Rapamycin exerts an antidepressant effect and enhances myelination in the prefrontal cortex of chronic restraint stress mice

Physical exercise mediates a cortical FMRP–mTOR pathway to improve resilience against chronic stress in adolescent mice

(2023) Lan Yan et al.   Translational Psychiatry

Low‑field magnetic stimulation improved cuprizone‑induced depression‑like symptoms and demyelination in female mice

(2022) Ali Mooshekhian et al.   Experimental and Therapeutic Medicine

Chronic stress disrupts the homeostasis and progeny progression of oligodendroglial lineage cells, associating immune oligodendrocytes with prefrontal cortex hypomyelination

(2022) Alexandros G. Kokkosis et al.   MOLECULAR PSYCHIATRY

PI3K/AKT/mTOR signalling inhibitor chrysophanol ameliorates neurobehavioural and neurochemical defects in propionic acid-induced experimental model of autism in adult rats

(2022) Aarti Sharma et al.   METABOLIC BRAIN DISEASE

Study on Antidepressant Effect and Mechanism of Crocin Mediated by the mTOR Signaling Pathway

(2022) Yan Wang et al.   NEUROCHEMICAL RESEARCH

Loureirin C and Xanthoceraside Prevent Abnormal Behaviors Associated with Downregulation of Brain Derived Neurotrophic Factor and AKT/mTOR/CREB Signaling in the Prefrontal Cortex Induced by Chronic Corticosterone Exposure in Mice

(2022) Yang Yang et al.   NEUROCHEMICAL RESEARCH

Raptor downregulation rescues neuronal phenotypes in mouse models of Tuberous Sclerosis Complex

(2022) Vasiliki Karalis et al.   Nature Communications

Difference in axon diameter and myelin thickness between excitatory and inhibitory callosally projecting axons in mice

(2022) Kaustuv Basu et al.   CEREBRAL CORTEX

Olig2 ablation in immature oligodendrocytes does not enhance CNS myelination and remyelination

(2022) Jiajia Wang et al.   JOURNAL OF NEUROSCIENCE

Canagliflozin attenuates chronic unpredictable mild stress induced neuroinflammation via modulating AMPK/mTOR autophagic signaling

(2022) Lobna H. Khedr et al.   NEUROPHARMACOLOGY

Resveratrol alleviates postpartum depression-like behavior by activating autophagy via SIRT1 and inhibiting AKT/mTOR pathway

(2022) Shan Ye et al.   BEHAVIOURAL BRAIN RESEARCH

Activated microglia drive demyelination via CSF1R signaling

(2021) Dave E. Marzan et al.   GLIA

Mechanisms of synaptic transmission dysregulation in the prefrontal cortex: pathophysiological implications

(2021) Zhen Yan et al.   MOLECULAR PSYCHIATRY

Microglia reprogram metabolic profiles for phenotype and function changes in central nervous system

(2021) Sheng Yang et al.   NEUROBIOLOGY OF DISEASE

Hippocampal Glycerol-3-Phosphate Acyltransferases 4 and BDNF in the Progress of Obesity-Induced Depression

(2021) Yin-qiong Huang et al.   Frontiers in Endocrinology

Enriched Environment Enhances the Myelin Regulatory Factor by mTOR Signaling and Protects the Myelin Membrane Against Oxidative Damage in Rats Exposed to Chronic Immobilization Stress

(2021) Gangadharan Thamizhoviya et al.   NEUROCHEMICAL RESEARCH

Oligodendrocyte progenitor cell fate and function in development and disease

(2021) Benjamin L.L. Clayton et al.   CURRENT OPINION IN CELL BIOLOGY

Astrocytes in depression and Alzheimer’s disease

(2021) Yang Liao et al.   Frontiers of Medicine

Microglia in depression: current perspectives

(2020) Xiaoning Jia et al.   Science China-Life Sciences

Radix Polygalae extract exerts antidepressant effects in behavioral despair mice and chronic restraint stress-induced rats probably by promoting autophagy and inhibiting neuroinflammation

(2020) Yunfeng Zhou et al.   JOURNAL OF ETHNOPHARMACOLOGY

Myelin sheath structure and regeneration in peripheral nerve injury repair

(2019) Bin Liu et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Myelin and oligodendrocyte lineage cell dysfunctions: New players in the etiology and treatment of depression and stress‐related disorders

(2019) Enrica Boda   EUROPEAN JOURNAL OF NEUROSCIENCE

The antidepressant effects of ɑ-tocopherol are related to activation of autophagy via the AMPK/mTOR pathway

(2018) Xiaoyan Huang et al.   EUROPEAN JOURNAL OF PHARMACOLOGY

mTORC2, but not mTORC1, is required for hippocampal mGluR-LTD and associated behaviors

(2018) Ping Jun Zhu et al.   NATURE NEUROSCIENCE

Myelination and mTOR

(2017) Gianluca Figlia et al.   GLIA

Chronic social defeat reduces myelination in the mouse medial prefrontal cortex

(2017) Michael L. Lehmann et al.   Scientific Reports

Rapamycin suppresses microglial activation and reduces the development of neuropathic pain after spinal cord injury

(2016) Satoshi Tateda et al.   JOURNAL OF ORTHOPAEDIC RESEARCH

Pathogenesis of depression: Insights from human and rodent studies

(2016) C. Ménard et al.   NEUROSCIENCE

Rapamycin increases neuronal survival, reduces inflammation and astrocyte proliferation after spinal cord injury

(2015) Yona Goldshmit et al.   MOLECULAR AND CELLULAR NEUROSCIENCE

Desvenlafaxine prevents white matter injury and improves the decreased phosphorylation of the rate-limiting enzyme of cholesterol synthesis in a chronic mouse model of depression

(2014) Junhui Wang et al.   JOURNAL OF NEUROCHEMISTRY

Human intraretinal myelination: Axon diameters and axon/myelin thickness ratios

(2013) Thomas FitzGibbon et al.   INDIAN JOURNAL OF OPHTHALMOLOGY

Signaling through ERK1/2 Controls Myelin Thickness during Myelin Repair in the Adult Central Nervous System

(2013) S. L. Fyffe-Maricich et al.   JOURNAL OF NEUROSCIENCE

The TSC-mTOR pathway regulates macrophage polarization

(2013) Vanessa Byles et al.   Nature Communications

NADPH Oxidase Mediates Depressive Behavior Induced by Chronic Stress in Mice

(2012) J.-S. Seo et al.   JOURNAL OF NEUROSCIENCE

Impaired adult myelination in the prefrontal cortex of socially isolated mice

(2012) Jia Liu et al.   NATURE NEUROSCIENCE

Rheb1 Is Required for mTORC1 and Myelination in Postnatal Brain Development

(2011) Jia Zou et al.   DEVELOPMENTAL CELL

NG2-glia as Multipotent Neural Stem Cells: Fact or Fantasy?

(2011) William D. Richardson et al.   NEURON

White matter abnormalities in major depression: Evidence from post-mortem, neuroimaging and genetic studies

(2010) Ming Wei Tham et al.   JOURNAL OF AFFECTIVE DISORDERS

Behavioral animal models of depression

(2010) Hua-Cheng Yan et al.   Neuroscience Bulletin

Subcortical oligodendrocyte- and astrocyte-associated gene expression in subjects with schizophrenia, major depression and bipolar disorder

(2009) Kevin Barley et al.   SCHIZOPHRENIA RESEARCH