CD27 expression on Treg cells limits immune responses against tumors

CD70 expression determines the therapeutic efficacy of expanded human regulatory T cells

(2020) Rebeca Arroyo Hornero et al.   Communications Biology

Essential and non-overlapping IL-2Rα-dependent processes for thymic development and peripheral homeostasis of regulatory T cells

(2019) Kevin H. Toomer et al.   Nature Communications

Regulatory T cells in cancer immunosuppression — implications for anticancer therapy

(2019) Yosuke Togashi et al.   Nature Reviews Clinical Oncology

The NF-κB RelA Transcription Factor Is Critical for Regulatory T Cell Activation and Stability

(2019) Emilie Ronin et al.   Frontiers in Immunology

PD-1 Blockade and CD27 Stimulation Activate Distinct Transcriptional Programs That Synergize for CD8+T-Cell–Driven Antitumor Immunity

(2018) Sarah L. Buchan et al.   CLINICAL CANCER RESEARCH

Regulation and Function of the PD-L1 Checkpoint

(2018) Chong Sun et al.   IMMUNITY

Treg-specific deletion of NKAP results in severe, systemic autoimmunity due to peripheral loss of Tregs

(2018) Barsha Dash et al.   JOURNAL OF AUTOIMMUNITY

PD-L1 expression on malignant cells is no prerequisite for checkpoint therapy

(2017) Jan Willem Kleinovink et al.   OncoImmunology

CD27 Agonism Plus PD-1 Blockade Recapitulates CD4+ T-cell Help in Therapeutic Anticancer Vaccination

(2016) T. Ahrends et al.   CANCER RESEARCH

Regulatory T Cells: Differentiation and Function

(2016) G. Plitas et al.   Cancer Immunology Research

Thymus-derived regulatory T cells restrain pro-inflammatory Th1 responses by downregulating CD70 on dendritic cells

(2015) M. Dhainaut et al.   EMBO JOURNAL

A CD40/CD40L feedback loop drives the breakdown of CD8+T-cell tolerance following depletion of suppressive CD4+T cells

(2014) Sabine Muth et al.   EUROPEAN JOURNAL OF IMMUNOLOGY

Regulation of the tolerogenic function of steady-state DCs

(2014) Hans Christian Probst et al.   EUROPEAN JOURNAL OF IMMUNOLOGY

Promiscuous Foxp3-cre activity reveals a differential requirement for CD28 in Foxp3+ and Foxp3− T cells

(2014) Dean Franckaert et al.   IMMUNOLOGY AND CELL BIOLOGY

Predicting immunogenic tumour mutations by combining mass spectrometry and exome sequencing

(2014) Mahesh Yadav et al.   NATURE

Rapid Rebound of the Treg Compartment in DEREG Mice Limits the Impact of Treg Depletion on Mycobacterial Burden, but Prevents Autoimmunity

(2014) Luciana Berod et al.   PLoS One

CD27 Signaling Increases the Frequency of Regulatory T Cells and Promotes Tumor Growth

(2012) C. Claus et al.   CANCER RESEARCH

Release of dendritic cells from cognate CD4+ T-cell recognition results in impaired peripheral tolerance and fatal cytotoxic T-cell mediated autoimmunity

(2012) S. Muth et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Molecular Mechanisms of Treg-Mediated T Cell Suppression

(2012) Angelika Schmidt et al.   Frontiers in Immunology

Cell-autonomous and -non-autonomous roles of CTLA-4 in immune regulation

(2011) Kajsa Wing et al.   TRENDS IN IMMUNOLOGY

Conditional Regulatory T-Cell Depletion Releases Adaptive Immunity Preventing Carcinogenesis and Suppressing Established Tumor Growth

(2010) M. W. L. Teng et al.   CANCER RESEARCH

Efficient Treg depletion induces T-cell infiltration and rejection of large tumors

(2010) Xingrui Li et al.   EUROPEAN JOURNAL OF IMMUNOLOGY

Role of CD27/CD70 pathway of activation in immunity and tolerance

(2010) Julie Denoeud et al.   JOURNAL OF LEUKOCYTE BIOLOGY

Mechanisms of Foxp3+ T Regulatory Cell-Mediated Suppression

(2009) Ethan M. Shevach   IMMUNITY

FoxP3+ regulatory T cells essentially contribute to peripheral CD8+ T-cell tolerance induced by steady-state dendritic cells

(2009) A. Schildknecht et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Regulatory T Cells and Immune Tolerance

(2008) Shimon Sakaguchi et al.   CELL

Regulatory T Cell-Derived Interleukin-10 Limits Inflammation at Environmental Interfaces

(2008) Yuri P. Rubtsov et al.   IMMUNITY

Expression of Costimulatory Ligand CD70 on Steady-State Dendritic Cells Breaks CD8+ T Cell Tolerance and Permits Effective Immunity

(2008) Anna M. Keller et al.   IMMUNITY

The Foxp3+ regulatory T cell: a jack of all trades, master of regulation

(2008) Qizhi Tang et al.   NATURE IMMUNOLOGY