Targeted assembly of ectopic kinetochores to induce chromosome‐specific segmental aneuploidies

KaryoCreate: A CRISPR-based technology to study chromosome-specific aneuploidy by targeting human centromeres

(2023) Nazario Bosco et al.   CELL

A kinesin‐based approach for inducing chromosome‐specific mis‐segregation in human cells

(2023) My Anh Truong et al.   EMBO JOURNAL

Complete genomic and epigenetic maps of human centromeres

(2022) Nicolas Altemose et al.   SCIENCE

The complete sequence of a human genome

(2022) Sergey Nurk et al.   SCIENCE

Nuclear chromosome locations dictate segregation error frequencies

(2022) Sjoerd J. Klaasen et al.   NATURE

MPS1 localizes to end-on microtubule-attached kinetochores to promote microtubule release

(2022) Daniel Hayward et al.   CURRENT BIOLOGY

Chromothripsis as an on-target consequence of CRISPR–Cas9 genome editing

(2021) Mitchell L. Leibowitz et al.   NATURE GENETICS

Systems approaches identify the consequences of monosomy in somatic human cells

(2021) Narendra Kumar Chunduri et al.   Nature Communications

Genotoxic stress in constitutive trisomies induces autophagy and the innate immune response via the cGAS-STING pathway

(2021) Maria Krivega et al.   Communications Biology

Mechanisms generating cancer genome complexity from a single cell division error

(2020) Neil T. Umbreit et al.   SCIENCE

Specific mechanisms of chromosomal instability indicate therapeutic sensitivities in high-grade serous ovarian carcinoma.

(2020) Naoka Tamura et al.   CANCER RESEARCH

A dCas9-Based System Identifies a Central Role for Ctf19 in Kinetochore-Derived Suppression of Meiotic Recombination

(2020) Lisa-Marie Kuhl et al.   GENETICS

Ongoing chromosomal instability and karyotype evolution in human colorectal cancer organoids

(2019) Ana C. F. Bolhaqueiro et al.   NATURE GENETICS

Identification of novel breakpoints for locus- and region-specific translocations in 293 cells by molecular cytogenetics before and after irradiation

(2019) Regina L. Binz et al.   Scientific Reports

Human chromosome‐specific aneuploidy is influenced by DNA ‐dependent centromeric features

(2019) Marie Dumont et al.   EMBO JOURNAL

Nuclease dead Cas9 is a programmable roadblock for DNA replication

(2019) Kelsey S. Whinn et al.   Scientific Reports

Genomic and Functional Approaches to Understanding Cancer Aneuploidy

(2018) Alison M. Taylor et al.   CANCER CELL

Dynamics of sister chromatid resolution during cell cycle progression

(2018) Rugile Stanyte et al.   JOURNAL OF CELL BIOLOGY

CRISPOR: intuitive guide selection for CRISPR/Cas9 genome editing experiments and screens

(2018) Jean-Paul Concordet et al.   NUCLEIC ACIDS RESEARCH

Multiple phosphorylations control recruitment of the KMN network onto kinetochores

(2018) Masatoshi Hara et al.   NATURE CELL BIOLOGY

Genome-scale CRISPR-Cas9 knockout and transcriptional activation screening

(2017) Julia Joung et al.   Nature Protocols

Hit-and-run epigenetic editing prevents senescence entry in primary breast cells from healthy donors

(2017) Emily A. Saunderson et al.   Nature Communications

Inner centromere localization of the CPC maintains centromere cohesion and allows mitotic checkpoint silencing

(2017) Rutger C. C. Hengeveld et al.   Nature Communications

Live cell imaging of low- and non-repetitive chromosome loci using CRISPR-Cas9

(2017) Peiwu Qin et al.   Nature Communications

Baculoviral delivery of CRISPR/Cas9 facilitates efficient genome editing in human cells

(2017) Sanne Hindriksen et al.   PLoS One

The presence of extra chromosomes leads to genomic instability

(2016) Verena Passerini et al.   Nature Communications

Aurora B prevents premature removal of spindle assembly checkpoint proteins from the kinetochore: A key role for Aurora B in mitosis

(2016) Mark D. Gurden et al.   Oncotarget

Detecting Genetic Mosaicism in Cultures of Human Pluripotent Stem Cells

(2016) Duncan Baker et al.   Stem Cell Reports

A Meta-Analysis of Retinoblastoma Copy Numbers Refines the List of Possible Driver Genes Involved in Tumor Progression

(2016) Irsan E. Kooi et al.   PLoS One

Distinct Organization and Regulation of the Outer Kinetochore KMN Network Downstream of CENP-C and CENP-T

(2015) Florencia Rago et al.   CURRENT BIOLOGY

An efficient and scalable analysis framework for variant extraction and refinement from population-scale DNA sequence data

(2015) Goo Jun et al.   GENOME RESEARCH

Multicolor CRISPR labeling of chromosomal loci in human cells

(2015) Hanhui Ma et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Cas-OFFinder: a fast and versatile algorithm that searches for potential off-target sites of Cas9 RNA-guided endonucleases

(2014) S. Bae et al.   BIOINFORMATICS

A Protein-Tagging System for Signal Amplification in Gene Expression and Fluorescence Imaging

(2014) Marvin E. Tanenbaum et al.   CELL

Dynamic Imaging of Genomic Loci in Living Human Cells by an Optimized CRISPR/Cas System

(2013) Baohui Chen et al.   CELL

Induced dicentric chromosome formation promotes genomic rearrangements and tumorigenesis

(2013) Karen E. Gascoigne et al.   CHROMOSOME RESEARCH

The CCAN recruits CENP-A to the centromere and forms the structural core for kinetochore assembly

(2013) Tetsuya Hori et al.   JOURNAL OF CELL BIOLOGY

Fast gapped-read alignment with Bowtie 2

(2012) Ben Langmead et al.   NATURE METHODS

Induced Ectopic Kinetochore Assembly Bypasses the Requirement for CENP-A Nucleosomes

(2011) Karen E. Gascoigne et al.   CELL

Evidence that Aurora B is implicated in spindle checkpoint signalling independently of error correction

(2011) Stefano Santaguida et al.   EMBO JOURNAL

Lac operator repeats generate a traceable fragile site in mammalian cells

(2011) Ariana Jacome et al.   EMBO REPORTS

Targeting the Mitotic Checkpoint for Cancer Therapy with NMS-P715, an Inhibitor of MPS1 Kinase

(2010) R. Colombo et al.   CANCER RESEARCH

CCAN Makes Multiple Contacts with Centromeric DNA to Provide Distinct Pathways to the Outer Kinetochore

(2008) Tetsuya Hori et al.   CELL

Mps1 kinase activity restrains anaphase during an unperturbed mitosis and targets Mad2 to kinetochores

(2008) Anthony Tighe et al.   JOURNAL OF CELL BIOLOGY

Examining the link between chromosomal instability and aneuploidy in human cells

(2008) Sarah L. Thompson et al.   JOURNAL OF CELL BIOLOGY

Monosomal Karyotype in Acute Myeloid Leukemia: A Better Indicator of Poor Prognosis Than a Complex Karyotype

(2008) Dimitri A. Breems et al.   JOURNAL OF CLINICAL ONCOLOGY