Understanding muscle regenerative decline with aging: new approaches to bring back youthfulness to aged stem cells

Aging Disrupts Muscle Stem Cell Function by Impairing Matricellular WISP1 Secretion from Fibro-Adipogenic Progenitors

(2019) Laura Lukjanenko et al.   Cell Stem Cell

Elevated H3K27ac in aged skeletal muscle leads to increase in extracellular matrix and fibrogenic conversion of muscle satellite cells

(2019) Jiajian Zhou et al.   AGING CELL

The transcription factor Slug represses p16Ink4a and regulates murine muscle stem cell aging

(2019) Pei Zhu et al.   Nature Communications

New mechanisms driving muscle stem cell regenerative decline with aging

(2018) Pedro Sousa-Victor et al.   INTERNATIONAL JOURNAL OF DEVELOPMENTAL BIOLOGY

Cellular and epigenetic drivers of stem cell ageing

(2018) Maria Ermolaeva et al.   NATURE REVIEWS MOLECULAR CELL BIOLOGY

Somatic mutagenesis in satellite cells associates with human skeletal muscle aging

(2018) Irene Franco et al.   Nature Communications

The AMPK/p27 Kip1 Axis Regulates Autophagy/Apoptosis Decisions in Aged Skeletal Muscle Stem Cells

(2018) James P. White et al.   Stem Cell Reports

Myeloid cell-derived tumor necrosis factor-alpha promotes sarcopenia and regulates muscle cell fusion with aging muscle fibers

(2018) Ying Wang et al.   AGING CELL

Impaired Notch Signaling Leads to a Decrease in p53 Activity and Mitotic Catastrophe in Aged Muscle Stem Cells

(2018) Ling Liu et al.   Cell Stem Cell

Aging of the immune system causes reductions in muscle stem cell populations, promotes their shift to a fibrogenic phenotype, and modulates sarcopenia

(2018) Ying Wang et al.   FASEB JOURNAL

The exerkine apelin reverses age-associated sarcopenia

(2018) Claire Vinel et al.   NATURE MEDICINE

Incorporation of macrophages into engineered skeletal muscle enables enhanced muscle regeneration

(2018) Mark Juhas et al.   Nature Biomedical Engineering

Age-related declines in α-Klotho drive progenitor cell mitochondrial dysfunction and impaired muscle regeneration

(2018) A. Sahu et al.   Nature Communications

Regenerative Medicine Approaches for Age-Related Muscle Loss and Sarcopenia: A Mini-Review

(2017) Juan Diego Naranjo et al.   GERONTOLOGY

Downregulation of the Apelinergic Axis Accelerates Aging, whereas Its Systemic Restoration Improves the Mammalian Healthspan

(2017) Rahul Rai et al.   Cell Reports

Loss of adult skeletal muscle stem cells drives age-related neuromuscular junction degeneration

(2017) Wenxuan Liu et al.   eLife

Lack of evidence for GDF11 as a rejuvenator of aged skeletal muscle satellite cells

(2016) Aaron C. Hinken et al.   AGING CELL

Impaired energy metabolism of senescent muscle satellite cells is associated with oxidative modifications of glycolytic enzymes

(2016) Martín A. Baraibar et al.   Aging-US

Age-associated NF-κB signaling in myofibers alters the satellite cell niche and re-strains muscle stem cell function

(2016) Juhyun Oh et al.   Aging-US

Dysfunctional autophagy is a driver of muscle stem cell functional decline with aging

(2016) Laura García-Prat et al.   Autophagy

In Vivo Amelioration of Age-Associated Hallmarks by Partial Reprogramming

(2016) Alejandro Ocampo et al.   CELL

Quantification of GDF11 and Myostatin in Human Aging and Cardiovascular Disease

(2016) Marissa J. Schafer et al.   Cell Metabolism

Is Growth Differentiation Factor 11 a Realistic Therapeutic for Aging-Dependent Muscle Defects?Response to Harper et al

(2016) Shavonn C. Harper et al.   CIRCULATION RESEARCH

Satellite cell depletion prevents fiber hypertrophy in skeletal muscle

(2016) Ingrid M. Egner et al.   DEVELOPMENT

Exercise conditioning in old mice improves skeletal muscle regeneration

(2016) Sophie Joanisse et al.   FASEB JOURNAL

Poor Repair of Skeletal Muscle in Aging Mice Reflects a Defect in Local, Interleukin-33-Dependent Accumulation of Regulatory T Cells

(2016) Wilson Kuswanto et al.   IMMUNITY

Regenerative decline of stem cells in sarcopenia

(2016) Pedro Sousa-Victor et al.   MOLECULAR ASPECTS OF MEDICINE

Epigenetic stress responses induce muscle stem-cell ageing by Hoxa9 developmental signals

(2016) Simon Schwörer et al.   NATURE

Autophagy maintains stemness by preventing senescence

(2016) Laura García-Prat et al.   NATURE

Targeting β1-integrin signaling enhances regeneration in aged and dystrophic muscle in mice

(2016) Michelle Rozo et al.   NATURE MEDICINE

Loss of fibronectin from the aged stem cell niche affects the regenerative capacity of skeletal muscle in mice

(2016) Laura Lukjanenko et al.   NATURE MEDICINE

NAD+ repletion improves mitochondrial and stem cell function and enhances life span in mice

(2016) H. Zhang et al.   SCIENCE

A single heterochronic blood exchange reveals rapid inhibition of multiple tissues by old blood

(2016) Justin Rebo et al.   Nature Communications

GDF11 Increases with Age and Inhibits Skeletal Muscle Regeneration

(2015) Marc A. Egerman et al.   Cell Metabolism

Circulating Growth Differentiation Factor 11/8 Levels Decline With AgeNovelty and Significance

(2015) Tommaso Poggioli et al.   CIRCULATION RESEARCH

Blunted hypertrophic response in old mouse muscle is associated with a lower satellite cell density and is not alleviated by resveratrol

(2015) Sam B. Ballak et al.   EXPERIMENTAL GERONTOLOGY

Clearance of senescent cells by ABT263 rejuvenates aged hematopoietic stem cells in mice

(2015) Jianhui Chang et al.   NATURE MEDICINE

Muscle stem cell aging: regulation and rejuvenation

(2015) Pedro Sousa-Victor et al.   TRENDS IN ENDOCRINOLOGY AND METABOLISM

Muscle stem cells contribute to myofibres in sedentary adult mice

(2015) Alexandra C. Keefe et al.   Nature Communications

Pervasive satellite cell contribution to uninjured adult muscle fibers

(2015) Bradley Pawlikowski et al.   Skeletal Muscle

Rethinking Differentiation: Stem Cells, Regeneration, and Plasticity

(2014) Alejandro Sánchez Alvarado et al.   CELL

Induction of autophagy supports the bioenergetic demands of quiescent muscle stem cell activation

(2014) Ann H Tang et al.   EMBO JOURNAL

Geriatric muscle stem cells switch reversible quiescence into senescence

(2014) Pedro Sousa-Victor et al.   NATURE

Impact of genomic damage and ageing on stem cell function

(2014) Axel Behrens et al.   NATURE CELL BIOLOGY

Inhibition of JAK-STAT signaling stimulates adult satellite cell function

(2014) Feodor D Price et al.   NATURE MEDICINE

STAT3 signaling controls satellite cell expansion and skeletal muscle repair

(2014) Matthew Timothy Tierney et al.   NATURE MEDICINE

Rejuvenation of the muscle stem cell population restores strength to injured aged muscles

(2014) Benjamin D Cosgrove et al.   NATURE MEDICINE

Inducible depletion of satellite cells in adult, sedentary mice impairs muscle regenerative capacity without affecting sarcopenia

(2014) Christopher S Fry et al.   NATURE MEDICINE

p38 MAPK signaling underlies a cell-autonomous loss of stem cell self-renewal in skeletal muscle of aged mice

(2014) Jennifer D Bernet et al.   NATURE MEDICINE

Restoring Systemic GDF11 Levels Reverses Age-Related Dysfunction in Mouse Skeletal Muscle

(2014) M. Sinha et al.   SCIENCE

More efficient repair of DNA double-strand breaks in skeletal muscle stem cells compared to their committed progeny

(2014) Leyla Vahidi Ferdousi et al.   Stem Cell Research

Oxytocin is an age-specific circulating hormone that is necessary for muscle maintenance and regeneration

(2014) Christian Elabd et al.   Nature Communications

The Hallmarks of Aging

(2013) Carlos López-Otín et al.   CELL

Regulation of the muscle fiber microenvironment by activated satellite cells during hypertrophy

(2013) Christopher S. Fry et al.   FASEB JOURNAL

Satellite Cells and the Muscle Stem Cell Niche

(2013) Hang Yin et al.   PHYSIOLOGICAL REVIEWS

Dual role of the caspase enzymes in satellite cells from aged and young subjects

(2013) S Fulle et al.   Cell Death & Disease

Chromatin Modifications as Determinants of Muscle Stem Cell Quiescence and Chronological Aging

(2013) Ling Liu et al.   Cell Reports

Complement C1q Activates Canonical Wnt Signaling and Promotes Aging-Related Phenotypes

(2012) Atsuhiko T. Naito et al.   CELL

Short-Term Calorie Restriction Enhances Skeletal Muscle Stem Cell Function

(2012) Massimiliano Cerletti et al.   Cell Stem Cell

Stem cell therapies for muscle disorders

(2012) Francesco S. Tedesco et al.   CURRENT OPINION IN NEUROLOGY

Satellite cells are essential for skeletal muscle regeneration: the cell on the edge returns centre stage

(2012) F. Relaix et al.   DEVELOPMENT

A matter of life and death: self-renewal in stem cells

(2012) Elaine Fuchs et al.   EMBO REPORTS

Proinflammatory Macrophages Enhance the Regenerative Capacity of Human Myoblasts by Modifying Their Kinetics of Proliferation and Differentiation

(2012) Maximilien Bencze et al.   MOLECULAR THERAPY

The aged niche disrupts muscle stem cell quiescence

(2012) Joe V. Chakkalakal et al.   NATURE

p38/MKP-1–regulated AKT coordinates macrophage transitions and resolution of inflammation during tissue repair

(2011) Eusebio Perdiguero et al.   JOURNAL OF CELL BIOLOGY

Sprouty1 Regulates Reversible Quiescence of a Self-Renewing Adult Muscle Stem Cell Pool during Regeneration

(2010) Kelly L. Shea et al.   Cell Stem Cell

Prevention of Muscle Aging by Myofiber-Associated Satellite Cell Transplantation

(2010) J. K. Hall et al.   Science Translational Medicine

Interleukin-6 Is an Essential Regulator of Satellite Cell-Mediated Skeletal Muscle Hypertrophy

(2008) Antonio L. Serrano et al.   Cell Metabolism

Imbalance between pSmad3 and Notch induces CDK inhibitors in old muscle stem cells

(2008) Morgan E. Carlson et al.   NATURE