Engineering Nano- and Microparticles to Tune Immunity

Antigen Release Kinetics in the Phagosome Are Critical to Cross-Presentation Efficiency

(2014) S. W. Howland et al.   JOURNAL OF IMMUNOLOGY

PRINT: A Novel Platform Toward Shape and Size Specific Nanoparticle Theranostics

(2011) Jillian L. Perry et al.   ACCOUNTS OF CHEMICAL RESEARCH

The effects of polymeric nanostructure shape on drug delivery

(2011) Shrinivas Venkataraman et al.   ADVANCED DRUG DELIVERY REVIEWS

Cell-Based Drug Delivery Devices Using Phagocytosis-Resistant Backpacks

(2011) Nishit Doshi et al.   ADVANCED MATERIALS

Patchy, Anisotropic Microspheres with Soft Protein Islets

(2011) Kaladhar Kamalasanan et al.   ANGEWANDTE CHEMIE-INTERNATIONAL EDITION

Folate-targeted nanoparticles show efficacy in the treatment of inflammatory arthritis

(2011) Thommey P. Thomas et al.   ARTHRITIS AND RHEUMATISM

Mannosylated Dextran Nanoparticles: A pH-Sensitive System Engineered for Immunomodulation through Mannose Targeting

(2011) Lina Cui et al.   BIOCONJUGATE CHEMISTRY

Simultaneous in vivo tracking of dendritic cells and priming of an antigen-specific immune response

(2011) Young-Woock Noh et al.   BIOMATERIALS

Induction of potent anti-tumor responses while eliminating systemic side effects via liposome-anchored combinatorial immunotherapy

(2011) Brandon Kwong et al.   BIOMATERIALS

The induction of innate and adaptive immunity by biodegradable poly(γ-glutamic acid) nanoparticles via a TLR4 and MyD88 signaling pathway

(2011) Tomofumi Uto et al.   BIOMATERIALS

The impact of nanoparticle ligand density on dendritic-cell targeted vaccines

(2011) Arunima Bandyopadhyay et al.   BIOMATERIALS

The influence of PEG chain length and targeting moiety on antibody-mediated delivery of nanoparticle vaccines to human dendritic cells

(2011) Luis J. Cruz et al.   BIOMATERIALS

Induction of anti-tumor cytotoxic T cell responses through PLGA-nanoparticle mediated antigen delivery

(2011) Zhiping Zhang et al.   BIOMATERIALS

From stem cell to red cell: regulation of erythropoiesis at multiple levels by multiple proteins, RNAs, and chromatin modifications

(2011) S. M. Hattangadi et al.   BLOOD

In situ vaccination against mycosis fungoides by intratumoral injection of a TLR9 agonist combined with radiation: a phase 1/2 study

(2011) Y. H. Kim et al.   BLOOD

Targeted Therapeutic Remodeling of the Tumor Microenvironment Improves an HER-2 DNA Vaccine and Prevents Recurrence in a Murine Breast Cancer Model

(2011) D. Liao et al.   CANCER RESEARCH

Enhancement of anti-tumor immunity through local modulation of CTLA-4 and GITR by dendritic cells

(2011) Scott K. Pruitt et al.   EUROPEAN JOURNAL OF IMMUNOLOGY

An Artificial Antigen-presenting Cell with Paracrine Delivery of IL-2 Impacts the Magnitude and Direction of the T Cell Response

(2011) Erin R. Steenblock et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

In vivo distribution of surface-modified PLGA nanoparticles following intravaginal delivery

(2011) Yen Cu et al.   JOURNAL OF CONTROLLED RELEASE

Liposomal Encapsulation of Glucocorticoids Alters Their Mode of Action in the Treatment of Experimental Autoimmune Encephalomyelitis

(2011) Nils Schweingruber et al.   JOURNAL OF IMMUNOLOGY

CD8- Dendritic Cells and Macrophages Cross-Present Poly(D,L-lactate-co-glycolate) Acid Microsphere-Encapsulated Antigen In Vivo

(2011) C. Schliehe et al.   JOURNAL OF IMMUNOLOGY

Peptide-MHC-based nanovaccines for the treatment of autoimmunity: a “one size fits all” approach?

(2011) Xavier Clemente-Casares et al.   JOURNAL OF MOLECULAR MEDICINE-JMM

A Single Intrathecal Injection of DNA and an Asymmetric Cationic Lipid as Lipoplexes Ameliorates Experimental Autoimmune Encephalomyelitis

(2011) Srikanth Yellayi et al.   MOLECULAR PHARMACEUTICS

Mannose-Functionalized “Pathogen-like” Polyanhydride Nanoparticles Target C-Type Lectin Receptors on Dendritic Cells

(2011) Brenda Carrillo-Conde et al.   MOLECULAR PHARMACEUTICS

In Vitroandin VivomRNA Delivery Using Lipid-Enveloped pH-Responsive Polymer Nanoparticles

(2011) Xingfang Su et al.   MOLECULAR PHARMACEUTICS

Cancer immunotherapy comes of age

(2011) Ira Mellman et al.   NATURE

Programming the magnitude and persistence of antibody responses with innate immunity

(2011) Sudhir Pai Kasturi et al.   NATURE

Therapeutic siRNA silencing in inflammatory monocytes in mice

(2011) Florian Leuschner et al.   NATURE BIOTECHNOLOGY

Immunological mechanisms of vaccination

(2011) Bali Pulendran et al.   NATURE IMMUNOLOGY

Interbilayer-crosslinked multilamellar vesicles as synthetic vaccines for potent humoral and cellular immune responses

(2011) James J. Moon et al.   NATURE MATERIALS

A multifunctional core–shell nanoparticle for dendritic cell-based cancer immunotherapy

(2011) Nam-Hyuk Cho et al.   Nature Nanotechnology

Alpha-alumina nanoparticles induce efficient autophagy-dependent cross-presentation and potent antitumour response

(2011) Haiyan Li et al.   Nature Nanotechnology

Immunotherapy for the treatment of prostate cancer

(2011) Giuseppe Di Lorenzo et al.   Nature Reviews Clinical Oncology

Cell transfer immunotherapy for metastatic solid cancer—what clinicians need to know

(2011) Steven A. Rosenberg   Nature Reviews Clinical Oncology

Activation of Antigen-Specific T Cell-Responses by Mannan-Decorated PLGA Nanoparticles

(2011) Samar Hamdy et al.   PHARMACEUTICAL RESEARCH

Design of a Protective Single-Dose Intranasal Nanoparticle-Based Vaccine Platform for Respiratory Infectious Diseases

(2011) Bret D. Ulery et al.   PLoS One

Direct activation of antigen-presenting cells is required for CD8+ T-cell priming and tumor vaccination

(2011) W. Kratky et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

In situ engineering of the lymph node microenvironment via intranodal injection of adjuvant-releasing polymer particles

(2011) C. M. Jewell et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Nanoparticle conjugation of antigen enhances cytotoxic T-cell responses in pulmonary vaccination

(2011) C. Nembrini et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Using mechanobiological mimicry of red blood cells to extend circulation times of hydrogel microparticles

(2011) T. J. Merkel et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Erythrocyte membrane-camouflaged polymeric nanoparticles as a biomimetic delivery platform

(2011) C.-M. J. Hu et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

A Phosphorus-Based Dendrimer Targets Inflammation and Osteoclastogenesis in Experimental Arthritis

(2011) M. Hayder et al.   Science Translational Medicine

T Cells with Chimeric Antigen Receptors Have Potent Antitumor Effects and Can Establish Memory in Patients with Advanced Leukemia

(2011) M. Kalos et al.   Science Translational Medicine

T cells enhance gold nanoparticle delivery to tumors in vivo

(2011) Laura C Kennedy et al.   Nanoscale Research Letters

Nanoparticulate Cellular Patches for Cell-Mediated Tumoritropic Delivery

(2010) Hao Cheng et al.   ACS Nano

Intracellular Delivery of a Protein Antigen with an Endosomal-Releasing Polymer Enhances CD8 T-Cell Production and Prophylactic Vaccine Efficacy

(2010) Suzanne Foster et al.   BIOCONJUGATE CHEMISTRY

Traffic of poly(lactic acid) nanoparticulate vaccine vehicle from intestinal mucus to sub-epithelial immune competent cells

(2010) Charlotte Primard et al.   BIOMATERIALS

The use of calcium phosphate nanoparticles encapsulating Toll-like receptor ligands and the antigen hemagglutinin to induce dendritic cell maturation and T cell activation

(2010) Viktoriya Sokolova et al.   BIOMATERIALS

Engineering complement activation on polypropylene sulfide vaccine nanoparticles

(2010) Susan N. Thomas et al.   BIOMATERIALS

Characterization of Particle Translocation through Mucin Hydrogels

(2010) Oliver Lieleg et al.   BIOPHYSICAL JOURNAL

Macrophage Diversity Enhances Tumor Progression and Metastasis

(2010) Bin-Zhi Qian et al.   CELL

Development of Nanoparticles for Antimicrobial Drug Delivery

(2010) L. Zhang et al.   CURRENT MEDICINAL CHEMISTRY

Polylactide-cyclosporin A nanoparticles for targeted immunosuppression

(2010) Jamil Azzi et al.   FASEB JOURNAL

Reversal of Autoimmunity by Boosting Memory-like Autoregulatory T Cells

(2010) Sue Tsai et al.   IMMUNITY

From Vaccines to Memory and Back

(2010) Federica Sallusto et al.   IMMUNITY

Intracellular Toll-like Receptors

(2010) Amanda L. Blasius et al.   IMMUNITY

Sialic acid and glycopeptides conjugated PLGA nanoparticles for central nervous system targeting: In vivo pharmacological evidence and biodistribution

(2010) G. Tosi et al.   JOURNAL OF CONTROLLED RELEASE

Dual role of CpG as immune modulator and physical crosslinker in ovalbumin loaded N-trimethyl chitosan (TMC) nanoparticles for nasal vaccination

(2010) Bram Slütter et al.   JOURNAL OF CONTROLLED RELEASE

Administration routes affect the quality of immune responses: A cross-sectional evaluation of particulate antigen-delivery systems

(2010) Deepa Mohanan et al.   JOURNAL OF CONTROLLED RELEASE

Targeted PLGA nano- but not microparticles specifically deliver antigen to human dendritic cells via DC-SIGN in vitro

(2010) Luis J. Cruz et al.   JOURNAL OF CONTROLLED RELEASE

Angiopep-2 modified PE-PEG based polymeric micelles for amphotericin B delivery targeted to the brain

(2010) Kun Shao et al.   JOURNAL OF CONTROLLED RELEASE

Immunity by formulation design: Induction of high CD8+ T-cell responses by poly(I:C) incorporated into the CAF01 adjuvant via a double emulsion method

(2010) Pernille Nordly et al.   JOURNAL OF CONTROLLED RELEASE

Active targeting of dendritic cells with mannan-decorated PLGA nanoparticles

(2010) Zahra Ghotbi et al.   JOURNAL OF DRUG TARGETING

TLR9-Targeted Biodegradable Nanoparticles as Immunization Vectors Protect against West Nile Encephalitis

(2010) S. L. Demento et al.   JOURNAL OF IMMUNOLOGY

Particle Shape: A New Design Parameter for Passive Targeting In Splenotropic Drug Delivery

(2010) Padma V. Devarajan et al.   JOURNAL OF PHARMACEUTICAL SCIENCES

Needle-shaped polymeric particles induce transient disruption of cell membranes

(2010) N. Doshi et al.   Journal of the Royal Society Interface

Lactoferrin-Conjugated Biodegradable Polymersome Holding Doxorubicin and Tetrandrine for Chemotherapy of Glioma Rats

(2010) Zhiqing Pang et al.   MOLECULAR PHARMACEUTICS

Modulation of CD4+ T Lymphocyte Lineage Outcomes with Targeted, Nanoparticle-Mediated Cytokine Delivery

(2010) Jason Park et al.   MOLECULAR PHARMACEUTICS

Multistrain influenza protection induced by a nanoparticulate mucosal immunotherapeutic

(2010) W Tai et al.   Mucosal Immunology

Nanoscale particle therapies for wounds and ulcers

(2010) Roberta Cortivo et al.   Nanomedicine

Landmark approval for Dendreon's cancer vaccine

(2010) Laura DeFrancesco   NATURE BIOTECHNOLOGY

The role of pattern-recognition receptors in innate immunity: update on Toll-like receptors

(2010) Taro Kawai et al.   NATURE IMMUNOLOGY

Nanogel antigenic protein-delivery system for adjuvant-free intranasal vaccines

(2010) Tomonori Nochi et al.   NATURE MATERIALS

Therapeutic cell engineering with surface-conjugated synthetic nanoparticles

(2010) Matthias T Stephan et al.   NATURE MEDICINE

Delivering nanomedicine to solid tumors

(2010) Rakesh K. Jain et al.   Nature Reviews Clinical Oncology

New Therapies for Castration-Resistant Prostate Cancer

(2010) Dan L. Longo   NEW ENGLAND JOURNAL OF MEDICINE

Improved Survival with Ipilimumab in Patients with Metastatic Melanoma

(2010) F. Stephen Hodi et al.   NEW ENGLAND JOURNAL OF MEDICINE

Exploiting cross-priming to generate protective CD8 T-cell immunity rapidly

(2010) N.-L. L. Pham et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Competing feedback loops shape IL-2 signaling between helper and regulatory T lymphocytes in cellular microenvironments

(2010) D. Busse et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Mechanisms Underlying Lineage Commitment and Plasticity of Helper CD4+ T Cells

(2010) J. J. O'Shea et al.   SCIENCE

Regulation of Adaptive Immunity by the Innate Immune System

(2010) A. Iwasaki et al.   SCIENCE

Antigen delivery to dendritic cells by poly(propylene sulfide) nanoparticles with disulfide conjugated peptides: Cross-presentation and T cell activation

(2010) Sachiko Hirosue et al.   VACCINE

A Protective Vaccine Delivery System for In Vivo T Cell Stimulation Using Nanoengineered Polymer Hydrogel Capsules

(2009) Amy Sexton et al.   ACS Nano

Ultralow-Fouling, Functionalizable, and Hydrolyzable Zwitterionic Materials and Their Derivatives for Biological Applications

(2009) Shaoyi Jiang et al.   ADVANCED MATERIALS

Antigen Delivery with Poly(Propylacrylic Acid) Conjugation Enhances MHC-1 Presentation and T-Cell Activation

(2009) Suzanne Flanary et al.   BIOCONJUGATE CHEMISTRY

Cytosolic Delivery Mediated via Electrostatic Surface Binding of Protein, Virus, or siRNA Cargos to pH-Responsive Core−Shell Gel Particles

(2009) Yuhua Hu et al.   BIOMACROMOLECULES

The induction of tumor apoptosis in B16 melanoma following STAT3 siRNA delivery with a lipid-substituted polyethylenimine

(2009) Aws Alshamsan et al.   BIOMATERIALS

In vivo Administration of Artificial Antigen-Presenting Cells Activates Low-Avidity T Cells for Treatment of Cancer

(2009) S. Ugel et al.   CANCER RESEARCH

Design of bio-mimetic particles with enhanced vascular interaction

(2009) Sei-Young Lee et al.   JOURNAL OF BIOMECHANICS

Albumin nanoparticles targeted with Apo E enter the CNS by transcytosis and are delivered to neurones

(2009) Anja Zensi et al.   JOURNAL OF CONTROLLED RELEASE

Immune response to controlled release of immunomodulating peptides in a murine experimental autoimmune encephalomyelitis (EAE) model

(2009) Hong Zhao et al.   JOURNAL OF CONTROLLED RELEASE

Size and shape effects in the biodistribution of intravascularly injected particles

(2009) P. Decuzzi et al.   JOURNAL OF CONTROLLED RELEASE

Macrophage Delivery of Nanoformulated Antiretroviral Drug to the Brain in a Murine Model of NeuroAIDS

(2009) H. Dou et al.   JOURNAL OF IMMUNOLOGY

Flexible Filaments forin VivoImaging and Delivery: Persistent Circulation of Filomicelles Opens the Dosage Window for Sustained Tumor Shrinkage

(2009) David A. Christian et al.   MOLECULAR PHARMACEUTICS

Development of a Poly(d,l-lactic-co-glycolic acid) Nanoparticle Formulation of STAT3 Inhibitor JSI-124: Implication for Cancer Immunotherapy

(2009) Ommoleila Molavi et al.   MOLECULAR PHARMACEUTICS

RNAi-mediated CCR5 Silencing by LFA-1-targeted Nanoparticles Prevents HIV Infection in BLT Mice

(2009) Sang-Soo Kim et al.   MOLECULAR THERAPY

Materials engineering for immunomodulation

(2009) Jeffrey A. Hubbell et al.   NATURE

Autophagy genes in immunity

(2009) Herbert W Virgin et al.   NATURE IMMUNOLOGY

Intravaginal gene silencing using biodegradable polymer nanoparticles densely loaded with small-interfering RNA

(2009) Kim A. Woodrow et al.   NATURE MATERIALS

Uptake of particulate vaccine adjuvants by dendritic cells activates the NALP3 inflammasome

(2009) Fiona A. Sharp et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Biodegradable polymer nanoparticles that rapidly penetrate the human mucus barrier

(2009) B. C. Tang et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Red blood cell-mimicking synthetic biomaterial particles

(2009) N. Doshi et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Acetalated dextran is a chemically and biologically tunable material for particulate immunotherapy

(2009) K. E. Broaders et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

NLR-mediated control of inflammasome assembly in the host response against bacterial pathogens

(2009) Igor E. Brodsky et al.   SEMINARS IN IMMUNOLOGY

Inflammasome-activating nanoparticles as modular systems for optimizing vaccine efficacy

(2009) Stacey L. Demento et al.   VACCINE

Mucus-penetrating nanoparticles for drug and gene delivery to mucosal tissues

(2008) Samuel K. Lai et al.   ADVANCED DRUG DELIVERY REVIEWS

Binding, Internalization, and Antigen Presentation of Vaccine-Loaded Nanoengineered Capsules in Blood

(2008) Robert De Rose et al.   ADVANCED MATERIALS

Addressing the PEG Mucoadhesivity Paradox to Engineer Nanoparticles that “Slip” through the Human Mucus Barrier

(2008) Ying-Ying Wang et al.   ANGEWANDTE CHEMIE-INTERNATIONAL EDITION

TAT-conjugated nanoparticles for the CNS delivery of anti-HIV drugs

(2008) Kavitha S. Rao et al.   BIOMATERIALS

The Receptor-Mediated Endocytosis of Nonspherical Particles

(2008) P. Decuzzi et al.   BIOPHYSICAL JOURNAL

Synthetic CD4+ T Cell-Targeted Antigen-Presenting Cells Elicit Protective Antitumor Responses

(2008) S. Caserta et al.   CANCER RESEARCH

Intramammary Application of Non-Methylated-CpG Oligodeoxynucleotides (CpG) Inhibits both Local and Systemic Mammary Carcinogenesis in Female BALB/c Her-2/neu Transgenic Mice

(2008) Cristina Mastini et al.   CURRENT CANCER DRUG TARGETS

Nanoparticles target distinct dendritic cell populations according to their size

(2008) Vania Manolova et al.   EUROPEAN JOURNAL OF IMMUNOLOGY

Deliberately provoking local inflammation drives tumors to become their own protective vaccine site

(2008) Connie Jackaman et al.   INTERNATIONAL IMMUNOLOGY

Vaccine adjuvant systems: Enhancing the efficacy of sub-unit protein antigens

(2008) Yvonne Perrie et al.   INTERNATIONAL JOURNAL OF PHARMACEUTICS

The effect of shape on the margination dynamics of non-neutrally buoyant particles in two-dimensional shear flows

(2008) F. Gentile et al.   JOURNAL OF BIOMECHANICS

Inhibition of “self” engulfment through deactivation of myosin-II at the phagocytic synapse between human cells

(2008) Richard K. Tsai et al.   JOURNAL OF CELL BIOLOGY

The Role of the Extracellular Matrix in Tissue Distribution of Macromolecules in Normal and Pathological Tissues: Potential Therapeutic Consequences

(2008) Helge Wiig et al.   MICROCIRCULATION

Controlled Surface Modification with Poly(ethylene)glycol Enhances Diffusion of PLGA Nanoparticles in Human Cervical Mucus

(2008) Yen Cu et al.   MOLECULAR PHARMACEUTICS

Control of Endothelial Targeting and Intracellular Delivery of Therapeutic Enzymes by Modulating the Size and Shape of ICAM-1-targeted Carriers

(2008) Silvia Muro et al.   MOLECULAR THERAPY

A Comprehensive Platform for Ex Vivo T-cell Expansion Based on Biodegradable Polymeric Artificial Antigen-presenting Cells

(2008) Erin R Steenblock et al.   MOLECULAR THERAPY

Surface Functionalization of Living Cells with Multilayer Patches

(2008) Albert J. Swiston et al.   NANO LETTERS

Physical approaches to biomaterial design

(2008) Samir Mitragotri et al.   NATURE MATERIALS

The effect of particle design on cellular internalization pathways

(2008) S. E. A. Gratton et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Polymer-supported lipid shells, onions, and flowers

(2008) Anna Bershteyn et al.   Soft Matter

TLR ligands and antigen need to be coencapsulated into the same biodegradable microsphere for the generation of potent cytotoxic T lymphocyte responses

(2008) Eva Schlosser et al.   VACCINE

The potency of the adjuvant, CpG oligos, is enhanced by encapsulation in PLG microparticles

(2007) Padma Malyala et al.   JOURNAL OF PHARMACEUTICAL SCIENCES