How Are Natural-Based Polymers Shaping the Future of Cancer Immunotherapy—A Review

The Tumor Microenvironment in Tumorigenesis and Therapy Resistance Revisited

(2023) Kevin Dzobo et al.   Cancers

Combination of hyaluronic acid conjugates with immunogenic cell death inducer and CpG for glioblastoma local chemo-immunotherapy elicits an immune response and induces long-term survival

(2023) Giuseppina Catania et al.   BIOMATERIALS

Reactive oxygen species reprogram macrophages to suppress antitumor immune response through the exosomal miR-155-5p/PD-L1 pathway

(2022) Xiang Li et al.   JOURNAL OF EXPERIMENTAL & CLINICAL CANCER RESEARCH

Injectable hydrogel platform with biodegradable Dawson-type polyoxometalate and R848 for combinational photothermal-immunotherapy of cancer

(2022) Yandi Liu et al.   Biomaterials Science

Identification and validation of Osteopontin and receptor for hyaluronic acid-mediated motility (RHAMM, CD168) for potential immunotherapeutic significance of in lung squamous cell carcinoma

(2022) Gao Shan et al.   INTERNATIONAL IMMUNOPHARMACOLOGY

PD-L1 siRNA–hyaluronic acid conjugate for dual-targeted cancer immunotherapy

(2022) Suyeon Kim et al.   JOURNAL OF CONTROLLED RELEASE

Immunosuppressive cells in cancer: mechanisms and potential therapeutic targets

(2022) Yan Tie et al.   Journal of Hematology & Oncology

New modular platform based on multi-adjuvanted amphiphilic chitosan nanoparticles for efficient lipopeptide vaccine delivery against group A streptococcus

(2022) Abdin Shakirin Mohamad Norpi et al.   Asian Journal of Pharmaceutical Sciences

A Probody® T-cell-engaging bispecific antibody targeting EGFR and CD3 inhibits colon cancer growth with limited toxicity

(2022) Leila M. Boustany et al.   CANCER RESEARCH

Dissolvable Self‐Locking Microneedle Patches Integrated with Immunomodulators for Cancer Immunotherapy

(2022) Seung‐Hwan Joo et al.   ADVANCED MATERIALS

Hyaluronic acid (HA)-coated naproxen-nanoparticles selectively target breast cancer stem cells through COX-independent pathways

(2021) Eva Espinosa-Cano et al.   Materials Science & Engineering C-Materials for Biological Applications

BNT162b vaccines protect rhesus macaques from SARS-CoV-2

(2021) Annette B. Vogel et al.   NATURE

Hyaluronan is a natural and effective immunological adjuvant for protein-based vaccines

(2021) Anna Dalla Pietà et al.   Cellular & Molecular Immunology

Novel topical and transdermal delivery of colchicine with chitosan based biocomposite nanofiberous system; formulation, optimization, characterization, ex vivo skin deposition/permeation, and anti-melanoma evaluation

(2021) Hamed Morad et al.   MATERIALS CHEMISTRY AND PHYSICS

A Comparative Review of Natural and Synthetic Biopolymer Composite Scaffolds

(2021) M. Sai Bhargava Reddy et al.   Polymers

Persistent Luminescence Immune Hydrogel for Photodynamic‐Immunotherapy of Tumors In Vivo

(2021) Gang Shu et al.   ADVANCED FUNCTIONAL MATERIALS

Microneedle‐Based Local Delivery of CCL22 and IL‐2 Enriches T reg Homing to the Skin Allograft and Enables Temporal Monitoring of Immunotherapy Efficacy

(2021) Núria Puigmal et al.   ADVANCED FUNCTIONAL MATERIALS

Chitosan and alginate salt as biomaterials are potential natural adjuvants for killed cholera vaccine

(2021) Nourhan H. AbdelAllah et al.   JOURNAL OF BIOMEDICAL MATERIALS RESEARCH PART A

CD27 expression on Treg cells limits immune responses against tumors

(2021) Sabine Muth et al.   JOURNAL OF MOLECULAR MEDICINE-JMM

Balancing Quality, Cost, and Access During Delivery of Newer Cellular and Immunotherapy Treatments

(2021) Praveen Ramakrishnan Geethakumari et al.   Current Hematologic Malignancy Reports

CX-072 (pacmilimab), a Probody® PD-L1 inhibitor, in advanced or recurrent solid tumors (PROCLAIM-CX-072): an open-label dose-finding and first-in-human study

(2021) Aung Naing et al.   Journal for ImmunoTherapy of Cancer

Conditional PD-1/PD-L1 Probody Therapeutics Induce Comparable Antitumor Immunity but Reduced Systemic Toxicity Compared with Traditional Anti–PD-1/PD-L1 Agents

(2021) Hikmat H. Assi et al.   Cancer Immunology Research

Construction of a core-shell microneedle system to achieve targeted co-delivery of checkpoint inhibitors for melanoma immunotherapy

(2020) Peipei Yang et al.   Acta Biomaterialia

Stable Chitosan-Based Nanoparticles Using Polyphosphoric Acid or Hexametaphosphate for Tandem Ionotropic/Covalent Crosslinking and Subsequent Investigation as Novel Vehicles for Drug Delivery

(2020) Ramzi Mukred Saeed et al.   Frontiers in Bioengineering and Biotechnology

Marine-Derived Polymeric Materials and Biomimetics: An Overview

(2020) Marion Claverie et al.   Polymers

A three-dimensional hyaluronic acid-based niche enhances the therapeutic efficacy of human natural killer cell-based cancer immunotherapy

(2020) Young Ha Ahn et al.   BIOMATERIALS

Chimeric Antigen Receptor Designed to Prevent Ubiquitination and Downregulation Showed Durable Antitumor Efficacy

(2020) Wentao Li et al.   IMMUNITY

SARS-CoV-2 mRNA vaccine design enabled by prototype pathogen preparedness

(2020) Kizzmekia S. Corbett et al.   NATURE

Polymeric Nanoparticles for Drug Delivery: Recent Developments and Future Prospects

(2020) Belén Begines et al.   Nanomaterials

Chitosan/γ-PGA nanoparticles-based immunotherapy as adjuvant to radiotherapy in breast cancer

(2020) Flávia Castro et al.   BIOMATERIALS

Preventing Ubiquitination Improves CAR T Cell Therapy via ‘CAR Merry-Go-Around’

(2020) Nicole M. Chapman et al.   IMMUNITY

Scaffolds for Wound Healing Applications

(2020) Irina Negut et al.   Polymers

Efficacy and Safety of the mRNA-1273 SARS-CoV-2 Vaccine

(2020) Lindsey R. Baden et al.   NEW ENGLAND JOURNAL OF MEDICINE

Safety and Efficacy of the BNT162b2 mRNA Covid-19 Vaccine

(2020) Fernando P. Polack et al.   NEW ENGLAND JOURNAL OF MEDICINE

Marine-derived drugs: Recent advances in cancer therapy and immune signaling

(2020) Abdullah F.U.H. Saeed et al.   BIOMEDICINE & PHARMACOTHERAPY

Tumor microenvironment as a therapeutic target in cancer

(2020) Yi Xiao et al.   PHARMACOLOGY & THERAPEUTICS

Efficient ovalbumin delivery using a novel multifunctional micellar platform for targeted melanoma immunotherapy

(2019) Muye He et al.   INTERNATIONAL JOURNAL OF PHARMACEUTICS

Dendritic Cell-Targeted pH-Responsive Extracellular Vesicles for Anticancer Vaccination

(2019) Hyuk Lee et al.   Pharmaceutics

A 3D Macroporous Alginate Graphene Scaffold with an Extremely Slow Release of a Loaded Cargo for In Situ Long-Term Activation of Dendritic Cells

(2019) Arjyabaran Sinha et al.   Advanced Healthcare Materials

Artificially Reprogrammed Macrophages as Tumor-Tropic Immunosuppression-Resistant Biologics to Realize Therapeutics Production and Immune Activation

(2019) Chu-Xin Li et al.   ADVANCED MATERIALS

Cationic polymer modified PLGA nanoparticles encapsulating Alhagi honey polysaccharides as a vaccine delivery system for ovalbumin to improve immune responses

(2019) Adelijiang Wusiman et al.   International Journal of Nanomedicine

Systemic clinical tumor regressions and potentiation of PD1 blockade with in situ vaccination

(2019) Linda Hammerich et al.   NATURE MEDICINE

Downregulation of A2AR by siRNA loaded PEG-chitosan-lactate nanoparticles restores the T cell mediated anti-tumor responses through blockage of PKA/CREB signaling pathway

(2019) Ali Masjedi et al.   INTERNATIONAL JOURNAL OF BIOLOGICAL MACROMOLECULES

Formulation and preclinical evaluation of a toll-like receptor 7/8 agonist as an anti-tumoral immunomodulator

(2019) Ruolin Lu et al.   JOURNAL OF CONTROLLED RELEASE

Phototherapy using immunologically modified carbon nanotubes to potentiate checkpoint blockade for metastatic breast cancer

(2019) Yong Li et al.   Nanomedicine-Nanotechnology Biology and Medicine

Scaffolding polymeric biomaterials: Are naturally occurring biological macromolecules more appropriate for tissue engineering?

(2019) Mojtaba Abbasian et al.   INTERNATIONAL JOURNAL OF BIOLOGICAL MACROMOLECULES

A Three-in-One Immunotherapy Nanoweapon via Cascade-Amplifying Cancer-Immunity Cycle against Tumor Metastasis, Relapse, and Postsurgical Regrowth

(2019) Qian Li et al.   NANO LETTERS

Enhanced anti-tumor immunotherapy by dissolving microneedle patch loaded ovalbumin

(2019) Sung-Ju Lee et al.   PLoS One

Biodegradable Microneedle Patch Delivering Antigenic Peptide–Hyaluronate Conjugate for Cancer Immunotherapy

(2019) Hyemin Kim et al.   ACS Biomaterials-Science & Engineering

Synergistic triple-combination therapy with hyaluronic acid-shelled PPy/CPT nanoparticles results in tumor regression and prevents tumor recurrence and metastasis in 4T1 breast cancer

(2019) Wei Sun et al.   BIOMATERIALS

Chitosan Nanoparticles Strengthen Vγ9Vδ2 T-Cell Cytotoxicity Through Upregulation Of Killing Molecules And Cytoskeleton Polarization

(2019) Li Lin et al.   International Journal of Nanomedicine

Medical devices biomaterials – A review

(2019) AJ Festas et al.   PROCEEDINGS OF THE INSTITUTION OF MECHANICAL ENGINEERS PART L-JOURNAL OF MATERIALS-DESIGN AND APPLICATIONS

Photodynamic Therapy Combined with Antihypoxic Signaling and CpG Adjuvant as an In Situ Tumor Vaccine Based on Metal–Organic Framework Nanoparticles to Boost Cancer Immunotherapy

(2019) Zhixiong Cai et al.   Advanced Healthcare Materials

Degradation-regulated architecture of injectable smart hydrogels enhances humoral immune response and potentiates antitumor activity in human lung carcinoma

(2019) Huu Thuy Trang Duong et al.   BIOMATERIALS

Role of Tumor-Mediated Dendritic Cell Tolerization in Immune Evasion

(2019) Nicholas C. DeVito et al.   Frontiers in Immunology

High Molecular Weight Chitosan-Complexed RNA Nanoadjuvant for Effective Cancer Immunotherapy

(2019) Jin Joo Choi et al.   Pharmaceutics

Enhancing immunogenicity of antigens through sustained intradermal delivery using chitosan microneedles with a patch-dissolvable design

(2018) Mei-Chin Chen et al.   Acta Biomaterialia

Hyaluronic Acid Surface Modified Liposomes Prepared via Orthogonal Aminoxy Coupling: Synthesis of Nontoxic Aminoxylipids Based on Symmetrically α-Branched Fatty Acids, Preparation of Liposomes by Microfluidic Mixing, and Targeting to Cancer Cells Expressing CD44

(2018) Eliška Bartheldyová et al.   BIOCONJUGATE CHEMISTRY

Sodium Hyaluronate/Chitosan Composite Microneedles as a Single-Dose Intradermal Immunization System

(2018) Yu-Hsiu Chiu et al.   BIOMACROMOLECULES

Application of water-soluble polyvinyl alcohol-based film patches on laser microporated skin facilitates intradermal macromolecule and nanoparticle delivery

(2018) Laura Engelke et al.   EUROPEAN JOURNAL OF PHARMACEUTICS AND BIOPHARMACEUTICS

Release characteristics of cellulose sulphate capsules and production of cytokines from encapsulated cells

(2018) Brian Salmons et al.   INTERNATIONAL JOURNAL OF PHARMACEUTICS

Hyaluronic acid based low viscosity hydrogel as a novel carrier for Convection Enhanced Delivery of CAR T cells

(2018) Ahmet F. Atik et al.   JOURNAL OF CLINICAL NEUROSCIENCE

Preparation and characterization of gellan gum/glucosamine/clioquinol film as oral cancer treatment patch

(2018) Wanchi Tsai et al.   Materials Science & Engineering C-Materials for Biological Applications

CAR-T cells: the long and winding road to solid tumors

(2018) Maria Michela D’Aloia et al.   Cell Death & Disease

Photothermally Controlled MHC Class I Restricted CD8+ T-Cell Responses Elicited by Hyaluronic Acid Decorated Gold Nanoparticles as a Vaccine for Cancer Immunotherapy

(2018) Fengqiang Cao et al.   Advanced Healthcare Materials

Automated Expansion of Primary Human T Cells in Scalable and Cell-Friendly Hydrogel Microtubes for Adoptive Immunotherapy

(2018) Haishuang Lin et al.   Advanced Healthcare Materials

H2O2-Responsive Nanoparticle Based on the Supramolecular Self-Assemble of Cyclodextrin

(2018) Zhenqiang Dong et al.   Frontiers in Pharmacology

Combined local immunostimulatory radioisotope therapy and systemic immune checkpoint blockade imparts potent antitumour responses

(2018) Yu Chao et al.   Nature Biomedical Engineering

PD-1 Blockade for Improving the Antitumor Efficiency of Polymer-Doxorubicin Nanoprodrug

(2018) Fan Gao et al.   Small

An Immunologically Modified Nanosystem Based on Noncovalent Binding Between Single-Walled Carbon Nanotubes and Glycated Chitosan

(2018) Leton Chandra Saha et al.   TECHNOLOGY IN CANCER RESEARCH & TREATMENT

Cytokines in clinical cancer immunotherapy

(2018) Pedro Berraondo et al.   BRITISH JOURNAL OF CANCER

Hyaluronan-based dissolving microneedles with high antigen content for intradermal vaccination: Formulation, physicochemical characterization and immunogenicity assessment

(2018) Mara Leone et al.   EUROPEAN JOURNAL OF PHARMACEUTICS AND BIOPHARMACEUTICS

Injectable Biodegradable Chitosan-Alginate 3D Porous Gel Scaffold for mRNA Vaccine Delivery

(2018) Jingxuan Yan et al.   MACROMOLECULAR BIOSCIENCE

Monoclonal antibodies in cancer immunotherapy

(2018) Ilgin Kimiz-Gebologlu et al.   MOLECULAR BIOLOGY REPORTS

Biopolymers codelivering engineered T cells and STING agonists can eliminate heterogeneous tumors

(2017) Tyrel T. Smith et al.   JOURNAL OF CLINICAL INVESTIGATION

Masked Chimeric Antigen Receptor for Tumor-Specific Activation

(2017) Xiaolu Han et al.   MOLECULAR THERAPY

Increased efficacy of a dendritic cell–based therapeutic cancer vaccine with adenosine receptor antagonist and CD73 inhibitor

(2017) Samaneh Arab et al.   TUMOR BIOLOGY

T cell-targeting nanoparticles focus delivery of immunotherapy to improve antitumor immunity

(2017) Daniela Schmid et al.   Nature Communications

An oxygen sensitive self-decision making engineered CAR T-cell

(2017) Alexandre Juillerat et al.   Scientific Reports

Multicomponent Injectable Hydrogels for Antigen-Specific Tolerogenic Immune Modulation

(2017) Catia S. Verbeke et al.   Advanced Healthcare Materials

Superhydrophobic Surfaces Made from Naturally Derived Hydrophobic Materials

(2017) Seyed Mohammad Reza Razavi et al.   ACS Sustainable Chemistry & Engineering

Cancer Immunotherapy Using CAR-T Cells: From the Research Bench to the Assembly Line

(2017) Diogo Gomes-Silva et al.   Biotechnology Journal

Mucoadhesive Chitosan-Pectinate Nanoparticles for the Delivery of Curcumin to the Colon

(2016) Enas Alkhader et al.   AAPS PHARMSCITECH

Enhanced Cancer Immunotherapy by Microneedle Patch-Assisted Delivery of Anti-PD1 Antibody

(2016) Chao Wang et al.   NANO LETTERS

Development and characterization of chitosan/hyaluronan film for transdermal delivery of thiocolchicoside

(2015) Federica Bigucci et al.   CARBOHYDRATE POLYMERS

Ex vivo skin permeation and retention studies on chitosan–ibuprofen–gellan ternary nanogel prepared by in situ ionic gelation technique—a tool for controlled transdermal delivery of ibuprofen

(2015) Amos Olusegun Abioye et al.   INTERNATIONAL JOURNAL OF PHARMACEUTICS

Shape and size-dependent immune response to antigen-carrying nanoparticles

(2015) Sunny Kumar et al.   JOURNAL OF CONTROLLED RELEASE

Biodegradable Nanoellipsoidal Artificial Antigen Presenting Cells for Antigen Specific T-Cell Activation

(2015) Randall A. Meyer et al.   Small

Recent insights into cutaneous immunization: How to vaccinate via the skin

(2015) Laura Engelke et al.   VACCINE

Injectable, Pore-Forming Hydrogels for In Vivo Enrichment of Immature Dendritic Cells

(2015) Catia S. Verbeke et al.   Advanced Healthcare Materials

High and Low Molecular Weight Hyaluronic Acid Differentially Influence Macrophage Activation

(2015) Jamie E. Rayahin et al.   ACS Biomaterials-Science & Engineering

Interactions between Hyaluronan and Its Receptors (CD44, RHAMM) Regulate the Activities of Inflammation and Cancer

(2015) Suniti Misra et al.   Frontiers in Immunology

High and Low Molecular Weight Hyaluronic Acid Differentially Influence Macrophage Activation

(2015) Jamie E. Rayahin et al.   ACS Biomaterials Science & Engineering

Hyaluronan: Biosynthesis and signaling

(2014) Davide Vigetti et al.   BIOCHIMICA ET BIOPHYSICA ACTA-GENERAL SUBJECTS

Mechanism of Activation-Induced Cell Death of T Cells and Regulation of FasL Expression

(2014) Rieko Arakaki et al.   CRITICAL REVIEWS IN IMMUNOLOGY

Squalene emulsion potentiates the adjuvant activity of the TLR4 agonist, GLA, via inflammatory caspases, IL-18, and IFN-γ

(2014) Anthony L. Desbien et al.   EUROPEAN JOURNAL OF IMMUNOLOGY

Biopolymer implants enhance the efficacy of adoptive T-cell therapy

(2014) Sirkka B Stephan et al.   NATURE BIOTECHNOLOGY

Particle shape dependence of CD8+ T cell activation by artificial antigen presenting cells

(2013) Joel C. Sunshine et al.   BIOMATERIALS

Nanoscale artificial antigen presenting cells for T cell immunotherapy

(2013) Karlo Perica et al.   Nanomedicine-Nanotechnology Biology and Medicine

Engineering Nano- and Microparticles to Tune Immunity

(2012) James J. Moon et al.   ADVANCED MATERIALS

Cell encapsulation technology as a novel strategy for human anti-tumor immunotherapy

(2011) F Schwenter et al.   CANCER GENE THERAPY

Hallmarks of Cancer: The Next Generation

(2011) Douglas Hanahan et al.   CELL

Hydrogen peroxide fuels aging, inflammation, cancer metabolism and metastasis

(2011) Michael P Lisanti et al.   CELL CYCLE

CD8+ T Cells: Foot Soldiers of the Immune System

(2011) Nu Zhang et al.   IMMUNITY

Perforin pores in the endosomal membrane trigger the release of endocytosed granzyme B into the cytosol of target cells

(2011) Jerome Thiery et al.   NATURE IMMUNOLOGY

Normal T cell homeostasis: the conversion of naive cells into memory-phenotype cells

(2011) Jonathan Sprent et al.   NATURE IMMUNOLOGY

T cell exhaustion

(2011) E John Wherry   NATURE IMMUNOLOGY

Adoptive T cell therapy of cancer

(2010) Malcolm K Brenner et al.   CURRENT OPINION IN IMMUNOLOGY

Diffusion of interleukin-2 from cells overlaid with cytocompatible enzyme-crosslinked gelatin hydrogels

(2010) Chong Wing Yung et al.   JOURNAL OF BIOMEDICAL MATERIALS RESEARCH PART A

Intratumoral Immunotherapy of Established Solid Tumors With Chitosan/IL-12

(2010) David A. Zaharoff et al.   JOURNAL OF IMMUNOTHERAPY

PD-1 and CTLA-4 combination blockade expands infiltrating T cells and reduces regulatory T and myeloid cells within B16 melanoma tumors

(2010) M. A. Curran et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

A Comprehensive Platform for Ex Vivo T-cell Expansion Based on Biodegradable Polymeric Artificial Antigen-presenting Cells

(2008) Erin R Steenblock et al.   MOLECULAR THERAPY

Interleukin-21: Basic Biology and Implications for Cancer and Autoimmunity

(2007) Rosanne Spolski et al.   Annual Review of Immunology

The Biology of Interleukin-2

(2007) Thomas R. Malek   Annual Review of Immunology