An Analysis of the Novel Fluorocycline TP-6076 Bound to Both the Ribosome and Multidrug Efflux Pump AdeJ from Acinetobacter baumannii

A ‘Build and Retrieve’ methodology to simultaneously solve cryo-EM structures of membrane proteins

(2021) Chih-Chia Su et al.   NATURE METHODS

Cryoelectron Microscopy Structures of AdeB Illuminate Mechanisms of Simultaneous Binding and Exporting of Substrates

(2021) Christopher E. Morgan et al.   mBio

Cryo-EM Determination of Eravacycline-Bound Structures of the Ribosome and the Multidrug Efflux Pump AdeJ of Acinetobacter baumannii

(2021) Zhemin Zhang et al.   mBio

Cryo-electron Microscopy Structure of the Acinetobacter baumannii 70S Ribosome and Implications for New Antibiotic Development

(2020) Christopher E. Morgan et al.   mBio

Acinetobacter baumannii Efflux Pumps and Antibiotic Resistance

(2020) Seyyed Naser Abdi et al.   Infection and Drug Resistance

Cryo-EM Structures of a Gonococcal Multidrug Efflux Pump Illuminate a Mechanism of Drug Recognition and Resistance

(2020) Meinan Lyu et al.   mBio

Emerging High‐Level Tigecycline Resistance: Novel Tetracycline Destructases Spread via the Mobile Tet(X)

(2020) Liang‐Xing Fang et al.   BIOESSAYS

Emergence of tigecycline- and eravacycline-resistant Tet(X4)-producing Enterobacteriaceae in the gut microbiota of healthy Singaporeans

(2020) Yichen Ding et al.   JOURNAL OF ANTIMICROBIAL CHEMOTHERAPY

Improvement of cryo-EM maps by density modification

(2020) Thomas C. Terwilliger et al.   NATURE METHODS

Structural and Functional Diversity of Resistance–Nodulation–Cell Division Transporters

(2020) Philip A. Klenotic et al.   CHEMICAL REVIEWS

A small molecule that mitigates bacterial infection disrupts Gram-negative cell membranes and is inhibited by cholesterol and neutral lipids

(2020) Jamie L. Dombach et al.   PLoS Pathogens

Cryo-Electron Microscopy Structure of an Acinetobacter baumannii Multidrug Efflux Pump

(2019) Chih-Chia Su et al.   mBio

In vitro activity of the novel fluorocycline TP-6076 against carbapenem-resistant Acinetobacter baumannii

(2019) Harald Seifert et al.   INTERNATIONAL JOURNAL OF ANTIMICROBIAL AGENTS

Ribosome-Targeting Antibiotics: Modes of Action, Mechanisms of Resistance, and Implications for Drug Design

(2018) Jinzhong Lin et al.   Annual Review of Biochemistry

Activity of TP-6076 against carbapenem-resistant Acinetobacter baumannii isolates collected from inpatients in Greek hospitals

(2018) Matthew E. Falagas et al.   INTERNATIONAL JOURNAL OF ANTIMICROBIAL AGENTS

Substrate Specificities and Efflux Efficiencies of RND Efflux Pumps of Acinetobacter baumannii

(2018) Inga V. Leus et al.   JOURNAL OF BACTERIOLOGY

Discovery, research, and development of new antibiotics: the WHO priority list of antibiotic-resistant bacteria and tuberculosis

(2018) Evelina Tacconelli et al.   LANCET INFECTIOUS DISEASES

A cell-based infection assay identifies efflux pump modulators that reduce bacterial intracellular load

(2018) Abigail L. Reens et al.   PLoS Pathogens

Real-space refinement in PHENIX for cryo-EM and crystallography

(2018) Pavel V. Afonine et al.   Acta Crystallographica Section D-Structural Biology

cryoSPARC: algorithms for rapid unsupervised cryo-EM structure determination

(2017) Ali Punjani et al.   NATURE METHODS

Kinetics of drug–ribosome interactions defines the cidality of macrolide antibiotics

(2017) Maxim S. Svetlov et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Structures and transport dynamics of a Campylobacter jejuni multidrug efflux pump

(2017) Chih-Chia Su et al.   Nature Communications

The cryo-EM structure of hibernating 100S ribosome dimer from pathogenic Staphylococcus aureus

(2017) Donna Matzov et al.   Nature Communications

Review of Eravacycline, a Novel Fluorocycline Antibacterial Agent

(2016) George G. Zhanel et al.   DRUGS

Colistin-Resistant Acinetobacter baumannii: Beyond Carbapenem Resistance

(2015) Zubair A. Qureshi et al.   CLINICAL INFECTIOUS DISEASES

The role of RND efflux pump and global regulators in tigecycline resistance in clinicalAcinetobacter baumanniiisolates

(2015) Henan Li et al.   Future Microbiology

Contribution of Resistance-Nodulation-Cell Division Efflux Systems to Antibiotic Resistance and Biofilm Formation in Acinetobacter baumannii

(2015) Eun-Jeong Yoon et al.   mBio

Crystal structure of the Alcanivorax borkumensis YdaH transporter reveals an unusual topology

(2015) Jani Reddy Bolla et al.   Nature Communications

Structure and Function of Neisseria gonorrhoeae MtrF Illuminates a Class of Antimetabolite Efflux Pumps

(2015) Chih-Chia Su et al.   Cell Reports

Properties of AdeABC and AdeIJK Efflux Systems of Acinetobacter baumannii Compared with Those of the AcrAB-TolC System of Escherichia coli

(2014) Etsuko Sugawara et al.   ANTIMICROBIAL AGENTS AND CHEMOTHERAPY

Activity of Eravacycline against Enterobacteriaceae and Acinetobacter baumannii, Including Multidrug-Resistant Isolates, from New York City

(2014) Marie Abdallah et al.   ANTIMICROBIAL AGENTS AND CHEMOTHERAPY

Triclosan Can Select for an AdeIJK-Overexpressing Mutant of Acinetobacter baumannii ATCC 17978 That Displays Reduced Susceptibility to Multiple Antibiotics

(2014) Dinesh M. Fernando et al.   ANTIMICROBIAL AGENTS AND CHEMOTHERAPY

Tetracycline antibiotics and resistance mechanisms

(2014) Fabian Nguyen et al.   BIOLOGICAL CHEMISTRY

A systematic review and meta-analysis of the effects of antibiotic consumption on antibiotic resistance

(2014) Brian G Bell et al.   BMC INFECTIOUS DISEASES

Eravacycline for the treatment of intra-abdominal infections

(2014) Matteo Bassetti et al.   EXPERT OPINION ON INVESTIGATIONAL DRUGS

Crystal Structure of the Neisseria gonorrhoeae MtrD Inner Membrane Multidrug Efflux Pump

(2014) Jani Reddy Bolla et al.   PLoS One

Ribosome-targeting antibiotics and mechanisms of bacterial resistance

(2013) Daniel N. Wilson   NATURE REVIEWS MICROBIOLOGY

Structural basis for potent inhibitory activity of the antibiotic tigecycline during protein synthesis

(2013) L. Jenner et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

How Should We Think About the Ribosome?

(2012) Peter B. Moore   Annual Review of Biophysics

Expression of the Resistance-Nodulation-Cell Division Pump AdeIJK in Acinetobacter baumannii Is Regulated by AdeN, a TetR-Type Regulator

(2012) Nicolas Rosenfeld et al.   ANTIMICROBIAL AGENTS AND CHEMOTHERAPY

Multidrug binding properties of the AcrB efflux pump characterized by molecular dynamics simulations

(2012) A. V. Vargiu et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Role of helix 44 of 16S rRNA in the fidelity of translation initiation

(2012) D. Qin et al.   RNA

The history of the tetracyclines

(2011) Mark L. Nelson et al.   Annals of the New York Academy of Sciences

Insights into Acinetobacter baumannii pathogenicity

(2011) Gustavo M. Cerqueira et al.   IUBMB LIFE

Multidrug-resistant Acinetobacter baumannii: mechanisms of virulence and resistance

(2010) Nicola C. Gordon et al.   INTERNATIONAL JOURNAL OF ANTIMICROBIAL AGENTS

MolProbity: all-atom structure validation for macromolecular crystallography

(2009) Vincent B. Chen et al.   ACTA CRYSTALLOGRAPHICA SECTION D-BIOLOGICAL CRYSTALLOGRAPHY

Fluorescently labeled ribosomes as a tool for analyzing antibiotic binding

(2009) B. Llano-Sotelo et al.   RNA

Functional Cloning and Characterization of the Multidrug Efflux Pumps NorM from Neisseria gonorrhoeae and YdhE from Escherichia coli

(2008) F. Long et al.   ANTIMICROBIAL AGENTS AND CHEMOTHERAPY

Acinetobacter baumannii: Emergence of a Successful Pathogen

(2008) A. Y. Peleg et al.   CLINICAL MICROBIOLOGY REVIEWS

A structural understanding of the dynamic ribosome machine

(2008) Thomas A. Steitz   NATURE REVIEWS MOLECULAR CELL BIOLOGY