Mechanisms of synaptic transmission dysregulation in the prefrontal cortex: pathophysiological implications

Large-Scale Exome Sequencing Study Implicates Both Developmental and Functional Changes in the Neurobiology of Autism

(2020) F. Kyle Satterstrom et al.   CELL

Reversal of synaptic and behavioral deficits in a 16p11.2 duplication mouse model via restoration of the GABA synapse regulator Npas4

(2020) Benjamin Rein et al.   MOLECULAR PSYCHIATRY

Human and mouse single-nucleus transcriptomics reveal TREM2-dependent and TREM2-independent cellular responses in Alzheimer’s disease

(2020) Yingyue Zhou et al.   NATURE MEDICINE

β-amyloid redirects norepinephrine signaling to activate the pathogenic GSK3β/tau cascade

(2020) Fang Zhang et al.   Science Translational Medicine

Decreased Density of Perineuronal Net in Prelimbic Cortex Is Linked to Depressive-Like Behavior in Young-Aged Rats

(2020) Zhoulong Yu et al.   Frontiers in Molecular Neuroscience

Dopamine Differentially Regulates Response Dynamics of Prefrontal Cortical Principal Neurons and Interneurons to Optogenetic Stimulation of Inputs from Ventral Tegmental Area

(2020) Ping Zhong et al.   CEREBRAL CORTEX

Muscarinic M1 Receptors Modulate Working Memory Performance and Activity via KCNQ Potassium Channels in the Primate Prefrontal Cortex

(2020) Veronica C. Galvin et al.   NEURON

16p11.2 Copy Number Variations and Neurodevelopmental Disorders

(2020) Benjamin Rein et al.   TRENDS IN NEUROSCIENCES

DNA Methyltransferases in Depression: An Update

(2020) Zhenghao Duan et al.   Frontiers in Psychiatry

Targeting histone K4 trimethylation for treatment of cognitive and synaptic deficits in mouse models of Alzheimer’s disease

(2020) Qing Cao et al.   Science Advances

Amelioration of autism-like social deficits by targeting histone methyltransferases EHMT1/2 in Shank3-deficient mice

(2019) Zi-Jun Wang et al.   MOLECULAR PSYCHIATRY

Optogenetic stimulation of medial prefrontal cortex Drd1 neurons produces rapid and long-lasting antidepressant effects

(2019) Brendan D. Hare et al.   Nature Communications

Cortical GABAergic Dysfunction in Stress and Depression: New Insights for Therapeutic Interventions

(2019) Manoela V. Fogaça et al.   Frontiers in Cellular Neuroscience

A Disinhibitory Microcircuit Mediates Conditioned Social Fear in the Prefrontal Cortex

(2019) Haifeng Xu et al.   NEURON

Genome-wide meta-analysis of depression identifies 102 independent variants and highlights the importance of the prefrontal brain regions

(2019) David M. Howard et al.   NATURE NEUROSCIENCE

Noradrenergic α1-Adrenoceptor Actions in the Primate Dorsolateral Prefrontal Cortex

(2019) Dibyadeep Datta et al.   JOURNAL OF NEUROSCIENCE

Inhibition of EHMT1/2 rescues synaptic and cognitive functions for Alzheimer’s disease

(2019) Yan Zheng et al.   BRAIN

NV-5138 as a fast-acting antidepressant via direct activation of mTORC1 signaling

(2019) Yuto Hasegawa et al.   JOURNAL OF CLINICAL INVESTIGATION

Deletion of autism risk gene Shank3 disrupts prefrontal connectivity

(2019) Marco Pagani et al.   JOURNAL OF NEUROSCIENCE

Single-cell transcriptomic analysis of Alzheimer’s disease

(2019) Hansruedi Mathys et al.   NATURE

VIP Interneurons Contribute to Avoidance Behavior by Regulating Information Flow across Hippocampal-Prefrontal Networks

(2019) Anthony T. Lee et al.   NEURON

Reduced Prefrontal Synaptic Connectivity and Disturbed Oscillatory Population Dynamics in the CNTNAP2 Model of Autism

(2019) Maria T. Lazaro et al.   Cell Reports

Ventral hippocampal projections to the medial prefrontal cortex regulate social memory

(2019) Mary L Phillips et al.   eLife

The Autism-Associated Gene Scn2a Contributes to Dendritic Excitability and Synaptic Function in the Prefrontal Cortex

(2019) Perry W.E. Spratt et al.   NEURON

Behavioral, circuitry, and molecular aberrations by region-specific deficiency of the high-risk autism gene Cul3

(2019) Maximiliano Rapanelli et al.   MOLECULAR PSYCHIATRY

Prefrontal cortical ChAT-VIP interneurons provide local excitation by cholinergic synaptic transmission and control attention

(2019) Joshua Obermayer et al.   Nature Communications

Neuroplasticity in cognitive and psychological mechanisms of depression: an integrative model

(2019) Rebecca B. Price et al.   MOLECULAR PSYCHIATRY

Somatostatin interneurons in the prefrontal cortex control affective state discrimination in mice

(2019) Diego Scheggia et al.   NATURE NEUROSCIENCE

Oligomeric Aβ in the monkey brain impacts synaptic integrity and induces accelerated cortical aging

(2019) Danielle Beckman et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Alzheimer’s-like pathology in aging rhesus macaques: Unique opportunity to study the etiology and treatment of Alzheimer’s disease

(2019) Amy F. T. Arnsten et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Antidepressant administration modulates stress-induced DNA methylation and DNA methyltransferase expression in rat prefrontal cortex and hippocampus

(2018) Amanda J. Sales et al.   BEHAVIOURAL BRAIN RESEARCH

Thalamic Control of Cognition and Social Behavior Via Regulation of Gamma-Aminobutyric Acidergic Signaling and Excitation/Inhibition Balance in the Medial Prefrontal Cortex

(2018) Brielle R. Ferguson et al.   BIOLOGICAL PSYCHIATRY

Juvenile stress induces behavioral change and affects perineuronal net formation in juvenile mice

(2018) Hiroshi Ueno et al.   BMC NEUROSCIENCE

Synaptic markers of cognitive decline in neurodegenerative diseases: a proteomic approach

(2018) Erika Bereczki et al.   BRAIN

Brain-wide Electrical Spatiotemporal Dynamics Encode Depression Vulnerability

(2018) Rainbo Hultman et al.   CELL

Chemogenetic Activation of Prefrontal Cortex Rescues Synaptic and Behavioral Deficits in a Mouse Model of 16p11.2 Deletion Syndrome

(2018) Wei Wang et al.   JOURNAL OF NEUROSCIENCE

Social deficits in Shank3-deficient mouse models of autism are rescued by histone deacetylase (HDAC) inhibition

(2018) Luye Qin et al.   NATURE NEUROSCIENCE

Hippocampus-driven feed-forward inhibition of the prefrontal cortex mediates relapse of extinguished fear

(2018) Roger Marek et al.   NATURE NEUROSCIENCE

Cell-specific histone modification maps in the human frontal lobe link schizophrenia risk to the neuronal epigenome

(2018) Kiran Girdhar et al.   NATURE NEUROSCIENCE

Developmental and genetic regulation of the human cortex transcriptome illuminate schizophrenia pathogenesis

(2018) Andrew E. Jaffe et al.   NATURE NEUROSCIENCE

Blocking NMDAR Disrupts Spike Timing and Decouples Monkey Prefrontal Circuits: Implications for Activity-Dependent Disconnection in Schizophrenia

(2018) Jennifer L. Zick et al.   NEURON

Reciprocal Circuits Linking the Prefrontal Cortex with Dorsal and Ventral Thalamic Nuclei

(2018) David P. Collins et al.   NEURON

Histone deacetylase inhibitor MS-275 restores social and synaptic function in a Shank3-deficient mouse model of autism

(2018) Kaijie Ma et al.   NEUROPSYCHOPHARMACOLOGY

The effects of ketamine on prefrontal glutamate neurotransmission in healthy and depressed subjects

(2018) Chadi G. Abdallah et al.   NEUROPSYCHOPHARMACOLOGY

Shared molecular neuropathology across major psychiatric disorders parallels polygenic overlap

(2018) Michael J. Gandal et al.   SCIENCE

Translational control of depression-like behavior via phosphorylation of eukaryotic translation initiation factor 4E

(2018) Argel Aguilar-Valles et al.   Nature Communications

Cognitive Function and Monoamine Neurotransmission in Schizophrenia: Evidence From Positron Emission Tomography Studies

(2018) Harumasa Takano   Frontiers in Psychiatry

Evaluation of chromatin accessibility in prefrontal cortex of individuals with schizophrenia

(2018) Julien Bryois et al.   Nature Communications

The Impact of Stress and Major Depressive Disorder on Hippocampal and Medial Prefrontal Cortex Morphology

(2018) Emily L. Belleau et al.   BIOLOGICAL PSYCHIATRY

Neurodevelopmental disease genes implicated by de novo mutation and copy number variation morbidity

(2018) Bradley P. Coe et al.   NATURE GENETICS

Somatostatin Interneurons Facilitate Hippocampal-Prefrontal Synchrony and Prefrontal Spatial Encoding

(2018) Atheir I. Abbas et al.   NEURON

VGF and its C-terminal peptide TLQP-62 in ventromedial prefrontal cortex regulate depression-related behaviors and the response to ketamine

(2018) Cheng Jiang et al.   NEUROPSYCHOPHARMACOLOGY

Activity-dependent brain-derived neurotrophic factor signaling is required for the antidepressant actions of (2R,6R)-hydroxynorketamine

(2018) Kenichi Fukumoto et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Stress Exposure in Dopamine D4 Receptor Knockout Mice Induces Schizophrenia-Like Behaviors via Disruption of GABAergic Transmission

(2018) Tao Tan et al.   SCHIZOPHRENIA BULLETIN

The expression of plasticity-related genes in an acute model of stress is modulated by chronic desipramine in a time-dependent manner within medial prefrontal cortex

(2017) Nicoletta Nava et al.   EUROPEAN NEUROPSYCHOPHARMACOLOGY

Epigenetic mechanisms underlying NMDA receptor hypofunction in the prefrontal cortex of juvenile animals in the MAM model for schizophrenia

(2017) Yelena Gulchina et al.   JOURNAL OF NEUROCHEMISTRY

VGF function in depression and antidepressant efficacy

(2017) C Jiang et al.   MOLECULAR PSYCHIATRY

Prefrontal cortex output circuits guide reward seeking through divergent cue encoding

(2017) James M. Otis et al.   NATURE

Thalamic amplification of cortical connectivity sustains attentional control

(2017) L. Ian Schmitt et al.   NATURE

Prefrontal cortical control of a brainstem social behavior circuit

(2017) Tamara B Franklin et al.   NATURE NEUROSCIENCE

Delay activity of specific prefrontal interneuron subtypes modulates memory-guided behavior

(2017) Tsukasa Kamigaki et al.   NATURE NEUROSCIENCE

Amygdala inputs to prefrontal cortex guide behavior amid conflicting cues of reward and punishment

(2017) Anthony Burgos-Robles et al.   NATURE NEUROSCIENCE

Prefrontal cortical GABAergic and NMDA glutamatergic regulation of delayed responding

(2017) Meagan L. Auger et al.   NEUROPHARMACOLOGY

HDAC1 links early life stress to schizophrenia-like phenotypes

(2017) Sanaz Bahari-Javan et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Serotonin enhances excitability and gamma frequency temporal integration in mouse prefrontal fast-spiking interneurons

(2017) Jegath C Athilingam et al.   eLife

Oxytocin improves behavioral and electrophysiological deficits in a novel Shank3-deficient rat

(2017) Hala Harony-Nicolas et al.   eLife

Inflammation and the neural diathesis-stress hypothesis of schizophrenia: a reconceptualization

(2017) O D Howes et al.   Translational Psychiatry

Synaptic proteins predict cognitive decline in Alzheimer's disease and Lewy body dementia

(2016) Erika Bereczki et al.   Alzheimers & Dementia

A pilot integrative genomics study of GABA and glutamate neurotransmitter systems in suicide, suicidal behavior, and major depressive disorder

(2016) Honglei Yin et al.   AMERICAN JOURNAL OF MEDICAL GENETICS PART B-NEUROPSYCHIATRIC GENETICS

Targeting Prefrontal Cortical Systems for Drug Development: Potential Therapies for Cognitive Disorders

(2016) Amy F.T. Arnsten et al.   Annual Review of Pharmacology and Toxicology

Bidirectional Homeostatic Regulation of a Depression-Related Brain State by Gamma-Aminobutyric Acidergic Deficits and Ketamine Treatment

(2016) Zhen Ren et al.   BIOLOGICAL PSYCHIATRY

Epigenetic profiling of human brain differential DNA methylation networks in schizophrenia

(2016) Sheng-An Lee et al.   BMC Medical Genomics

The Clinical TMS Society Consensus Review and Treatment Recommendations for TMS Therapy for Major Depressive Disorder

(2016) Tarique Perera et al.   Brain Stimulation

A Cortical Circuit for Sexually Dimorphic Oxytocin-Dependent Anxiety Behaviors

(2016) Kun Li et al.   CELL

Histone Acetylome-wide Association Study of Autism Spectrum Disorder

(2016) Wenjie Sun et al.   CELL

GABA interneurons mediate the rapid antidepressant-like effects of scopolamine

(2016) Eric S. Wohleb et al.   JOURNAL OF CLINICAL INVESTIGATION

Histone Modification of Nedd4 Ubiquitin Ligase Controls the Loss of AMPA Receptors and Cognitive Impairment Induced by Repeated Stress

(2016) J. Wei et al.   JOURNAL OF NEUROSCIENCE

Neuropeptide Y Impairs Retrieval of Extinguished Fear and Modulates Excitability of Neurons in the Infralimbic Prefrontal Cortex

(2016) L. L. Vollmer et al.   JOURNAL OF NEUROSCIENCE

Inhibitory Gating of Basolateral Amygdala Inputs to the Prefrontal Cortex

(2016) Laura M. McGarry et al.   JOURNAL OF NEUROSCIENCE

Synaptic Actin Dysregulation, a Convergent Mechanism of Mental Disorders?

(2016) Zhen Yan et al.   JOURNAL OF NEUROSCIENCE

Transiently increased glutamate cycling in rat PFC is associated with rapid onset of antidepressant-like effects

(2016) G M I Chowdhury et al.   MOLECULAR PSYCHIATRY

Whole-transcriptome brain expression and exon-usage profiling in major depression and suicide: evidence for altered glial, endothelial and ATPase activity

(2016) S P Pantazatos et al.   MOLECULAR PSYCHIATRY

The ADHD-linked human dopamine D4 receptor variant D4.7 induces over-suppression of NMDA receptor function in prefrontal cortex

(2016) Luye Qin et al.   NEUROBIOLOGY OF DISEASE

Distinct Roles of Parvalbumin- and Somatostatin-Expressing Interneurons in Working Memory

(2016) Dohoung Kim et al.   NEURON

Presynaptic serotonin 2A receptors modulate thalamocortical plasticity and associative learning

(2016) Alexander Barre et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Ketamine and Rapid-Acting Antidepressants: A Window into a New Neurobiology for Mood Disorder Therapeutics

(2015) Chadi G. Abdallah et al.   Annual Review of Medicine

Prefrontal Cortical Gamma-Aminobutyric Acid Transmission and Cognitive Function: Drawing Links to Schizophrenia from Preclinical Research

(2015) Maric T. Tse et al.   BIOLOGICAL PSYCHIATRY

Stress Impairs Prefrontal Cortical Function via D1 Dopamine Receptor Interactions With Hyperpolarization-Activated Cyclic Nucleotide-Gated Channels

(2015) Nao J. Gamo et al.   BIOLOGICAL PSYCHIATRY

Aberrant NMDA receptor DNA methylation detected by epigenome-wide analysis of hippocampus and prefrontal cortex in major depression

(2015) Oliver Kaut et al.   EUROPEAN ARCHIVES OF PSYCHIATRY AND CLINICAL NEUROSCIENCE

Aberrant regulation of synchronous network activity by the attention-deficit/hyperactivity disorder-associated human dopamine D4 receptor variant D4.7 in the prefrontal cortex

(2015) Ping Zhong et al.   JOURNAL OF PHYSIOLOGY-LONDON

Hippocampal–prefrontal input supports spatial encoding in working memory

(2015) Timothy Spellman et al.   NATURE

Thalamic control of sensory selection in divided attention

(2015) Ralf D. Wimmer et al.   NATURE

Stress weakens prefrontal networks: molecular insults to higher cognition

(2015) Amy F T Arnsten   NATURE NEUROSCIENCE

Cell-Type-Specific Activity in Prefrontal Cortex during Goal-Directed Behavior

(2015) Lucas Pinto et al.   NEURON

Disruption of hippocampal–prefrontal cortex activity by dopamine D2R-dependent LTD of NMDAR transmission

(2015) Paul James Banks et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

The impact of NMDA receptor hypofunction on GABAergic neurons in the pathophysiology of schizophrenia

(2015) Samuel M. Cohen et al.   SCHIZOPHRENIA RESEARCH

‘Activity-silent’ working memory in prefrontal cortex: a dynamic coding framework

(2015) Mark G. Stokes   TRENDS IN COGNITIVE SCIENCES

Autism-like Deficits in Shank3-Deficient Mice Are Rescued by Targeting Actin Regulators

(2015) Lara J. Duffney et al.   Cell Reports

Decreased SGK1 Expression and Function Contributes to Behavioral Deficits Induced by Traumatic Stress

(2015) Pawel Licznerski et al.   PLOS BIOLOGY

Schizophrenia: a tale of two critical periods for prefrontal cortical development

(2015) L D Selemon et al.   Translational Psychiatry

Functional and Structural Remodeling of Glutamate Synapses in Prefrontal and Frontal Cortex Induced by Behavioral Stress

(2015) Laura Musazzi et al.   Frontiers in Psychiatry

Methylphenidate Exerts Dose-Dependent Effects on Glutamate Receptors and Behaviors

(2014) Jia Cheng et al.   BIOLOGICAL PSYCHIATRY

Oxytocin Modulates Female Sociosexual Behavior through a Specific Class of Prefrontal Cortical Interneurons

(2014) Miho Nakajima et al.   CELL

Distinct Physiological Effects of Dopamine D4 Receptors on Prefrontal Cortical Pyramidal Neurons and Fast-Spiking Interneurons

(2014) Ping Zhong et al.   CEREBRAL CORTEX

Synergistic Regulation of Glutamatergic Transmission by Serotonin and Norepinephrine Reuptake Inhibitors in Prefrontal Cortical Neurons

(2014) Eunice Y. Yuen et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Synaptic Modifications in the Medial Prefrontal Cortex in Susceptibility and Resilience to Stress

(2014) M. Wang et al.   JOURNAL OF NEUROSCIENCE

Stress and corticosterone increase the readily releasable pool of glutamate vesicles in synaptic terminals of prefrontal and frontal cortex

(2014) G Treccani et al.   MOLECULAR PSYCHIATRY

Synaptic, transcriptional and chromatin genes disrupted in autism

(2014) Silvia De Rubeis et al.   NATURE

Biological insights from 108 schizophrenia-associated genetic loci

(2014)   NATURE

REDD1 is essential for stress-induced synaptic loss and depressive behavior

(2014) Kristie T Ota et al.   NATURE MEDICINE

Alterations in the serotonin system in schizophrenia: A systematic review and meta-analysis of postmortem and molecular imaging studies

(2014) Sudhakar Selvaraj et al.   NEUROSCIENCE AND BIOBEHAVIORAL REVIEWS

Patches of Disorganization in the Neocortex of Children with Autism

(2014) Rich Stoner et al.   NEW ENGLAND JOURNAL OF MEDICINE

cAMP-PKA phosphorylation of tau confers risk for degeneration in aging association cortex

(2014) Becky C. Carlyle et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

GluN2B-containing NMDA receptors regulate depression-like behavior and are critical for the rapid antidepressant actions of ketamine

(2014) Oliver H Miller et al.   eLife

Role of Prefrontal Cortex Glucocorticoid Receptors in Stress and Emotion

(2013) Jessica M. McKlveen et al.   BIOLOGICAL PSYCHIATRY

Developmental Pattern of Perineuronal Nets in the Human Prefrontal Cortex and Their Deficit in Schizophrenia

(2013) Sarah A. Mauney et al.   BIOLOGICAL PSYCHIATRY

Spatial and Temporal Mapping of De Novo Mutations in Schizophrenia to a Fetal Prefrontal Cortical Network

(2013) Suleyman Gulsuner et al.   CELL

Integrated Systems Approach Identifies Genetic Nodes and Networks in Late-Onset Alzheimer’s Disease

(2013) Bin Zhang et al.   CELL

Modulation of Hippocampus-Prefrontal Cortex Synaptic Transmission and Disruption of Executive Cognitive Functions by MK-801

(2013) K. Blot et al.   CEREBRAL CORTEX

The emerging family of CULLIN3-RING ubiquitin ligases (CRL3s): cellular functions and disease implications

(2013) Pascal Genschik et al.   EMBO JOURNAL

Ketamine-induced antidepressant effects are associated with AMPA receptors-mediated upregulation of mTOR and BDNF in rat hippocampus and prefrontal cortex

(2013) W. Zhou et al.   EUROPEAN PSYCHIATRY

Amygdala inputs drive feedforward inhibition in the medial prefrontal cortex

(2013) Jonathan Dilgen et al.   JOURNAL OF NEUROPHYSIOLOGY

Aβ impairs nicotinic regulation of inhibitory synaptic transmission and interneuron excitability in prefrontal cortex

(2013) Guo-Jun Chen et al.   Molecular Neurodegeneration

Altered parvalbumin basket cell inputs in the dorsolateral prefrontal cortex of schizophrenia subjects

(2013) J R Glausier et al.   MOLECULAR PSYCHIATRY

Contrasting changes in DRD1 and DRD2 splice variant expression in schizophrenia and affective disorders and associations with SNPs in postmortem brain

(2013) S S Kaalund et al.   MOLECULAR PSYCHIATRY

The activity-dependent transcription factor NPAS4 regulates domain-specific inhibition

(2013) Brenda L. Bloodgood et al.   NATURE

Distinct behavioural and network correlates of two interneuron types in prefrontal cortex

(2013) D. Kvitsiani et al.   NATURE

Cortical interneurons that specialize in disinhibitory control

(2013) Hyun-Jae Pi et al.   NATURE

The Brain on Stress: Vulnerability and Plasticity of the Prefrontal Cortex over the Life Course

(2013) Bruce S. McEwen et al.   NEURON

NMDA Receptors Subserve Persistent Neuronal Firing during Working Memory in Dorsolateral Prefrontal Cortex

(2013) Min Wang et al.   NEURON

Adolescent Stress-Induced Epigenetic Control of Dopaminergic Neurons via Glucocorticoids

(2013) M. Niwa et al.   SCIENCE

SHANK3 haploinsufficiency: a “common” but underdiagnosed highly penetrant monogenic cause of autism spectrum disorders

(2013) Catalina Betancur et al.   Molecular Autism

Executive Functions

(2012) Adele Diamond   Annual Review of Psychology

Constellation of HCN Channels and cAMP Regulating Proteins in Dendritic Spines of the Primate Prefrontal Cortex: Potential Substrate for Working Memory Deficits in Schizophrenia

(2012) Constantinos D. Paspalas et al.   CEREBRAL CORTEX

Fluoxetine (Prozac) and Serotonin Act on Excitatory Synaptic Transmission to Suppress Single Layer 2/3 Pyramidal Neuron-Triggered Cell Assemblies in the Human Prefrontal Cortex

(2012) G. Komlosi et al.   JOURNAL OF NEUROSCIENCE

Histone deacetylase 6 gates the synaptic action of acute stress in prefrontal cortex

(2012) Janine B. Lee et al.   JOURNAL OF PHYSIOLOGY-LONDON

Decreased expression of synapse-related genes and loss of synapses in major depressive disorder

(2012) Hyo Jung Kang et al.   NATURE MEDICINE

Repeated Stress Causes Cognitive Impairment by Suppressing Glutamate Receptor Expression and Function in Prefrontal Cortex

(2012) Eunice Y. Yuen et al.   NEURON

Dendritic spine pathology in schizophrenia

(2012) J.R. Glausier et al.   NEUROSCIENCE

Epigenetic Signatures of Autism

(2011) Hennady P. Shulha   ARCHIVES OF GENERAL PSYCHIATRY

Catecholamine Influences on Dorsolateral Prefrontal Cortical Networks

(2011) Amy F.T. Arnsten   BIOLOGICAL PSYCHIATRY

Brain-Derived Neurotrophic Factor Val66Met Allele Impairs Basal and Ketamine-Stimulated Synaptogenesis in Prefrontal Cortex

(2011) Rong-Jian Liu et al.   BIOLOGICAL PSYCHIATRY

Antidepressant-like effect induced by systemic and intra-hippocampal administration of DNA methylation inhibitors

(2011) Amanda J Sales et al.   BRITISH JOURNAL OF PHARMACOLOGY

Perisomatic inhibition and cortical circuit dysfunction in schizophrenia

(2011) David A Lewis et al.   CURRENT OPINION IN NEUROBIOLOGY

Cellular Mechanisms for Dopamine D4Receptor-induced Homeostatic Regulation of α-Amino-3-hydroxy-5-methyl-4-isoxazolepropionic Acid (AMPA) Receptors

(2011) Eunice Y. Yuen et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Transcriptomic analysis of autistic brain reveals convergent molecular pathology

(2011) Irina Voineagu et al.   NATURE

Neuronal basis of age-related working memory decline

(2011) Min Wang et al.   NATURE

The stressed synapse: the impact of stress and glucocorticoids on glutamate transmission

(2011) Maurizio Popoli et al.   NATURE REVIEWS NEUROSCIENCE

A Cortical Substrate for Memory-Guided Orienting in the Rat

(2011) Jeffrey C. Erlich et al.   NEURON

D2 receptor overexpression in the striatum leads to a deficit in inhibitory transmission and dopamine sensitivity in mouse prefrontal cortex

(2011) Y.-C. Li et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

The mTOR signaling pathway in the prefrontal cortex is compromised in major depressive disorder

(2011) Courtney S. Jernigan et al.   PROGRESS IN NEURO-PSYCHOPHARMACOLOGY & BIOLOGICAL PSYCHIATRY

Epigenetic dysregulation of HTR2A in the brain of patients with schizophrenia and bipolar disorder

(2011) Hamid Mostafavi Abdolmaleky et al.   SCHIZOPHRENIA RESEARCH

Lack of Change in Markers of Presynaptic Terminal Abundance Alongside Subtle Reductions in Markers of Presynaptic Terminal Plasticity in Prefrontal Cortex of Schizophrenia Patients

(2010) Samantha J. Fung et al.   BIOLOGICAL PSYCHIATRY

Reducing Prefrontal Gamma-Aminobutyric Acid Activity Induces Cognitive, Behavioral, and Dopaminergic Abnormalities That Resemble Schizophrenia

(2010) Takeshi Enomoto et al.   BIOLOGICAL PSYCHIATRY

Concerted changes in transcripts in the prefrontal cortex precede neuropathology in Alzheimer's disease

(2010) Koen Bossers et al.   BRAIN

The Stress Hormone Corticosterone Increases Synaptic α-Amino-3-hydroxy-5-methyl-4-isoxazolepropionic Acid (AMPA) Receptors via Serum- and Glucocorticoid-inducible Kinase (SGK) Regulation of the GDI-Rab4 Complex

(2010) Wenhua Liu et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Selective Changes in Thin Spine Density and Morphology in Monkey Prefrontal Cortex Correlate with Aging-Related Cognitive Impairment

(2010) D. Dumitriu et al.   JOURNAL OF NEUROSCIENCE

Mechanisms for acute stress-induced enhancement of glutamatergic transmission and working memory

(2010) E Y Yuen et al.   MOLECULAR PSYCHIATRY

Homeostatic regulation of glutamatergic transmission by dopamine D4 receptors

(2010) E. Y. Yuen et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

mTOR-Dependent Synapse Formation Underlies the Rapid Antidepressant Effects of NMDA Antagonists

(2010) N. Li et al.   SCIENCE

The Neuropsychopharmacology of Fronto-Executive Function: Monoaminergic Modulation

(2009) T.W. Robbins et al.   Annual Review of Neuroscience

The functional neuroanatomy of depression: Distinct roles for ventromedial and dorsolateral prefrontal cortex

(2009) Michael Koenigs et al.   BEHAVIOURAL BRAIN RESEARCH

Glutamatergic deficits and parvalbumin-containing inhibitory neurons in the prefrontal cortex in schizophrenia

(2009) BKY Bitanihirwe et al.   BMC Psychiatry

Dopamine D4 Receptors Regulate AMPA Receptor Trafficking and Glutamatergic Transmission in GABAergic Interneurons of Prefrontal Cortex

(2009) E. Y. Yuen et al.   JOURNAL OF NEUROSCIENCE

RACK1 is involved in β-amyloid impairment of muscarinic regulation of GABAergic transmission

(2009) Wenhua Liu et al.   NEUROBIOLOGY OF AGING

Stress at Learning Facilitates Memory Formation by Regulating AMPA Receptor Trafficking Through a Glucocorticoid Action

(2009) Lisa Conboy et al.   NEUROPSYCHOPHARMACOLOGY

Acute stress enhances glutamatergic transmission in prefrontal cortex and facilitates working memory

(2009) E. Y. Yuen et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

The Dual-State Theory of Prefrontal Cortex Dopamine Function with Relevance to Catechol-O-Methyltransferase Genotypes and Schizophrenia

(2008) Daniel Durstewitz et al.   BIOLOGICAL PSYCHIATRY

Activation of 5-HT2A/CReceptors Counteracts 5-HT1ARegulation ofN-Methyl-D-aspartate Receptor Channels in Pyramidal Neurons of Prefrontal Cortex

(2008) Eunice Y. Yuen et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Distinct Regions of Prefrontal Cortex Mediate Resistance and Vulnerability to Depression

(2008) M. Koenigs et al.   JOURNAL OF NEUROSCIENCE

Serotonin facilitates long-term depression induction in prefrontal cortex via p38 MAPK/Rab5-mediated enhancement of AMPA receptor internalization

(2008) Ping Zhong et al.   JOURNAL OF PHYSIOLOGY-LONDON

Activity-dependent regulation of inhibitory synapse development by Npas4

(2008) Yingxi Lin et al.   NATURE

A History of Corticosterone Exposure Regulates Fear Extinction and Cortical NR2B, GluR2/3 and BDNF

(2008) Shannon L Gourley et al.   NEUROPSYCHOPHARMACOLOGY

Association between Microdeletion and Microduplication at 16p11.2 and Autism

(2008) Lauren A. Weiss et al.   NEW ENGLAND JOURNAL OF MEDICINE

Reduced levels of NR2A and NR2B subunits of NMDA receptor and PSD-95 in the prefrontal cortex in major depression

(2008) Anteneh M. Feyissa et al.   PROGRESS IN NEURO-PSYCHOPHARMACOLOGY & BIOLOGICAL PSYCHIATRY

Anatomical Abnormalities of the Anterior Cingulate Cortex in Schizophrenia: Bridging the Gap Between Neuroimaging and Neuropathology

(2008) A. Fornito et al.   SCHIZOPHRENIA BULLETIN

Altered excitatory-inhibitory balance in the NMDA-hypofunction model of schizophrenia

(2008) Colin Kehrer   Frontiers in Molecular Neuroscience

Cellular Mechanisms Underlying the Antidepressant Effects of Ketamine: Role of α-Amino-3-Hydroxy-5-Methylisoxazole-4-Propionic Acid Receptors

(2007) Sungho Maeng et al.   BIOLOGICAL PSYCHIATRY

Regulation of the NMDA receptor-mediated synaptic response by acetylcholinesterase inhibitors and its impairment in an animal model of Alzheimer's disease

(2007) Guojun Chen et al.   NEUROBIOLOGY OF AGING