Clemastine Alleviates Depressive-Like Behavior Through Reversing the Imbalance of Microglia-Related Pro-inflammatory State in Mouse Hippocampus

Glycyrrhizic acid ameliorates the kynurenine pathway in association with its antidepressant effect

(2018) Bo Wang et al.   BEHAVIOURAL BRAIN RESEARCH

Microglial activation mediates chronic mild stress-induced depressive- and anxiety-like behavior in adult rats

(2018) Ya-Lin Wang et al.   Journal of Neuroinflammation

Microglia Polarization and Endoplasmic Reticulum Stress in Chronic Social Defeat Stress Induced Depression Mouse

(2018) Jie Tang et al.   NEUROCHEMICAL RESEARCH

Neuropsychopharmacology of JNJ-55308942: evaluation of a clinical candidate targeting P2X7 ion channels in animal models of neuroinflammation and anhedonia

(2018) Anindya Bhattacharya et al.   NEUROPSYCHOPHARMACOLOGY

A P2X7 receptor antagonist reverses behavioural alterations, microglial activation and neuroendocrine dysregulation in an unpredictable chronic mild stress (UCMS) model of depression in mice

(2018) Rai Khalid Farooq et al.   PSYCHONEUROENDOCRINOLOGY

Microglial signatures and their role in health and disease

(2018) Oleg Butovsky et al.   NATURE REVIEWS NEUROSCIENCE

Inhibition of MyD88 Signaling Skews Microglia/Macrophage Polarization and Attenuates Neuronal Apoptosis in the Hippocampus After Status Epilepticus in Mice

(2018) Jin-Tao Liu et al.   Neurotherapeutics

Antidiabetic drug glyburide modulates depressive-like behavior comorbid with insulin resistance

(2017) Wen-Jun Su et al.   Journal of Neuroinflammation

Microglial recruitment of IL-1β-producing monocytes to brain endothelium causes stress-induced anxiety

(2017) D B McKim et al.   MOLECULAR PSYCHIATRY

P2X7 receptor-sensitivity of astrocytes and neurons in the substantia gelatinosa of organotypic spinal cord slices of the mouse depends on the length of the culture period

(2017) Po Gao et al.   NEUROSCIENCE

The P2X7 Receptor Primes IL-1β and the NLRP3 Inflammasome in Astrocytes Exposed to Mechanical Strain

(2017) Farraj Albalawi et al.   Frontiers in Cellular Neuroscience

The P2X7 Receptor-Interleukin-1 Liaison

(2017) Anna Lisa Giuliani et al.   Frontiers in Pharmacology

The microglial ATP-gated ion channel P2X7 as a CNS drug target

(2016) Anindya Bhattacharya et al.   GLIA

Actions of the antihistaminergic clemastine on presymptomatic SOD1-G93A mice ameliorate ALS disease progression

(2016) Savina Apolloni et al.   Journal of Neuroinflammation

Clemastine Enhances Myelination in the Prefrontal Cortex and Rescues Behavioral Changes in Socially Isolated Mice

(2016) J. Liu et al.   JOURNAL OF NEUROSCIENCE

Early P2X7R-related astrogliosis in autoimmune encephalomyelitis

(2016) Tomasz Grygorowicz et al.   MOLECULAR AND CELLULAR NEUROSCIENCE

A meta-analysis of blood cytokine network alterations in psychiatric patients: comparisons between schizophrenia, bipolar disorder and depression

(2016) D R Goldsmith et al.   MOLECULAR PSYCHIATRY

Density of GFAP-immunoreactive astrocytes is decreased in left hippocampi in major depressive disorder

(2016) J.A. Cobb et al.   NEUROSCIENCE

P2X7 as a new target for chrysophanol to treat lipopolysaccharide-induced depression in mice

(2016) Kai Zhang et al.   NEUROSCIENCE LETTERS

Role of neuro-immunological factors in the pathophysiology of mood disorders

(2016) Anindya Bhattacharya et al.   PSYCHOPHARMACOLOGY

Inflammation and increased IDO in hippocampus contribute to depression-like behavior induced by estrogen deficiency

(2015) Yongjun Xu et al.   BEHAVIOURAL BRAIN RESEARCH

Illness Progression, Recent Stress, and Morphometry of Hippocampal Subfields and Medial Prefrontal Cortex in Major Depression

(2015) Michael T. Treadway et al.   BIOLOGICAL PSYCHIATRY

Inhibition of tumor necrosis factor improves sleep continuity in patients with treatment resistant depression and high inflammation

(2015) Jeremy F. Weinberger et al.   BRAIN BEHAVIOR AND IMMUNITY

Up-regulation of P2X7 receptors mediating proliferation of Schwann cells after sciatic nerve injury

(2015) Xian-min Song et al.   Purinergic Signalling

Depression as a Microglial Disease

(2015) Raz Yirmiya et al.   TRENDS IN NEUROSCIENCES

Minocycline treatment ameliorates interferon-alpha- induced neurogenic defects and depression-like behaviors in mice

(2015) Lian-Shun Zheng et al.   Frontiers in Cellular Neuroscience

Clemastine rescues behavioral changes and enhances remyelination in the cuprizone mouse model of demyelination

(2015) Zhifang Li et al.   Neuroscience Bulletin

Microglial NLRP3 inflammasome activation mediates IL-1β-related inflammation in prefrontal cortex of depressive rats

(2014) Ying Pan et al.   BRAIN BEHAVIOR AND IMMUNITY

Clemastine Confers Neuroprotection and Induces an Anti-Inflammatory Phenotype in SOD1G93A Mouse Model of Amyotrophic Lateral Sclerosis

(2014) Savina Apolloni et al.   MOLECULAR NEUROBIOLOGY

Mental health: A world of depression

(2014) Kerri Smith   NATURE

Micropillar arrays as a high-throughput screening platform for therapeutics in multiple sclerosis

(2014) Feng Mei et al.   NATURE MEDICINE

Swimming exercise ameliorates depression-like behavior in chronically stressed rats: Relevant to proinflammatory cytokines and IDO activation

(2013) Weina Liu et al.   BEHAVIOURAL BRAIN RESEARCH

NLRP3 inflammasome is activated in mononuclear blood cells from patients with major depressive disorder

(2013) Elísabet Alcocer-Gómez et al.   BRAIN BEHAVIOR AND IMMUNITY

Dynamic microglial alterations underlie stress-induced depressive-like behavior and suppressed neurogenesis

(2013) T Kreisel et al.   MOLECULAR PSYCHIATRY

Neurochemical Changes in the Mouse Hippocampus Underlying the Antidepressant Effect of Genetic Deletion of P2X7 Receptors

(2013) Cecilia Csölle et al.   PLoS One

Innate immunity in the central nervous system

(2012) Richard M. Ransohoff et al.   JOURNAL OF CLINICAL INVESTIGATION

A Randomized Controlled Trial of the Tumor Necrosis Factor Antagonist Infliximab for Treatment-Resistant Depression

(2012) Charles L. Raison et al.   JAMA Psychiatry

Clemastine causes immune suppression through inhibition of extracellular signal-regulated kinase–dependent proinflammatory cytokines

(2011) Pål Johansen et al.   JOURNAL OF ALLERGY AND CLINICAL IMMUNOLOGY

Clemastine Potentiates the Human P2X7 Receptor by Sensitizing It to Lower ATP Concentrations

(2011) Wolfgang Nörenberg et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Psychoneuroimmunology Meets Neuropsychopharmacology: Translational Implications of the Impact of Inflammation on Behavior

(2011) Ebrahim Haroon et al.   NEUROPSYCHOPHARMACOLOGY

Resilience and reduced c-Fos expression in P2X7 receptor knockout mice exposed to repeated forced swim test

(2011) A.A. Boucher et al.   NEUROSCIENCE

Microglia: biology and pathology

(2009) Manuel B. Graeber et al.   ACTA NEUROPATHOLOGICA

Behavioral profile of P2X7 receptor knockout mice in animal models of depression and anxiety: Relevance for neuropsychiatric disorders

(2008) Ana M. Basso et al.   BEHAVIOURAL BRAIN RESEARCH