Dynamic interplay between human alpha-satellite DNA structure and centromere functions

Centromeres as universal hotspots of DNA breakage, driving RAD51-mediated recombination during quiescence

(2023) Xanita Saayman et al.   MOLECULAR CELL

Targeted assembly of ectopic kinetochores to induce chromosome‐specific segmental aneuploidies

(2023) Laura Tovini et al.   EMBO JOURNAL

A kinesin‐based approach for inducing chromosome‐specific mis‐segregation in human cells

(2023) My Anh Truong et al.   EMBO JOURNAL

Visualization of the three-dimensional structure of the human centromere in mitotic chromosomes by superresolution microscopy

(2023) Elena Di Tommaso et al.   MOLECULAR BIOLOGY OF THE CELL

Emerging roles of DNA repair factors in the stability of centromeres

(2023) Francesca Marcon et al.   SEMINARS IN CELL & DEVELOPMENTAL BIOLOGY

The implications of satellite DNA instability on cellular function and evolution

(2023) Jullien M. Flynn et al.   SEMINARS IN CELL & DEVELOPMENTAL BIOLOGY

CENP-B-mediated DNA loops regulate activity and stability of human centromeres

(2022) Florian Chardon et al.   MOLECULAR CELL

Complete genomic and epigenetic maps of human centromeres

(2022) Nicolas Altemose et al.   SCIENCE

Epigenetic patterns in a complete human genome

(2022) Ariel Gershman et al.   SCIENCE

The complete sequence of a human genome

(2022) Sergey Nurk et al.   SCIENCE

Recombination of repeat elements generates somatic complexity in human genomes

(2022) Giovanni Pascarella et al.   CELL

Nuclear chromosome locations dictate segregation error frequencies

(2022) Sjoerd J. Klaasen et al.   NATURE

Semi-automated assembly of high-quality diploid human reference genomes

(2022) Erich D. Jarvis et al.   NATURE

RNA polymerase III is required for the repair of DNA double-strand breaks by homologous recombination

(2021) Sijie Liu et al.   CELL

CENP-A chromatin prevents replication stress at centromeres to avoid structural aneuploidy

(2021) Simona Giunta et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

The structure, function and evolution of a complete human chromosome 8

(2021) Glennis A. Logsdon et al.   NATURE

RNA transcripts stimulate homologous recombination by forming DR-loops

(2021) Jian Ouyang et al.   NATURE

R-loops as Janus-faced modulators of DNA repair

(2021) Aline Marnef et al.   NATURE CELL BIOLOGY

Immune evasion in HPV− head and neck precancer–cancer transition is driven by an aneuploid switch involving chromosome 9p loss

(2021) William N. William et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

CENP-B promotes the centromeric localization of ZFAT to control transcription of non-coding RNA

(2021) Shuhei Ishikura et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

DNA-RNA hybrids at DSBs interfere with repair by homologous recombination

(2021) Pedro Ortega et al.   eLife

Assembly principles and stoichiometry of a complete human kinetochore module

(2021) Kai Walstein et al.   Science Advances

Variation and Evolution of Human Centromeres: A Field Guide and Perspective

(2021) Karen H. Miga et al.   Annual Review of Genetics

Diverse mechanisms of centromere specification

(2021) Barbara G. Mellone et al.   CURRENT BIOLOGY

Activation of homologous recombination in G1 preserves centromeric integrity

(2021) Duygu Yilmaz et al.   NATURE

The Aurora B gradient sustains kinetochore stability in anaphase

(2021) Diana Papini et al.   Cell Reports

What makes a centromere?

(2020) Paul B. Talbert et al.   EXPERIMENTAL CELL RESEARCH

Genome-wide Nucleotide-Resolution Mapping of DNA Replication Patterns, Single-Strand Breaks, and Lesions by GLOE-Seq

(2020) Annie M. Sriramachandran et al.   MOLECULAR CELL

Centromeres under Pressure: Evolutionary Innovation in Conflict with Conserved Function

(2020) Elisa Balzano et al.   Genes

A dCas9-Based System Identifies a Central Role for Ctf19 in Kinetochore-Derived Suppression of Meiotic Recombination

(2020) Lisa-Marie Kuhl et al.   GENETICS

Stable inheritance of CENP-A chromatin: Inner strength versus dynamic control

(2020) Sreyoshi Mitra et al.   JOURNAL OF CELL BIOLOGY

Pervasive chromosomal instability and karyotype order in tumour evolution

(2020) Thomas B. K. Watkins et al.   NATURE

Genome (in)stability at tandem repeats

(2020) Elisa Balzano et al.   SEMINARS IN CELL & DEVELOPMENTAL BIOLOGY

Kinetochores, cohesin and DNA breaks: controlling meiotic recombination within pericentromeres

(2019) Lisa-Marie Kuhl et al.   YEAST

The nucleosomes that mark centromere location on chromosomes old and new

(2019) Craig W. Gambogi et al.   Essays in Biochemistry

Mosaic origin of the eukaryotic kinetochore

(2019) Eelco C. Tromer et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

The structure of the Ctf19c/CCAN from budding yeast

(2019) Stephen M Hinshaw et al.   eLife

Next-Generation Sequencing Enables Spatiotemporal Resolution of Human Centromere Replication Timing

(2019) Dashiell J. Massey et al.   Genes

Structure of the inner kinetochore CCAN complex assembled onto a centromeric nucleosome

(2019) Kaige Yan et al.   NATURE

CENP-A nucleosome clusters form rosette-like structures around HJURP during G1

(2019) Leonid Andronov et al.   Nature Communications

Genomic and Functional Approaches to Understanding Cancer Aneuploidy

(2018) Alison M. Taylor et al.   CANCER CELL

Simple and Complex Centromeric Satellites inDrosophilaSibling Species

(2018) Paul B. Talbert et al.   GENETICS

Non-B-Form DNA Is Enriched at Centromeres

(2018) Sivakanthan Kasinathan et al.   MOLECULAR BIOLOGY AND EVOLUTION

Simple and Complex Centromeric Satellites inDrosophilaSibling Species

(2018) Paul B. Talbert et al.   GENETICS

The dark side of centromeres: types, causes and consequences of structural abnormalities implicating centromeric DNA

(2018) V. Barra et al.   Nature Communications

Repetitive Fragile Sites: Centromere Satellite DNA As a Source of Genome Instability in Human Diseases

(2018) Elizabeth M. Black et al.   Genes

Genome-wide analysis of somatic copy number alterations and chromosomal breakages in osteosarcoma

(2017) Jan Smida et al.   INTERNATIONAL JOURNAL OF CANCER

Integrity of the human centromere DNA repeats is protected by CENP-A, CENP-C, and CENP-T

(2017) Simona Giunta et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

A mitosis-specific and R loop–driven ATR pathway promotes faithful chromosome segregation

(2017) Lilian Kabeche et al.   SCIENCE

CENP-B protects centromere chromatin integrity by facilitating histone deposition via the H3.3-specific chaperone Daxx

(2017) Viacheslav M. Morozov et al.   Epigenetics & Chromatin

Transient RNA-DNA Hybrids Are Required for Efficient Double-Strand Break Repair

(2016) Corina Ohle et al.   CELL

Structure of centromere chromatin: from nucleosome to chromosomal architecture

(2016) Thomas Schalch et al.   CHROMOSOMA

Unattached kinetochores rather than intrakinetochore tension arrest mitosis in taxol-treated cells

(2016) Valentin Magidson et al.   JOURNAL OF CELL BIOLOGY

Insights from biochemical reconstitution into the architecture of human kinetochores

(2016) John R. Weir et al.   NATURE

Mechanisms underlying structural variant formation in genomic disorders

(2016) Claudia M. B. Carvalho et al.   NATURE REVIEWS GENETICS

Rad51 and Rad54 promote noncrossover recombination between centromere repeats on the same chromatid to prevent isochromosome formation

(2016) Atsushi T. Onaka et al.   NUCLEIC ACIDS RESEARCH

Repression of harmful meiotic recombination in centromeric regions

(2016) Mridula Nambiar et al.   SEMINARS IN CELL & DEVELOPMENTAL BIOLOGY

Chromatin Ring Formation at Plant Centromeres

(2016) Veit Schubert et al.   Frontiers in Plant Science

The Molecular Biology of Spindle Assembly Checkpoint Signaling Dynamics

(2015) Andrea Musacchio   CURRENT BIOLOGY

ATRX contributes to epigenetic asymmetry and silencing of major satellite transcripts in the maternal genome of the mouse embryo

(2015) R. De La Fuente et al.   DEVELOPMENT

DNA Sequence-Specific Binding of CENP-B Enhances the Fidelity of Human Centromere Function

(2015) Daniele Fachinetti et al.   DEVELOPMENTAL CELL

The CENP-L-N Complex Forms a Critical Node in an Integrated Meshwork of Interactions at the Centromere-Kinetochore Interface

(2015) Kara L. McKinley et al.   MOLECULAR CELL

Adaptive changes in the kinetochore architecture facilitate proper spindle assembly

(2015) Valentin Magidson et al.   NATURE CELL BIOLOGY

The molecular basis for centromere identity and function

(2015) Kara L. McKinley et al.   NATURE REVIEWS MOLECULAR CELL BIOLOGY

Meiosis: An Overview of Key Differences from Mitosis

(2015) Hiroyuki Ohkura   Cold Spring Harbor Perspectives in Biology

The kinetochore prevents centromere-proximal crossover recombination during meiosis

(2015) Nadine Vincenten et al.   eLife

The Centromere: Chromatin Foundation for the Kinetochore Machinery

(2014) Tatsuo Fukagawa et al.   DEVELOPMENTAL CELL

The Kinetochore

(2014) I. M. Cheeseman   Cold Spring Harbor Perspectives in Biology

The quantitative architecture of centromeric chromatin

(2014) Dani L Bodor et al.   eLife

Cumulative Haploinsufficiency and Triplosensitivity Drive Aneuploidy Patterns and Shape the Cancer Genome

(2013) Teresa Davoli et al.   CELL

Induced dicentric chromosome formation promotes genomic rearrangements and tumorigenesis

(2013) Karen E. Gascoigne et al.   CHROMOSOME RESEARCH

The CCAN recruits CENP-A to the centromere and forms the structural core for kinetochore assembly

(2013) Tetsuya Hori et al.   JOURNAL OF CELL BIOLOGY

New histone supply regulates replication fork speed and PCNA unloading

(2013) Jakob Mejlvang et al.   JOURNAL OF CELL BIOLOGY

A Conserved Mechanism for Centromeric Nucleosome Recognition by Centromere Protein CENP-C

(2013) H. Kato et al.   SCIENCE

Human centromere genomics: now it's personal

(2012) Karen E. Hayden   CHROMOSOME RESEARCH

Nonallelic homologous recombination between retrotransposable elements is a driver of de novo unbalanced translocations

(2012) C. Robberecht et al.   GENOME RESEARCH

Global analysis of genome, transcriptome and proteome reveals the response to aneuploidy in human cells

(2012) Silvia Stingele et al.   Molecular Systems Biology

Transcription in the maintenance of centromere chromatin identity

(2012) F. L. Chan et al.   NUCLEIC ACIDS RESEARCH

Active transcription and essential role of RNA polymerase II at the centromere during mitosis

(2012) F. L. Chan et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

LINE-1 Elements in Structural Variation and Disease

(2011) Christine R. Beck et al.   Annual Review of Genomics and Human Genetics

Evidence for a high mutation rate at rapidly evolving yeast centromeres

(2011) Douda Bensasson   BMC EVOLUTIONARY BIOLOGY

Induced Ectopic Kinetochore Assembly Bypasses the Requirement for CENP-A Nucleosomes

(2011) Karen E. Gascoigne et al.   CELL

Direct Binding of Cenp-C to the Mis12 Complex Joins the Inner and Outer Kinetochore

(2011) Emanuela Screpanti et al.   CURRENT BIOLOGY

CENP-C Is a Structural Platform for Kinetochore Assembly

(2011) Marcin R. Przewloka et al.   CURRENT BIOLOGY

How does genome instability affect lifespan?

(2011) Takehiko Kobayashi   GENES TO CELLS

Merotelic kinetochore attachment: causes and effects

(2011) Juraj Gregan et al.   TRENDS IN CELL BIOLOGY

Evidence that Weakened Centromere Cohesion Is a Leading Cause of Age-Related Aneuploidy in Oocytes

(2010) Teresa Chiang et al.   CURRENT BIOLOGY

Regulated targeting of protein phosphatase 1 to the outer kinetochore by KNL1 opposes Aurora B kinase

(2010) Dan Liu et al.   JOURNAL OF CELL BIOLOGY

Dissecting the role of MPS1 in chromosome biorientation and the spindle checkpoint through the small molecule inhibitor reversine

(2010) Stefano Santaguida et al.   JOURNAL OF CELL BIOLOGY

Sustained Mps1 activity is required in mitosis to recruit O-Mad2 to the Mad1–C-Mad2 core complex

(2010) Laura Hewitt et al.   JOURNAL OF CELL BIOLOGY

The MIS12 complex is a protein interaction hub for outer kinetochore assembly

(2010) Arsen Petrovic et al.   JOURNAL OF CELL BIOLOGY

Dual recognition of CENP-A nucleosomes is required for centromere assembly

(2010) Christopher W. Carroll et al.   JOURNAL OF CELL BIOLOGY

A super-resolution map of the vertebrate kinetochore

(2010) S. A. Ribeiro et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

A role for recombination in centromere function

(2010) Ramsay J. McFarlane et al.   TRENDS IN GENETICS

Copy Number Variation in Human Health, Disease, and Evolution

(2009) Feng Zhang et al.   Annual Review of Genomics and Human Genetics

Regulation of kinetochore–microtubule attachments by Aurora B kinase

(2009) Dan Liu et al.   BIOCHEMICAL SOCIETY TRANSACTIONS

HJURP Is a Cell-Cycle-Dependent Maintenance and Deposition Factor of CENP-A at Centromeres

(2009) Elaine M. Dunleavy et al.   CELL

Centromere-Specific Assembly of CENP-A Nucleosomes Is Mediated by HJURP

(2009) Daniel R. Foltz et al.   CELL

CCAN Makes Multiple Contacts with Centromeric DNA to Provide Distinct Pathways to the Outer Kinetochore

(2008) Tetsuya Hori et al.   CELL

Implications for Kinetochore-Microtubule Attachment from the Structure of an Engineered Ndc80 Complex

(2008) Claudio Ciferri et al.   CELL

Pericentric Chromatin Is Organized into an Intramolecular Loop in Mitosis

(2008) Elaine Yeh et al.   CURRENT BIOLOGY

A tale of two centromeres—diversity of structure but conservation of function in plants and animals

(2008) James A. Birchler et al.   FUNCTIONAL & INTEGRATIVE GENOMICS

Centromere mitotic recombination in mammalian cells

(2008) Isabel Jaco et al.   JOURNAL OF CELL BIOLOGY

Examining the link between chromosomal instability and aneuploidy in human cells

(2008) Sarah L. Thompson et al.   JOURNAL OF CELL BIOLOGY