The role of the NLRP3 inflammasome and pyroptosis in cardiovascular diseases
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Title
The role of the NLRP3 inflammasome and pyroptosis in cardiovascular diseases
Authors
Keywords
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Journal
Nature Reviews Cardiology
Volume -, Issue -, Pages -
Publisher
Springer Science and Business Media LLC
Online
2023-11-04
DOI
10.1038/s41569-023-00946-3
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Note: Only part of the references are listed.- P805 Selnoflast, a potent NLRP3 inhibitor - results from a phase 1b experimental medicine study in patients with Ulcerative Colitis
- (2023) B Klughammer et al. Journal of Crohns & Colitis
- Pharmacological Inhibition of the NLRP3 Inflammasome: Structure, Molecular Activation, and Inhibitor-NLRP3 Interaction
- (2023) Qiang Ma PHARMACOLOGICAL REVIEWS
- Rationale and design of the ARAMIS trial: Anakinra versus placebo, a double blind randomized controlled trial for the treatment of acute myocarditis
- (2023) Mathieu Kerneis et al. Archives of Cardiovascular Diseases
- NLRP3 inflammasome-driven IL-1β and IL-18 contribute to lipopolysaccharide-induced septic cardiomyopathy
- (2023) Kenta Fujimura et al. JOURNAL OF MOLECULAR AND CELLULAR CARDIOLOGY
- Treatment of Idiopathic Recurrent Pericarditis With Goflikicept
- (2023) Valentina Yu. Myachikova et al. JOURNAL OF THE AMERICAN COLLEGE OF CARDIOLOGY
- Therapeutic potential of colchicine in cardiovascular medicine: a pharmacological review
- (2022) Fan-shun Zhang et al. ACTA PHARMACOLOGICA SINICA
- The Selective NLRP3-inflammasome inhibitor MCC950 Mitigates Post-resuscitation Myocardial Dysfunction and Improves Survival in a Rat Model of Cardiac Arrest and Resuscitation
- (2022) Guanghui Zheng et al. CARDIOVASCULAR DRUGS AND THERAPY
- Heart Disease and Stroke Statistics—2022 Update: A Report From the American Heart Association
- (2022) Connie W. Tsao et al. CIRCULATION
- Gasdermin D pores are dynamically regulated by local phosphoinositide circuitry
- (2022) Ana Beatriz Santa Cruz Garcia et al. Nature Communications
- Mitochondria Fusion upon SERCA Inhibition Prevents Activation of the NLRP3 Inflammasome in Human Monocytes
- (2022) Ana Catarina Pereira et al. Cells
- Colchicine prevents disease progression in viral myocarditis via modulating the NLRP3 inflammasome in the cardiosplenic axis
- (2022) Kathleen Pappritz et al. ESC Heart Failure
- COlchicine to Prevent PeriprocEdural Myocardial Injury in Percutaneous Coronary Intervention (COPE-PCI): Coronary Microvascular Physiology Pilot Substudy
- (2022) Justin Cole et al. JOURNAL OF INTERVENTIONAL CARDIOLOGY
- TET2-Driven Clonal Hematopoiesis and Response to Canakinumab
- (2022) Eric C. Svensson et al. JAMA Cardiology
- ATP6AP2 knockdown in cardiomyocyte deteriorates heart function via compromising autophagic flux and NLRP3 inflammasome activation
- (2022) Lei Li et al. Cell Death Discovery
- Colchicine alleviates inflammation and improves diastolic dysfunction in heart failure rats with preserved ejection fraction
- (2022) Song Shen et al. EUROPEAN JOURNAL OF PHARMACOLOGY
- Pre-Procedural Colchicine in Patients with Acute ST-Elevation Myocardial Infarction Undergoing Percutaneous Coronary Intervention: a Randomized Controlled Trial (PodCAST-PCI)
- (2022) Seyed Hossein Hosseini et al. JOURNAL OF CARDIOVASCULAR PHARMACOLOGY
- Gasdermins: New Therapeutic Targets in Host Defense, Inflammatory Diseases, and Cancer
- (2022) Laura Magnani et al. Frontiers in Immunology
- Systematic Review of Safety and Efficacy of IL-1-Targeted Biologics in Treating Immune-Mediated Disorders
- (2022) Dennis D. Arnold et al. Frontiers in Immunology
- Involvement of pyroptosis pathway in epicardial adipose tissue - myocardium axis in experimental heart failure with preserved ejection fraction
- (2022) Yi-Yuan Xia et al. BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS
- DFV890: a new oral NLRP3 inhibitor—tested in an early phase 2a randomised clinical trial in patients with COVID-19 pneumonia and impaired respiratory function
- (2022) Ildiko Madurka et al. INFECTION
- NLRP3 Inflammasome/Pyroptosis: A Key Driving Force in Diabetic Cardiomyopathy
- (2022) Lixia Zhang et al. INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
- Safety, Tolerability, Pharmacokinetics, and Pharmacodynamics of the Oral NLRP3 Inflammasome Inhibitor ZYIL1: First‐in‐Human Phase 1 Studies (Single Ascending Dose and Multiple Ascending Dose)
- (2022) Deven V. Parmar et al. Clinical Pharmacology in Drug Development
- Inhibiting the inflammasome with MCC950 counteracts muscle pyroptosis and improves Duchenne muscular dystrophy
- (2022) Nicolas Dubuisson et al. Frontiers in Immunology
- NINJ1 mediates plasma membrane rupture during lytic cell death
- (2021) Nobuhiko Kayagaki et al. NATURE
- NLRP3 inflammasome as a key driver of vascular disease
- (2021) Masafumi Takahashi CARDIOVASCULAR RESEARCH
- An update on the regulatory mechanisms of NLRP3 inflammasome activation
- (2021) Seungwha Paik et al. Cellular & Molecular Immunology
- RRx-001 ameliorates inflammatory diseases by acting as a potent covalent NLRP3 inhibitor
- (2021) Yun Chen et al. Cellular & Molecular Immunology
- Treatment Effects of Interleukin-6 Receptor Antibodies for Modulating the Systemic Inflammatory Response After Out-of-Hospital Cardiac Arrest (The IMICA Trial)
- (2021) Martin Abild Stengaard Meyer et al. CIRCULATION
- Interleukin-6 Signaling and Anti-Interleukin-6 Therapeutics in Cardiovascular Disease
- (2021) Paul M Ridker et al. CIRCULATION RESEARCH
- Colchicine to Prevent Periprocedural Myocardial Injury in Percutaneous Coronary Intervention: The COPE-PCI Pilot Trial
- (2021) Justin Cole et al. Circulation-Cardiovascular Interventions
- Efficacy and safety of low-dose colchicine in patients with coronary disease: a systematic review and meta-analysis of randomized trials
- (2021) Aernoud T L Fiolet et al. EUROPEAN HEART JOURNAL
- Colchicine and the heart
- (2021) Massimo Imazio et al. EUROPEAN HEART JOURNAL
- Randomized Trial of Interleukin-6 Receptor Inhibition in Patients With Acute ST-Segment Elevation Myocardial Infarction
- (2021) Kaspar Broch et al. JOURNAL OF THE AMERICAN COLLEGE OF CARDIOLOGY
- Interleukin-1 blockade with RPH-104 in patients with acute ST-elevation myocardial infarction: study design and rationale
- (2021) M. Samsonov et al. Journal of Translational Medicine
- IL-6 inhibition with ziltivekimab in patients at high atherosclerotic risk (RESCUE): a double-blind, randomised, placebo-controlled, phase 2 trial
- (2021) Paul M Ridker et al. LANCET
- Gasdermin D pore structure reveals preferential release of mature interleukin-1
- (2021) Shiyu Xia et al. NATURE
- Gasdermin D mediates the maturation and release of IL-1α downstream of inflammasomes
- (2021) Kohsuke Tsuchiya et al. Cell Reports
- Caspase-11-Gasdermin D-Mediated Pyroptosis Is Involved in the Pathogenesis of Atherosclerosis
- (2021) Mengqing Jiang et al. Frontiers in Pharmacology
- Discovery of RRx-001, a Myc and CD47 Downregulating Small Molecule with Tumor Targeted Cytotoxicity and Healthy Tissue Cytoprotective Properties in Clinical Development
- (2021) Bryan Oronsky et al. JOURNAL OF MEDICINAL CHEMISTRY
- Effects of colchicine on major adverse cardiac events in next 6-month period after acute coronary syndrome occurrence; a randomized placebo-control trial
- (2021) Mehdi Akrami et al. BMC Cardiovascular Disorders
- Interleukin-1β suppression dampens inflammatory leukocyte production and uptake in atherosclerosis
- (2021) Jan Hettwer et al. CARDIOVASCULAR RESEARCH
- Interleukin-1 and the NLRP3 Inflammasome in Pericardial Disease
- (2021) Alessandra Vecchié et al. Current Cardiology Reports
- Interleukin-1 blockade with anakinra and heart failure following ST-segment elevation myocardial infarction: results from a pooled analysis of the VCUART clinical trials
- (2021) Antonio Abbate et al. European Heart Journal-Cardiovascular Pharmacotherapy
- Exacerbated post‐infarct pathological myocardial remodelling in diabetes is associated with impaired autophagy and aggravated NLRP3 inflammasome activation
- (2021) Shuai Mao et al. ESC Heart Failure
- Activation of autophagy inhibits NLRP3 inflammasome activation and attenuates myocardial ischemia‐reperfusion injury in diabetic rats
- (2020) Dengwen Zhang et al. Journal of Diabetes Investigation
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- (2020) Jonathan Muri et al. eLife
- Interleukin‐1 Blockade Inhibits the Acute Inflammatory Response in Patients With ST‐Segment–Elevation Myocardial Infarction
- (2020) Antonio Abbate et al. Journal of the American Heart Association
- Blockade of β-adrenergic signaling suppresses inflammasome and alleviates cardiac fibrosis
- (2020) Shipeng Dang et al. Annals of Translational Medicine
- Interleukin-1 and the Inflammasome as Therapeutic Targets in Cardiovascular Disease
- (2020) Antonio Abbate et al. CIRCULATION RESEARCH
- ACUTE EFFECTS OF INTERLEUKIN-1 BLOCKADE USING ANAKINRA IN PATIENTS WITH ACUTE PERICARDITIS
- (2020) George F. Wohlford et al. JOURNAL OF CARDIOVASCULAR PHARMACOLOGY
- Targeting the NLRP3 Inflammasome With Inhibitor MCC950 Prevents Aortic Aneurysms and Dissections in Mice
- (2020) Pingping Ren et al. Journal of the American Heart Association
- NLRP3 inflammasome-mediated pyroptosis contributes to the pathogenesis of non-ischemic dilated cardiomyopathy
- (2020) Cheng Zeng et al. Redox Biology
- Cathepsin B Is Required for NLRP3 Inflammasome Activation in Macrophages, Through NLRP3 Interaction
- (2020) Angélique Chevriaux et al. Frontiers in Cell and Developmental Biology
- Function and Regulation of Noncanonical Caspase-4/5/11 Inflammasome
- (2020) Sampsa Matikainen et al. JOURNAL OF IMMUNOLOGY
- Inflammasome activation and regulation: toward a better understanding of complex mechanisms
- (2020) Danping Zheng et al. Cell Discovery
- Inhibition of Interleukin-1β and Reduction in Atherothrombotic Cardiovascular Events in the CANTOS Trial
- (2020) Brendan M. Everett et al. JOURNAL OF THE AMERICAN COLLEGE OF CARDIOLOGY
- Colchicine in Patients with Chronic Coronary Disease
- (2020) Stefan M. Nidorf et al. NEW ENGLAND JOURNAL OF MEDICINE
- The covalent NLRP3-inflammasome inhibitor Oridonin relieves myocardial infarction induced myocardial fibrosis and cardiac remodeling in mice
- (2020) Ri-Feng Gao et al. INTERNATIONAL IMMUNOPHARMACOLOGY
- Modulation of Interleukin-1 and -18 Mediated Injury in Donation after Circulatory Death Mouse Hearts
- (2020) Mohammed Quader et al. JOURNAL OF SURGICAL RESEARCH
- An overview of the non-canonical inflammasome
- (2020) Kevin P. Downs et al. MOLECULAR ASPECTS OF MEDICINE
- Phase 3 Trial of Interleukin-1 Trap Rilonacept in Recurrent Pericarditis
- (2020) Allan L. Klein et al. NEW ENGLAND JOURNAL OF MEDICINE
- Recruitment of pro-IL-1α to mitochondrial cardiolipin, via shared LC3 binding domain, inhibits mitophagy and drives maximal NLRP3 activation
- (2020) Jargalsaikhan Dagvadorj et al. PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA
- Inflammation and NLRP3 Inflammasome Activation Initiated in Response to Pressure Overload by Ca 2+ /Calmodulin-Dependent Protein Kinase II δ Signaling in Cardiomyocytes Are Essential for Adverse Cardiac Remodeling
- (2019) Takeshi Suetomi et al. CIRCULATION
- Anti-Inflammatory Therapy with Canakinumab for the Prevention of Hospitalization for Heart Failure
- (2019) Brendan M. Everett et al. CIRCULATION
- The NLRP3 Inflammasome Inhibitor, OLT1177 (Dapansutrile), Reduces Infarct Size and Preserves Contractile Function After Ischemia Reperfusion Injury in the Mouse
- (2019) Stefano Toldo et al. JOURNAL OF CARDIOVASCULAR PHARMACOLOGY
- Cell-Specific Roles of NLRP3 Inflammasome in Myocardial Infarction
- (2019) Masafumi Takahashi JOURNAL OF CARDIOVASCULAR PHARMACOLOGY
- A randomized, placebo-controlled trial of canakinumab in patients with peripheral artery disease
- (2019) Kerry S Russell et al. VASCULAR MEDICINE
- NLRP3 Inflammasome Promotes Myocardial Remodeling During Diet-Induced Obesity
- (2019) Marina Sokolova et al. Frontiers in Immunology
- Inflammasome Formation in Granulomas in Cardiac Sarcoidosis
- (2019) Jordana Kron et al. Circulation-Arrhythmia and Electrophysiology
- Residual inflammatory risk associated with interleukin-18 and interleukin-6 after successful interleukin-1β inhibition with canakinumab: further rationale for the development of targeted anti-cytokine therapies for the treatment of atherothrombosis
- (2019) Paul M Ridker et al. EUROPEAN HEART JOURNAL
- The selective NLRP3-inflammasome inhibitor MCC950 reduces myocardial fibrosis and improves cardiac remodeling in a mouse model of myocardial infarction
- (2019) Rifeng Gao et al. INTERNATIONAL IMMUNOPHARMACOLOGY
- Bruton's Tyrosine Kinase Inhibition Attenuates the Cardiac Dysfunction Caused by Cecal Ligation and Puncture in Mice
- (2019) Caroline E. O'Riordan et al. Frontiers in Immunology
- Aerobic Exercise Induces Cardiac Fat Loss and Alters Cardiac Muscle Mass Through an Interleukin-6 Receptor–Dependent Mechanism
- (2019) Regitse Højgaard Christensen et al. CIRCULATION
- Efficacy and Safety of Low-Dose Colchicine after Myocardial Infarction
- (2019) Jean-Claude Tardif et al. NEW ENGLAND JOURNAL OF MEDICINE
- Effects of Interleukin-1β Inhibition on Blood Pressure, Incident Hypertension, and Residual Inflammatory Risk
- (2019) Alexander MK Rothman et al. HYPERTENSION
- Usefulness of Canakinumab to Improve Exercise Capacity in Patients With Chronic Systolic Heart Failure and Elevated C-Reactive Protein
- (2018) Cory Trankle et al. AMERICAN JOURNAL OF CARDIOLOGY
- Enhanced Cardiomyocyte NLRP3 Inflammasome Signaling Promotes Atrial Fibrillation
- (2018) Chunxia Yao et al. CIRCULATION
- Structural Insights of Benzenesulfonamide Analogues as NLRP3 Inflammasome Inhibitors: Design, Synthesis, and Biological Characterization
- (2018) Jacob Fulp et al. JOURNAL OF MEDICINAL CHEMISTRY
- OLT1177, a β-sulfonyl nitrile compound, safe in humans, inhibits the NLRP3 inflammasome and reverses the metabolic cost of inflammation
- (2018) Carlo Marchetti et al. PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA
- Inflammasome, pyroptosis, and cytokines in myocardial ischemia-reperfusion injury
- (2018) Stefano Toldo et al. AMERICAN JOURNAL OF PHYSIOLOGY-HEART AND CIRCULATORY PHYSIOLOGY
- IL-1 Blockade in Patients With Heart Failure With Preserved Ejection Fraction
- (2018) Benjamin W. Van Tassell et al. Circulation-Heart Failure
- An Orally Available NLRP3 Inflammasome Inhibitor Prevents Western Diet–Induced Cardiac Dysfunction in Mice
- (2018) Salvatore Carbone et al. JOURNAL OF CARDIOVASCULAR PHARMACOLOGY
- Overview of the IL-1 family in innate inflammation and acquired immunity
- (2017) Charles A. Dinarello IMMUNOLOGICAL REVIEWS
- Reduction of Myocardial Ischemia–Reperfusion Injury by Inhibiting Interleukin-1 Alpha
- (2017) Adolfo G. Mauro et al. JOURNAL OF CARDIOVASCULAR PHARMACOLOGY
- Identification of a selective and direct NLRP3 inhibitor to treat inflammatory disorders
- (2017) Hua Jiang et al. JOURNAL OF EXPERIMENTAL MEDICINE
- Inflammasome and Autophagy Regulation: A Two-way Street
- (2017) Qian Sun et al. MOLECULAR MEDICINE
- The NLRP3 inflammasome in acute myocardial infarction
- (2017) Stefano Toldo et al. Nature Reviews Cardiology
- Antiinflammatory Therapy with Canakinumab for Atherosclerotic Disease
- (2017) Paul M Ridker et al. NEW ENGLAND JOURNAL OF MEDICINE
- Inhibition of NLRP3 inflammasome by thioredoxin-interacting protein in mouse Kupffer cells as a regulatory mechanism for non-alcoholic fatty liver disease development
- (2017) Kun He et al. Oncotarget
- Design, Synthesis, and Evaluation of Acrylamide Derivatives as Direct NLRP3 Inflammasome Inhibitors
- (2016) Mattia Cocco et al. ChemMedChem
- Treating Life-Threatening Myocarditis by Blocking Interleukin-1*
- (2016) Giulio Cavalli et al. CRITICAL CARE MEDICINE
- Inflammasome-independent NLRP3 is required for epithelial-mesenchymal transition in colon cancer cells
- (2016) Hong Wang et al. EXPERIMENTAL CELL RESEARCH
- Inhibition of the NLRP3 inflammasome limits the inflammatory injury following myocardial ischemia–reperfusion in the mouse
- (2016) Stefano Toldo et al. INTERNATIONAL JOURNAL OF CARDIOLOGY
- Effect of Anakinra on Recurrent Pericarditis Among Patients With Colchicine Resistance and Corticosteroid Dependence
- (2016) Antonio Brucato et al. JAMA-JOURNAL OF THE AMERICAN MEDICAL ASSOCIATION
- Interleukin-1 Blockade in Acute Decompensated Heart Failure
- (2016) Benjamin W. Van Tassell et al. JOURNAL OF CARDIOVASCULAR PHARMACOLOGY
- Inflammation as a Driver of Adverse Left Ventricular Remodeling After Acute Myocardial Infarction
- (2016) Peter C. Westman et al. JOURNAL OF THE AMERICAN COLLEGE OF CARDIOLOGY
- Inflammasome-activated gasdermin D causes pyroptosis by forming membrane pores
- (2016) Xing Liu et al. NATURE
- NEK7 is an essential mediator of NLRP3 activation downstream of potassium efflux
- (2016) Yuan He et al. NATURE
- Pharmacological Inhibition of NLRP3 Inflammasome Attenuates Myocardial Ischemia/Reperfusion Injury by Activation of RISK and Mitochondrial Pathways
- (2016) Raffaella Mastrocola et al. Oxidative Medicine and Cellular Longevity
- The Inflammasome in Myocardial Injury and Cardiac Remodeling
- (2015) Stefano Toldo et al. ANTIOXIDANTS & REDOX SIGNALING
- Targeting Interleukin-1β Reduces Leukocyte Production After Acute Myocardial Infarction
- (2015) Hendrik B. Sager et al. CIRCULATION
- Anti-Inflammatory Treatment With Colchicine in Acute Myocardial InfarctionClinical Perspective
- (2015) Spyridon Deftereos et al. CIRCULATION
- Pharmacologic Inhibition of the NLRP3 Inflammasome Preserves Cardiac Function After Ischemic and Nonischemic Injury in the Mouse
- (2015) Carlo Marchetti et al. JOURNAL OF CARDIOVASCULAR PHARMACOLOGY
- A small-molecule inhibitor of the NLRP3 inflammasome for the treatment of inflammatory diseases
- (2015) Rebecca C Coll et al. NATURE MEDICINE
- The protective role of interleukin-18 binding protein in a murine model of cardiac ischemia/reperfusion injury
- (2015) Haifeng Gu et al. TRANSPLANT INTERNATIONAL
- Bruton’s tyrosine kinase is essential for NLRP3 inflammasome activation and contributes to ischaemic brain injury
- (2015) Minako Ito et al. Nature Communications
- Human caspase-4 and caspase-5 regulate the one-step non-canonical inflammasome activation in monocytes
- (2015) Elena Viganò et al. Nature Communications
- Defective mitochondrial fission augments NLRP3 inflammasome activation
- (2015) Sangjun Park et al. Scientific Reports
- Interleukin-18 mediates interleukin-1-induced cardiac dysfunction
- (2014) Stefano Toldo et al. AMERICAN JOURNAL OF PHYSIOLOGY-HEART AND CIRCULATORY PHYSIOLOGY
- NLRP3 and downstream cytokine expression elevated in the monocytes of patients with coronary artery disease
- (2014) Lili Wang et al. Archives of Medical Science
- TXNIP mediates NLRP3 inflammasome activation in cardiac microvascular endothelial cells as a novel mechanism in myocardial ischemia/reperfusion injury
- (2014) Yi Liu et al. BASIC RESEARCH IN CARDIOLOGY
- Independent roles of the priming and the triggering of the NLRP3 inflammasome in the heart
- (2014) Stefano Toldo et al. CARDIOVASCULAR RESEARCH
- Unified Polymerization Mechanism for the Assembly of ASC-Dependent Inflammasomes
- (2014) Alvin Lu et al. CELL
- Induction of MicroRNA-21 With Exogenous Hydrogen Sulfide Attenuates Myocardial Ischemic and Inflammatory Injury in Mice
- (2014) S. Toldo et al. Circulation-Cardiovascular Genetics
- The effect of interleukin-1 receptor antagonist therapy on markers of inflammation in non-ST elevation acute coronary syndromes: the MRC-ILA Heart Study
- (2014) A. C. Morton et al. EUROPEAN HEART JOURNAL
- NLRP3 Inflammasome as a Novel Player in Myocardial Infarction
- (2014) Masafumi Takahashi International Heart Journal
- Nlrp3 plays no role in acute cardiac infarction due to low cardiac expression
- (2014) Willeke M.C. Jong et al. INTERNATIONAL JOURNAL OF CARDIOLOGY
- Formation of the inflammasome in acute myocarditis
- (2014) Stefano Toldo et al. INTERNATIONAL JOURNAL OF CARDIOLOGY
- Safety, tolerability, pharmacokinetics, and pharmacodynamics of single-dose antiinterleukin- 18 mAb GSK1070806 in healthy and obese subjects
- (2014) Prafull Mistry et al. INTERNATIONAL JOURNAL OF CLINICAL PHARMACOLOGY AND THERAPEUTICS
- Release of Interleukin-1α or Interleukin-1β Depends on Mechanism of Cell Death
- (2014) Hazel England et al. JOURNAL OF BIOLOGICAL CHEMISTRY
- Interleukin-1β Blockade Improves Left Ventricular Systolic/Diastolic Function and Restores Contractility Reserve in Severe Ischemic Cardiomyopathy in the Mouse
- (2014) Stefano Toldo et al. JOURNAL OF CARDIOVASCULAR PHARMACOLOGY
- Cutting Edge: IL-1α Is a Crucial Danger Signal Triggering Acute Myocardial Inflammation during Myocardial Infarction
- (2014) Jérôme Lugrin et al. JOURNAL OF IMMUNOLOGY
- Anti-Inflammatory Strategies for Ventricular Remodeling Following ST-Segment Elevation Acute Myocardial Infarction
- (2014) Ignacio M. Seropian et al. JOURNAL OF THE AMERICAN COLLEGE OF CARDIOLOGY
- Efficacy and safety of colchicine for treatment of multiple recurrences of pericarditis (CORP-2): a multicentre, double-blind, placebo-controlled, randomised trial
- (2014) Massimo Imazio et al. LANCET
- Cardiac Fibroblasts Contribute to Myocardial Dysfunction in Mice with Sepsis: The Role of NLRP3 Inflammasome Activation
- (2014) Wenbo Zhang et al. PLoS One
- Anti-Inflammatory Treatment With Colchicine in Stable Chronic Heart Failure
- (2014) Spyridon Deftereos et al. JACC-Heart Failure
- Effects of Interleukin-1 Blockade With Anakinra on Adverse Cardiac Remodeling and Heart Failure After Acute Myocardial Infarction [from the Virginia Commonwealth University-Anakinra Remodeling Trial (2) (VCU-ART2) Pilot Study]
- (2013) Antonio Abbate et al. AMERICAN JOURNAL OF CARDIOLOGY
- Effects of Interleukin-1 Blockade With Anakinra on Aerobic Exercise Capacity in Patients With Heart Failure and Preserved Ejection Fraction (from the D-HART Pilot Study)
- (2013) Benjamin Wallace Van Tassell et al. AMERICAN JOURNAL OF CARDIOLOGY
- Colchicine for Recurrent Pericarditis (CORP)
- (2013) Massimo Imazio ANNALS OF INTERNAL MEDICINE
- The NLRP3 inflammasome is up-regulated in cardiac fibroblasts and mediates myocardial ischaemia–reperfusion injury
- (2013) Øystein Sandanger et al. CARDIOVASCULAR RESEARCH
- NOD2 Deficiency Protects against Cardiac Remodeling after Myocardial Infarction in Mice
- (2013) Xiang Li et al. CELLULAR PHYSIOLOGY AND BIOCHEMISTRY
- Targeting Interleukin-1 in Heart Disease
- (2013) Benjamin W. Van Tassell et al. CIRCULATION
- Interleukin-23 Deficiency Leads to Impaired Wound Healing and Adverse Prognosis After Myocardial Infarction
- (2013) Konstantinos Savvatis et al. Circulation-Heart Failure
- Mitochondrial Cardiolipin Is Required for Nlrp3 Inflammasome Activation
- (2013) Shankar S. Iyer et al. IMMUNITY
- Interleukin-1β induces a reversible cardiomyopathy in the mouse
- (2013) Benjamin W. Van Tassell et al. INFLAMMATION RESEARCH
- A Novel Pharmacologic Inhibitor of the NLRP3 Inflammasome Limits Myocardial Injury After Ischemia–Reperfusion in the Mouse
- (2013) Carlo Marchetti et al. JOURNAL OF CARDIOVASCULAR PHARMACOLOGY
- Colchicine Treatment for the Prevention of Bare-Metal Stent Restenosis in Diabetic Patients
- (2013) Spyridon Deftereos et al. JOURNAL OF THE AMERICAN COLLEGE OF CARDIOLOGY
- A Randomized Trial of Colchicine for Acute Pericarditis
- (2013) Massimo Imazio et al. NEW ENGLAND JOURNAL OF MEDICINE
- Interleukin-1α
- (2013) Peleg Rider et al. SEMINARS IN IMMUNOLOGY
- Interleukin-1β blockade improves cardiac remodelling after myocardial infarction without interrupting the inflammasome in the mouse
- (2012) Stefano Toldo et al. EXPERIMENTAL PHYSIOLOGY
- Inflammasome Activators Induce Interleukin-1α Secretion via Distinct Pathways with Differential Requirement for the Protease Function of Caspase-1
- (2012) Olaf Groß et al. IMMUNITY
- Inflammasome-Independent NLRP3 Augments TGF- Signaling in Kidney Epithelium
- (2012) W. Wang et al. JOURNAL OF IMMUNOLOGY
- Low-Dose Colchicine for Secondary Prevention of Cardiovascular Disease
- (2012) Stefan M. Nidorf et al. JOURNAL OF THE AMERICAN COLLEGE OF CARDIOLOGY
- Activation of autophagy by inflammatory signals limits IL-1β production by targeting ubiquitinated inflammasomes for destruction
- (2012) Chong-Shan Shi et al. NATURE IMMUNOLOGY
- Post-infarct cardiac rupture: Recent insights on pathogenesis and therapeutic interventions
- (2012) Xiao-Ming Gao et al. PHARMACOLOGY & THERAPEUTICS
- Enhanced Interleukin-1 Activity Contributes to Exercise Intolerance in Patients with Systolic Heart Failure
- (2012) Benjamin W. Van Tassell et al. PLoS One
- Deletion of the Innate Immune NLRP3 Receptor Abolishes Cardiac Ischemic Preconditioning and Is Associated with Decreased Il-6/STAT3 Signaling
- (2012) Coert J. Zuurbier et al. PLoS One
- Interleukin-1 in the pathogenesis and treatment of inflammatory diseases
- (2011) C. A. Dinarello BLOOD
- Inflammasome Activation of Cardiac Fibroblasts Is Essential for Myocardial Ischemia/Reperfusion Injury
- (2011) Masanori Kawaguchi et al. CIRCULATION
- Genetic inactivation of IL-1 signaling enhances atherosclerotic plaque instability and reduces outward vessel remodeling in advanced atherosclerosis in mice
- (2011) Matthew R. Alexander et al. JOURNAL OF CLINICAL INVESTIGATION
- Alterations in the Interleukin-1/Interleukin-1 Receptor Antagonist Balance Modulate Cardiac Remodeling following Myocardial Infarction in the Mouse
- (2011) Antonio Abbate et al. PLoS One
- The inflammasome promotes adverse cardiac remodeling following acute myocardial infarction in the mouse
- (2011) E. Mezzaroma et al. PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA
- Interleukin-1 Blockade With Anakinra to Prevent Adverse Cardiac Remodeling After Acute Myocardial Infarction (Virginia Commonwealth University Anakinra Remodeling Trial [VCU-ART] Pilot Study)
- (2010) Antonio Abbate et al. AMERICAN JOURNAL OF CARDIOLOGY
- BAY 11-7082, a Nuclear Factor-κB Inhibitor, Reduces Inflammation and Apoptosis in a Rat Cardiac Ischemia-Reperfusion Injury Model
- (2010) Yong Sook Kim et al. International Heart Journal
- Anti-inflammatory Compounds Parthenolide and Bay 11-7082 Are Direct Inhibitors of the Inflammasome
- (2010) Christine Juliana et al. JOURNAL OF BIOLOGICAL CHEMISTRY
- Interleukin-1 Trap Attenuates Cardiac Remodeling After Experimental Acute Myocardial Infarction in Mice
- (2010) Benjamin W Van Tassell et al. JOURNAL OF CARDIOVASCULAR PHARMACOLOGY
- A role for mitochondria in NLRP3 inflammasome activation
- (2010) Rongbin Zhou et al. NATURE
- NLRP3 inflammasomes are required for atherogenesis and activated by cholesterol crystals
- (2010) Peter Duewell et al. NATURE
- Autophagy proteins regulate innate immune responses by inhibiting the release of mitochondrial DNA mediated by the NALP3 inflammasome
- (2010) Kiichi Nakahira et al. NATURE IMMUNOLOGY
- Activation of the NLRP3 inflammasome by islet amyloid polypeptide provides a mechanism for enhanced IL-1β in type 2 diabetes
- (2010) Seth L Masters et al. NATURE IMMUNOLOGY
- Cholesterol Crystals Activate the NLRP3 Inflammasome in Human Macrophages: A Novel Link between Cholesterol Metabolism and Inflammation
- (2010) Kristiina Rajamäki et al. PLoS One
- Caspase-1 recognizes extended cleavage sites in its natural substrates
- (2009) Jerry Shen et al. ATHEROSCLEROSIS
- Size and Shape of Protein Molecules at the Nanometer Level Determined by Sedimentation, Gel Filtration, and Electron Microscopy
- (2009) Harold P. Erickson BIOLOGICAL PROCEDURES ONLINE
- Lowering interleukin-1 activity with anakinra improves myocardial deformation in rheumatoid arthritis
- (2009) I Ikonomidis et al. HEART
- Neutralization of Interleukin-18 Ameliorates Ischemia/Reperfusion-induced Myocardial Injury
- (2009) Kaliyamurthi Venkatachalam et al. JOURNAL OF BIOLOGICAL CHEMISTRY
- Glyburide inhibits the Cryopyrin/Nalp3 inflammasome
- (2009) Mohamed Lamkanfi et al. JOURNAL OF CELL BIOLOGY
- Differential requirement for the activation of the inflammasome for processing and release of IL-1 in monocytes and macrophages
- (2008) M. G. Netea et al. BLOOD
- Inhibition of Interleukin-1 by Anakinra Improves Vascular and Left Ventricular Function in Patients With Rheumatoid Arthritis
- (2008) Ignatios Ikonomidis et al. CIRCULATION
- Anakinra, a Recombinant Human Interleukin-1 Receptor Antagonist, Inhibits Apoptosis in Experimental Acute Myocardial Infarction
- (2008) Antonio Abbate et al. CIRCULATION
- Loss of the autophagy protein Atg16L1 enhances endotoxin-induced IL-1β production
- (2008) Tatsuya Saitoh et al. NATURE
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