Nonadditive functional interactions between ligand-binding sites of the multidrug efflux pump AdeB from Acinetobacter baumannii

Functional Diversity of Gram-Negative Permeability Barriers Reflected in Antibacterial Activities and Intracellular Accumulation of Antibiotics

(2023) Inga V. Leus et al.   ANTIMICROBIAL AGENTS AND CHEMOTHERAPY

Infectious Diseases Society of America 2023 Guidance on the Treatment of Antimicrobial Resistant Gram-Negative Infections

(2023) Pranita D Tamma et al.   CLINICAL INFECTIOUS DISEASES

An Analysis of the Novel Fluorocycline TP-6076 Bound to Both the Ribosome and Multidrug Efflux Pump AdeJ from Acinetobacter baumannii

(2022) Christopher E. Morgan et al.   mBio

Cryoelectron Microscopy Structures of AdeB Illuminate Mechanisms of Simultaneous Binding and Exporting of Substrates

(2021) Christopher E. Morgan et al.   mBio

Multidrug Resistance Efflux Pumps in Acinetobacter spp.: An Update

(2021) Vanessa Kornelsen et al.   ANTIMICROBIAL AGENTS AND CHEMOTHERAPY

Acinetobacter baumannii Antibiotic Resistance Mechanisms

(2021) Ioannis Kyriakidis et al.   Pathogens

Cryo-EM Determination of Eravacycline-Bound Structures of the Ribosome and the Multidrug Efflux Pump AdeJ of Acinetobacter baumannii

(2021) Zhemin Zhang et al.   mBio

Allosteric drug transport mechanism of multidrug transporter AcrB

(2021) Heng-Keat Tam et al.   Nature Communications

Structural and functional analysis of the promiscuous AcrB and AdeB efflux pumps suggests different drug binding mechanisms

(2021) Alina Ornik-Cha et al.   Nature Communications

Drug Permeation against Efflux by Two Transporters

(2020) Paramita Saha et al.   ACS Infectious Diseases

Mechanism of eravacycline resistance in Acinetobacter baumannii mediated by a deletion mutation in the sensor kinase adeS, leading to elevated expression of the efflux pump AdeABC

(2020) Yue Shi et al.   INFECTION GENETICS AND EVOLUTION

Antibiotic Resistance Profiles, Molecular Mechanisms and Innovative Treatment Strategies of Acinetobacter baumannii

(2020) Corneliu Ovidiu Vrancianu et al.   Microorganisms

A “Drug Sweeping” State of the TriABC Triclosan Efflux Pump from Pseudomonas aeruginosa

(2020) Lucien Fabre et al.   STRUCTURE

Antibiotic export by MexB multidrug efflux transporter is allosterically controlled by a MexA-OprM chaperone-like complex

(2020) Marie Glavier et al.   Nature Communications

Cryo-Electron Microscopy Structure of an Acinetobacter baumannii Multidrug Efflux Pump

(2019) Chih-Chia Su et al.   mBio

AcrB: a mean, keen, drug efflux machine

(2019) Jessica Kobylka et al.   Annals of the New York Academy of Sciences

Substrate Specificities and Efflux Efficiencies of RND Efflux Pumps of Acinetobacter baumannii

(2018) Inga V. Leus et al.   JOURNAL OF BACTERIOLOGY

Multiple entry pathways within the efflux transporter AcrB contribute to multidrug recognition

(2018) Martijn Zwama et al.   Nature Communications

Small Molecule Condensin Inhibitors

(2018) Hang Zhao et al.   ACS Infectious Diseases

Synergy between Active Efflux and Outer Membrane Diffusion Defines Rules of Antibiotic Permeation into Gram-Negative Bacteria

(2017) Ganesh Krishnamoorthy et al.   mBio

Breaking the permeability barrier ofEscherichia coliby controlled hyperporination of the outer membrane.

(2016) Ganesh Krishnamoorthy et al.   ANTIMICROBIAL AGENTS AND CHEMOTHERAPY

Contribution of the Ade Resistance-Nodulation-Cell Division-Type Efflux Pumps to Fitness and Pathogenesis of Acinetobacter baumannii

(2016) Eun-Jeong Yoon et al.   mBio

RND-Type Efflux Pumps in Multidrug-Resistant Clinical Isolates of Acinetobacter baumannii: Major Role for AdeABC Overexpression and AdeRS Mutations

(2013) Eun-Jeong Yoon et al.   ANTIMICROBIAL AGENTS AND CHEMOTHERAPY

Construction of Mobilizable Mini-Tn7Vectors for Bioluminescent Detection of Gram-Negative Bacteria and Single-Copy PromoterluxReporter Analysis

(2013) F. Heath Damron et al.   APPLIED AND ENVIRONMENTAL MICROBIOLOGY

Transport of drugs by the multidrug transporter AcrB involves an access and a deep binding pocket that are separated by a switch-loop

(2012) T. Eicher et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Overexpression of the adeB Gene in Clinical Isolates of Tigecycline-Nonsusceptible Acinetobacter baumannii without Insertion Mutations in adeRS

(2010) J.-R. Sun et al.   ANTIMICROBIAL AGENTS AND CHEMOTHERAPY

RT-PCR and Statistical Analyses of adeABC Expression in Clinical Isolates of Acinetobacter calcoaceticus–Acinetobacter baumannii Complex

(2010) Alexey Ruzin et al.   Microbial Drug Resistance

Crystal Structure of the Multidrug Exporter MexB from Pseudomonas aeruginosa

(2009) Gaby Sennhauser et al.   JOURNAL OF MOLECULAR BIOLOGY