A Legionella toxin exhibits tRNA mimicry and glycosyl transferase activity to target the translation machinery and trigger a ribotoxic stress response

5′ Untranslated mRNA Regions Allow Bypass of Host Cell Translation Inhibition by Legionella pneumophila

(2022) Erion Lipo et al.   INFECTION AND IMMUNITY

The metaeffector MesI regulates the activity of the Legionella effector SidI through direct protein-protein interactions

(2021) Alix McCloskey et al.   MICROBES AND INFECTION

Non-canonical activation of the ER stress sensor ATF6 by Legionella pneumophila effectors

(2021) Nnejiuwa U Ibe et al.   Life Science Alliance

The Legionella pneumophila metaeffector Lpg2505 (MesI) regulates SidI-mediated translation inhibition and novel glycosyl hydrolase activity

(2020) Ashley M. Joseph et al.   INFECTION AND IMMUNITY

Mitochondrial stress is relayed to the cytosol by an OMA1–DELE1–HRI pathway

(2020) Xiaoyan Guo et al.   NATURE

ZAKα Recognizes Stalled Ribosomes through Partially Redundant Sensor Domains

(2020) Anna Constance Vind et al.   MOLECULAR CELL

The ATF3 Transcription Factor Is a Short-Lived Substrate of the Arg/N-Degron Pathway

(2020) Tri T. M. Vu et al.   BIOCHEMISTRY

Ribosome Collisions Trigger General Stress Responses to Regulate Cell Fate

(2020) Colin Chih-Chien Wu et al.   CELL

EDF1 coordinates cellular responses to ribosome collisions

(2020) Niladri K Sinha et al.   eLife

Diverse motif ensembles specify non-redundant DNA binding activities of AP-1 family members in macrophages

(2019) Gregory J. Fonseca et al.   Nature Communications

Legionella pneumophila translocated translation inhibitors are required for bacterial-induced host cell cycle arrest

(2019) Asaf Sol et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

A Legionella pneumophila Kinase Phosphorylates the Hsp70 Chaperone Family to Inhibit Eukaryotic Protein Synthesis

(2019) Steven M. Moss et al.   Cell Host & Microbe

Mechanisms and functions of ribosome-associated protein quality control

(2019) Claudio A. P. Joazeiro   NATURE REVIEWS MOLECULAR CELL BIOLOGY

Design, Synthesis, and Structure–Activity Relationships of 1,2,3-Triazole Benzenesulfonamides as New Selective Leucine-Zipper and Sterile-α Motif Kinase (ZAK) Inhibitors

(2019) Jianzhang Yang et al.   JOURNAL OF MEDICINAL CHEMISTRY

Emerging structural insights into glycosyltransferase-mediated synthesis of glycans

(2019) Kelley W. Moremen et al.   Nature Chemical Biology

The Legionella effector LtpM is a new type of phosphoinositide-activated glucosyltransferase

(2018) Nadezhda Levanova et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

ZNF598 Is a Quality Control Sensor of Collided Ribosomes

(2018) Szymon Juszkiewicz et al.   MOLECULAR CELL

tRNA Translocation by the Eukaryotic 80S Ribosome and the Impact of GTP Hydrolysis

(2018) Julia Flis et al.   Cell Reports

MotionCor2: anisotropic correction of beam-induced motion for improved cryo-electron microscopy

(2017) Shawn Q Zheng et al.   NATURE METHODS

cryoSPARC: algorithms for rapid unsupervised cryo-EM structure determination

(2017) Ali Punjani et al.   NATURE METHODS

The Encyclopedia of DNA elements (ENCODE): data portal update

(2017) Carrie A Davis et al.   NUCLEIC ACIDS RESEARCH

MultipleLegionella pneumophilaeffector virulence phenotypes revealed through high-throughput analysis of targeted mutant libraries

(2017) Stephanie R. Shames et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

MolProbity: More and better reference data for improved all-atom structure validation

(2017) Christopher J. Williams et al.   PROTEIN SCIENCE

Positive and Negative Regulation of the Master Metabolic Regulator mTORC1 by Two Families of Legionella pneumophila Effectors

(2017) Justin A. De Leon et al.   Cell Reports

Global analysis of gene expression reveals mRNA superinduction is required for the inducible immune response to a bacterial pathogen

(2017) Kevin C Barry et al.   eLife

Mefloquine targets the Plasmodium falciparum 80S ribosome to inhibit protein synthesis

(2017) Wilson Wong et al.   Nature Microbiology

A Structural, Functional, and Computational Analysis of BshA, the First Enzyme in the Bacillithiol Biosynthesis Pathway

(2016) Kelsey R. Winchell et al.   BIOCHEMISTRY

Decoding Mammalian Ribosome-mRNA States by Translational GTPase Complexes

(2016) Sichen Shao et al.   CELL

Crystal Structures of the uL3 Mutant Ribosome: Illustration of the Importance of Ribosomal Proteins for Translation Efficiency

(2016) Justine Mailliot et al.   JOURNAL OF MOLECULAR BIOLOGY

Gctf: Real-time CTF determination and correction

(2016) Kai Zhang   JOURNAL OF STRUCTURAL BIOLOGY

An atlas of human kinase regulation

(2016) David Ochoa et al.   Molecular Systems Biology

Near-optimal probabilistic RNA-seq quantification

(2016) Nicolas L Bray et al.   NATURE BIOTECHNOLOGY

The extended loops of ribosomal proteins uL4 and uL22 ofEscherichia colicontribute to ribosome assembly and protein translation

(2016) Marlon G. Lawrence et al.   NUCLEIC ACIDS RESEARCH

Activation of GCN2 kinase by ribosome stalling links translation elongation with translation initiation

(2016) Ryuta Ishimura et al.   eLife

Macrophage cell death and transcriptional response are actively triggered by the fungal virulence factor Cbp1 duringH.capsulatuminfection

(2015) Dervla T. Isaac et al.   MOLECULAR MICROBIOLOGY

limma powers differential expression analyses for RNA-sequencing and microarray studies

(2015) Matthew E. Ritchie et al.   NUCLEIC ACIDS RESEARCH

Inhibition of host cell translation elongation byLegionella pneumophilablocks the host cell unfolded protein response

(2015) Andrew D. Hempstead et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Legionella suppresses the host unfolded protein response via multiple mechanisms

(2015) Sean Treacy-Abarca et al.   Nature Communications

Structural basis for the inhibition of the eukaryotic ribosome

(2014) Nicolas Garreau de Loubresse et al.   NATURE

A Legionella effector modulates host cytoskeletal structure by inhibiting actin polymerization

(2013) Zhenhua Guo et al.   MICROBES AND INFECTION

Caspase-11 stimulates rapid flagellin-independent pyroptosis in response to Legionella pneumophila

(2013) C. L. Case et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Pharmacological brake-release of mRNA translation enhances cognitive memory

(2013) Carmela Sidrauski et al.   eLife

Domain organization of Legionella effector SetA

(2012) Thomas Jank et al.   CELLULAR MICROBIOLOGY

Activation of Host Mitogen-Activated Protein Kinases by Secreted Legionella pneumophila Effectors That Inhibit Host Protein Translation

(2012) Mary F. Fontana et al.   INFECTION AND IMMUNITY

RELION: Implementation of a Bayesian approach to cryo-EM structure determination

(2012) Sjors H.W. Scheres   JOURNAL OF STRUCTURAL BIOLOGY

An integrated encyclopedia of DNA elements in the human genome

(2012)   NATURE

RSEM: accurate transcript quantification from RNA-Seq data with or without a reference genome

(2011) Bo Li et al.   BMC BIOINFORMATICS

The NumPy Array: A Structure for Efficient Numerical Computation

(2011) Stéfan van der Walt et al.   COMPUTING IN SCIENCE & ENGINEERING

Modulation of Rab GTPase function by a protein phosphocholine transferase

(2011) Shaeri Mukherjee et al.   NATURE

Secreted Bacterial Effectors That Inhibit Host Protein Synthesis Are Critical for Induction of the Innate Immune Response to Virulent Legionella pneumophila

(2011) Mary F. Fontana et al.   PLoS Pathogens

Features and development ofCoot

(2010) P. Emsley et al.   ACTA CRYSTALLOGRAPHICA SECTION D-BIOLOGICAL CRYSTALLOGRAPHY

PHENIX: a comprehensive Python-based system for macromolecular structure solution

(2010) Paul D. Adams et al.   ACTA CRYSTALLOGRAPHICA SECTION D-BIOLOGICAL CRYSTALLOGRAPHY

Modulation of Host Cell Function byLegionella pneumophilaType IV Effectors

(2010) Andree Hubber et al.   Annual Review of Cell and Developmental Biology

RNAstructure: software for RNA secondary structure prediction and analysis

(2010) Jessica S Reuter et al.   BMC BIOINFORMATICS

Acceptor Substrate Discrimination in Phosphatidyl-myo-inositol Mannoside Synthesis

(2010) Sarah M. Batt et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

MDM2 Mediates Ubiquitination and Degradation of Activating Transcription Factor 3

(2010) Pingli Mo et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

The Amoebal MAP Kinase Response to Legionella pneumophila Is Regulated by DupA

(2009) Zhiru Li et al.   Cell Host & Microbe

Targeting eEF1A by aLegionella pneumophilaeffector leads to inhibition of protein synthesis and induction of host stress response

(2009) Xihui Shen et al.   CELLULAR MICROBIOLOGY

Structural Basis of the Action of Glucosyltransferase Lgt1 from Legionella pneumophila

(2009) Wei Lü et al.   JOURNAL OF MOLECULAR BIOLOGY

Formation of the First Peptide Bond: The Structure of EF-P Bound to the 70S Ribosome

(2009) G. Blaha et al.   SCIENCE

Lgt: a Family of Cytotoxic Glucosyltransferases Produced by Legionella pneumophila

(2008) Y. Belyi et al.   JOURNAL OF BACTERIOLOGY

Structure/function analysis of yeast ribosomal protein L2

(2008) Arturas Meskauskas et al.   NUCLEIC ACIDS RESEARCH

Type IV Secretion-Dependent Activation of Host MAP Kinases Induces an Increased Proinflammatory Cytokine Response to Legionella pneumophila

(2008) Sunny Shin et al.   PLoS Pathogens