Targeting IL-1 in depression

Depression and sickness behavior are Janus-faced responses to shared inflammatory pathways

(2012) Michael Maes et al.   BMC Medicine

Interleukin-1 (IL-1) family of cytokines: Role in Type 2 Diabetes

(2012) Monisha Banerjee et al.   CLINICA CHIMICA ACTA

Circulating cytokine concentrations are not associated with major depressive disorder in a community-based cohort

(2012) Gunnar Einvik et al.   GENERAL HOSPITAL PSYCHIATRY

New drug targets in depression: inflammatory, cell-mediated immune, oxidative and nitrosative stress, mitochondrial, antioxidant, and neuroprogressive pathways. And new drug candidates—Nrf2 activators and GSK-3 inhibitors

(2012) Michael Maes et al.   INFLAMMOPHARMACOLOGY

Inflammatory and Neurodegenerative Pathways in Depression: A New Avenue for Antidepressant Development?

(2011) M. Catena-Dell'Osso et al.   CURRENT MEDICINAL CHEMISTRY

Synergistic Reversal of Type 1 Diabetes in NOD Mice With Anti-CD3 and Interleukin-1 Blockade: Evidence of Improved Immune Regulation

(2011) V. Ablamunits et al.   DIABETES

Interleukin-1beta Promoter (−31T/C and −511C/T) Polymorphisms in Major Recurrent Depression

(2011) Paulina Borkowska et al.   JOURNAL OF MOLECULAR NEUROSCIENCE

Regulatory immune responses induced by IL-1 receptor antagonist in rheumatoid arthritis

(2011) Xiaoyin Niu et al.   MOLECULAR IMMUNOLOGY

The Effect of Antidepressant Medication Treatment on Serum Levels of Inflammatory Cytokines: A Meta-Analysis

(2011) Jonas Hannestad et al.   NEUROPSYCHOPHARMACOLOGY

Interleukin-1β: A New Regulator of the Kynurenine Pathway Affecting Human Hippocampal Neurogenesis

(2011) Patricia A Zunszain et al.   NEUROPSYCHOPHARMACOLOGY

Mechanistic explanations how cell-mediated immune activation, inflammation and oxidative and nitrosative stress pathways and their sequels and concomitants play a role in the pathophysiology of unipolar depression

(2011) Brian Leonard et al.   NEUROSCIENCE AND BIOBEHAVIORAL REVIEWS

Preliminary studies related to anti-interleukin-1β therapy in children with newly diagnosed type 1 diabetes

(2011) Kathryn M. Sumpter et al.   PEDIATRIC DIABETES

Sterile inflammation of endothelial cell-derived apoptotic bodies is mediated by interleukin-1 

(2011) Y. Berda-Haddad et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Activation of cell-mediated immunity in depression: Association with inflammation, melancholia, clinical staging and the fatigue and somatic symptom cluster of depression

(2011) Michael Maes et al.   PROGRESS IN NEURO-PSYCHOPHARMACOLOGY & BIOLOGICAL PSYCHIATRY

Injection-site reactions upon Kineret (anakinra) administration: experiences and explanations

(2011) Christina Kaiser et al.   RHEUMATOLOGY INTERNATIONAL

Interleukin-1β Serum Levels is Increased in Antidepressant-Free Elderly Depressed Patients

(2010) Breno Satler Diniz et al.   AMERICAN JOURNAL OF GERIATRIC PSYCHIATRY

Interleukin-1 receptor antagonist (IL-1Ra) and IL-1Ra producing mesenchymal stem cells as modulators of diabetogenesis

(2010) Vladislav Volarevic et al.   AUTOIMMUNITY

Immune modulation of learning, memory, neural plasticity and neurogenesis

(2010) Raz Yirmiya et al.   BRAIN BEHAVIOR AND IMMUNITY

Is exogenous administration of IL-1ra (anakinra) likely to induce severe depression?

(2010) Annie Pierre Jonville-Bera et al.   EUROPEAN JOURNAL OF CLINICAL PHARMACOLOGY

Associations between interleukin-1 (IL-1) gene variations or IL-1 receptor antagonist levels and the development of type 2 diabetes

(2010) K. Luotola et al.   JOURNAL OF INTERNAL MEDICINE

Pro-gliogenic effect of IL-1α in the differentiation of embryonic neural precursor cellsin vitro

(2010) Maria Antonietta Ajmone-Cat et al.   JOURNAL OF NEUROCHEMISTRY

Regulatory T cells increased while IL-1β decreased during antidepressant therapy

(2010) Hubertus Himmerich et al.   JOURNAL OF PSYCHIATRIC RESEARCH

Pathways underlying neuroprogression in bipolar disorder: Focus on inflammation, oxidative stress and neurotrophic factors

(2010) M. Berk et al.   NEUROSCIENCE AND BIOBEHAVIORAL REVIEWS

Serum anti-inflammatory markers in general population subjects with elevated depressive symptoms

(2010) Soili M. Lehto et al.   NEUROSCIENCE LETTERS

Cytokines mediated inflammation and decreased neurogenesis in animal models of depression

(2010) Cai Song et al.   PROGRESS IN NEURO-PSYCHOPHARMACOLOGY & BIOLOGICAL PSYCHIATRY

In animal models, psychosocial stress-induced (neuro)inflammation, apoptosis and reduced neurogenesis are associated to the onset of depression

(2010) Marta Kubera et al.   PROGRESS IN NEURO-PSYCHOPHARMACOLOGY & BIOLOGICAL PSYCHIATRY

Depression is an inflammatory disease, but cell-mediated immune activation is the key component of depression

(2010) Michael Maes   PROGRESS IN NEURO-PSYCHOPHARMACOLOGY & BIOLOGICAL PSYCHIATRY

Emerging tendency towards autoimmune process in major depressive patients: A novel insight from Th17 cells

(2010) Yili Chen et al.   PSYCHIATRY RESEARCH

Immunological and Inflammatory Functions of the Interleukin-1 Family

(2009) Charles A. Dinarello   Annual Review of Immunology

The Interleukin 1 Beta (IL1B) Gene Is Associated with Failure to Achieve Remission and Impaired Emotion Processing in Major Depression

(2009) Bernhard T. Baune et al.   BIOLOGICAL PSYCHIATRY

A Meta-Analysis of Cytokines in Major Depression

(2009) Yekta Dowlati et al.   BIOLOGICAL PSYCHIATRY

IL-1/IL-1ra balance in the brain revisited – Evidence from transgenic mouse models

(2009) S. Spulber et al.   BRAIN BEHAVIOR AND IMMUNITY

Dynamics of macrophage polarization reveal new mechanism to inhibit IL-1β release through pyrophosphates

(2009) Pablo Pelegrin et al.   EMBO JOURNAL

IL-1β receptor blockade protects islets against pro-inflammatory cytokine induced necrosis and apoptosis

(2009) Alice Schwarznau et al.   JOURNAL OF CELLULAR PHYSIOLOGY

Reductions of acetylcholine release and nerve growth factor expression are correlated with memory impairment induced by interleukin-1β administrations: effects of omega-3 fatty acid EPA treatment

(2009) Pornnarin Taepavarapruk et al.   JOURNAL OF NEUROCHEMISTRY

Stress and IL-1β contribute to the development of depressive-like behavior following peripheral nerve injury

(2009) G J Norman et al.   MOLECULAR PSYCHIATRY

Interleukin-1 Beta −511C/T Genetic Polymorphism is Associated with Age of Onset of Geriatric Depression

(2009) Jen-Ping Hwang et al.   NEUROMOLECULAR MEDICINE

Central infusion of interleukin-1 receptor antagonist blocks the reduction in social behavior produced by prior stressor exposure

(2009) Hiroyuki Arakawa et al.   PHYSIOLOGY & BEHAVIOR

Depressive symptomatology is associated with decreased interleukin-1 beta and increased interleukin-1 receptor antagonist levels in males

(2009) Yrjö Ovaskainen et al.   PSYCHIATRY RESEARCH

Associations of Depression With C-Reactive Protein, IL-1, and IL-6: A Meta-Analysis

(2009) M Bryant Howren et al.   PSYCHOSOMATIC MEDICINE

Focus Issue: Unraveling Signaling Complexity

(2009) N. R. Gough et al.   Science Signaling

Pro-inflammatory biomakers in depression: Treatment with venlafaxine

(2009) John E. Piletz et al.   WORLD JOURNAL OF BIOLOGICAL PSYCHIATRY

Interleukin-1 Receptor Antagonist and Incident Depressive Symptoms Over 6 Years in Older Persons: The InCHIANTI Study

(2008) Yuri Milaneschi et al.   BIOLOGICAL PSYCHIATRY

Symptoms of Postpartum Depression Associated With Elevated Levels of Interleukin-1 Beta During the First Month Postpartum

(2008) E. J. Corwin et al.   Biological Research for Nursing

CD4 T cells: fates, functions, and faults

(2008) J. Zhu et al.   BLOOD

Inhibition of Interleukin-1 by Anakinra Improves Vascular and Left Ventricular Function in Patients With Rheumatoid Arthritis

(2008) Ignatios Ikonomidis et al.   CIRCULATION

Anakinra, a Recombinant Human Interleukin-1 Receptor Antagonist, Inhibits Apoptosis in Experimental Acute Myocardial Infarction

(2008) Antonio Abbate et al.   CIRCULATION

Interleukin-1 (IL-1): A central regulator of stress responses

(2008) Inbal Goshen et al.   FRONTIERS IN NEUROENDOCRINOLOGY

The inflammatory & neurodegenerative (I&ND) hypothesis of depression: leads for future research and new drug developments in depression

(2008) Michael Maes et al.   METABOLIC BRAIN DISEASE

Cytokine Genes TNF, IL1A, IL1B, IL6, IL1RN and IL10, and Childhood-Onset Mood Disorders

(2008) V.L. Misener et al.   NEUROPSYCHOBIOLOGY

IL-1 is an essential mediator of the antineurogenic and anhedonic effects of stress

(2008) J. W. Koo et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Interleukin-1β impairs brain derived neurotrophic factor-induced signal transduction

(2007) Liqi Tong et al.   NEUROBIOLOGY OF AGING