Formulated siRNAs targeting Rankl prevent osteolysis and enhance chemotherapeutic response in osteosarcoma models

Bisphosphonate-associated adverse events

(2014) Peter Papapetrou   Hormones-International Journal of Endocrinology and Metabolism

Inhibition of RANKL increases the anti-tumor effect of the EGFR inhibitor panitumumab in a murine model of bone metastasis

(2010) Jude Canon et al.   BONE

Glucose Transporter Protein 1–Targeted RNA Interference Inhibits Growth and Invasion of the Osteosarcoma Cell Line MG63 In Vitro

(2010) Jian Fan et al.   CANCER BIOTHERAPY AND RADIOPHARMACEUTICALS

Advantages of bioluminescence imaging to follow siRNA or chemotherapeutic treatments in osteosarcoma preclinical models

(2010) J Rousseau et al.   CANCER GENE THERAPY

Loss of Osteoclasts Contributes to Development of Osteosarcoma Pulmonary Metastases

(2010) L. Endo-Munoz et al.   CANCER RESEARCH

Novel Bone-Targeted Strategies in Oncology

(2010) S. Vallet et al.   CLINICAL CANCER RESEARCH

Pediatric osteogenic sarcoma

(2010) Han Jo Kim et al.   CURRENT OPINION IN PEDIATRICS

Bisphosphonates and RANK ligand inhibitors for the treatment and prevention of metastatic bone disease

(2010) H.L. Neville-Webbe et al.   EUROPEAN JOURNAL OF CANCER

MVA-nef induces HIV-1-specific polyfunctional and proliferative T-cell responses revealed by the combination of short- and long-term immune assays

(2010) S Kutscher et al.   GENE THERAPY

Preventing metastases to bone: Denosumab or bisphosphonates?

(2010) Mark S Nanes   JOURNAL OF BONE AND MINERAL RESEARCH

Renal toxicity in patients with multiple myeloma receiving zoledronic acid vs. ibandronate: A retrospective medical records review

(2010) MeiSheng Duh et al.   Journal of Cancer Research and Therapeutics

Denosumab Compared With Zoledronic Acid for the Treatment of Bone Metastases in Patients With Advanced Breast Cancer: A Randomized, Double-Blind Study

(2010) Alison T. Stopeck et al.   JOURNAL OF CLINICAL ONCOLOGY

Denosumab for the Treatment of Osteoporosis

(2010) Jameel Iqbal et al.   Current Osteoporosis Reports

Enhanced chemosensitivity of drug-resistant osteosarcoma cells by lentivirus-mediated Bcl-2 silencing

(2009) Yao Zhao et al.   BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS

RNA Interference Technologies and Therapeutics

(2009) Marta López-Fraga et al.   BIODRUGS

Control of RANKL gene expression

(2009) Charles A. O'Brien   BONE

High-Dose Zoledronic Acid Impacts Bone Remodeling with Effects on Osteoblastic Lineage and Bone Mechanical Properties

(2009) S. Pozzi et al.   CLINICAL CANCER RESEARCH

RANKL inhibition: Clinical implications for the management of patients with multiple myeloma and solid tumors with bone metastases

(2009) Evangelos Terpos et al.   EXPERT OPINION ON BIOLOGICAL THERAPY

Effects of denosumab in patients with bone metastases with and without previous bisphosphonate exposure

(2009) Jean-Jacques Body et al.   JOURNAL OF BONE AND MINERAL RESEARCH

siRNA and Innate Immunity

(2009) Marjorie Robbins et al.   OLIGONUCLEOTIDES

Efficient suppression of murine arthritis by combined anticytokine small interfering RNA lipoplexes

(2008) Maroun Khoury et al.   ARTHRITIS AND RHEUMATISM

Risks and benefits of bisphosphonates

(2008) R E Coleman   BRITISH JOURNAL OF CANCER

Current and future treatments of bone metastases

(2008) JCM Clark et al.   EXPERT OPINION ON EMERGING DRUGS

Frequency and Risk Factors Associated With Osteonecrosis of the Jaw in Cancer Patients Treated With Intravenous Bisphosphonates

(2008) Ana O Hoff et al.   JOURNAL OF BONE AND MINERAL RESEARCH

RANK ligand inhibition plus docetaxel improves survival and reduces tumor burden in a murine model of prostate cancer bone metastasis

(2008) R. E. Miller et al.   MOLECULAR CANCER THERAPEUTICS

Therapeutic efficacy of soluble receptor activator of nuclear factor-κB-Fc delivered by nonviral gene transfer in a mouse model of osteolytic osteosarcoma

(2008) François Lamoureux et al.   MOLECULAR CANCER THERAPEUTICS

Sequence- and target-independent angiogenesis suppression by siRNA via TLR3

(2008) Mark E. Kleinman et al.   NATURE