A kinesin‐based approach for inducing chromosome‐specific mis‐segregation in human cells

KaryoCreate: A CRISPR-based technology to study chromosome-specific aneuploidy by targeting human centromeres

(2023) Nazario Bosco et al.   CELL

Targeted assembly of ectopic kinetochores to induce chromosome‐specific segmental aneuploidies

(2023) Laura Tovini et al.   EMBO JOURNAL

The complete sequence of a human genome

(2022) Sergey Nurk et al.   SCIENCE

Nuclear chromosome locations dictate segregation error frequencies

(2022) Sjoerd J. Klaasen et al.   NATURE

The impact of monosomies, trisomies and segmental aneuploidies on chromosomal stability

(2022) Dorine C. Hintzen et al.   PLoS One

RAD21 is a driver of chromosome 8 gain in Ewing sarcoma to mitigate replication stress

(2021) Xiaofeng A. Su et al.   GENES & DEVELOPMENT

Chromothripsis as an on-target consequence of CRISPR–Cas9 genome editing

(2021) Mitchell L. Leibowitz et al.   NATURE GENETICS

Causes and consequences of micronuclei

(2021) Ksenia Krupina et al.   CURRENT OPINION IN CELL BIOLOGY

Gene copy-number changes and chromosomal instability induced by aneuploidy confer resistance to chemotherapy

(2021) Marica Rosaria Ippolito et al.   DEVELOPMENTAL CELL

Chromosomal instability accelerates the evolution of resistance to anti-cancer therapies

(2021) Devon A. Lukow et al.   DEVELOPMENTAL CELL

Reconstructing single-cell karyotype alterations in colorectal cancer identifies punctuated and gradual diversification patterns

(2021) Yannik Bollen et al.   NATURE GENETICS

Kinetochore life histories reveal an Aurora-B-dependent error correction mechanism in anaphase

(2021) Onur Sen et al.   DEVELOPMENTAL CELL

An optimized toolbox for the optogenetic control of intracellular transport

(2020) Wilco Nijenhuis et al.   JOURNAL OF CELL BIOLOGY

The evolutionary history of 2,658 cancers

(2020) Moritz Gerstung et al.   NATURE

Mechanisms generating cancer genome complexity from a single cell division error

(2020) Neil T. Umbreit et al.   SCIENCE

Catalytically inactive Cas9 impairs DNA replication fork progression to induce focal genomic instability

(2020) Goro Doi et al.   NUCLEIC ACIDS RESEARCH

Ongoing chromosomal instability and karyotype evolution in human colorectal cancer organoids

(2019) Ana C. F. Bolhaqueiro et al.   NATURE GENETICS

Context is everything: aneuploidy in cancer

(2019) Uri Ben-David et al.   NATURE REVIEWS GENETICS

Human chromosome‐specific aneuploidy is influenced by DNA ‐dependent centromeric features

(2019) Marie Dumont et al.   EMBO JOURNAL

Genomic and Functional Approaches to Understanding Cancer Aneuploidy

(2018) Alison M. Taylor et al.   CANCER CELL

A Kinesin-14 Motor Activates Neocentromeres to Promote Meiotic Drive in Maize

(2018) R. Kelly Dawe et al.   CELL

Profound Tissue Specificity in Proliferation Control Underlies Cancer Drivers and Aneuploidy Patterns

(2018) Laura Magill Sack et al.   CELL

Quantitative proteomic and phosphoproteomic comparison of human colon cancer DLD-1 cells differing in ploidy and chromosome stability

(2018) Cristina Viganó et al.   MOLECULAR BIOLOGY OF THE CELL

Non-random Mis-segregation of Human Chromosomes

(2018) Joseph Thomas Worrall et al.   Cell Reports

Nuclear envelope assembly defects link mitotic errors to chromothripsis

(2018) Shiwei Liu et al.   NATURE

Multiplexed protein maps link subcellular organization to cellular states

(2018) Gabriele Gut et al.   SCIENCE

Genetic interactions between specific chromosome copy number alterations dictate complex aneuploidy patterns

(2018) Madhwesh C. Ravichandran et al.   GENES & DEVELOPMENT

CRISPR-Sirius: RNA scaffolds for signal amplification in genome imaging

(2018) Hanhui Ma et al.   NATURE METHODS

Spindle assembly checkpoint satisfaction occurs via end-on but not lateral attachments under tension

(2017) Jonathan Kuhn et al.   JOURNAL OF CELL BIOLOGY

Multiple kinesin-14 family members drive microtubule minus end–directed transport in plant cells

(2017) Moé Yamada et al.   JOURNAL OF CELL BIOLOGY

Genetically Encoded Tools for Optical Dissection of the Mammalian Cell Cycle

(2017) Asako Sakaue-Sawano et al.   MOLECULAR CELL

Targeted Deletion of an Entire Chromosome Using CRISPR/Cas9

(2017) Fatwa Adikusuma et al.   MOLECULAR THERAPY

p53 Prohibits Propagation of Chromosome Segregation Errors that Produce Structural Aneuploidies

(2017) Mar Soto et al.   Cell Reports

Baculoviral delivery of CRISPR/Cas9 facilitates efficient genome editing in human cells

(2017) Sanne Hindriksen et al.   PLoS One

Multiplexed labeling of genomic loci with dCas9 and engineered sgRNAs using CRISPRainbow

(2016) Hanhui Ma et al.   NATURE BIOTECHNOLOGY

Selective Y centromere inactivation triggers chromosome shattering in micronuclei and repair by non-homologous end joining

(2016) Peter Ly et al.   NATURE CELL BIOLOGY

The presence of extra chromosomes leads to genomic instability

(2016) Verena Passerini et al.   Nature Communications

A Cas9 Variant for Efficient Generation of Indel-Free Knockin or Gene-Corrected Human Pluripotent Stem Cells

(2016) Sara E. Howden et al.   Stem Cell Reports

Chromothripsis and Kataegis Induced by Telomere Crisis

(2015) John Maciejowski et al.   CELL

Chromothripsis from DNA damage in micronuclei

(2015) Cheng-Zhong Zhang et al.   NATURE

Multicolor CRISPR labeling of chromosomal loci in human cells

(2015) Hanhui Ma et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Photostick: a method for selective isolation of target cells from culture

(2015) Miao-Ping Chien et al.   Chemical Science

Kinetochore–microtubule attachment is sufficient to satisfy the human spindle assembly checkpoint

(2015) Banafsheh Etemad et al.   Nature Communications

Chromosome mis-segregation and cytokinesis failure in trisomic human cells

(2015) Joshua M Nicholson et al.   eLife

Characterization of Aneuploid Populations with Trisomy 7 and 20 Derived from Diploid Human Colonic Epithelial Cells

(2015) Peter Ly et al.   NEOPLASIA

A chromosome separation checkpoint

(2014) Helder Maiato et al.   BIOESSAYS

Establishment of a replication fork barrier following induction of DNA binding in mammalian cells

(2014) Paolo Beuzer et al.   CELL CYCLE

Recruitment of Mad1 to metaphase kinetochores is sufficient to reactivate the mitotic checkpoint

(2014) Edward R. Ballister et al.   JOURNAL OF CELL BIOLOGY

Regulation of kinetochore–microtubule attachments through homeostatic control during mitosis

(2014) Kristina M. Godek et al.   NATURE REVIEWS MOLECULAR CELL BIOLOGY

CRISPR-Mediated Modular RNA-Guided Regulation of Transcription in Eukaryotes

(2013) Luke A. Gilbert et al.   CELL

Pan-cancer patterns of somatic copy number alteration

(2013) Travis I Zack et al.   NATURE GENETICS

Cancer cells preferentially lose small chromosomes

(2012) Pascal H.G. Duijf et al.   INTERNATIONAL JOURNAL OF CANCER

Phylogenetic Analysis of the Kinesin Superfamily from Physcomitrella

(2012) Zhiyuan Shen et al.   Frontiers in Plant Science

Lac operator repeats generate a traceable fragile site in mammalian cells

(2011) Ariana Jacome et al.   EMBO REPORTS

Chromosome Segregation Errors as a Cause of DNA Damage and Structural Chromosome Aberrations

(2011) A. Janssen et al.   SCIENCE

Chromosome 7 and 19 Trisomy in Cultured Human Neural Progenitor Cells

(2009) Dhruv Sareen et al.   PLoS One

Aneuploidy Underlies Rapid Adaptive Evolution of Yeast Cells Deprived of a Conserved Cytokinesis Motor

(2008) Giulia Rancati et al.   CELL

Midzone activation of aurora B in anaphase produces an intracellular phosphorylation gradient

(2008) Brian G. Fuller et al.   NATURE

Genome stability is ensured by temporal control of kinetochore–microtubule dynamics

(2008) Samuel F. Bakhoum et al.   NATURE CELL BIOLOGY

The Repertoire and Dynamics of Evolutionary Adaptations to Controlled Nutrient-Limited Environments in Yeast

(2008) David Gresham et al.   PLoS Genetics