Study on Antidepressant Effect and Mechanism of Crocin Mediated by the mTOR Signaling Pathway

H2S-mediated aerobic exercise antagonizes the hippocampal inflammatory response in CUMS-depressed mice

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Puerarin ameliorates depression-like behaviors of with chronic unpredictable mild stress mice by remodeling their gut microbiota

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Baicalin Attenuates Oxygen–Glucose Deprivation/Reoxygenation–Induced Injury by Modulating the BDNF-TrkB/PI3K/Akt and MAPK/Erk1/2 Signaling Axes in Neuron–Astrocyte Cocultures

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Merazin Hydrate Produces Rapid Antidepressant Effects Depending on Activating mTOR Signaling by Upregulating Downstream Synaptic Proteins in the Hippocampus

(2021) Chao Lu et al.   ACS Chemical Neuroscience

Fibroblast Growth Factor 21 and Autophagy Modulation Ameliorates Amyloid β‐Induced Alzheimer Disease Pathology in Rats

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Stable Isotope-Resolved Metabolomics Studies on Corticosteroid-Induced PC12 Cells: A Strategy for Evaluating Glucose Catabolism in an in Vitro Model of Depression

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Global prevalence and burden of depressive and anxiety disorders in 204 countries and territories in 2020 due to the COVID-19 pandemic

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The neuroprotective potential of carotenoids in vitro and in vivo

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Hederagenin Protects PC12 Cells Against Corticosterone-Induced Injury by the Activation of the PI3K/AKT Pathway

(2021) Ruohong Lin et al.   Frontiers in Pharmacology

Rapid and Prolonged Antidepressant-like Effect of Crocin Is Associated with GHSR-Mediated Hippocampal Plasticity-related Proteins in Mice Exposed to Prenatal Stress

(2020) Ruyan Wu et al.   ACS Chemical Neuroscience

Serum metabonomic study on the antidepressant-like effects of ellagic acid in a chronic unpredictable mild stress-induced (CUMS) mouse model

(2020) Xiaoxia Huang et al.   JOURNAL OF AGRICULTURAL AND FOOD CHEMISTRY

Crocin Reverses Depression-Like Behavior in Parkinson Disease Mice via VTA-mPFC Pathway

(2020) Juanjuan Tang et al.   MOLECULAR NEUROBIOLOGY

The Rab5–Rab11 Endosomal Pathway is Required for BDNF-Induced CREB Transcriptional Regulation in Hippocampal Neurons

(2020) Andrés González-Gutiérrez et al.   JOURNAL OF NEUROSCIENCE

Sedum takesimense Protects PC12 Cells against Corticosterone-Induced Neurotoxicity by Inhibiting Neural Apoptosis

(2020) Hea-Yeon Yun et al.   Nutrients

Sestrin modulator NV-5138 produces rapid antidepressant effects via direct mTORC1 activation

(2019) Taro Kato et al.   JOURNAL OF CLINICAL INVESTIGATION

Crocin ameliorates chronic obstructive pulmonary disease-induced depression via PI3K/Akt mediated suppression of inflammation

(2019) Yupeng Xie et al.   EUROPEAN JOURNAL OF PHARMACOLOGY

Neuroprotective effect of crocin against rotenone-induced Parkinson's disease in rats: Interplay between PI3K/Akt/mTOR signaling pathway and enhanced expression of miRNA-7 and miRNA-221

(2019) Rania M. Salama et al.   NEUROPHARMACOLOGY

Antidepressant activity of crocin-I is associated with amelioration of neuroinflammation and attenuates oxidative damage induced by corticosterone in mice

(2019) Qingfeng Xiao et al.   PHYSIOLOGY & BEHAVIOR

Deciphering the Differential Effective and Toxic Responses of Bupleuri Radix following the Induction of Chronic Unpredictable Mild Stress and in Healthy Rats Based on Serum Metabolic Profiles

(2018) Xiaoxia Gao et al.   Frontiers in Pharmacology

Involvement of PI3K/Akt/FoxO3a and PKA/CREB Signaling Pathways in the Protective Effect of Fluoxetine Against Corticosterone-Induced Cytotoxicity in PC12 Cells

(2016) Bingqing Zeng et al.   JOURNAL OF MOLECULAR NEUROSCIENCE

Drug-Induced Liver Injury Associated With Antidepressive Psychopharmacotherapy: An Explorative Assessment Based on Quantitative Signal Detection Using Different MedDRA Terms

(2015) Maximilian Gahr et al.   JOURNAL OF CLINICAL PHARMACOLOGY

Involvement of PI3K/Akt Signaling Pathway and Its Downstream Intracellular Targets in the Antidepressant-Like Effect of Creatine

(2015) Mauricio P. Cunha et al.   MOLECULAR NEUROBIOLOGY

Differential effects of antidepressant drugs on mTOR signalling in rat hippocampal neurons

(2014) Sung Woo Park et al.   INTERNATIONAL JOURNAL OF NEUROPSYCHOPHARMACOLOGY

Reduced phosphorylation of the mTOR signaling pathway components in the amygdala of rats exposed to chronic stress

(2012) Agata Chandran et al.   PROGRESS IN NEURO-PSYCHOPHARMACOLOGY & BIOLOGICAL PSYCHIATRY

Curcumin reverses corticosterone-induced depressive-like behavior and decrease in brain BDNF levels in rats

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Effects ofBDNFPolymorphisms on Antidepressant Action

(2011) Shih-Jen Tsai et al.   Psychiatry Investigation

Mammalian Target of Rapamycin (mTOR) Activation Increases Axonal Growth Capacity of Injured Peripheral Nerves

(2010) Namiko Abe et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

mTOR-Dependent Synapse Formation Underlies the Rapid Antidepressant Effects of NMDA Antagonists

(2010) N. Li et al.   SCIENCE

The neuronal MAP kinase cascade: a biochemical signal integration system subserving synaptic plasticity and memory

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