Microglial NLRP3 inflammasome activation mediates diabetes-induced depression-like behavior via triggering neuroinflammation

Inhibition of Microglial NLRP3 with MCC950 Attenuates Microglial Morphology and NLRP3/Caspase-1/IL-1β Signaling In Stress-induced Mice

(2022) Qing Liu et al.   Journal of Neuroimmune Pharmacology

An update on the regulatory mechanisms of NLRP3 inflammasome activation

(2021) Seungwha Paik et al.   Cellular & Molecular Immunology

Microglia NLRP3 Inflammasomes Activation Involving Diabetic Neuroinflammation in Diabetic Mice and BV2 Cells

(2021) Yuan Li et al.   CURRENT PHARMACEUTICAL DESIGN

Bibliometrics Analysis of the Research Status and Trends of the Association Between Depression and Insulin From 2010 to 2020

(2021) Xiaohan Zou et al.   Frontiers in Psychiatry

NLRP3 inflammasome-dependent pyroptosis and apoptosis in hippocampus neurons mediates depressive-like behavior in diabetic mice

(2020) Dong-Xia Li et al.   BEHAVIOURAL BRAIN RESEARCH

Stress-induced NLRP3 inflammasome activation negatively regulates fear memory in mice

(2020) Yuan Dong et al.   Journal of Neuroinflammation

The Association between Diabetes Complications, Diabetes Distress, and Depressive Symptoms in Patients with Type 2 Diabetes Mellitus

(2020) Qian-Qian Yang et al.   Clinical Nursing Research

GABA-mediated activated microglia induce neuroinflammation in the hippocampus of mice following cold exposure through the NLRP3 inflammasome and NF-κB signaling pathways

(2020) Limin Lang et al.   INTERNATIONAL IMMUNOPHARMACOLOGY

Minocycline prevents depression‐like behavior in streptozotocin‐induced diabetic mice

(2020) Masashi Sakurai et al.   NEUROPATHOLOGY

Markers of central inflammation in major depressive disorder: A systematic review and meta-analysis of studies examining cerebrospinal fluid, positron emission tomography and post-mortem brain tissue

(2019) Daniela Enache et al.   BRAIN BEHAVIOR AND IMMUNITY

Depression-like behavior, hyperglycemia, oxidative stress, and neuroinflammation presented in diabetic mice are reversed by the administration of 1-methyl-3-(phenylselanyl)-1H-indole

(2019) Suely Ribeiro Bampi et al.   JOURNAL OF PSYCHIATRIC RESEARCH

The integrative biology of type 2 diabetes

(2019) Michael Roden et al.   NATURE

Inflammation in psychiatric disorders: what comes first?

(2018) Moisés E. Bauer et al.   Annals of the New York Academy of Sciences

Inhibiting the NLRP3 Inflammasome Activation with MCC950 Ameliorates Diabetic Encephalopathy in db/db Mice

(2018) Yadong Zhai et al.   MOLECULES

Sucrose preference test for measurement of stress-induced anhedonia in mice

(2018) Meng-Ying Liu et al.   Nature Protocols

Global, regional, and national incidence, prevalence, and years lived with disability for 354 diseases and injuries for 195 countries and territories, 1990–2017: a systematic analysis for the Global Burden of Disease Study 2017

(2018) Spencer L James et al.   LANCET

Clemastine Alleviates Depressive-Like Behavior Through Reversing the Imbalance of Microglia-Related Pro-inflammatory State in Mouse Hippocampus

(2018) Wen-Jun Su et al.   Frontiers in Cellular Neuroscience

Paeoniflorin Suppressed High Glucose-Induced Retinal Microglia MMP-9 Expression and Inflammatory Response via Inhibition of TLR4/NF-κB Pathway Through Upregulation of SOCS3 in Diabetic Retinopathy

(2017) Su-Hua Zhu et al.   INFLAMMATION

Antidiabetic drug glyburide modulates depressive-like behavior comorbid with insulin resistance

(2017) Wen-Jun Su et al.   Journal of Neuroinflammation

Specific inhibition of NLRP3 in chikungunya disease reveals a role for inflammasomes in alphavirus-induced inflammation

(2017) Weiqiang Chen et al.   Nature Microbiology

Microglia antioxidant systems and redox signalling

(2016) F Vilhardt et al.   BRITISH JOURNAL OF PHARMACOLOGY

Streptozotocin diabetic mice display depressive-like behavior and alterations in the structure, neurotransmission and plasticity of medial prefrontal cortex interneurons

(2015) Esther Castillo-Gómez et al.   BRAIN RESEARCH BULLETIN

Molecular mechanisms regulating NLRP3 inflammasome activation

(2015) Eun-Kyeong Jo et al.   Cellular & Molecular Immunology

NLRP3 at the interface of metabolism and inflammation

(2015) Moritz Haneklaus et al.   IMMUNOLOGICAL REVIEWS

NLRP3 Inflammasome Mediates Chronic Mild Stress-Induced Depression in Mice via Neuroinflammation

(2015) Y. Zhang et al.   INTERNATIONAL JOURNAL OF NEUROPSYCHOPHARMACOLOGY

Indoleamine-2,3-Dioxygenase/Kynurenine Pathway as a Potential Pharmacological Target to Treat Depression Associated with Diabetes

(2015) Isabella Caroline da Silva Dias et al.   MOLECULAR NEUROBIOLOGY

Stress-Induced Depressive Behaviors Require a Functional NLRP3 Inflammasome

(2015) Elísabet Alcocer-Gómez et al.   MOLECULAR NEUROBIOLOGY

Activation and Regulation of NLRP3 Inflammasome by Intrathecal Application of SDF-1a in a Spinal Cord Injury Model

(2015) Adib Zendedel et al.   MOLECULAR NEUROBIOLOGY

A small-molecule inhibitor of the NLRP3 inflammasome for the treatment of inflammatory diseases

(2015) Rebecca C Coll et al.   NATURE MEDICINE

High-Fat Diet Induced Anxiety and Anhedonia: Impact on Brain Homeostasis and Inflammation

(2015) Sophie Dutheil et al.   NEUROPSYCHOPHARMACOLOGY

The link between depression and diabetes: the search for shared mechanisms

(2015) Calum D Moulton et al.   Lancet Diabetes & Endocrinology

NLRP3 Inflammasome Is Expressed and Functional in Mouse Brain Microglia but Not in Astrocytes

(2015) Audrey Gustin et al.   PLoS One

Microglial NLRP3 inflammasome activation mediates IL-1β-related inflammation in prefrontal cortex of depressive rats

(2014) Ying Pan et al.   BRAIN BEHAVIOR AND IMMUNITY

NIDDK International Conference Report on Diabetes and Depression: Current Understanding and Future Directions

(2014) Richard I.G. Holt et al.   DIABETES CARE

Decreased sucrose preference in patients with type 2 diabetes mellitus

(2014) Ji Hee Yu et al.   DIABETES RESEARCH AND CLINICAL PRACTICE

NLRP3 Deficiency Ameliorates Neurovascular Damage in Experimental Ischemic Stroke

(2014) Fan Yang et al.   JOURNAL OF CEREBRAL BLOOD FLOW AND METABOLISM

Increased oxidative stress in prefrontal cortex and hippocampus is related to depressive-like behavior in streptozotocin-diabetic rats

(2013) Helen de Morais et al.   BEHAVIOURAL BRAIN RESEARCH

NLRP3 inflammasome is activated in mononuclear blood cells from patients with major depressive disorder

(2013) Elísabet Alcocer-Gómez et al.   BRAIN BEHAVIOR AND IMMUNITY

Involvement of Inflammasome Activation in Lipopolysaccharide-induced Mice Depressive-like Behaviors

(2013) Yi Zhang et al.   CNS Neuroscience & Therapeutics

The specific PKR inhibitor C16 prevents apoptosis and IL-1β production in an acute excitotoxic rat model with a neuroinflammatory component

(2013) C. Tronel et al.   NEUROCHEMISTRY INTERNATIONAL

Diabetic db/db mice exhibit central nervous system and peripheral molecular alterations as seen in neurological disorders

(2013) A Ernst et al.   Translational Psychiatry

Depression and type 2 diabetes: a causal association?

(2013) Adam G Tabák et al.   Lancet Diabetes & Endocrinology

Upregulated NLRP3 Inflammasome Activation in Patients With Type 2 Diabetes

(2012) Hye-Mi Lee et al.   DIABETES

Targeting IL-1 in depression

(2012) Michael Maes et al.   EXPERT OPINION ON THERAPEUTIC TARGETS

Epidemiology of depression and diabetes: A systematic review

(2012) Tapash Roy et al.   JOURNAL OF AFFECTIVE DISORDERS

Inducible nitric oxide synthase is involved in the modulation of depressive behaviors induced by unpredictable chronic mild stress

(2012) Yun-Li Peng et al.   Journal of Neuroinflammation

P2X7-mediated calcium influx triggers a sustained, PI3K-dependent increase in metabolic acid production by osteoblast-like cells

(2011) Matthew W. Grol et al.   AMERICAN JOURNAL OF PHYSIOLOGY-ENDOCRINOLOGY AND METABOLISM

Increased IL-1β activation, the culprit not only for defective insulin secretion but also for insulin resistance?

(2011) Marianne Böni-Schnetzler et al.   CELL RESEARCH

Prevention of the β-amyloid peptide-induced inflammatory process by inhibition of double-stranded RNA-dependent protein kinase in primary murine mixed co-cultures

(2011) J Couturier et al.   Journal of Neuroinflammation

The Effect of Antidepressant Medication Treatment on Serum Levels of Inflammatory Cytokines: A Meta-Analysis

(2011) Jonas Hannestad et al.   NEUROPSYCHOPHARMACOLOGY

Depressive phenotypes evoked by experimental diabetes are reversed by insulin

(2011) Nancy Ho et al.   PHYSIOLOGY & BEHAVIOR

Insulin Reveals Akt Signaling as a Novel Regulator of Norepinephrine Transporter Trafficking and Norepinephrine Homeostasis

(2010) S. D. Robertson et al.   JOURNAL OF NEUROSCIENCE

The NLRP3 Inflammasome: A Sensor for Metabolic Danger?

(2010) K. Schroder et al.   SCIENCE

The Female Urine Sniffing Test: A Novel Approach for Assessing Reward-Seeking Behavior in Rodents

(2009) Oz Malkesman et al.   BIOLOGICAL PSYCHIATRY

Thioredoxin-interacting protein links oxidative stress to inflammasome activation

(2009) Rongbin Zhou et al.   NATURE IMMUNOLOGY

Innate Immune Activation Through Nalp3 Inflammasome Sensing of Asbestos and Silica

(2008) C. Dostert et al.   SCIENCE