Non-canonical activation of the ER stress sensor ATF6 by Legionella pneumophila effectors

Intracellular proliferation of Anaplasma phagocytophilum is promoted via modulation of endoplasmic reticulum stress signaling in host cells

(2020) Yuko Yoshikawa et al.   MICROBIOLOGY AND IMMUNOLOGY

Paradoxical Pro-inflammatory Responses by Human Macrophages to an Amoebae Host-Adapted Legionella Effector

(2020) Christopher Price et al.   Cell Host & Microbe

Targeting Eukaryotic mRNA Translation by Legionella pneumophila

(2020) Yury Belyi   Frontiers in Molecular Biosciences

Ceapins block the unfolded protein response sensor ATF6α by inducing a neomorphic inter-organelle tether

(2019) Sandra Elizabeth Torres et al.   eLife

Seneca valley virus activates autophagy through the PERK and ATF6 UPR pathways

(2019) Lei Hou et al.   VIROLOGY

Targeting of RNA Polymerase II by a nuclear Legionella pneumophila Dot/Icm effector SnpL

(2018) Ralf Schuelein et al.   CELLULAR MICROBIOLOGY

Pharmacologic inhibition of S1P attenuates ATF6 expression, causes ER stress and contributes to apoptotic cell death

(2018) Paul Lebeau et al.   TOXICOLOGY AND APPLIED PHARMACOLOGY

A general method to fine-tune fluorophores for live-cell and in vivo imaging

(2017) Jonathan B Grimm et al.   NATURE METHODS

Beyond Paralogs: The Multiple Layers of Redundancy in Bacterial Pathogenesis

(2017) Soma Ghosh et al.   Frontiers in Cellular and Infection Microbiology

From Many Hosts, One Accidental Pathogen: The Diverse Protozoan Hosts of Legionella

(2017) David K. Boamah et al.   Frontiers in Cellular and Infection Microbiology

Genomic analysis of 38 Legionella species identifies large and diverse effector repertoires

(2016) David Burstein et al.   NATURE GENETICS

Ceapins are a new class of unfolded protein response inhibitors, selectively targeting the ATF6α branch

(2016) Ciara M Gallagher et al.   eLife

Ceapins inhibit ATF6α signaling by selectively preventing transport of ATF6α to the Golgi apparatus during ER stress

(2016) Ciara M Gallagher et al.   eLife

Inhibition of host cell translation elongation byLegionella pneumophilablocks the host cell unfolded protein response

(2015) Andrew D. Hempstead et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Legionella suppresses the host unfolded protein response via multiple mechanisms

(2015) Sean Treacy-Abarca et al.   Nature Communications

Histone Acetylation and Flagellin Are Essential for Legionella pneumophila-Induced Cytokine Expression

(2014) B. Schmeck et al.   JOURNAL OF IMMUNOLOGY

Bacteria, the endoplasmic reticulum and the unfolded protein response: friends or foes?

(2014) Jean Celli et al.   NATURE REVIEWS MICROBIOLOGY

Legionella pneumophilaSubversion of Host Vesicular Transport by SidC Effector Proteins

(2014) Florian A. Horenkamp et al.   TRAFFIC

Legionella pneumophila Effector RomA Uniquely Modifies Host Chromatin to Repress Gene Expression and Promote Intracellular Bacterial Replication

(2013) Monica Rolando et al.   Cell Host & Microbe

The Unfolded Protein Response Transducer ATF6 Represents a Novel Transmembrane-type Endoplasmic Reticulum-associated Degradation Substrate Requiring Both Mannose Trimming and SEL1L Protein

(2013) Satoshi Horimoto et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

IL-1  Signaling Initiates the Inflammatory Response to Virulent Legionella pneumophila In Vivo

(2013) K. C. Barry et al.   JOURNAL OF IMMUNOLOGY

ATF6 Signaling Is Required for Efficient West Nile Virus Replication by Promoting Cell Survival and Inhibition of Innate Immune Responses

(2012) R. L. Ambrose et al.   JOURNAL OF VIROLOGY

Aggravating Genetic Interactions Allow a Solution to Redundancy in a Bacterial Pathogen

(2012) T. J. O'Connor et al.   SCIENCE

Extensive recombination events and horizontal gene transfer shaped the Legionella pneumophila genomes

(2011) Laura Gomez-Valero et al.   BMC GENOMICS

Modulation of Rab GTPase function by a protein phosphocholine transferase

(2011) Shaeri Mukherjee et al.   NATURE

Aminoacyl-tRNA-Charged Eukaryotic Elongation Factor 1A Is the Bona Fide Substrate for Legionella pneumophila Effector Glucosyltransferases

(2011) Tina Tzivelekidis et al.   PLoS One

Secreted Bacterial Effectors That Inhibit Host Protein Synthesis Are Critical for Induction of the Innate Immune Response to Virulent Legionella pneumophila

(2011) Mary F. Fontana et al.   PLoS Pathogens

Modulation of Host Cell Function byLegionella pneumophilaType IV Effectors

(2010) Andree Hubber et al.   Annual Review of Cell and Developmental Biology

Endoplasmic reticulum stress is induced and modulated by enterovirus 71

(2010) Jia-Rong Jheng et al.   CELLULAR MICROBIOLOGY

Membrane phospholipid synthesis and endoplasmic reticulum function

(2008) Paolo Fagone et al.   JOURNAL OF LIPID RESEARCH

The Legionella pneumophila replication vacuole: making a cosy niche inside host cells

(2008) Ralph R. Isberg et al.   NATURE REVIEWS MICROBIOLOGY