Sarcopenic obesity: emerging mechanisms and therapeutic potential

Three‐dimensional chromatin re‐organization during muscle stem cell aging

(2023) Benjamin A. Yang et al.   AGING CELL

Sarcopenic obesity research perspectives outlined by the sarcopenic obesity global leadership initiative (SOGLI) – Proceedings from the SOGLI consortium meeting in Rome November 2022

(2023) Gianluca Gortan Cappellari et al.   CLINICAL NUTRITION

Metformin and Insulin Resistance: A Review of the Underlying Mechanisms behind Changes in GLUT4-Mediated Glucose Transport

(2022) Rok Herman et al.   INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES

Definition and Diagnostic Criteria for Sarcopenic Obesity: ESPEN and EASO Consensus Statement

(2022) Lorenzo M. Donini et al.   Obesity Facts

S1P/S1PR3 signalling axis protects against obesity-induced metabolic dysfunction

(2022) Sagarika Chakrabarty et al.   Adipocyte

Short-term exposure to a clinical dose of metformin increases skeletal muscle mitochondrial H2O2 emission and production in healthy, older adults: A randomized controlled trial

(2022) Alec I. McKenzie et al.   EXPERIMENTAL GERONTOLOGY

GlyNAC (Glycine and N-Acetylcysteine) Supplementation in Mice Increases Length of Life by Correcting Glutathione Deficiency, Oxidative Stress, Mitochondrial Dysfunction, Abnormalities in Mitophagy and Nutrient Sensing, and Genomic Damage

(2022) Premranjan Kumar et al.   Nutrients

Whey Protein, L-Leucine and Vitamin D Supplementation for Preserving Lean Mass during a Low-Calorie Diet in Sarcopenic Obese Women

(2022) Elisabetta Camajani et al.   Nutrients

Mitochondrial uncoupling attenuates sarcopenic obesity by enhancing skeletal muscle mitophagy and quality control

(2022) Wagner S. Dantas et al.   Journal of Cachexia Sarcopenia and Muscle

Supplementing Glycine and N-Acetylcysteine (GlyNAC) in Older Adults Improves Glutathione Deficiency, Oxidative Stress, Mitochondrial Dysfunction, Inflammation, Physical Function, and Aging Hallmarks: A Randomized Clinical Trial

(2022) Premranjan Kumar et al.   JOURNALS OF GERONTOLOGY SERIES A-BIOLOGICAL SCIENCES AND MEDICAL SCIENCES

Blocking ActRIIB and restoring appetite reverses cachexia and improves survival in mice with lung cancer

(2022) Andre Lima Queiroz et al.   Nature Communications

The ameliorating effects of metformin on disarrangement ongoing in gastrocnemius muscle of sarcopenic and obese sarcopenic mice

(2022) Qiong Lyu et al.   BIOCHIMICA ET BIOPHYSICA ACTA-MOLECULAR BASIS OF DISEASE

Senescence atlas reveals an aged-like inflamed niche that blunts muscle regeneration

(2022) Victoria Moiseeva et al.   NATURE

Effect of Bimagrumab vs Placebo on Body Fat Mass Among Adults With Type 2 Diabetes and Obesity

(2021) Steven B. Heymsfield et al.   JAMA Network Open

Mitochondrial uncoupler SHC517 reverses obesity in mice without affecting food intake

(2021) Sing-Young Chen et al.   METABOLISM-CLINICAL AND EXPERIMENTAL

Sarcopenia and Menopause: The Role of Estradiol

(2021) Annalisa Geraci et al.   Frontiers in Endocrinology

Glycine and N‐acetylcysteine (GlyNAC) supplementation in older adults improves glutathione deficiency, oxidative stress, mitochondrial dysfunction, inflammation, insulin resistance, endothelial dysfunction, genotoxicity, muscle strength, and cognition: Results of a pilot clinical trial

(2021) Premranjan Kumar et al.   Clinical and Translational Medicine

Global prevalence of sarcopenic obesity in older adults: A systematic review and meta-analysis

(2021) Qianqian Gao et al.   CLINICAL NUTRITION

Intranasal Oxytocin Improves Lean Muscle Mass and Lowers LDL Cholesterol in Older Adults with Sarcopenic Obesity: A Pilot Randomized Controlled Trial

(2021) Sara E. Espinoza et al.   Journal of the American Medical Directors Association

Lipids activate skeletal muscle mitochondrial fission and quality control networks to induce insulin resistance in humans

(2021) Christopher L. Axelrod et al.   METABOLISM-CLINICAL AND EXPERIMENTAL

Control of satellite cell function in muscle regeneration and its disruption in ageing

(2021) Pedro Sousa-Victor et al.   NATURE REVIEWS MOLECULAR CELL BIOLOGY

Metformin induces muscle atrophy by transcriptional regulation of myostatin via HDAC6 and FoxO3a

(2021) Min Ju Kang et al.   Journal of Cachexia Sarcopenia and Muscle

Reference values of body composition parameters and visceral adipose tissue (VAT) by DXA in adults aged 18–81 years—results from the LEAD cohort

(2020) Alina Ofenheimer et al.   EUROPEAN JOURNAL OF CLINICAL NUTRITION

Regulation of adipose tissue inflammation by interleukin 6

(2020) Myoung Sook Han et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

AICAR and nicotinamide treatment synergistically augment the proliferation and attenuate senescence-associated changes in mesenchymal stromal cells

(2020) Mohammadhossein Khorraminejad-Shirazi et al.   Stem Cell Research & Therapy

Chronic Adipose Tissue Inflammation Linking Obesity to Insulin Resistance and Type 2 Diabetes

(2020) Federica Zatterale et al.   Frontiers in Physiology

In vivo analysis of γH2AX+ cells in skeletal muscle from aged and obese humans

(2020) Cory M. Dungan et al.   FASEB JOURNAL

Mitochondrial uncoupler BAM15 reverses diet-induced obesity and insulin resistance in mice

(2020) Stephanie J. Alexopoulos et al.   Nature Communications

Health Consequences of Sarcopenic Obesity: A Narrative Review

(2020) Eun Roh et al.   Frontiers in Endocrinology

Aging shifts mitochondrial dynamics toward fission to promote germline stem cell loss

(2020) Oyundari Amartuvshin et al.   AGING CELL

BAM15‐mediated mitochondrial uncoupling protects against obesity and improves glycemic control

(2020) Christopher L Axelrod et al.   EMBO Molecular Medicine

Effects of Resistance Training on Muscle Size and Strength in Very Elderly Adults: A Systematic Review and Meta-Analysis of Randomized Controlled Trials

(2020) Jozo Grgic et al.   SPORTS MEDICINE

Cellular and Molecular Mechanisms of Metformin Action

(2020) Traci E LaMoia et al.   ENDOCRINE REVIEWS

Supplementing Glycine and N-acetylcysteine (GlyNAC) in Aging HIV Patients Improves Oxidative Stress, Mitochondrial Dysfunction, Inflammation, Endothelial Dysfunction, Insulin Resistance, Genotoxicity, Strength, and Cognition: Results of an Open-Label Clinical Trial

(2020) Premranjan Kumar et al.   Biomedicines

Caloric restriction: implications for sarcopenia and potential mechanisms

(2020) Wen-qing Xie et al.   Aging-US

Safety and pharmacokinetics of bimagrumab in healthy older and obese adults with body composition changes in the older cohort

(2020) Daniel Rooks et al.   Journal of Cachexia Sarcopenia and Muscle

Adiponectin promotes muscle regeneration through binding to T-cadherin

(2019) Yoshimitsu Tanaka et al.   Scientific Reports

The obesity transition: stages of the global epidemic

(2019) Lindsay M Jaacks et al.   Lancet Diabetes & Endocrinology

Resveratrol prevents sarcopenic obesity by reversing mitochondrial dysfunction and oxidative stress via the PKA/LKB1/AMPK pathway

(2019) Yujie Huang et al.   Aging-US

Long-Term Weight Loss With Metformin or Lifestyle Intervention in the Diabetes Prevention Program Outcomes Study

(2019) John W. Apolzan et al.   ANNALS OF INTERNAL MEDICINE

Testosterone replacement therapy and cardiovascular risk

(2019) Thiago Gagliano-Jucá et al.   Nature Reviews Cardiology

The impact of muscle function, muscle mass and sarcopenia on independent ageing in very old Swedish men

(2019) Kristin Franzon et al.   BMC Geriatrics

The S1P analog FTY720 reverses obesity but not age-induced anabolic resistance to muscle contraction.

(2019) Donato A. Rivas et al.   AMERICAN JOURNAL OF PHYSIOLOGY-CELL PHYSIOLOGY

Physical function‐derived cut‐points for the diagnosis of sarcopenia and dynapenia from the Canadian longitudinal study on aging

(2019) Anne‐Julie Tessier et al.   Journal of Cachexia Sarcopenia and Muscle

Metformin blunts muscle hypertrophy in response to progressive resistance exercise training in older adults: A randomized, double‐blind, placebo‐controlled, multicenter trial: The MASTERS trial

(2019) R. Grace Walton et al.   AGING CELL

Late‐onset hypogonadism: metabolic impact

(2019) M. Grossmann et al.   Andrology

Understanding muscle regenerative decline with aging: new approaches to bring back youthfulness to aged stem cells

(2019) Pura Muñoz‐Cánoves et al.   FEBS Journal

Sarcopenic obesity: hidden muscle wasting and its impact for survival and complications of cancer therapy

(2018) V E Baracos et al.   ANNALS OF ONCOLOGY

Effects of Combined Whole-Body Electromyostimulation and Protein Supplementation on Local and Overall Muscle/Fat Distribution in Older Men with Sarcopenic Obesity: The Randomized Controlled Franconia Sarcopenic Obesity (FranSO) Study

(2018) Wolfgang Kemmler et al.   CALCIFIED TISSUE INTERNATIONAL

The AMPK agonist 5‐aminoimidazole‐4‐carboxamide ribonucleotide (AICAR), but not metformin, prevents inflammation‐associated cachectic muscle wasting

(2018) Derek T Hall et al.   EMBO Molecular Medicine

The effects of obesity on skeletal muscle contractile function

(2018) Jason Tallis et al.   JOURNAL OF EXPERIMENTAL BIOLOGY

Effects of elastic band exercise on lean mass and physical capacity in older women with sarcopenic obesity: A randomized controlled trial

(2018) Chun-De Liao et al.   Scientific Reports

Efficacy and Safety of Low Frequency Whole-Body Electromyostimulation (WB-EMS) to Improve Health-Related Outcomes in Non-athletic Adults. A Systematic Review

(2018) Wolfgang Kemmler et al.   Frontiers in Physiology

Association of Body Mass Index With Lifetime Risk of Cardiovascular Disease and Compression of Morbidity

(2018) Sadiya S. Khan et al.   JAMA Cardiology

OUP accepted manuscript

(2018)   AGE AND AGEING

Dietary protein intake is associated with lean mass change in older, community-dwelling adults: the Health, Aging, and Body Composition (Health ABC) Study

(2018) Denise K Houston et al.   AMERICAN JOURNAL OF CLINICAL NUTRITION

Mitochondrial dynamics in skeletal muscle insulin resistance and type 2 diabetes

(2018) CiarÁn E. Fealy et al.   Translational Research

Obese subcutaneous adipose tissue impairs human myogenesis, particularly in old skeletal muscle, via resistin-mediated activation of NFκB

(2018) Mary F. O’Leary et al.   Scientific Reports

OUP accepted manuscript

(2018)   Advances in Nutrition

Metformin inhibits mitochondrial adaptations to aerobic exercise training in older adults

(2018) Adam R. Konopka et al.   AGING CELL

Structure and Physiological Regulation of AMPK

(2018) Yan Yan et al.   INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES

Effects of Different Types of Exercise on Body Composition, Muscle Strength, and IGF-1 in the Elderly with Sarcopenic Obesity

(2017) Hung-Ting Chen et al.   JOURNAL OF THE AMERICAN GERIATRICS SOCIETY

Effects of elastic resistance exercise on body composition and physical capacity in older women with sarcopenic obesity

(2017) Chun-De Liao et al.   MEDICINE

Effect of bimagrumab on thigh muscle volume and composition in men with casting-induced atrophy

(2017) Daniel S. Rooks et al.   Journal of Cachexia Sarcopenia and Muscle

Alterations in the in vitro and in vivo regulation of muscle regeneration in healthy ageing and the influence of sarcopenia

(2017) Joanna Brzeszczyńska et al.   Journal of Cachexia Sarcopenia and Muscle

Resistance training for activity limitations in older adults with skeletal muscle function deficits: a systematic review

(2017) Evan V Papa et al.   Clinical Interventions in Aging

Whole-body electromyostimulation and protein supplementation favorably affect sarcopenic obesity in community-dwelling older men at risk: the randomized controlled FranSO study

(2017) Wolfgang Kemmler et al.   Clinical Interventions in Aging

Adiponectin, Leptin, and Fatty Acids in the Maintenance of Metabolic Homeostasis through Adipose Tissue Crosstalk

(2016) Jennifer H. Stern et al.   Cell Metabolism

Effects of Whole-Body Electromyostimulation versus High-Intensity Resistance Exercise on Body Composition and Strength: A Randomized Controlled Study

(2016) Wolfgang Kemmler et al.   Evidence-based Complementary and Alternative Medicine

5,7-Dimethoxyflavone Attenuates Obesity by Inhibiting Adipogenesis in 3T3-L1 Adipocytes and High-Fat Diet-Induced Obese C57BL/6J Mice

(2016) Youngwoo Song et al.   JOURNAL OF MEDICINAL FOOD

Excessive fatty acid oxidation induces muscle atrophy in cancer cachexia

(2016) Tomoya Fukawa et al.   NATURE MEDICINE

Adiponectin, the past two decades

(2016) Zhao V. Wang et al.   Journal of Molecular Cell Biology

Exercise restores muscle stem cell mobilization, regenerative capacity and muscle metabolic alterations via adiponectin/AdipoR1 activation in SAMP10 mice

(2016) Aiko Inoue et al.   Journal of Cachexia Sarcopenia and Muscle

Impact of whole body electromyostimulation on cardiometabolic risk factors in older women with sarcopenic obesity: the randomized controlled FORMOsA-sarcopenic obesity study

(2016) Katharina Wittmann et al.   Clinical Interventions in Aging

Deciphering the role of Nuclear Factor-κB in cellular senescence

(2016) Simon Vaughan et al.   Aging-US

The impact of obesity on skeletal muscle strength and structure through adolescence to old age

(2015) D. J. Tomlinson et al.   BIOGERONTOLOGY

Defects in Mitochondrial Efficiency and H2O2Emissions in Obese Women Are Restored to a Lean Phenotype With Aerobic Exercise Training

(2015) Adam R. Konopka et al.   DIABETES

Sarcopenic obesity and metabolic syndrome in adult Caucasian subjects

(2015) Eleonora Poggiogalle et al.   Journal of Nutrition Health & Aging

Chronic Treatment with the AMPK Agonist AICAR Prevents Skeletal Muscle Pathology but Fails to Improve Clinical Outcome in a Mouse Model of Severe Spinal Muscular Atrophy

(2015) Clàudia Cerveró et al.   Neurotherapeutics

Improved insulin sensitivity after exercise training is linked to reduced plasma C14:0 ceramide in obesity and type 2 diabetes

(2015) Takhar Kasumov et al.   Obesity

Muscle stem cells contribute to myofibres in sedentary adult mice

(2015) Alexandra C. Keefe et al.   Nature Communications

A Comprehensive Inter-Tissue Crosstalk Analysis Underlying Progression and Control of Obesity and Diabetes

(2015) Pawan Samdani et al.   Scientific Reports

The ins and outs of muscle stem cell aging

(2015) Andrew S. Brack et al.   Skeletal Muscle

Muscle ectopic fat deposition contributes to anabolic resistance in obese sarcopenic old rats through eIF2α activation

(2014) Nicolas Tardif et al.   AGING CELL

Lipid-Induced Insulin Resistance Is Associated With an Impaired Skeletal Muscle Protein Synthetic Response to Amino Acid Ingestion in Healthy Young Men

(2014) Francis B. Stephens et al.   DIABETES

AMPK controls exercise endurance, mitochondrial oxidative capacity, and skeletal muscle integrity

(2014) Louise Lantier et al.   FASEB JOURNAL

Skeletal Muscle Lipid Content and Oxidative Activity in Relation to Muscle Fiber Type in Aging and Metabolic Syndrome

(2014) Marine Gueugneau et al.   JOURNALS OF GERONTOLOGY SERIES A-BIOLOGICAL SCIENCES AND MEDICAL SCIENCES

AMPK agonist AICAR improves cognition and motor coordination in young and aged mice

(2014) T. Kobilo et al.   LEARNING & MEMORY

Impaired mitochondrial fatty acid oxidation and insulin resistance in aging: novel protective role of glutathione

(2013) Dan Nguyen et al.   AGING CELL

Abnormal protein turnover and anabolic resistance to exercise in sarcopenic obesity

(2013) Mats I. Nilsson et al.   FASEB JOURNAL

An Antibody Blocking Activin Type II Receptors Induces Strong Skeletal Muscle Hypertrophy and Protects from Atrophy

(2013) E. Lach-Trifilieff et al.   MOLECULAR AND CELLULAR BIOLOGY

Plasma Sphingosine-1-Phosphate Is Elevated in Obesity

(2013) Greg M. Kowalski et al.   PLoS One

Sarcopenic obesity

(2013) Matthew F. Bouchonville et al.   Current Opinion in Endocrinology Diabetes and Obesity

AMP-activated protein kinase stimulates myostatin expression in C2C12 cells

(2012) Arun K. Das et al.   BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS

Chronic Caloric Restriction Preserves Mitochondrial Function in Senescence without Increasing Mitochondrial Biogenesis

(2012) Ian R. Lanza et al.   Cell Metabolism

Leptin impairs myogenesis in C2C12 cells through JAK/STAT and MEK signaling pathways

(2012) Maja Pijet et al.   CYTOKINE

The Sphingosine-1-Phosphate Analog FTY720 Reduces Muscle Ceramide Content and Improves Glucose Tolerance in High Fat-Fed Male Mice

(2012) Clinton R. Bruce et al.   ENDOCRINOLOGY

Role and potential mechanisms of anabolic resistance in sarcopenia

(2012) Prashanth H. Haran et al.   Journal of Cachexia Sarcopenia and Muscle

Modulation of reactive oxygen species in skeletal muscle by myostatin is mediated through NF-κB

(2011) Sandhya Sriram et al.   AGING CELL

Deficient synthesis of glutathione underlies oxidative stress in aging and can be corrected by dietary cysteine and glycine supplementation

(2011) R. V. Sekhar et al.   AMERICAN JOURNAL OF CLINICAL NUTRITION

Leptin in Sarcopenic Visceral Obesity: Possible Link between Adipocytes and Myocytes

(2011) Katsuhiko Kohara et al.   PLoS One

The adipokine leptin increases skeletal muscle mass and significantly alters skeletal muscle miRNA expression profile in aged mice

(2010) Mark W. Hamrick et al.   BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS

Metformin selectively attenuates mitochondrial H2O2 emission without affecting respiratory capacity in skeletal muscle of obese rats

(2010) Daniel A. Kane et al.   FREE RADICAL BIOLOGY AND MEDICINE

Globular Adiponectin as a Complete Mesoangioblast Regulator: Role in Proliferation, Survival, Motility, and Skeletal Muscle Differentiation

(2010) Tania Fiaschi et al.   MOLECULAR BIOLOGY OF THE CELL

Fingolimod (FTY720): discovery and development of an oral drug to treat multiple sclerosis

(2010) Volker Brinkmann et al.   NATURE REVIEWS DRUG DISCOVERY

Dynamic regulation of PGC-1α localization and turnover implicates mitochondrial adaptation in calorie restriction and the stress response

(2009) Rozalyn M. Anderson et al.   AGING CELL

Myostatin reduces Akt/TORC1/p70S6K signaling, inhibiting myoblast differentiation and myotube size

(2009) Anne Ulrike Trendelenburg et al.   AMERICAN JOURNAL OF PHYSIOLOGY-CELL PHYSIOLOGY

Leptin receptor 170 kDa (OB-R170) protein expression is reduced in obese human skeletal muscle: a potential mechanism of leptin resistance

(2009) T. Fuentes et al.   EXPERIMENTAL PHYSIOLOGY

Skeletal Muscle Hypertrophy Following Resistance Training Is Accompanied by a Fiber Type-Specific Increase in Satellite Cell Content in Elderly Men

(2009) L. B. Verdijk et al.   JOURNALS OF GERONTOLOGY SERIES A-BIOLOGICAL SCIENCES AND MEDICAL SCIENCES

The NF- B Family of Transcription Factors and Its Regulation

(2009) A. Oeckinghaus et al.   Cold Spring Harbor Perspectives in Biology

Plasma Ceramides Are Elevated in Obese Subjects With Type 2 Diabetes and Correlate With the Severity of Insulin Resistance

(2008) J. M. Haus et al.   DIABETES

Circulating adiponectin levels associate with inflammatory markers, insulin resistance and metabolic syndrome independent of obesity

(2008) J Hung et al.   INTERNATIONAL JOURNAL OF OBESITY

Nutrition, Inflammation, and Leptin Levels in Aging and Frailty

(2008) Ruth E. Hubbard et al.   JOURNAL OF THE AMERICAN GERIATRICS SOCIETY