Biomechanical Forces Shape the Tumor Microenvironment

Dynamic Contrast-Enhanced Magnetic Resonance Imaging of Tumor-Induced Lymph Flow

(2015) Alanna Ruddell et al.   NEOPLASIA

Increased Plasma Colloid Osmotic Pressure Facilitates the Uptake of Therapeutic Macromolecules in a Xenograft Tumor Model

(2015) Matthias Hofmann et al.   NEOPLASIA

Orthodontic mechanical tension effects on the myofibroblast expression of alpha-smooth muscle actin

(2010) Yao Meng et al.   ANGLE ORTHODONTIST

Gene Expression Profiles in 3D Tumor Analogs Indicate Compressive Strain Differentially Enhances Metastatic Potential

(2010) Zoe N. Demou   ANNALS OF BIOMEDICAL ENGINEERING

Mechanical Force Affects Expression of an In Vitro Metastasis-Like Phenotype in HCT-8 Cells

(2010) Xin Tang et al.   BIOPHYSICAL JOURNAL

Cancer Cell Stiffness: Integrated Roles of Three-Dimensional Matrix Stiffness and Transforming Potential

(2010) Erin L. Baker et al.   BIOPHYSICAL JOURNAL

Transmural Flow Modulates Cell and Fluid Transport Functions of Lymphatic Endothelium

(2010) Dimana O. Miteva et al.   CIRCULATION RESEARCH

Quantitative Endoscopic Ultrasound Elastography: An Accurate Method for the Differentiation of Solid Pancreatic Masses

(2010) Julio Iglesias–Garcia et al.   GASTROENTEROLOGY

Endogenous patterns of mechanical stress are required for branching morphogenesis

(2010) Nikolce Gjorevski et al.   Integrative Biology

Compressive mechanical force augments osteoclastogenesis by bone marrow macrophages through activation of c-Fms-mediated signaling

(2010) Eui-Sic Cho et al.   JOURNAL OF CELLULAR BIOCHEMISTRY

Mechanical stiffness of liver tissues in relation to integrin β1 expression may influence the development of hepatic cirrhosis and hepatocellular carcinoma

(2010) Gang Zhao et al.   JOURNAL OF SURGICAL ONCOLOGY

Tumor Microvasculature and Microenvironment: Novel Insights Through Intravital Imaging in Pre-Clinical Models

(2010) DAI FUKUMURA et al.   MICROCIRCULATION

Extracellular matrix rigidity modulates neuroblastoma cell differentiation and N-myc expression

(2010) Wilbur A Lam et al.   Molecular Cancer

Allosteric inhibition of lysyl oxidase–like-2 impedes the development of a pathologic microenvironment

(2010) Vivian Barry-Hamilton et al.   NATURE MEDICINE

Matrix Rigidity Regulates Cancer Cell Growth and Cellular Phenotype

(2010) Robert W. Tilghman et al.   PLoS One

Shear Stress Modulation of Smooth Muscle Cell Marker Genes in 2-D and 3-D Depends on Mechanotransduction by Heparan Sulfate Proteoglycans and ERK1/2

(2010) Zhong-Dong Shi et al.   PLoS One

Induction of Lymphoidlike Stroma and Immune Escape by Tumors That Express the Chemokine CCL21

(2010) J. D. Shields et al.   SCIENCE

Endothelial cell traction and ECM density influence both capillary morphogenesis and maintenance in 3-D

(2009) Ekaterina Kniazeva et al.   AMERICAN JOURNAL OF PHYSIOLOGY-CELL PHYSIOLOGY

Interstitial flow promotes vascular fibroblast, myofibroblast, and smooth muscle cell motility in 3-D collagen I via upregulation of MMP-1

(2009) Zhong-Dong Shi et al.   AMERICAN JOURNAL OF PHYSIOLOGY-HEART AND CIRCULATORY PHYSIOLOGY

Interstitial flow induces MMP-1 expression and vascular SMC migration in collagen I gels via an ERK1/2-dependent and c-Jun-mediated mechanism

(2009) Zhong-Dong Shi et al.   AMERICAN JOURNAL OF PHYSIOLOGY-HEART AND CIRCULATORY PHYSIOLOGY

Extracellular Matrix Stiffness and Architecture Govern Intracellular Rheology in Cancer

(2009) Erin L. Baker et al.   BIOPHYSICAL JOURNAL

The Mechanical Rigidity of the Extracellular Matrix Regulates the Structure, Motility, and Proliferation of Glioma Cells

(2009) T. A. Ulrich et al.   CANCER RESEARCH

Matrix Crosslinking Forces Tumor Progression by Enhancing Integrin Signaling

(2009) Kandice R. Levental et al.   CELL

Cell-Cycle Control by Physiological Matrix Elasticity and In Vivo Tissue Stiffening

(2009) Eric A. Klein et al.   CURRENT BIOLOGY

Liver stiffness measurement in patients with cirrhosis and hepatocellular carcinoma: a case–control study

(2009) Pierre Nahon et al.   EUROPEAN JOURNAL OF GASTROENTEROLOGY & HEPATOLOGY

Study of tumor blood perfusion and its variation due to vascular normalization by anti-angiogenic therapy based on 3D angiogenic microvasculature

(2009) Jie Wu et al.   JOURNAL OF BIOMECHANICS

Cells in 3D matrices under interstitial flow: Effects of extracellular matrix alignment on cell shear stress and drag forces

(2009) John A. Pedersen et al.   JOURNAL OF BIOMECHANICS

Matrix Architecture Dictates Three-Dimensional Migration Modes of Human Macrophages: Differential Involvement of Proteases and Podosome-Like Structures

(2009) E. Van Goethem et al.   JOURNAL OF IMMUNOLOGY

Measuring microenvironment mechanical stress of rat liver during diethylnitrosamine induced hepatocarcinogenesis by atomic force microscope

(2009) Zhao Gang et al.   MICROSCOPY RESEARCH AND TECHNIQUE

Biomechanical regulation of blood vessel growth during tissue vascularization

(2009) Witold W Kilarski et al.   NATURE MEDICINE

Matrix density-induced mechanoregulation of breast cell phenotype, signaling and gene expression through a FAK–ERK linkage

(2009) P P Provenzano et al.   ONCOGENE

Micro-Environmental Mechanical Stress Controls Tumor Spheroid Size and Morphology by Suppressing Proliferation and Inducing Apoptosis in Cancer Cells

(2009) Gang Cheng et al.   PLoS One

Non-Linear Elasticity of Extracellular Matrices Enables Contractile Cells to Communicate Local Position and Orientation

(2009) Jessamine P. Winer et al.   PLoS One

Differential Matrix Rigidity Response in Breast Cancer Cell Lines Correlates with the Tissue Tropism

(2009) Ana Kostic et al.   PLoS One

Guiding cell migration in 3D: A collagen matrix with graded directional stiffness

(2009) Ektoras Hadjipanayi et al.   CELL MOTILITY AND THE CYTOSKELETON

Contact Guidance Mediated Three-Dimensional Cell Migration is Regulated by Rho/ROCK-Dependent Matrix Reorganization

(2008) Paolo P. Provenzano et al.   BIOPHYSICAL JOURNAL

Collagen density promotes mammary tumor initiation and progression

(2008) Paolo P Provenzano et al.   BMC Medicine

A Balance of Substrate Mechanics and Matrix Chemistry Regulates Endothelial Cell Network Assembly

(2008) Joseph P. Califano et al.   Cellular and Molecular Bioengineering

Tumor interstitial fluid pressure may regulate angiogenic factors in osteosarcoma

(2008) Saminathan S. Nathan et al.   JOURNAL OF ORTHOPAEDIC RESEARCH

Three-dimensional lithographically defined organotypic tissue arrays for quantitative analysis of morphogenesis and neoplastic progression

(2008) Celeste M Nelson et al.   Nature Protocols

Mechanotransduction gone awry

(2008) Diana E. Jaalouk et al.   NATURE REVIEWS MOLECULAR CELL BIOLOGY

Tumor-derived endothelial cells exhibit aberrant Rho-mediated mechanosensing and abnormal angiogenesis in vitro

(2008) K. Ghosh et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Hemodynamic shear stress and the endothelium in cardiovascular pathophysiology

(2008) Peter F Davies   Nature clinical practice. Cardiovascular medicine