- Home
- Publications
- Publication Search
- Publication Details
Title
Alternative cleavage and polyadenylation in health and disease
Authors
Keywords
-
Journal
NATURE REVIEWS GENETICS
Volume -, Issue -, Pages -
Publisher
Springer Science and Business Media LLC
Online
2019-07-02
DOI
10.1038/s41576-019-0145-z
References
Ask authors/readers for more resources
Related references
Note: Only part of the references are listed.- Activation of the Endonuclease that Defines mRNA 3′ Ends Requires Incorporation into an 8-Subunit Core Cleavage and Polyadenylation Factor Complex
- (2019) Chris H. Hill et al. MOLECULAR CELL
- TAPAS: tool for alternative polyadenylation site analysis
- (2018) Ashraful Arefeen et al. BIOINFORMATICS
- Inference of the human polyadenylation code
- (2018) Michael K K Leung et al. BIOINFORMATICS
- APAtrap: identification and quantification of alternative polyadenylation sites from RNA-seq data
- (2018) Congting Ye et al. BIOINFORMATICS
- Recurrent tumor-specific regulation of alternative polyadenylation of cancer-related genes
- (2018) Zhuyi Xue et al. BMC GENOMICS
- Nudt21 Controls Cell Fate by Connecting Alternative Polyadenylation to Chromatin Signaling
- (2018) Justin Brumbaugh et al. CELL
- Molecular Mechanisms for CFIm-Mediated Regulation of mRNA Alternative Polyadenylation
- (2018) Yong Zhu et al. MOLECULAR CELL
- An integrative model for alternative polyadenylation, IntMAP, delineates mTOR-modulated endoplasmic reticulum stress response
- (2018) Jae-Woong Chang et al. NUCLEIC ACIDS RESEARCH
- Widespread intronic polyadenylation diversifies immune cell transcriptomes
- (2018) Irtisha Singh et al. Nature Communications
- A compendium of conserved cleavage and polyadenylation events in mammalian genes
- (2018) Ruijia Wang et al. GENOME RESEARCH
- Widespread intronic polyadenylation inactivates tumour suppressor genes in leukaemia
- (2018) Shih-Han Lee et al. NATURE
- Terminal exon characterization with TECtool reveals an abundance of cell-specific isoforms
- (2018) Andreas J. Gruber et al. NATURE METHODS
- Reconstitution of mammalian Cleavage Factor II involved in 3' processing of mRNA precursors
- (2018) Peter Schäfer et al. RNA
- What Are 3′ UTRs Doing?
- (2018) Christine Mayr Cold Spring Harbor Perspectives in Biology
- A Membraneless Organelle Associated with the Endoplasmic Reticulum Enables 3′UTR-Mediated Protein-Protein Interactions
- (2018) Weirui Ma et al. CELL
- Alternative 3′ UTRs direct localization of functionally diverse protein isoforms in neuronal compartments
- (2018) Camilla Ciolli Mattioli et al. NUCLEIC ACIDS RESEARCH
- Genome-wide profiling of the 3' ends of polyadenylated RNAs
- (2017) Piero Sanfilippo et al. METHODS
- Salmon provides fast and bias-aware quantification of transcript expression
- (2017) Rob Patro et al. NATURE METHODS
- U1 snRNP telescripting regulates a size–function-stratified human genome
- (2017) Jung-Min Oh et al. NATURE STRUCTURAL & MOLECULAR BIOLOGY
- Short poly(A) tails are a conserved feature of highly expressed genes
- (2017) Sarah Azoubel Lima et al. NATURE STRUCTURAL & MOLECULAR BIOLOGY
- Alternative start and termination sites of transcription drive most transcript isoform differences across human tissues
- (2017) Alejandro Reyes et al. NUCLEIC ACIDS RESEARCH
- PolyA_DB 3 catalogs cleavage and polyadenylation sites identified by deep sequencing in multiple genomes
- (2017) Ruijia Wang et al. NUCLEIC ACIDS RESEARCH
- Poly(A)-ClickSeq: click-chemistry for next-generation 3΄-end sequencing without RNA enrichment or fragmentation
- (2017) Andrew Routh et al. NUCLEIC ACIDS RESEARCH
- Molecular basis for the recognition of the human AAUAAA polyadenylation signal
- (2017) Yadong Sun et al. PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA
- Cleavage and polyadenylation: Ending the message expands gene regulation
- (2017) Jonathan Neve et al. RNA Biology
- U1 snRNP telescripting regulates a size–function-stratified human genome
- (2017) Jung-Min Oh et al. NATURE STRUCTURAL & MOLECULAR BIOLOGY
- Short poly(A) tails are a conserved feature of highly expressed genes
- (2017) Sarah Azoubel Lima et al. NATURE STRUCTURAL & MOLECULAR BIOLOGY
- High-Resolution RNA Maps Suggest Common Principles of Splicing and Polyadenylation Regulation by TDP-43
- (2017) Gregor Rot et al. Cell Reports
- Highly accessible AU-rich regions in 3’ untranslated regions are hotspots for binding of regulatory factors
- (2017) Mireya Plass et al. PLoS Computational Biology
- Structural insights into the assembly and polyA signal recognition mechanism of the human CPSF complex
- (2017) Marcello Clerici et al. eLife
- From IPEX syndrome to FOXP3 mutation: a lesson on immune dysregulation
- (2016) Rosa Bacchetta et al. Annals of the New York Academy of Sciences
- Roar: detecting alternative polyadenylation with standard mRNA sequencing libraries
- (2016) Elena Grassi et al. BMC BIOINFORMATICS
- mTAIL-seq reveals dynamic poly(A) tail regulation in oocyte-to-embryo development
- (2016) Jaechul Lim et al. GENES & DEVELOPMENT
- A comprehensive analysis of 3′ end sequencing data sets reveals novel polyadenylation signals and the repressive role of heterogeneous ribonucleoprotein C on cleavage and polyadenylation
- (2016) Andreas J. Gruber et al. GENOME RESEARCH
- Regulation of Poly(A) Tail and Translation during the Somatic Cell Cycle
- (2016) Jong-Eun Park et al. MOLECULAR CELL
- Distal Alternative Last Exons Localize mRNAs to Neural Projections
- (2016) J. Matthew Taliaferro et al. MOLECULAR CELL
- Near-optimal probabilistic RNA-seq quantification
- (2016) Nicolas L Bray et al. NATURE BIOTECHNOLOGY
- Robust transcriptome-wide discovery of RNA-binding protein binding sites with enhanced CLIP (eCLIP)
- (2016) Eric L Van Nostrand et al. NATURE METHODS
- Alternative polyadenylation of mRNA precursors
- (2016) Bin Tian et al. NATURE REVIEWS MOLECULAR CELL BIOLOGY
- αCP binding to a cytosine-rich subset of polypyrimidine tracts drives a novel pathway of cassette exon splicing in the mammalian transcriptome
- (2016) Xinjun Ji et al. NUCLEIC ACIDS RESEARCH
- Evolution and Biological Roles of Alternative 3′UTRs
- (2016) Christine Mayr TRENDS IN CELL BIOLOGY
- ATtRACT—a database of RNA-binding proteins and associated motifs
- (2016) Girolamo Giudice et al. Database-The Journal of Biological Databases and Curation
- PAPERCLIP Identifies MicroRNA Targets and a Role of CstF64/64tau in Promoting Non-canonical poly(A) Site Usage
- (2016) Hun-Way Hwang et al. Cell Reports
- Chromatoid Body Protein TDRD6 Supports Long 3’ UTR Triggered Nonsense Mediated mRNA Decay
- (2016) Grigorios Fanourgakis et al. PLoS Genetics
- UPF2-Dependent Nonsense-Mediated mRNA Decay Pathway Is Essential for Spermatogenesis by Selectively Eliminating Longer 3'UTR Transcripts
- (2016) Jianqiang Bao et al. PLoS Genetics
- 3’UTR Shortening Potentiates MicroRNA-Based Repression of Pro-differentiation Genes in Proliferating Human Cells
- (2016) Yonit Hoffman et al. PLoS Genetics
- Tunable protein synthesis by transcript isoforms in human cells
- (2016) Stephen N Floor et al. eLife
- Biochemical Properties and Biological Functions of FET Proteins
- (2015) Jacob C. Schwartz et al. Annual Review of Biochemistry
- Position-specific binding of FUS to nascent RNA regulates mRNA length
- (2015) Akio Masuda et al. GENES & DEVELOPMENT
- Alternative 3′ UTRs act as scaffolds to regulate membrane protein localization
- (2015) Binyamin D. Berkovits et al. NATURE
- StringTie enables improved reconstruction of a transcriptome from RNA-seq reads
- (2015) Mihaela Pertea et al. NATURE BIOTECHNOLOGY
- mRNA 3′-UTR shortening is a molecular signature of mTORC1 activation
- (2015) Jae-Woong Chang et al. Nature Communications
- Systematic Profiling of Poly(A)+ Transcripts Modulated by Core 3’ End Processing and Splicing Factors Reveals Regulatory Rules of Alternative Cleavage and Polyadenylation
- (2015) Wencheng Li et al. PLoS Genetics
- Comparative assessment of methods for the computational inference of transcript isoform abundance from RNA-seq data
- (2015) Alexander Kanitz et al. GENOME BIOLOGY
- A change-point model for identifying 3′UTR switching by next-generation RNA sequencing
- (2014) Wei Wang et al. BIOINFORMATICS
- Fip1 regulates mRNA alternative polyadenylation to promote stem cell self-renewal
- (2014) B. Lackford et al. EMBO JOURNAL
- CPSF30 and Wdr33 directly bind to AAUAAA in mammalian mRNA 3′ processing
- (2014) Serena L. Chan et al. GENES & DEVELOPMENT
- Reconstitution of CPSF active in polyadenylation: recognition of the polyadenylation signal by WDR33
- (2014) Lars Schönemann et al. GENES & DEVELOPMENT
- CFIm25 links alternative polyadenylation to glioblastoma tumour suppression
- (2014) Chioniso P. Masamha et al. NATURE
- Poly(A)-tail profiling reveals an embryonic switch in translational control
- (2014) Alexander O. Subtelny et al. NATURE
- Genome-wide identification of transcript start and end sites by transcript isoform sequencing
- (2014) Vicent Pelechano et al. Nature Protocols
- APASdb: a database describing alternative poly(A) sites and selection of heterogeneous cleavage sites downstream of poly(A) signals
- (2014) Leiming You et al. NUCLEIC ACIDS RESEARCH
- Global 3′ UTR shortening has a limited effect on protein abundance in proliferating T cells
- (2014) Andreas R. Gruber et al. Nature Communications
- Dynamic analyses of alternative polyadenylation from RNA-seq reveal a 3′-UTR landscape across seven tumour types
- (2014) Zheng Xia et al. Nature Communications
- Kinetic competition during the transcription cycle results in stochastic RNA processing
- (2014) Antoine Coulon et al. eLife
- Implications of polyadenylation in health and disease
- (2014) Ana Curinha et al. Nucleus
- Direct Competition between hnRNP C and U2AF65 Protects the Transcriptome from the Exonization of Alu Elements
- (2013) Kathi Zarnack et al. CELL
- Ubiquitously transcribed genes use alternative polyadenylation to achieve tissue-specific expression
- (2013) S. Lianoglou et al. GENES & DEVELOPMENT
- 3' UTR-isoform choice has limited influence on the stability and translational efficiency of most mRNAs in mouse fibroblasts
- (2013) N. Spies et al. GENOME RESEARCH
- CP Poly(C) Binding Proteins Act as Global Regulators of Alternative Polyadenylation
- (2013) X. Ji et al. MOLECULAR AND CELLULAR BIOLOGY
- Promoter directionality is controlled by U1 snRNP and polyadenylation signals
- (2013) Albert E. Almada et al. NATURE
- The Cancer Genome Atlas Pan-Cancer analysis project
- (2013) John N Weinstein et al. NATURE GENETICS
- Alternative cleavage and polyadenylation: extent, regulation and function
- (2013) Ran Elkon et al. NATURE REVIEWS GENETICS
- Overlapping and distinct functions of CstF64 and CstF64 in mammalian mRNA 3' processing
- (2013) C. Yao et al. RNA
- The Conserved Intronic Cleavage and Polyadenylation Site of CstF-77 Gene Imparts Control of 3′ End Processing Activity through Feedback Autoregulation and by U1 snRNP
- (2013) Wenting Luo et al. PLoS Genetics
- Means to an end: mechanisms of alternative polyadenylation of messenger RNA precursors
- (2013) Andreas R. Gruber et al. Wiley Interdisciplinary Reviews-RNA
- The Poly(A)-Binding Protein Nuclear 1 Suppresses Alternative Cleavage and Polyadenylation Sites
- (2012) Mathias Jenal et al. CELL
- U1 snRNP Determines mRNA Length and Regulates Isoform Expression
- (2012) Michael G. Berg et al. CELL
- Decreased efficiency of MSH6 mRNA polyadenylation linked to a 20-base-pair duplication in Lynch syndrome families
- (2012) Adrien Decorsière et al. CELL CYCLE
- A quantitative atlas of polyadenylation in five mammals
- (2012) Adnan Derti et al. GENOME RESEARCH
- Analysis of alternative cleavage and polyadenylation by 3′ region extraction and deep sequencing
- (2012) Mainul Hoque et al. NATURE METHODS
- Transcriptome-wide analyses of CstF64-RNA interactions in global regulation of mRNA alternative polyadenylation
- (2012) C. Yao et al. PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA
- Cleavage factor Imis a key regulator of 3′ UTR length
- (2012) Andreas R. Gruber et al. RNA Biology
- Genome-wide Analysis of Pre-mRNA 3′ End Processing Reveals a Decisive Role of Human Cleavage Factor I in the Regulation of 3′ UTR Length
- (2012) Georges Martin et al. Cell Reports
- E2F mediates enhanced alternative polyadenylation in proliferation
- (2012) Ran Elkon et al. GENOME BIOLOGY
- Differential genome-wide profiling of tandem 3' UTRs among human breast cancer and normal cells by high-throughput sequencing
- (2011) Y. Fu et al. GENOME RESEARCH
- A multiplex RNA-seq strategy to profile poly(A+) RNA: Application to analysis of transcription response and 3′ end formation
- (2011) Kristi Fox-Walsh et al. GENOMICS
- Induction of Antagonistic Soluble Decoy Receptor Tyrosine Kinases by Intronic PolyA Activation
- (2011) Sandra Vorlová et al. MOLECULAR CELL
- A germline variant in the TP53 polyadenylation signal confers cancer susceptibility
- (2011) Simon N Stacey et al. NATURE GENETICS
- RNA-binding protein HuR autoregulates its expression by promoting alternative polyadenylation site usage
- (2011) Weijun Dai et al. NUCLEIC ACIDS RESEARCH
- Complex and dynamic landscape of RNA polyadenylation revealed by PAS-Seq
- (2011) P. J. Shepard et al. RNA
- Crystal Structure of a Human Cleavage Factor CFIm25/CFIm68/RNA Complex Provides an Insight into Poly(A) Site Recognition and RNA Looping
- (2011) Qin Yang et al. STRUCTURE
- Comprehensive Polyadenylation Site Maps in Yeast and Human Reveal Pervasive Alternative Polyadenylation
- (2010) Fatih Ozsolak et al. CELL
- U1 snRNP protects pre-mRNAs from premature cleavage and polyadenylation
- (2010) Daisuke Kaida et al. NATURE
- Formation, regulation and evolution of Caenorhabditis elegans 3′UTRs
- (2010) Calvin H. Jan et al. NATURE
- MBNL1 binds GC motifs embedded in pyrimidines to regulate alternative splicing
- (2010) Emily S. Goers et al. NUCLEIC ACIDS RESEARCH
- RBPDB: a database of RNA-binding specificities
- (2010) K. B. Cook et al. NUCLEIC ACIDS RESEARCH
- Structural basis of UGUA recognition by the Nudix protein CFIm25 and implications for a regulatory role in mRNA 3' processing
- (2010) Q. Yang et al. PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA
- Recessive mutations in the INS gene result in neonatal diabetes through reduced insulin biosynthesis
- (2010) I. Garin et al. PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA
- Noncanonical transcript forms in yeast and their regulation during environmental stress
- (2010) O. K. Yoon et al. RNA
- Control of poly(A) tail length
- (2010) Christian R. Eckmann et al. Wiley Interdisciplinary Reviews-RNA
- Global Changes in Processing of mRNA 3' Untranslated Regions Characterize Clinically Distinct Cancer Subtypes
- (2009) P. Singh et al. CANCER RESEARCH
- Widespread Shortening of 3′UTRs by Alternative Cleavage and Polyadenylation Activates Oncogenes in Cancer Cells
- (2009) Christine Mayr et al. CELL
- The Spliceosome: Design Principles of a Dynamic RNP Machine
- (2009) Markus C. Wahl et al. CELL
- Poly(A) Tail Length Is Controlled by the Nuclear Poly(A)-binding Protein Regulating the Interaction between Poly(A) Polymerase and the Cleavage and Polyadenylation Specificity Factor
- (2009) Uwe Kühn et al. JOURNAL OF BIOLOGICAL CHEMISTRY
- Molecular Architecture of the Human Pre-mRNA 3′ Processing Complex
- (2009) Yongsheng Shi et al. MOLECULAR CELL
- Reprogramming of 3′ Untranslated Regions of mRNAs by Alternative Polyadenylation in Generation of Pluripotent Stem Cells from Different Cell Types
- (2009) Zhe Ji et al. PLoS One
- Distinct Role of Long 3′ UTR BDNF mRNA in Spine Morphology and Synaptic Plasticity in Hippocampal Neurons
- (2008) Juan Ji An et al. CELL
- Hu Antigen R (HuR) Functions as an Alternative Pre-mRNA Splicing Regulator of Fas Apoptosis-promoting Receptor on Exon Definition
- (2008) José M. Izquierdo JOURNAL OF BIOLOGICAL CHEMISTRY
- Localized Regulation of Axonal RanGTPase Controls Retrograde Injury Signaling in Peripheral Nerve
- (2008) Dmitry Yudin et al. NEURON
- Proliferating Cells Express mRNAs with Shortened 3' Untranslated Regions and Fewer MicroRNA Target Sites
- (2008) R. Sandberg et al. SCIENCE
Publish scientific posters with Peeref
Peeref publishes scientific posters from all research disciplines. Our Diamond Open Access policy means free access to content and no publication fees for authors.
Learn MoreAsk a Question. Answer a Question.
Quickly pose questions to the entire community. Debate answers and get clarity on the most important issues facing researchers.
Get Started