Mitochondria Fusion upon SERCA Inhibition Prevents Activation of the NLRP3 Inflammasome in Human Monocytes

The Mitochondrial Fission Regulator DRP1 Controls Post-Transcriptional Regulation of TNF-α

(2021) Fushan Gao et al.   Frontiers in Cellular and Infection Microbiology

Cell death induced by the ER stressor thapsigargin involves death receptor 5, a non-autophagic function of MAP1LC3B, and distinct contributions from unfolded protein response components

(2020) Paula Lindner et al.   Cell Communication and Signaling

Mitochondrial fission and fusion: A dynamic role in aging and potential target for age-related disease

(2020) Yasmine J. Liu et al.   MECHANISMS OF AGEING AND DEVELOPMENT

NLRP3 Inflammasome and Inflammatory Diseases

(2020) Zheng Wang et al.   Oxidative Medicine and Cellular Longevity

Linking Biochemical and Structural States of SERCA: Achievements, Challenges, and New Opportunities

(2020) Rodrigo Aguayo-Ortiz et al.   INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES

Thapsigargin—From Traditional Medicine to Anticancer Drug

(2020) Agata Jaskulska et al.   INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES

The Unfolded Protein Response: Detecting and Responding to Fluctuations in the Protein-Folding Capacity of the Endoplasmic Reticulum

(2019) G. Elif Karagöz et al.   Cold Spring Harbor Perspectives in Biology

Recent advances in the mechanisms of NLRP3 inflammasome activation and its inhibitors

(2019) Yang Yang et al.   Cell Death & Disease

Mitochondrial calcium: Transport and modulation of cellular processes in homeostasis and cancer (Review)

(2019) Susana Romero-Garcia et al.   INTERNATIONAL JOURNAL OF ONCOLOGY

Mitochondrial morphology regulates organellar Ca2+ uptake and changes cellular Ca2+ homeostasis

(2019) Alicia J. Kowaltowski et al.   FASEB JOURNAL

The Sigma-1 Receptor in Cellular Stress Signaling

(2019) Teruo Hayashi   Frontiers in Neuroscience

SERCA control of cell death and survival

(2018) Elie R. Chemaly et al.   CELL CALCIUM

The Unfolded Protein Response and Cell Fate Control

(2018) Claudio Hetz et al.   MOLECULAR CELL

Pharmacological profiling of sigma 1 receptor ligands by novel receptor homomer assays

(2018) Hideaki Yano et al.   NEUROPHARMACOLOGY

Mitofusin 2: from functions to disease

(2018) Riccardo Filadi et al.   Cell Death & Disease

The PERK Arm of the Unfolded Protein Response Regulates Mitochondrial Morphology during Acute Endoplasmic Reticulum Stress

(2018) Justine Lebeau et al.   Cell Reports

Inhibition of the sarco/endoplasmic reticulum (ER) Ca2+-ATPase by thapsigargin analogs induces cell death via ER Ca2+depletion and the unfolded protein response

(2017) Pankaj Sehgal et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Intracellular Ca 2+ Sensing: Its Role in Calcium Homeostasis and Signaling

(2017) Rafaela Bagur et al.   MOLECULAR CELL

Inhibition of Mitochondrial Fission and NOX2 Expression Prevent NLRP3 Inflammasome Activation in the Endothelium: The Role of Corosolic Acid Action in the Amelioration of Endothelial Dysfunction

(2016) Yi Li et al.   ANTIOXIDANTS & REDOX SIGNALING

Crystal structure of the human σ1 receptor

(2016) Hayden R. Schmidt et al.   NATURE

Mechanism and Regulation of NLRP3 Inflammasome Activation

(2016) Yuan He et al.   TRENDS IN BIOCHEMICAL SCIENCES

Role of Mitofusin-2 in mitochondrial localization and calcium uptake in skeletal muscle

(2015) Alina Ainbinder et al.   CELL CALCIUM

Cell death induced by endoplasmic reticulum stress

(2015) Raffaella Iurlaro et al.   FEBS Journal

Proteostasis control by the unfolded protein response

(2015) Claudio Hetz et al.   NATURE CELL BIOLOGY

Inflammasomes: mechanism of action, role in disease and therapeutics

(2015) Haitao Guo et al.   NATURE MEDICINE

The unfolded protein response: the dawn of a new field

(2015) Kazutoshi MORI   PROCEEDINGS OF THE JAPAN ACADEMY SERIES B-PHYSICAL AND BIOLOGICAL SCIENCES

Defective mitochondrial fission augments NLRP3 inflammasome activation

(2015) Sangjun Park et al.   Scientific Reports

NADPH oxidases: an overview from structure to innate immunity-associated pathologies

(2014) Arvind Panday et al.   Cellular & Molecular Immunology

Inflammasomes in the CNS

(2014) John G. Walsh et al.   NATURE REVIEWS NEUROSCIENCE

Stress-responsive regulation of mitochondria through the ER unfolded protein response

(2014) T. Kelly Rainbolt et al.   TRENDS IN ENDOCRINOLOGY AND METABOLISM

Characterization of the Human Sigma-1 Receptor Chaperone Domain Structure and Binding Immunoglobulin Protein (BiP) Interactions

(2013) Jose Luis Ortega-Roldan et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Sigma-1 Receptor Chaperone at the ER-Mitochondrion Interface Mediates the Mitochondrion-ER-Nucleus Signaling for Cellular Survival

(2013) Tomohisa Mori et al.   PLoS One

ER stress activates the NLRP3 inflammasome via an UPR-independent pathway

(2012) P Menu et al.   Cell Death & Disease

During autophagy mitochondria elongate, are spared from degradation and sustain cell viability

(2011) Ligia C. Gomes et al.   NATURE CELL BIOLOGY

Evolution of the mitochondrial fusion-fission cycle and its role in aging

(2011) A. Kowald et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

The Interplay Between Mitochondrial Dynamics and Mitophagy

(2010) Gilad Twig et al.   ANTIOXIDANTS & REDOX SIGNALING

Endoplasmic Reticulum Stress and the Inflammatory Basis of Metabolic Disease

(2010) Gökhan S. Hotamisligil   CELL

The sigma-1 receptor chaperone as an inter-organelle signaling modulator

(2010) Tsung-Ping Su et al.   TRENDS IN PHARMACOLOGICAL SCIENCES

Role of the Unfolded Protein Response Regulator GRP78/BiP in Development, Cancer, and Neurological Disorders

(2009) Miao Wang et al.   ANTIOXIDANTS & REDOX SIGNALING

SLP-2 is required for stress-induced mitochondrial hyperfusion

(2009) Daniel Tondera et al.   EMBO JOURNAL

MAM: more than just a housekeeper

(2009) Teruo Hayashi et al.   TRENDS IN CELL BIOLOGY