Human Platelet Lysates‐Based Hydrogels: A Novel Personalized 3D Platform for Spheroid Invasion Assessment

Cell force-mediated matrix reorganization underlies multicellular network assembly

(2019) Christopher D. Davidson et al.   Scientific Reports

Design of spherically structured 3D in vitro tumor models -Advances and prospects

(2018) L.P. Ferreira et al.   Acta Biomaterialia

Induction of quiescence (G0) in bone marrow stromal stem cells enhances their stem cell characteristics

(2018) Mohammad Rumman et al.   Stem Cell Research

Blood Plasma Derivatives for Tissue Engineering and Regenerative Medicine Therapies

(2018) Sara Catarina Nunes da Silva Santos et al.   TISSUE ENGINEERING PART B-REVIEWS

Exclusion from spheroid formation identifies loss of essential cell-cell adhesion molecules in colon cancer cells

(2018) Mira Stadler et al.   Scientific Reports

Three-Dimensional in Vitro Cell Culture Models in Drug Discovery and Drug Repositioning

(2018) Sigrid A. Langhans   Frontiers in Pharmacology

Hydrogel microenvironments for cancer spheroid growth and drug screening

(2018) Yunfeng Li et al.   Science Advances

Cell Adhesion and Matrix Stiffness: Coordinating Cancer Cell Invasion and Metastasis

(2018) Vasiliki Gkretsi et al.   Frontiers in Oncology

Bioinstructive microparticles for self-assembly of mesenchymal stem Cell-3D tumor spheroids

(2018) L.P. Ferreira et al.   BIOMATERIALS

Development of a Novel 3D Tumor-tissue Invasion Model for High-throughput, High-content Phenotypic Drug Screening

(2018) T. J. Puls et al.   Scientific Reports

Photopolymerizable Platelet Lysate Hydrogels for Customizable 3D Cell Culture Platforms

(2018) Sara C. Santos et al.   Advanced Healthcare Materials

EphrinB1 promotes cancer cell migration and invasion through the interaction with RhoGDI1

(2017) H J Cho et al.   ONCOGENE

Divide or Conquer: Cell Cycle Regulation of Invasive Behavior

(2017) Abraham Q. Kohrman et al.   TRENDS IN CELL BIOLOGY

Direct evidence for cell adhesion-mediated radioresistance (CAM-RR) on the level of individual integrin β1 clusters

(2017) Laura Babel et al.   Scientific Reports

The therapeutic potential of three-dimensional multipotent mesenchymal stromal cell spheroids

(2017) Yuriy Petrenko et al.   Stem Cell Research & Therapy

Matrix stiffness induces epithelial–mesenchymal transition and promotes chemoresistance in pancreatic cancer cells

(2017) A J Rice et al.   Oncogenesis

Three-dimensional spheroid culture targeting versatile tissue bioassays using a PDMS-based hanging drop array

(2017) Ching-Te Kuo et al.   Scientific Reports

Heralding a new paradigm in 3D tumor modeling

(2016) Eliza L.S. Fong et al.   BIOMATERIALS

Secreted Frizzled-Related Protein 2 (sFRP2) promotes osteosarcoma invasion and metastatic potential

(2016) Piti Techavichit et al.   BMC CANCER

Transforming growth factor β as regulator of cancer stemness and metastasis

(2016) Claudia Bellomo et al.   BRITISH JOURNAL OF CANCER

The complexity of integrins in cancer and new scopes for therapeutic targeting

(2016) Hellyeh Hamidi et al.   BRITISH JOURNAL OF CANCER

Recreating complex pathophysiologies in vitro with extracellular matrix surrogates for anticancer therapeutics screening

(2016) Naledi Shologu et al.   DRUG DISCOVERY TODAY

Cell spheroids: the new frontiers in in vitro models for cancer drug validation

(2016) Maria Chatzinikolaidou   DRUG DISCOVERY TODAY

3D spheroid culture enhances survival and therapeutic capacities of MSCs injected into ischemic kidney

(2016) Yong Xu et al.   JOURNAL OF CELLULAR AND MOLECULAR MEDICINE

The front and rear of collective cell migration

(2016) Roberto Mayor et al.   NATURE REVIEWS MOLECULAR CELL BIOLOGY

Overexpression of long non-coding RNA MFI2 promotes cell proliferation and suppresses apoptosis in human osteosarcoma

(2016) Zhixun Yin et al.   ONCOLOGY REPORTS

Personalized in vitro cancer models to predict therapeutic response: Challenges and a framework for improvement

(2016) Molly M. Morgan et al.   PHARMACOLOGY & THERAPEUTICS

Three-dimensional culture systems in cancer research: Focus on tumor spheroid model

(2016) Sritama Nath et al.   PHARMACOLOGY & THERAPEUTICS

Advancing biomaterials of human origin for tissue engineering

(2016) Fa-Ming Chen et al.   PROGRESS IN POLYMER SCIENCE

Spheroid Culture of Mesenchymal Stem Cells

(2016) Zoe Cesarz et al.   Stem Cells International

Modeling tumor microenvironments using custom-designed biomaterial scaffolds

(2016) Zen Liu et al.   Current Opinion in Chemical Engineering

Evaluation of Consistency in Spheroid Invasion Assays

(2016) Liliana R. Cisneros Castillo et al.   Scientific Reports

Invasive Cell Fate Requires G1 Cell-Cycle Arrest and Histone Deacetylase-Mediated Changes in Gene Expression

(2015) David Q. Matus et al.   DEVELOPMENTAL CELL

Concise Review: Quiescence in Adult Stem Cells: Biological Significance and Relevance to Tissue Regeneration

(2015) Mohammad Rumman et al.   STEM CELLS

Microenvironmental regulation of therapeutic response in cancer

(2015) Florian Klemm et al.   TRENDS IN CELL BIOLOGY

In vivo selection for spine-derived highly metastatic lung cancer cells is associated with increased migration, inflammation and decreased adhesion

(2015) Xiaopan Cai et al.   Oncotarget

N-Cadherin Induction by ECM Stiffness and FAK Overrides the Spreading Requirement for Proliferation of Vascular Smooth Muscle Cells

(2015) Keeley L. Mui et al.   Cell Reports

Media additives to promote spheroid circularity and compactness in hanging drop platform

(2015) Brendan M. Leung et al.   Biomaterials Science

A novel hanging spherical drop system for the generation of cellular spheroids and high throughput combinatorial drug screening

(2015) A. I. Neto et al.   Biomaterials Science

Superhydrophobic Chips for Cell Spheroids High-Throughput Generation and Drug Screening

(2014) Mariana B. Oliveira et al.   ACS Applied Materials & Interfaces

Compressive Stress Inhibits Proliferation in Tumor Spheroids through a Volume Limitation

(2014) Morgan Delarue et al.   BIOPHYSICAL JOURNAL

Remodelling the extracellular matrix in development and disease

(2014) Caroline Bonnans et al.   NATURE REVIEWS MOLECULAR CELL BIOLOGY

Embedded multicellular spheroids as a biomimetic 3D cancer model for evaluating drug and drug-device combinations

(2013) Kristie M. Charoen et al.   BIOMATERIALS

3D pancreatic carcinoma spheroids induce a matrix-rich, chemoresistant phenotype offering a better model for drug testing

(2013) Paola Longati et al.   BMC CANCER

Functional characterisation of osteosarcoma cell lines and identification of mRNAs and miRNAs associated with aggressive cancer phenotypes

(2013) S U Lauvrak et al.   BRITISH JOURNAL OF CANCER

Influence of tumour micro-environment heterogeneity on therapeutic response

(2013) Melissa R. Junttila et al.   NATURE

Vascular Endothelial Growth Factor Receptor-1 Activation Promotes Migration and Invasion of Breast Cancer Cells through Epithelial-Mesenchymal Transition

(2013) Qian Ning et al.   PLoS One

Mechanical Stress Impairs Mitosis Progression in Multi-Cellular Tumor Spheroids

(2013) Annaïck Desmaison et al.   PLoS One

TGF-β1 exposure induces epithelial to mesenchymal transition both in CSCs and non-CSCs of the A549 cell line, leading to an increase of migration ability in the CD133+ A549 cell fraction

(2013) V Tirino et al.   Cell Death & Disease

Three-dimensional cell culture: the missing link in drug discovery

(2012) Susan Breslin et al.   DRUG DISCOVERY TODAY

Screening therapeutic EMT blocking agents in a three-dimensional microenvironment

(2012) Amir R. Aref et al.   Integrative Biology

In vitro cell migration and invasion assays

(2012) Nina Kramer et al.   MUTATION RESEARCH-REVIEWS IN MUTATION RESEARCH

p21CIP1 mediates reciprocal switching between proliferation and invasion during metastasis

(2012) X Qian et al.   ONCOGENE

Alteration of Cellular Behavior and Response to PI3K Pathway Inhibition by Culture in 3D Collagen Gels

(2012) Brian Fallica et al.   PLoS One

ECM microenvironment regulates collective migration and local dissemination in normal and malignant mammary epithelium

(2012) K.-V. Nguyen-Ngoc et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Spheroid confrontation assay: A simple method to monitor the three-dimensional migration of different cell types in vitro

(2011) Kirsten Hattermann et al.   ANNALS OF ANATOMY-ANATOMISCHER ANZEIGER

384 hanging drop arrays give excellent Z-factors and allow versatile formation of co-culture spheroids

(2011) Amy Y. Hsiao et al.   BIOTECHNOLOGY AND BIOENGINEERING

Remodeling and homeostasis of the extracellular matrix: implications for fibrotic diseases and cancer

(2011) T. R. Cox et al.   Disease Models & Mechanisms

International Association for the Study of Lung Cancer/American Thoracic Society/European Respiratory Society International Multidisciplinary Classification of Lung Adenocarcinoma

(2011) William D. Travis et al.   Journal of Thoracic Oncology

Mechanical compression drives cancer cells toward invasive phenotype

(2011) J. M. Tse et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

E-Cadherin Protects Primary Hepatocyte Spheroids from Cell Death by a Caspase-Independent Mechanism

(2010) Jennifer L. Luebke-Wheeler et al.   CELL TRANSPLANTATION

Multicellular tumor spheroids: An underestimated tool is catching up again

(2010) Franziska Hirschhaeuser et al.   JOURNAL OF BIOTECHNOLOGY

Matrix Rigidity Regulates Cancer Cell Growth and Cellular Phenotype

(2010) Robert W. Tilghman et al.   PLoS One

Aggregation of human mesenchymal stromal cells (MSCs) into 3D spheroids enhances their antiinflammatory properties

(2010) T. J. Bartosh et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Epidermal growth factor signalling and bone metastasis

(2009) X Lu et al.   BRITISH JOURNAL OF CANCER

Matrix Crosslinking Forces Tumor Progression by Enhancing Integrin Signaling

(2009) Kandice R. Levental et al.   CELL

Collective cell migration in morphogenesis, regeneration and cancer

(2009) Peter Friedl et al.   NATURE REVIEWS MOLECULAR CELL BIOLOGY

Micro-Environmental Mechanical Stress Controls Tumor Spheroid Size and Morphology by Suppressing Proliferation and Inducing Apoptosis in Cancer Cells

(2009) Gang Cheng et al.   PLoS One

In vivo Switching of Human Melanoma Cells between Proliferative and Invasive States

(2008) K. S. Hoek et al.   CANCER RESEARCH

Compact spheroid formation by ovarian cancer cells is associated with contractile behavior and an invasive phenotype

(2008) Katharine L. Sodek et al.   INTERNATIONAL JOURNAL OF CANCER

Bone Marrow-Derived Human Mesenchymal Stem Cells Become Quiescent on Soft Substrates but Remain Responsive to Chemical or Mechanical Stimuli

(2008) Jessamine P. Winer et al.   TISSUE ENGINEERING PART A