Regulation and function of alternative polyadenylation in development and differentiation

Sites of transcription initiation drive mRNA isoform selection

(2023) Carlos Alfonso-Gonzalez et al.   CELL

Pseudouridine synthases modify human pre-mRNA co-transcriptionally and affect pre-mRNA processing

(2022) Nicole M. Martinez et al.   MOLECULAR CELL

Alternative polyadenylation by sequential activation of distal and proximal PolyA sites

(2022) Peng Tang et al.   NATURE STRUCTURAL & MOLECULAR BIOLOGY

Alternative Polyadenylation Utilization Results in Ribosome Assembly and mRNA Translation Deficiencies in a Model for Muscle Aging

(2022) Hailiang Mei et al.   JOURNALS OF GERONTOLOGY SERIES A-BIOLOGICAL SCIENCES AND MEDICAL SCIENCES

Enhancers regulate 3′ end processing activity to control expression of alternative 3′UTR isoforms

(2022) Buki Kwon et al.   Nature Communications

Regulation of alternative polyadenylation by the C2H2-zinc-finger protein Sp1

(2022) Jingwen Song et al.   MOLECULAR CELL

Context-specific regulation and function of mRNA alternative polyadenylation

(2022) Sibylle Mitschka et al.   NATURE REVIEWS MOLECULAR CELL BIOLOGY

Developmentally regulated alternate 3′ end cleavage of nascent transcripts controls dynamic changes in protein expression in an adult stem cell lineage

(2022) Cameron W. Berry et al.   GENES & DEVELOPMENT

The androgen receptor couples promoter recruitment of RNA processing factors to regulation of alternative polyadenylation at the 3' end of transcripts

(2022) Cinzia Caggiano et al.   NUCLEIC ACIDS RESEARCH

Diverse cell-specific patterns of alternative polyadenylation in Drosophila

(2022) Seungjae Lee et al.   Nature Communications

A Survey on Methods for Predicting Polyadenylation Sites from DNA Sequences, Bulk RNA-seq, and Single-cell RNA-seq

(2022) Wenbin Ye et al.   GENOMICS PROTEOMICS & BIOINFORMATICS

Comprehensive mapping of alternative polyadenylation site usage and its dynamics at single-cell resolution

(2022) Junliang Wang et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Alternative polyadenylation: methods, mechanism, function, and role in cancer

(2021) Yi Zhang et al.   JOURNAL OF EXPERIMENTAL & CLINICAL CANCER RESEARCH

Cytoplasmic cleavage of IMPA1 3′ UTR is necessary for maintaining axon integrity

(2021) Catia Andreassi et al.   Cell Reports

The RNA-Binding Protein HuD Regulates Alternative Splicing and Alternative Polyadenylation in the Mouse Neocortex

(2021) Rebecca M. Sena et al.   MOLECULES

On the function and relevance of alternative 3′‐ UTRs in gene expression regulation

(2021) Isabel Pereira‐Castro et al.   Wiley Interdisciplinary Reviews-RNA

Alternative polyadenylation dysregulation contributes to the differentiation block of acute myeloid leukemia

(2021) Amanda G Davis et al.   BLOOD

Intragenic heterochromatin‐mediated alternative polyadenylation modulates miRNA and pollen development in rice

(2021) Li‐Yuan You et al.   NEW PHYTOLOGIST

CircURI1 interacts with hnRNPM to inhibit metastasis by modulating alternative splicing in gastric cancer

(2021) Xiaolin Wang et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

The landscape of alternative polyadenylation in single cells of the developing mouse embryo

(2021) Vikram Agarwal et al.   Nature Communications

Casein Kinase 1δ Stabilizes Mature Axons by Inhibiting Transcription Termination of Ankyrin

(2020) Matthew L. LaBella et al.   DEVELOPMENTAL CELL

Alternative polyadenylation drives oncogenic gene expression in pancreatic ductal adenocarcinoma

(2020) Swati Venkat et al.   GENOME RESEARCH

A Cancer-Specific Ubiquitin Ligase Drives mRNA Alternative Polyadenylation by Ubiquitinating the mRNA 3′ End Processing Complex

(2020) Seung Wook Yang et al.   MOLECULAR CELL

DNA Methylation Regulates Alternative Polyadenylation via CTCF and the Cohesin Complex

(2020) Vishal Nanavaty et al.   MOLECULAR CELL

Requirement for cleavage factor IIm in the control of alternative polyadenylation in breast cancer cells

(2020) Rachael E Turner et al.   RNA

Elimination of Calm1 long 3' UTR mRNA isoform by CRISPR-Cas9 gene editing impairs dorsal root ganglion development and hippocampal neuron activation in mice

(2020) Bongmin Bae et al.   RNA

Alternative Polyadenylation: a new frontier in post transcriptional regulation

(2020) Fanggang Ren et al.   Biomarker Research

Role of alternative polyadenylation dynamics in acute myeloid leukaemia at single-cell resolution

(2019) Congting Ye et al.   RNA Biology

Regulation of NGF Signaling by an Axonal Untranslated mRNA

(2019) Hamish Crerar et al.   NEURON

Alternative cleavage and polyadenylation in health and disease

(2019) Andreas J. Gruber et al.   NATURE REVIEWS GENETICS

Alternative polyadenylation of single cells delineates cell types and serves as a prognostic marker in early stage breast cancer

(2019) Nayoung Kim et al.   PLoS One

FLAM-seq: full-length mRNA sequencing reveals principles of poly(A) tail length control

(2019) Ivano Legnini et al.   NATURE METHODS

RNA Binding Protein CELF2 Regulates Signal-Induced Alternative Polyadenylation by Competing with Enhancers of the Polyadenylation Machinery

(2019) Rakesh Chatrikhi et al.   Cell Reports

Alternative Splicing Regulatory Networks: Functions, Mechanisms, and Evolution

(2019) Jernej Ule et al.   MOLECULAR CELL

Alternative polyadenylation of Pax3 controls muscle stem cell fate and muscle function

(2019) Antoine de Morree et al.   SCIENCE

Recurrent tumor-specific regulation of alternative polyadenylation of cancer-related genes

(2018) Zhuyi Xue et al.   BMC GENOMICS

Nudt21 Controls Cell Fate by Connecting Alternative Polyadenylation to Chromatin Signaling

(2018) Justin Brumbaugh et al.   CELL

The distinct transcriptomes of slow and fast adult muscles are delineated by noncoding RNAs

(2018) Vered Raz et al.   FASEB JOURNAL

Dynamic changes in copper homeostasis and post-transcriptional regulation of Atp7a during myogenic differentiation

(2018) Katherine E. Vest et al.   Metallomics

Molecular Mechanisms for CFIm-Mediated Regulation of mRNA Alternative Polyadenylation

(2018) Yong Zhu et al.   MOLECULAR CELL

Alternative 3′ UTRs Modify the Localization, Regulatory Potential, Stability, and Plasticity of mRNAs in Neuronal Compartments

(2018) Georgi Tushev et al.   NEURON

Nuclear m6A reader YTHDC1 regulates alternative polyadenylation and splicing during mouse oocyte development

(2018) Seth D. Kasowitz et al.   PLoS Genetics

What Are 3′ UTRs Doing?

(2018) Christine Mayr   Cold Spring Harbor Perspectives in Biology

Alternative 3′ UTRs direct localization of functionally diverse protein isoforms in neuronal compartments

(2018) Camilla Ciolli Mattioli et al.   NUCLEIC ACIDS RESEARCH

RNA Splicing and Disease: Animal Models to Therapies

(2018) Matías Montes et al.   TRENDS IN GENETICS

Transcriptome 3′end organization by PCF11 links alternative polyadenylation to formation and neuronal differentiation of neuroblastoma

(2018) Anton Ogorodnikov et al.   Nature Communications

Regulators of alternative polyadenylation operate at the transition from mitosis to meiosis

(2017) Lingjuan Shan et al.   Journal of Genetics and Genomics

Molecular Regulation of Alternative Polyadenylation (APA) within the Drosophila Nervous System

(2017) Raul Vallejos Baier et al.   JOURNAL OF MOLECULAR BIOLOGY

Distinct regulation of alternative polyadenylation and gene expression by nuclear poly(A) polymerases

(2017) Weimin Li et al.   NUCLEIC ACIDS RESEARCH

Transcription elongation rate has a tissue-specific impact on alternative cleavage and polyadenylation in Drosophila melanogaster

(2017) Xiaochuan Liu et al.   RNA

The role of alternative polyadenylation in the antiviral innate immune response

(2017) Xin Jia et al.   Nature Communications

Widespread Translational Remodeling during Human Neuronal Differentiation

(2017) John D. Blair et al.   Cell Reports

Alternate splicing of transcripts shape macrophage response to Mycobacterium tuberculosis infection

(2017) Haroon Kalam et al.   PLoS Pathogens

Alternative cleavage and polyadenylation in spermatogenesis connects chromatin regulation with post-transcriptional control

(2016) Wencheng Li et al.   BMC BIOLOGY

CD5 expression is regulated during human T-cell activation by alternative polyadenylation, PTBP1, and miR-204

(2016) Rita G. Domingues et al.   EUROPEAN JOURNAL OF IMMUNOLOGY

Alternative polyadenylation of mRNA precursors

(2016) Bin Tian et al.   NATURE REVIEWS MOLECULAR CELL BIOLOGY

Widespread Shortening of 3’ Untranslated Regions and Increased Exon Inclusion Are Evolutionarily Conserved Features of Innate Immune Responses to Infection

(2016) Athma A. Pai et al.   PLoS Genetics

Regulation of alternative polyadenylation by Nkx2-5 and Xrn2 during mouse heart development

(2016) Keisuke Nimura et al.   eLife

Tunable protein synthesis by transcript isoforms in human cells

(2016) Stephen N Floor et al.   eLife

A decline in PABPN1 induces progressive muscle weakness in Oculopharyngeal muscle dystrophy and in muscle aging

(2016) Seyed Yahya Anvar et al.   Aging-US

A majority of m6A residues are in the last exons, allowing the potential for 3′ UTR regulation

(2015) Shengdong Ke et al.   GENES & DEVELOPMENT

ELAV Links Paused Pol II to Alternative Polyadenylation in the Drosophila Nervous System

(2015) Katarzyna Oktaba et al.   MOLECULAR CELL

Alternative 3′ UTRs act as scaffolds to regulate membrane protein localization

(2015) Binyamin D. Berkovits et al.   NATURE

PAX3 and PAX7 as upstream regulators of myogenesis

(2015) Margaret Buckingham et al.   SEMINARS IN CELL & DEVELOPMENTAL BIOLOGY

Systematic Profiling of Poly(A)+ Transcripts Modulated by Core 3’ End Processing and Splicing Factors Reveals Regulatory Rules of Alternative Cleavage and Polyadenylation

(2015) Wencheng Li et al.   PLoS Genetics

Dendritic targeting of short and long 3′ UTR BDNF mRNA is regulated by BDNF or NT-3 and distinct sets of RNA-binding proteins

(2015) Annalisa Vicario et al.   Frontiers in Molecular Neuroscience

Global 3′ UTR shortening has a limited effect on protein abundance in proliferating T cells

(2014) Andreas R. Gruber et al.   Nature Communications

Dynamic analyses of alternative polyadenylation from RNA-seq reveal a 3′-UTR landscape across seven tumour types

(2014) Zheng Xia et al.   Nature Communications

Ubiquitously transcribed genes use alternative polyadenylation to achieve tissue-specific expression

(2013) S. Lianoglou et al.   GENES & DEVELOPMENT

Widespread and extensive lengthening of 3' UTRs in the mammalian brain

(2013) P. Miura et al.   GENOME RESEARCH

The Poly(A)-Binding Protein Nuclear 1 Suppresses Alternative Cleavage and Polyadenylation Sites

(2012) Mathias Jenal et al.   CELL

Alternative Polyadenylation Mediates MicroRNA Regulation of Muscle Stem Cell Function

(2012) Stéphane C. Boutet et al.   Cell Stem Cell

IGF-I 3′ Untranslated Region: Strain-Specific Polymorphisms and Motifs Regulating IGF-I in Osteoblasts

(2012) Spenser S. Smith et al.   ENDOCRINOLOGY

ELAV mediates 3' UTR extension in the Drosophila nervous system

(2012) V. Hilgers et al.   GENES & DEVELOPMENT

Extensive alternative polyadenylation during zebrafish development

(2012) I. Ulitsky et al.   GENOME RESEARCH

Analysis of alternative cleavage and polyadenylation by 3′ region extraction and deep sequencing

(2012) Mainul Hoque et al.   NATURE METHODS

Cleavage factor Imis a key regulator of 3′ UTR length

(2012) Andreas R. Gruber et al.   RNA Biology

Global Patterns of Tissue-Specific Alternative Polyadenylation in Drosophila

(2012) Peter Smibert et al.   Cell Reports

RNA polymerase II kinetics inpolopolyadenylation signal selection

(2011) Pedro A B Pinto et al.   EMBO JOURNAL

Transcriptional activity regulates alternative cleavage and polyadenylation

(2011) Z. Ji et al.   Molecular Systems Biology

Neuron-specific ELAV/Hu proteins suppress HuR mRNA during neuronal differentiation by alternative polyadenylation

(2011) Kyle D. Mansfield et al.   NUCLEIC ACIDS RESEARCH

Neural-specific elongation of 3' UTRs during Drosophila development

(2011) V. Hilgers et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Complex and dynamic landscape of RNA polyadenylation revealed by PAS-Seq

(2011) P. J. Shepard et al.   RNA

Genomewide characterization of non-polyadenylated RNAs

(2011) Li Yang et al.   GENOME BIOLOGY

Distinct 3'UTRs differentially regulate activity-dependent translation of brain-derived neurotrophic factor (BDNF)

(2010) A. G. Lau et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Immunoglobulin heavy chain gene regulation through polyadenylation and splicing competition

(2010) Martha L. Peterson   Wiley Interdisciplinary Reviews-RNA

Widespread Shortening of 3′UTRs by Alternative Cleavage and Polyadenylation Activates Oncogenes in Cancer Cells

(2009) Christine Mayr et al.   CELL

Reprogramming of 3′ Untranslated Regions of mRNAs by Alternative Polyadenylation in Generation of Pluripotent Stem Cells from Different Cell Types

(2009) Zhe Ji et al.   PLoS One

Progressive lengthening of 3' untranslated regions of mRNAs by alternative polyadenylation during mouse embryonic development

(2009) Z. Ji et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Distinct Role of Long 3′ UTR BDNF mRNA in Spine Morphology and Synaptic Plasticity in Hippocampal Neurons

(2008) Juan Ji An et al.   CELL

Metabolism and regulation of canonical histone mRNAs: life without a poly(A) tail

(2008) William F. Marzluff et al.   NATURE REVIEWS GENETICS

Localized Regulation of Axonal RanGTPase Controls Retrograde Injury Signaling in Peripheral Nerve

(2008) Dmitry Yudin et al.   NEURON

Proliferating Cells Express mRNAs with Shortened 3' Untranslated Regions and Fewer MicroRNA Target Sites

(2008) R. Sandberg et al.   SCIENCE