Paeoniflorin Suppressed High Glucose-Induced Retinal Microglia MMP-9 Expression and Inflammatory Response via Inhibition of TLR4/NF-κB Pathway Through Upregulation of SOCS3 in Diabetic Retinopathy

CD40 in Retinal Müller Cells Induces P2X 7 -Dependent Cytokine Expression in Macrophages/Microglia in Diabetic Mice and Development of Early Experimental Diabetic Retinopathy

(2016) Jose-Andres C. Portillo et al.   DIABETES

Paeoniflorin suppresses IL-6/Stat3 pathway via upregulation of Socs3 in dendritic cells in response to 1-chloro-2,4-dinitrobenze

(2016) Dongmei Shi et al.   INTERNATIONAL IMMUNOPHARMACOLOGY

Role of Suppressor of Cytokine Signaling 3 (SOCS3) in Altering Activated Microglia Phenotype in APPswe/PS1dE9 Mice

(2016) Naotoshi Iwahara et al.   JOURNAL OF ALZHEIMERS DISEASE

Protective effect of paeoniflorin on inflammation and apoptosis in the cerebral cortex of a transgenic mouse model of Alzheimer's disease

(2016) XINYI GU et al.   Molecular Medicine Reports

Disruption of Fractalkine Signaling Leads to Microglial Activation and Neuronal Damage in the Diabetic Retina

(2015) Sandra M. Cardona et al.   ASN Neuro

Paeoniflorin attenuates Aβ1-42-induced inflammation and chemotaxis of microglia in vitro and inhibits NF-κB- and VEGF/Flt-1 signaling pathways

(2015) Huayan Liu et al.   BRAIN RESEARCH

Unknown

(2015) Sho-ichi Yamagishi et al.   MOLECULAR MEDICINE

RANIBIZUMAB PLUS PROMPT OR DEFERRED LASER FOR DIABETIC MACULAR EDEMA IN EYES WITH VITRECTOMY BEFORE ANTI-VASCULAR ENDOTHELIAL GROWTH FACTOR THERAPY

(2015) Susan B. Bressler et al.   RETINA-THE JOURNAL OF RETINAL AND VITREOUS DISEASES

Selective suppression of microglial activation by paeoniflorin attenuates morphine tolerance

(2014) C. Jiang et al.   EUROPEAN JOURNAL OF PAIN

Epigalloccatechin-3-gallate Inhibits Ocular Neovascularization and Vascular Permeability in Human Retinal Pigment Epithelial and Human Retinal Microvascular Endothelial Cells via Suppression of MMP-9 and VEGF Activation

(2014) Hak Lee et al.   MOLECULES

Chemokine Mediated Monocyte Trafficking into the Retina: Role of Inflammation in Alteration of the Blood-Retinal Barrier in Diabetic Retinopathy

(2014) Sampathkumar Rangasamy et al.   PLoS One

Microglia and Interleukin-1β in Ischemic Retinopathy Elicit Microvascular Degeneration Through Neuronal Semaphorin-3A

(2013) José Carlos Rivera et al.   ARTERIOSCLEROSIS THROMBOSIS AND VASCULAR BIOLOGY

Involvement of HMGB1 mediated signalling pathway in diabetic retinopathy: evidence from type 2 diabetic rats and ARPE-19 cells under diabetic condition

(2013) Xiao-Li Chen et al.   BRITISH JOURNAL OF OPHTHALMOLOGY

Role of Microglia in CNS Autoimmunity

(2013) Tobias Goldmann et al.   Clinical & Developmental Immunology

VEGF Secreted by Hypoxic Muller Cells Induces MMP-2 Expression and Activity in Endothelial Cells to Promote Retinal Neovascularization in Proliferative Diabetic Retinopathy

(2013) M. Rodrigues et al.   DIABETES

Myeloid depletion of SOCS3 enhances LPS-induced acute lung injury through CCAAT/enhancer binding protein δ pathway

(2013) Chunguang Yan et al.   FASEB JOURNAL

Photoreceptor cells are major contributors to diabetes-induced oxidative stress and local inflammation in the retina

(2013) Y. Du et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Pathophysiology and treatment of diabetic retinopathy

(2012) Francesco Bandello et al.   ACTA DIABETOLOGICA

Matrix metalloproteinases in diabetic retinopathy: potential role of MMP-9

(2012) Renu A Kowluru et al.   EXPERT OPINION ON INVESTIGATIONAL DRUGS

Mechanisms involved in the therapeutic effects of Paeonia lactiflora Pallas in rheumatoid arthritis

(2012) Wei Zhang et al.   INTERNATIONAL IMMUNOPHARMACOLOGY

Paeoniflorin Protects against Ischemia-Induced Brain Damages in Rats via Inhibiting MAPKs/NF-κB-Mediated Inflammatory Responses

(2012) Ruo-Bing Guo et al.   PLoS One

Signal transducer and activator of transcription-3/suppressor of cytokine signaling-3 (STAT3/SOCS3) axis in myeloid cells regulates neuroinflammation

(2012) H. Qin et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Retinal Microglial Activation and Inflammation Induced by Amadori-Glycated Albumin in a Rat Model of Diabetes

(2011) A. S. Ibrahim et al.   DIABETES

Comparative pharmacokinetic study of paeoniflorin and albiflorin after oral administration of Radix Paeoniae Rubra in normal rats and the acute cholestasis hepatitis rats

(2011) Fengjuan Jiang et al.   FITOTERAPIA

Toll-Like Receptor 4 Promotes Tubular Inflammation in Diabetic Nephropathy

(2011) M. Lin et al.   JOURNAL OF THE AMERICAN SOCIETY OF NEPHROLOGY

Convergence and amplification of toll-like receptor (TLR) and receptor for advanced glycation end products (RAGE) signaling pathways via high mobility group B1 (HMGB1)

(2008) Judy R. van Beijnum et al.   ANGIOGENESIS