Supplementing Glycine and N-Acetylcysteine (GlyNAC) in Older Adults Improves Glutathione Deficiency, Oxidative Stress, Mitochondrial Dysfunction, Inflammation, Physical Function, and Aging Hallmarks: A Randomized Clinical Trial

GlyNAC (Glycine and N-Acetylcysteine) Supplementation Improves Impaired Mitochondrial Fuel Oxidation and Lowers Insulin Resistance in Patients with Type 2 Diabetes: Results of a Pilot Study

(2022) Rajagopal V. Sekhar   Antioxidants

GlyNAC (Glycine and N-Acetylcysteine) Supplementation in Mice Increases Length of Life by Correcting Glutathione Deficiency, Oxidative Stress, Mitochondrial Dysfunction, Abnormalities in Mitophagy and Nutrient Sensing, and Genomic Damage

(2022) Premranjan Kumar et al.   Nutrients

Glycine and N‐acetylcysteine (GlyNAC) supplementation in older adults improves glutathione deficiency, oxidative stress, mitochondrial dysfunction, inflammation, insulin resistance, endothelial dysfunction, genotoxicity, muscle strength, and cognition: Results of a pilot clinical trial

(2021) Premranjan Kumar et al.   Clinical and Translational Medicine

Supplementing glycine and N-acetylcysteine (GlyNAC) rapidly improves health-related quality of life and lowers perception of fatigue in patients with HIV

(2021) Rajagopal V. Sekhar   AIDS

Dietary thiols accelerate aging of C. elegans

(2021) Ivan Gusarov et al.   Nature Communications

The quest to slow ageing through drug discovery

(2020) Linda Partridge et al.   NATURE REVIEWS DRUG DISCOVERY

Reductive Stress-Induced Mitochondrial Dysfunction and Cardiomyopathy

(2020) Wei-Xing Ma et al.   Oxidative Medicine and Cellular Longevity

Human shelterin protein POT 1 prevents severe telomere instability induced by homology‐directed DNA repair

(2020) Galina Glousker et al.   EMBO JOURNAL

Supplementing Glycine and N-acetylcysteine (GlyNAC) in Aging HIV Patients Improves Oxidative Stress, Mitochondrial Dysfunction, Inflammation, Endothelial Dysfunction, Insulin Resistance, Genotoxicity, Strength, and Cognition: Results of an Open-Label Clinical Trial

(2020) Premranjan Kumar et al.   Biomedicines

Glycine supplementation extends lifespan of male and female mice

(2019) Richard A. Miller et al.   AGING CELL

Mitochondrial dysfunction and oxidative stress in heart disease

(2019) Jessica N. Peoples et al.   EXPERIMENTAL AND MOLECULAR MEDICINE

Reactive Oxygen Species in Metabolic and Inflammatory Signaling

(2018) Steven J. Forrester et al.   CIRCULATION RESEARCH

Improved Cardiovascular Function in Old Mice After N-Acetyl Cysteine and Glycine Supplemented Diet: Inflammation and Mitochondrial Factors

(2018) Katarzyna A Cieslik et al.   JOURNALS OF GERONTOLOGY SERIES A-BIOLOGICAL SCIENCES AND MEDICAL SCIENCES

Towards Understanding Genomic Instability, Mitochondrial Dysfunction and Aging

(2018) Nima B Fakouri et al.   FEBS Journal

Oxidative stress in chronic lung disease: From mitochondrial dysfunction to dysregulated redox signaling

(2018) Albert van der Vliet et al.   MOLECULAR ASPECTS OF MEDICINE

Skeletal muscle insulin resistance: role of mitochondria and other ROS sources

(2017) Sergio Di Meo et al.   JOURNAL OF ENDOCRINOLOGY

Oxidant Mechanisms in Renal Injury and Disease

(2016) Brian B. Ratliff et al.   ANTIOXIDANTS & REDOX SIGNALING

CD38 Dictates Age-Related NAD Decline and Mitochondrial Dysfunction through an SIRT3-Dependent Mechanism

(2016) Juliana Camacho-Pereira et al.   Cell Metabolism

Energy metabolism and inflammation in brain aging and Alzheimer’s disease

(2016) Fei Yin et al.   FREE RADICAL BIOLOGY AND MEDICINE

Skeletal Muscle Regeneration, Repair and Remodelling in Aging: The Importance of Muscle Stem Cells and Vascularization

(2016) Sophie Joanisse et al.   GERONTOLOGY

Frameworks for Proof-of-Concept Clinical Trials of Interventions That Target Fundamental Aging Processes

(2016) Jamie Justice et al.   JOURNALS OF GERONTOLOGY SERIES A-BIOLOGICAL SCIENCES AND MEDICAL SCIENCES

Strategies and Challenges in Clinical Trials Targeting Human Aging

(2016) John C. Newman et al.   JOURNALS OF GERONTOLOGY SERIES A-BIOLOGICAL SCIENCES AND MEDICAL SCIENCES

Prevalence and trends in physical activity among older adults in the United States: A comparison across three national surveys

(2016) Sarah Kozey Keadle et al.   PREVENTIVE MEDICINE

Oxidative stress: A major pathogenesis and potential therapeutic target of antioxidative agents in Parkinson’s disease and Alzheimer’s disease

(2016) Tianfang Jiang et al.   PROGRESS IN NEUROBIOLOGY

The effect of an oral anti-oxidant, N-Acetyl-cysteine, on inflammatory and oxidative markers in pulmonary sarcoidosis

(2016) Nabeel Hamzeh et al.   RESPIRATORY MEDICINE

PINK1/Parkin-mediated mitophagy in mammalian cells

(2015) Akinori Eiyama et al.   CURRENT OPINION IN CELL BIOLOGY

Endoplasmic reticulum stress and Oxidative stress in the pathogenesis of Non-alcoholic fatty liver disease

(2015) N. U. Ashraf et al.   FREE RADICAL RESEARCH

Promoting basal levels of autophagy in the nervous system enhances longevity and oxidant resistance in adult Drosophila

(2014) Anne Simonsen et al.   Autophagy

Chronic Inflammation (Inflammaging) and Its Potential Contribution to Age-Associated Diseases

(2014) C. Franceschi et al.   JOURNALS OF GERONTOLOGY SERIES A-BIOLOGICAL SCIENCES AND MEDICAL SCIENCES

Impaired mitochondrial fatty acid oxidation and insulin resistance in aging: novel protective role of glutathione

(2013) Dan Nguyen et al.   AGING CELL

The Hallmarks of Aging

(2013) Carlos López-Otín et al.   CELL

The impact of aging on mitochondrial function and biogenesis pathways in skeletal muscle of sedentary high- and low-functioning elderly individuals

(2012) Anna-Maria Joseph et al.   AGING CELL

Mitochondrial Protein Acylation and Intermediary Metabolism: Regulation by Sirtuins and Implications for Metabolic Disease

(2012) John C. Newman et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Circulating Levels of TNF-α Are Associated with Impaired Glucose Tolerance, Increased Insulin Resistance, and Ethnicity: The Insulin Resistance Atherosclerosis Study

(2012) Nels C. Olson et al.   JOURNAL OF CLINICAL ENDOCRINOLOGY & METABOLISM

Deficient synthesis of glutathione underlies oxidative stress in aging and can be corrected by dietary cysteine and glycine supplementation

(2011) R. V. Sekhar et al.   AMERICAN JOURNAL OF CLINICAL NUTRITION

Pax7-expressing satellite cells are indispensable for adult skeletal muscle regeneration

(2011) R. Sambasivan et al.   DEVELOPMENT

Gait Speed and Survival in Older Adults

(2011) Stephanie Studenski   JAMA-JOURNAL OF THE AMERICAN MEDICAL ASSOCIATION

Effects of Oral Glutathione Supplementation on Systemic Oxidative Stress Biomarkers in Human Volunteers

(2011) Jason Allen et al.   JOURNAL OF ALTERNATIVE AND COMPLEMENTARY MEDICINE

Clearance of p16Ink4a-positive senescent cells delays ageing-associated disorders

(2011) Darren J. Baker et al.   NATURE

Oxidative Stress and Diabetic Complications

(2010) Ferdinando Giacco et al.   CIRCULATION RESEARCH

Glutathione Synthesis Is Diminished in Patients With Uncontrolled Diabetes and Restored by Dietary Supplementation With Cysteine and Glycine

(2010) R. V. Sekhar et al.   DIABETES CARE

Effects of rosiglitazone on abnormal lipid kinetics in HIV-associated dyslipidemic lipodystrophy: a stable isotope study

(2010) Rajagopal V. Sekhar et al.   METABOLISM-CLINICAL AND EXPERIMENTAL

Impaired Endothelial Nitric Oxide Bioavailability: A Common Link Between Aging, Hypertension, and Atherogenesis?

(2008) Thomas Walsh et al.   JOURNAL OF THE AMERICAN GERIATRICS SOCIETY