Indoleamine-2,3-Dioxygenase/Kynurenine Pathway as a Potential Pharmacological Target to Treat Depression Associated with Diabetes

Diabetes-associated depression: The serotonergic system as a novel multifunctional target

(2015) Deepali Gupta et al.   INDIAN JOURNAL OF PHARMACOLOGY

Tumor Necrosis Factor (TNF)-α-induced Repression of GKAP42 Protein Levels through cGMP-dependent Kinase (cGK)-Iα Causes Insulin Resistance in 3T3-L1 Adipocytes

(2015) Yasutoshi Ando et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

The link between depression and diabetes: the search for shared mechanisms

(2015) Calum D Moulton et al.   Lancet Diabetes & Endocrinology

Impact of Diabetes on Epidemiology, Treatment, and Outcomes of Patients With Heart Failure

(2015) Alessandra Dei Cas et al.   JACC-Heart Failure

Hyperglycemia and Diabetes Downregulate the Functional Expression of TRPV4 Channels in Retinal Microvascular Endothelium

(2015) Kevin Monaghan et al.   PLoS One

Protocol and Rationale-The Efficacy of Minocycline as an Adjunctive Treatment for Major Depressive Disorder: A Double Blind, Randomised, Placebo Controlled Trial

(2015) Olivia May Dean et al.   Clinical Psychopharmacology and Neuroscience

Huperzine A Ameliorates Cognitive Deficits in Streptozotocin-Induced Diabetic Rats

(2014) Xiao-Yuan Mao et al.   INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES

Glucocorticoid sensitization of microglia in a genetic mouse model of obesity and diabetes

(2014) Aditi Dey et al.   JOURNAL OF NEUROIMMUNOLOGY

Activation of brain indoleamine 2,3-dioxygenase contributes to epilepsy-associated depressive-like behavior in rats with chronic temporal lobe epilepsy

(2014) Wei Xie et al.   Journal of Neuroinflammation

The organization of the stress system and its dysregulation in depressive illness

(2014) P W Gold   MOLECULAR PSYCHIATRY

Activation of microglia and induction of pro-inflammatory cytokines in the hippocampus of type 2 diabetic rats

(2014) In Koo Hwang et al.   NEUROLOGICAL RESEARCH

Effect of docosahexaenoic acid on hippocampal neurons in high-glucose condition: Involvement of PI3K/AKT/nuclear factor-κB-mediated inflammatory pathways

(2014) R.-H. Yang et al.   NEUROSCIENCE

Antidepressant and Antioxidative Effect of Ibuprofen in the Rotenone Model of Parkinson’s Disease

(2014) Tiago Zaminelli et al.   NEUROTOXICITY RESEARCH

Imipramine and fluoxetine inhibit LPS-induced activation and affect morphology of microglial cells in the rat glial culture

(2014) Ewa Obuchowicz et al.   Pharmacological Reports

Effects of aspirin on immobile behavior and endocrine and immune changes in the forced swimming test: Comparison to fluoxetine and imipramine

(2014) Xi-ting Guan et al.   PHARMACOLOGY BIOCHEMISTRY AND BEHAVIOR

Is the Association Between Depressive Symptoms and Glucose Metabolism Bidirectional? Evidence From the English Longitudinal Study of Ageing

(2014) Panayotes Demakakos et al.   PSYCHOSOMATIC MEDICINE

Biochemical and Neurotransmitters Changes Associated with Tramadol in Streptozotocin-Induced Diabetes in Rats

(2014) Essam Ezzeldin et al.   Biomed Research International

Increased oxidative stress in prefrontal cortex and hippocampus is related to depressive-like behavior in streptozotocin-diabetic rats

(2013) Helen de Morais et al.   BEHAVIOURAL BRAIN RESEARCH

Depression as a Risk Factor for Diabetes

(2013) Francesco Rotella et al.   JOURNAL OF CLINICAL PSYCHIATRY

Brain effect of insulin and clonazepam in diabetic rats under depressive-like behavior

(2013) Carlos Alberto Yasin Wayhs et al.   METABOLIC BRAIN DISEASE

Insulin Resistance and Dysregulation of Tryptophan–Kynurenine and Kynurenine–Nicotinamide Adenine Dinucleotide Metabolic Pathways

(2013) Gregory Oxenkrug   MOLECULAR NEUROBIOLOGY

Cerebroprotective effects of ibuprofen on diabetic encephalopathy in rats

(2013) Yao-Wu Liu et al.   PHARMACOLOGY BIOCHEMISTRY AND BEHAVIOR

Impact of inflammation on neurotransmitter changes in major depression: An insight into the action of antidepressants

(2013) Brian E. Leonard   PROGRESS IN NEURO-PSYCHOPHARMACOLOGY & BIOLOGICAL PSYCHIATRY

Indoleamine 2,3-dioxygenase inhibition attenuates lipopolysaccharide induced persistent microglial activation and depressive-like complications in fractalkine receptor (CX3CR1)-deficient mice

(2012) Angela W. Corona et al.   BRAIN BEHAVIOR AND IMMUNITY

Minocycline

(2012) Olivia M. Dean et al.   CNS DRUGS

Metabolic and Inflammatory Links to Depression in Youth With Diabetes

(2012) K. K. Hood et al.   DIABETES CARE

Indoleamine 2,3-dioxygenase mediates anhedonia and anxiety-like behaviors caused by peripheral lipopolysaccharide immune challenge

(2012) Alexander Salazar et al.   HORMONES AND BEHAVIOR

Using the rat forced swim test to assess antidepressant-like activity in rodents

(2012) David A Slattery et al.   Nature Protocols

Toll-like receptors, the NLRP3 inflammasome and interleukin-1β in the development and progression of type 1 diabetes

(2012) Ellen K. Grishman et al.   PEDIATRIC RESEARCH

Diagnostic classifications in depression and somatization should include biomarkers, such as disorders in the tryptophan catabolite (TRYCAT) pathway

(2012) Michael Maes et al.   PSYCHIATRY RESEARCH

Mitochondrial detachment of hexokinase 1 in mood and psychotic disorders: Implications for brain energy metabolism and neurotrophic signaling

(2011) W.T. Regenold et al.   JOURNAL OF PSYCHIATRIC RESEARCH

Diabetic neuropathy: cellular mechanisms as therapeutic targets

(2011) Andrea M. Vincent et al.   Nature Reviews Neurology

Anti-inflammatory effects of fluoxetine in lipopolysaccharide(LPS)-stimulated microglial cells

(2011) Dexiang Liu et al.   NEUROPHARMACOLOGY

Psychoneuroimmunology Meets Neuropsychopharmacology: Translational Implications of the Impact of Inflammation on Behavior

(2011) Ebrahim Haroon et al.   NEUROPSYCHOPHARMACOLOGY

Chronic variable stress impairs energy metabolism in prefrontal cortex and hippocampus of rats: prevention by chronic antioxidant treatment

(2010) Bárbara Tagliari et al.   METABOLIC BRAIN DISEASE

Protein and lipid oxidative damage in streptozotocin-induced diabetic rats submitted to forced swimming test: the insulin and clonazepam effect

(2010) Carlos Alberto Yasin Wayhs et al.   METABOLIC BRAIN DISEASE

The new ‘5-HT’ hypothesis of depression: Cell-mediated immune activation induces indoleamine 2,3-dioxygenase, which leads to lower plasma tryptophan and an increased synthesis of detrimental tryptophan catabolites (TRYCATs), both of which contribute to the onset of depression

(2010) M. Maes et al.   PROGRESS IN NEURO-PSYCHOPHARMACOLOGY & BIOLOGICAL PSYCHIATRY

Depression is an inflammatory disease, but cell-mediated immune activation is the key component of depression

(2010) Michael Maes   PROGRESS IN NEURO-PSYCHOPHARMACOLOGY & BIOLOGICAL PSYCHIATRY

Food restriction and streptozotocin treatment decrease 5-HT1A and 5-HT2A receptor-mediated behavioral effects in rats

(2009) Jun-Xu Li et al.   BEHAVIOURAL PHARMACOLOGY

Minocycline effects on cerebral edema: Relations with inflammatory and oxidative stress markers following traumatic brain injury in mice

(2009) Shadi Homsi et al.   BRAIN RESEARCH

Oleic acid and peanut oil high in oleic acid reverse the inhibitory effect of insulin production of the inflammatory cytokine TNF-α both in vitro and in vivo systems

(2009) Evros K Vassiliou et al.   Lipids in Health and Disease

A Study on the Mechanisms by Which Minocycline Protects Against MDMA (‘Ecstasy’)-Induced Neurotoxicity of 5-HT Cortical Neurons

(2009) Laura Orio et al.   NEUROTOXICITY RESEARCH

Practical guidelines on the management and prevention of the diabetic foot

(2008) J. Apelqvist et al.   DIABETES-METABOLISM RESEARCH AND REVIEWS

Examining a Bidirectional Association Between Depressive Symptoms and Diabetes

(2008) Sherita Hill Golden   JAMA-JOURNAL OF THE AMERICAN MEDICAL ASSOCIATION

Minocycline attenuates lipopolysaccharide (LPS)-induced neuroinflammation, sickness behavior, and anhedonia

(2008) Christopher J Henry et al.   Journal of Neuroinflammation

From inflammation to sickness and depression: when the immune system subjugates the brain

(2007) Robert Dantzer et al.   NATURE REVIEWS NEUROSCIENCE

Antidepressant-like actions of minocycline combined with several glutamate antagonists

(2007) Miguel Molina-Hernández et al.   PROGRESS IN NEURO-PSYCHOPHARMACOLOGY & BIOLOGICAL PSYCHIATRY

Protective effect of minocycline, a semi-synthetic second-generation tetracycline against 3-nitropropionic acid (3-NP)-induced neurotoxicity

(2007) Manuj Ahuja et al.   TOXICOLOGY