Recruitment of pro-IL-1α to mitochondrial cardiolipin, via shared LC3 binding domain, inhibits mitophagy and drives maximal NLRP3 activation

Cutting Edge: Mitochondrial Assembly of the NLRP3 Inflammasome Complex Is Initiated at Priming

(2018) Eric I. Elliott et al.   JOURNAL OF IMMUNOLOGY

Function and regulation of IL-1α in inflammatory diseases and cancer

(2017) Ankit Malik et al.   IMMUNOLOGICAL REVIEWS

UCP3 is associated with Hax-1 in mitochondria in the presence of calcium ion

(2016) Katsuya Hirasaka et al.   BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS

The AIM2 inflammasome is a central regulator of intestinal homeostasis through the IL-18/IL-22/STAT3 pathway

(2016) Rojo A Ratsimandresy et al.   Cellular & Molecular Immunology

Interleukin 1α and the inflammatory process

(2016) Nelson C Di Paolo et al.   NATURE IMMUNOLOGY

Cardiolipin Interactions with Proteins

(2015) Joan Planas-Iglesias et al.   BIOPHYSICAL JOURNAL

Knockdown of interleukin-1α does not attenuate LPS-induced production of interleukin-1β in mouse macrophages

(2015) Tal Almog et al.   CYTOKINE

Lipopolysaccharide Induces Alveolar Macrophage Necrosis via CD14 and the P2X7 Receptor Leading to Interleukin-1α Release

(2015) Jargalsaikhan Dagvadorj et al.   IMMUNITY

Initiation and perpetuation of NLRP3 inflammasome activation and assembly

(2015) Eric I. Elliott et al.   IMMUNOLOGICAL REVIEWS

HAX-1 regulates cyclophilin-D levels and mitochondria permeability transition pore in the heart

(2015) Chi Keung Lam et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

The TLR and IL-1 signalling network at a glance

(2014) P. Cohen   JOURNAL OF CELL SCIENCE

Ion Channels Modulating Mouse Dendritic Cell Functions

(2014) N. Matzner et al.   JOURNAL OF IMMUNOLOGY

Calcium signaling and mitochondrial destabilization in the triggering of the NLRP3 inflammasome

(2014) Tiffany Horng   TRENDS IN IMMUNOLOGY

First-in-class cardiolipin-protective compound as a therapeutic agent to restore mitochondrial bioenergetics

(2013) Hazel H Szeto   BRITISH JOURNAL OF PHARMACOLOGY

The Adaptor MAVS Promotes NLRP3 Mitochondrial Localization and Inflammasome Activation

(2013) Naeha Subramanian et al.   CELL

Endogenous IL-1α is a chromatin-associated protein in mouse macrophages

(2013) Céline Lamacchia et al.   CYTOKINE

Mitochondrial Cardiolipin Is Required for Nlrp3 Inflammasome Activation

(2013) Shankar S. Iyer et al.   IMMUNITY

The Interleukin-1 Family: Back to the Future

(2013) Cecilia Garlanda et al.   IMMUNITY

Cardiolipin externalization to the outer mitochondrial membrane acts as an elimination signal for mitophagy in neuronal cells

(2013) Charleen T. Chu et al.   NATURE CELL BIOLOGY

Inflammasome Activators Induce Interleukin-1α Secretion via Distinct Pathways with Differential Requirement for the Protease Function of Caspase-1

(2012) Olaf Groß et al.   IMMUNITY

Oxidized Mitochondrial DNA Activates the NLRP3 Inflammasome during Apoptosis

(2012) Kenichi Shimada et al.   IMMUNITY

The calcium-sensing receptor regulates the NLRP3 inflammasome through Ca2+ and cAMP

(2012) Geun-Shik Lee et al.   NATURE

Critical role for calcium mobilization in activation of the NLRP3 inflammasome

(2012) T. Murakami et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Interleukin-1 receptor type-1 in non-hematopoietic cells is the target for the pro-atherogenic effects of interleukin-1 in apoE-deficient mice

(2011) Shay Shemesh et al.   ATHEROSCLEROSIS

Reduced atherosclerosis and inflammatory cytokines in apolipoprotein-E-deficient mice lacking bone marrow-derived interleukin-1α

(2011) Yehuda Kamari et al.   BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS

Differential susceptibility to lethal endotoxaemia in mice deficient in IL-1α, IL-1β or IL-1 receptor type I

(2010) LEO A.B. JOOSTEN et al.   APMIS

Differences in lipopolysaccharide-induced signaling between conventional dendritic cells and macrophages

(2010) Ivan Zanoni et al.   IMMUNOBIOLOGY

A role for mitochondria in NLRP3 inflammasome activation

(2010) Rongbin Zhou et al.   NATURE

Autophagy proteins regulate innate immune responses by inhibiting the release of mitochondrial DNA mediated by the NALP3 inflammasome

(2010) Kiichi Nakahira et al.   NATURE IMMUNOLOGY

Interleukin-1 (IL-1) Pathway

(2010) A. Weber et al.   Science Signaling

The anti-apoptotic protein HAX-1 is a regulator of cardiac function

(2009) W. Zhao et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

The Anti-apoptotic Protein HAX-1 Interacts with SERCA2 and Regulates Its Protein Levels to Promote Cell Survival

(2008) Elizabeth Vafiadaki et al.   MOLECULAR BIOLOGY OF THE CELL