BAM15‐mediated mitochondrial uncoupling protects against obesity and improves glycemic control

Low-intensity exercise induces acute shifts in liver and skeletal muscle substrate metabolism, but not chronic adaptations in tissue oxidative capacity

(2019) Scott E. Fuller et al.   JOURNAL OF APPLIED PHYSIOLOGY

Extensive metabolic remodeling after limiting mitochondrial lipid burden is consistent with an improved metabolic health profile

(2019) Sujoy Ghosh et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

2 years of calorie restriction and cardiometabolic risk (CALERIE): exploratory outcomes of a multicentre, phase 2, randomised controlled trial

(2019) William E Kraus et al.   Lancet Diabetes & Endocrinology

Liquid Sucrose Consumption Promotes Obesity and Impairs Glucose Tolerance Without Altering Circulating Insulin Levels

(2018) Susan J. Burke et al.   Obesity

AMP-Activated Protein Kinase (AMPK) Regulates Energy Metabolism through Modulating Thermogenesis in Adipose Tissue

(2018) Lingyan Wu et al.   Frontiers in Physiology

Mitochondrial uncoupler BAM15 inhibits artery constriction and potently activates AMPK in vascular smooth muscle cells

(2018) Yu Tai et al.   Acta Pharmaceutica Sinica B

Exercise training remodels human skeletal muscle mitochondrial fission and fusion machinery towards a pro-elongation phenotype

(2018) Christopher L. Axelrod et al.   Acta Physiologica

Small Molecule Mitochondrial Uncouplers and Their Therapeutic Potential

(2017) Elizabeth S. Childress et al.   JOURNAL OF MEDICINAL CHEMISTRY

FDA-Approved Anti-Obesity Drugs in the United States

(2016) Homayoun L. Daneschvar et al.   AMERICAN JOURNAL OF MEDICINE

Salsalate (Salicylate) Uncouples Mitochondria, Improves Glucose Homeostasis, and Reduces Liver Lipids Independent of AMPK-β1

(2016) Brennan K. Smith et al.   DIABETES

Body Composition, Food Intake, and Energy Expenditure in a Murine Model of Roux-en-Y Gastric Bypass Surgery

(2016) Zheng Hao et al.   OBESITY SURGERY

Novel targets for mitochondrial medicine

(2016) Wang Wang et al.   Science Translational Medicine

Controlled-release mitochondrial protonophore reverses diabetes and steatohepatitis in rats

(2015) R. J. Perry et al.   SCIENCE

Weight Loss by Ppc-1, a Novel Small Molecule Mitochondrial Uncoupler Derived from Slime Mold

(2015) Toshiyuki Suzuki et al.   PLoS One

The Chemical Uncoupler 2,4-Dinitrophenol (DNP) Protects against Diet-induced Obesity and Improves Energy Homeostasis in Mice at Thermoneutrality

(2014) Margalit Goldgof et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Global, regional, and national prevalence of overweight and obesity in children and adults during 1980–2013: a systematic analysis for the Global Burden of Disease Study 2013

(2014) Marie Ng et al.   LANCET

Niclosamide ethanolamine–induced mild mitochondrial uncoupling improves diabetic symptoms in mice

(2014) Hanlin Tao et al.   NATURE MEDICINE

Multiple Mitochondrial Alterations in a Case of Myopathy

(2014) H. Fujioka et al.   ULTRASTRUCTURAL PATHOLOGY

Measuring oxidative phosphorylation in human skin fibroblasts

(2013) Fang Ye et al.   ANALYTICAL BIOCHEMISTRY

Reversal of Hypertriglyceridemia, Fatty Liver Disease, and Insulin Resistance by a Liver-Targeted Mitochondrial Uncoupler

(2013) Rachel J. Perry et al.   Cell Metabolism

Fetuin-A is linked to improved glucose tolerance after short-term exercise training in nonalcoholic fatty liver disease

(2013) Steven K. Malin et al.   JOURNAL OF APPLIED PHYSIOLOGY

Multiple Muscle Cell Alterations in a Case of Encephalomyopathy

(2013) Hisashi Fujioka et al.   ULTRASTRUCTURAL PATHOLOGY

De novo lipogenesis in human fat and liver is linked to ChREBP-β and metabolic health

(2013) Leah Eissing et al.   Nature Communications

Identification of a novel mitochondrial uncoupler that does not depolarize the plasma membrane

(2013) Brandon M. Kenwood et al.   Molecular Metabolism

Comprehensive approach to the quantitative analysis of mitochondrial phospholipids by HPLC–MS

(2012) Junhwan Kim et al.   JOURNAL OF CHROMATOGRAPHY B-ANALYTICAL TECHNOLOGIES IN THE BIOMEDICAL AND LIFE SCIENCES

Fiji: an open-source platform for biological-image analysis

(2012) Johannes Schindelin et al.   NATURE METHODS

Stearoyl-CoA Desaturase-1 (SCD1) Augments Saturated Fatty Acid-Induced Lipid Accumulation and Inhibits Apoptosis in Cardiac Myocytes

(2012) Hiroki Matsui et al.   PLoS One

Assessing mitochondrial dysfunction in cells

(2011) Martin D. Brand et al.   BIOCHEMICAL JOURNAL

AMPK Phosphorylates and Inhibits SREBP Activity to Attenuate Hepatic Steatosis and Atherosclerosis in Diet-Induced Insulin-Resistant Mice

(2011) Yu Li et al.   Cell Metabolism

Inhibition of stearoyl-CoA desaturase1 activates AMPK and exhibits beneficial lipid metabolic effects in vitro

(2011) Eunha Kim et al.   EUROPEAN JOURNAL OF PHARMACOLOGY

The Subcellular Distribution of Small Molecules: A Meta-Analysis

(2011) Nan Zheng et al.   MOLECULAR PHARMACEUTICS

Wnt signaling regulates mitochondrial physiology and insulin sensitivity

(2010) J. C. Yoon et al.   GENES & DEVELOPMENT

Annual Medical Spending Attributable To Obesity: Payer-And Service-Specific Estimates

(2009) Eric A. Finkelstein et al.   HEALTH AFFAIRS

Antiobesity effects of the β-cell hormone amylin in combination with phentermine or sibutramine in diet-induced obese rats

(2008) J D Roth et al.   INTERNATIONAL JOURNAL OF OBESITY