Emerging structural insights into glycosyltransferase-mediated synthesis of glycans

Protein O-glucosylation: another essential role of glucose in biology

(2019) Hongjun Yu et al.   CURRENT OPINION IN STRUCTURAL BIOLOGY

Protein O-fucosylation: structure and function

(2019) Bernadette C Holdener et al.   CURRENT OPINION IN STRUCTURAL BIOLOGY

Structure of xyloglucan xylosyltransferase 1 reveals simple steric rules that define biological patterns of xyloglucan polymers

(2018) Alan T. Culbertson et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

HumanN-acetylglucosaminyltransferase II substrate recognition uses a modular architecture that includes a convergent exosite

(2018) Renuka Kadirvelraj et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Structure of the yeast oligosaccharyltransferase complex gives insight into eukaryotic N-glycosylation

(2018) Rebekka Wild et al.   SCIENCE

Structural basis for coupling protein transport and N-glycosylation at the mammalian endoplasmic reticulum

(2018) Katharina Braunger et al.   SCIENCE

Structural Basis for the Initiation of Glycosaminoglycan Biosynthesis by Human Xylosyltransferase 1

(2018) David C. Briggs et al.   STRUCTURE

Multiple Roles for O-Glycans in Notch Signalling

(2018) Shweta Varshney et al.   FEBS LETTERS

The atomic structure of a eukaryotic oligosaccharyltransferase complex

(2018) Lin Bai et al.   NATURE

Structure and mechanism of cancer-associated N-acetylglucosaminyltransferase-V

(2018) Masamichi Nagae et al.   Nature Communications

A perspective on structural and mechanistic aspects of protein O-fucosylation

(2018) Erandi Lira-Navarrete et al.   Acta Crystallographica Section F-Structural Biology Communications

Cryo-EM is uncovering the mechanism of eukaryotic protein N-glycosylation

(2018) Lin Bai et al.   FEBS Journal

Recent advancements in understanding mammalian O-mannosylation

(2017) M Osman Sheikh et al.   GLYCOBIOLOGY

Biological functions of fucose in mammals

(2017) Michael Schneider et al.   GLYCOBIOLOGY

O-Glycosylation modulates the stability of epidermal growth factor-like repeats and thereby regulates Notch trafficking

(2017) Hideyuki Takeuchi et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Expression system for structural and functional studies of human glycosylation enzymes

(2017) Kelley W Moremen et al.   Nature Chemical Biology

Recognition of EGF-like domains by the Notch-modifying O-fucosyltransferase POFUT1

(2017) Zhijie Li et al.   Nature Chemical Biology

Structural, mutagenic and in silico studies of xyloglucan fucosylation in Arabidopsis thaliana suggest a water-mediated mechanism

(2017) Breeanna R. Urbanowicz et al.   PLANT JOURNAL

The Cosmc connection to the Tn antigen in cancer

(2017) Tongzhong Ju et al.   Cancer Biomarkers

The Biochemistry of O-GlcNAc Transferase: Which Functions Make It Essential in Mammalian Cells?

(2016) Zebulon G. Levine et al.   Annual Review of Biochemistry

The reaction mechanism of retaining glycosyltransferases

(2016) A. Ardevol et al.   BIOCHEMICAL SOCIETY TRANSACTIONS

Recent structural and mechanistic insights into protein O-GalNAc glycosylation

(2016) R. Hurtado-Guerrero   BIOCHEMICAL SOCIETY TRANSACTIONS

Genetic and biochemical evidence that gastrulation defects in Pofut2 mutants result from defects in ADAMTS9 secretion

(2016) Brian A. Benz et al.   DEVELOPMENTAL BIOLOGY

Biological roles of glycans

(2016) Ajit Varki   GLYCOBIOLOGY

Sialylation of N-glycans: mechanism, cellular compartmentalization and function

(2016) Gaurang P. Bhide et al.   HISTOCHEMISTRY AND CELL BIOLOGY

A proactive role of water molecules in acceptor recognition by protein O-fucosyltransferase 2

(2016) Jessika Valero-González et al.   Nature Chemical Biology

Structural analysis of Notch-regulating Rumi reveals basis for pathogenic mutations

(2016) Hongjun Yu et al.   Nature Chemical Biology

Structure ofArabidopsis thalianaFUT1 Reveals a Variant of the GT-B Class Fold and Provides Insight into Xyloglucan Fucosylation

(2016) Joana Rocha et al.   PLANT CELL

Carbohydrate-binding domain of the POMGnT1 stem region modulatesO-mannosylation sites of α-dystroglycan

(2016) Naoyuki Kuwabara et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Structure and Protein–Protein Interactions of Human UDP-Glucuronosyltransferases

(2016) Ryoichi Fujiwara et al.   Frontiers in Pharmacology

A Native Ternary Complex Trapped in a Crystal Reveals the Catalytic Mechanism of a Retaining Glycosyltransferase

(2015) David Albesa-Jové et al.   ANGEWANDTE CHEMIE-INTERNATIONAL EDITION

Peters Plus Syndrome Mutations Disrupt a Noncanonical ER Quality-Control Mechanism

(2015) Deepika Vasudevan et al.   CURRENT BIOLOGY

Matriglycan: a novel polysaccharide that links dystroglycan to the basement membrane

(2015) T. Yoshida-Moriguchi et al.   GLYCOBIOLOGY

Novel UDP-GalNAc Derivative Structures Provide Insight into the Donor Specificity of Human Blood Group Glycosyltransferase

(2015) Gerd K. Wagner et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

High Resolution Structures of the Human ABO(H) Blood Group Enzymes in Complex with Donor Analogs Reveal That the Enzymes Utilize Multiple Donor Conformations to Bind Substrates in a Stepwise Manner

(2015) Susannah M. L. Gagnon et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Notch-modifying xylosyltransferase structures support an SNi-like retaining mechanism

(2015) Hongjun Yu et al.   Nature Chemical Biology

Structure of human ST8SiaIII sialyltransferase provides insight into cell-surface polysialylation

(2015) Gesa Volkers et al.   NATURE STRUCTURAL & MOLECULAR BIOLOGY

Dynamic interplay between catalytic and lectin domains of GalNAc-transferases modulates protein O-glycosylation

(2015) Erandi Lira-Navarrete et al.   Nature Communications

Structure of human ST8SiaIII sialyltransferase provides insight into cell-surface polysialylation

(2015) Gesa Volkers et al.   NATURE STRUCTURAL & MOLECULAR BIOLOGY

Substrate-Guided Front-Face Reaction Revealed by Combined Structural Snapshots and Metadynamics for the PolypeptideN-Acetylgalactosaminyltransferase 2

(2014) Erandi Lira-Navarrete et al.   ANGEWANDTE CHEMIE-INTERNATIONAL EDITION

The Challenge and Promise of Glycomics

(2014) Richard D. Cummings et al.   CHEMISTRY & BIOLOGY

The structure of human α-2,6-sialyltransferase reveals the binding mode of complex glycans

(2013) Bernd Kuhn et al.   ACTA CRYSTALLOGRAPHICA SECTION D-BIOLOGICAL CRYSTALLOGRAPHY

Enzymatic Basis forN-Glycan Sialylation

(2013) Lu Meng et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

The carbohydrate-active enzymes database (CAZy) in 2013

(2013) Vincent Lombard et al.   NUCLEIC ACIDS RESEARCH

Geometric Attributes of Retaining Glycosyltransferase Enzymes Favor an Orthogonal Mechanism

(2013) Brock Schuman et al.   PLoS One

Site-specificO-Glucosylation of the Epidermal Growth Factor-like (EGF) Repeats of Notch

(2012) Hideyuki Takeuchi et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Structural snapshots of the reaction coordinate for O-GlcNAc transferase

(2012) Michael B Lazarus et al.   Nature Chemical Biology

Vertebrate protein glycosylation: diversity, synthesis and function

(2012) Kelley W. Moremen et al.   NATURE REVIEWS MOLECULAR CELL BIOLOGY

Structure of a metal-independent bacterial glycosyltransferase that catalyzes the synthesis of histo-blood group A antigen

(2012) Nethaji Thiyagarajan et al.   Scientific Reports

Glycosylation, galectins and cellular signaling

(2011) Cecile Boscher et al.   CURRENT OPINION IN CELL BIOLOGY

Structural and Mechanistic Characterization of Leukocyte-Type Core 2 β1,6-N-Acetylglucosaminyltransferase: A Metal-Ion-Independent GT-A Glycosyltransferase

(2011) John E. Pak et al.   JOURNAL OF MOLECULAR BIOLOGY

Structural Insights into the Mechanism of Protein O-Fucosylation

(2011) Erandi Lira-Navarrete et al.   PLoS One

Features and development ofCoot

(2010) P. Emsley et al.   ACTA CRYSTALLOGRAPHICA SECTION D-BIOLOGICAL CRYSTALLOGRAPHY

O-fucosylation of thrombospondin type 1 repeats restricts epithelial to mesenchymal transition (EMT) and maintains epiblast pluripotency during mouse gastrulation

(2010) Jianguang Du et al.   DEVELOPMENTAL BIOLOGY

Crystal Structure of the Catalytic Domain ofDrosophilaβ1,4-Galactosyltransferase-7

(2010) Boopathy Ramakrishnan et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

The Sialome—Far More Than the Sum of Its Parts

(2010) Miriam Cohen et al.   OMICS-A JOURNAL OF INTEGRATIVE BIOLOGY

Advances in the Biology and Chemistry of Sialic Acids

(2009) Xi Chen et al.   ACS Chemical Biology

Metabolism, Cell Surface Organization, and Disease

(2009) James W. Dennis et al.   CELL

Structural insight into mammalian sialyltransferases

(2009) Francesco V Rao et al.   NATURE STRUCTURAL & MOLECULAR BIOLOGY

Structure and Function of β -1,4-Galactosyltransferase

(2008) Pradman Qasba et al.   CURRENT DRUG TARGETS

ABO(H) Blood Group A and B Glycosyltransferases Recognize Substrate via Specific Conformational Changes

(2008) Javier A. Alfaro et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Golgi  -mannosidase II cleaves two sugars sequentially in the same catalytic site

(2008) N. Shah et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Glycosyltransferases: Structures, Functions, and Mechanisms

(2007) L.L. Lairson et al.   Annual Review of Biochemistry