

mTOR Signal Transduction Pathways Contribute to TN-C FNIII A1 Overexpression by Mechanical Stress in Osteosarcoma Cells

(2014) Lianhe Zheng et al.   MOLECULES AND CELLS

Interstitial fluid flow in cancer: implications for disease progression and treatment

(2014) Jennifer Munson et al.   Cancer Management and Research

Embedded multicellular spheroids as a biomimetic 3D cancer model for evaluating drug and drug-device combinations

(2013) Kristie M. Charoen et al.   BIOMATERIALS

Insulin Growth Factor-Receptor (IGF-1R) Antibody Cixutumumab Combined with the mTOR Inhibitor Temsirolimus in Patients with Refractory Ewing's Sarcoma Family Tumors

(2012) A. Naing et al.   CLINICAL CANCER RESEARCH

Causes, consequences, and remedies for growth-induced solid stress in murine and human tumors

(2012) T. Stylianopoulos et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Biomechanical Forces Shape the Tumor Microenvironment

(2011) Adrian C. Shieh   ANNALS OF BIOMEDICAL ENGINEERING

Formulated siRNAs targeting Rankl prevent osteolysis and enhance chemotherapeutic response in osteosarcoma models

(2011) Julie Rousseau et al.   JOURNAL OF BONE AND MINERAL RESEARCH

Functional characterization of osteosarcoma cell lines provides representative models to study the human disease

(2011) Alexander B Mohseny et al.   LABORATORY INVESTIGATION

Small molecule inhibitors of ezrin inhibit the invasive phenotype of osteosarcoma cells

(2011) G Bulut et al.   ONCOGENE

Good prognosis of localized osteosarcoma in young patients treated with limb-salvage surgery and chemotherapy

(2011) Marta Hegyi et al.   PEDIATRIC BLOOD & CANCER

Mechanical compression drives cancer cells toward invasive phenotype

(2011) J. M. Tse et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Primary malignant bone tumors—recent developments

(2011) Meera Hameed et al.   SEMINARS IN DIAGNOSTIC PATHOLOGY

Osteosarcoma

(2010) Richard Gorlick et al.   JOURNAL OF BONE AND MINERAL RESEARCH

Mechanical signals as anabolic agents in bone

(2010) Engin Ozcivici et al.   Nature Reviews Rheumatology

Therapeutic efficacy of soluble receptor activator of nuclear factor-κB-Fc delivered by nonviral gene transfer in a mouse model of osteolytic osteosarcoma

(2008) François Lamoureux et al.   MOLECULAR CANCER THERAPEUTICS

The tumour microenvironment: a novel target for cancer therapy

(2008) E Hanna et al.   ORAL DISEASES

Biological Basis of Bone Formation, Remodeling, and Repair—Part III: Biomechanical Forces

(2008) Alexander C. Allori et al.   TISSUE ENGINEERING PART B-REVIEWS