Functional Diversity of Gram-Negative Permeability Barriers Reflected in Antibacterial Activities and Intracellular Accumulation of Antibiotics

Global burden of bacterial antimicrobial resistance in 2019: a systematic analysis

(2022) Christopher JL Murray et al.   LANCET

Condensins are essential for Pseudomonas aeruginosa corneal virulence through their control of lifestyle and virulence programs

(2022) Hang Zhao et al.   MOLECULAR MICROBIOLOGY

Leaks in the Pipeline: a Failure Analysis of Gram-Negative Antibiotic Development from 2010 to 2020

(2022) Neha K. Prasad et al.   ANTIMICROBIAL AGENTS AND CHEMOTHERAPY

Property space mapping of Pseudomonas aeruginosa permeability to small molecules

(2022) Inga V. Leus et al.   Scientific Reports

Predictive Rules of Efflux Inhibition and Avoidance in Pseudomonas aeruginosa

(2021) Jitender Mehla et al.   mBio

The Whole Is Bigger than the Sum of Its Parts: Drug Transport in the Context of Two Membranes with Active Efflux

(2021) Valentin V. Rybenkov et al.   CHEMICAL REVIEWS

How to Enter a Bacterium: Bacterial Porins and the Permeation of Antibiotics

(2021) Jigneshkumar Dahyabhai Prajapati et al.   CHEMICAL REVIEWS

Acinetobacter baumannii Antibiotic Resistance Mechanisms

(2021) Ioannis Kyriakidis et al.   Pathogens

Loss of RND-Type Multidrug Efflux Pumps Triggers Iron Starvation and Lipid A Modifications in Pseudomonas aeruginosa

(2021) Justyna W. Adamiak et al.   ANTIMICROBIAL AGENTS AND CHEMOTHERAPY

Rational design of a new antibiotic class for drug-resistant infections

(2021) Thomas F. Durand-Reville et al.   NATURE

Outer membrane permeability: Antimicrobials and diverse nutrients bypass porins in Pseudomonas aeruginosa

(2021) Johanna Ude et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Inactivation of AdeABC and AdeIJK efflux pumps elicits specific nonoverlapping transcriptional and phenotypic responses in Acinetobacter baumannii

(2020) Inga V. Leus et al.   MOLECULAR MICROBIOLOGY

Defining new chemical space for drug penetration into Gram-negative bacteria

(2020) Shibin Zhao et al.   Nature Chemical Biology

Development and optimization of a higher throughput bacterial compound accumulation assay

(2019) Marcella Widya et al.   ACS Infectious Diseases

Substrate Specificities and Efflux Efficiencies of RND Efflux Pumps of Acinetobacter baumannii

(2018) Inga V. Leus et al.   JOURNAL OF BACTERIOLOGY

Molecular Properties That Define the Activities of Antibiotics in Escherichia coli and Pseudomonas aeruginosa

(2018) Sarah J. Cooper et al.   ACS Infectious Diseases

Getting drugs into Gram-negative bacteria: Rational rules for permeation through general porins

(2018) Silvia Acosta-Gutierrez et al.   ACS Infectious Diseases

Evaluating LC–MS/MS To Measure Accumulation of Compounds within Bacteria

(2018) Ramkumar Iyer et al.   ACS Infectious Diseases

Predictive compound accumulation rules yield a broad-spectrum antibiotic

(2017) Michelle F. Richter et al.   NATURE

Synergy between Active Efflux and Outer Membrane Diffusion Defines Rules of Antibiotic Permeation into Gram-Negative Bacteria

(2017) Ganesh Krishnamoorthy et al.   mBio

Kinetic Control of Quorum Sensing in Pseudomonas aeruginosa by Multidrug Efflux Pumps

(2017) David Wolloscheck et al.   ACS Infectious Diseases

Bifurcation kinetics of drug uptake by Gram-negative bacteria

(2017) David A. Westfall et al.   PLoS One

Breaking the permeability barrier ofEscherichia coliby controlled hyperporination of the outer membrane.

(2016) Ganesh Krishnamoorthy et al.   ANTIMICROBIAL AGENTS AND CHEMOTHERAPY

Toward the Rational Design of Carbapenem Uptake in Pseudomonas aeruginosa

(2015) Vincent M. Isabella et al.   CHEMISTRY & BIOLOGY

ESKAPEing the labyrinth of antibacterial discovery

(2015) Ruben Tommasi et al.   NATURE REVIEWS DRUG DISCOVERY

General Platform for Systematic Quantitative Evaluation of Small-Molecule Permeability in Bacteria

(2014) Tony D. Davis et al.   ACS Chemical Biology

Inspection of the Engineered FhuA ΔC/Δ4L Protein Nanopore by Polymer Exclusion

(2012) David J. Niedzwiecki et al.   BIOPHYSICAL JOURNAL

ThepmrCABOperon Mediates Polymyxin Resistance inAcinetobacter baumanniiATCC 17978 and Clinical Isolates through Phosphoethanolamine Modification of Lipid A

(2011) Luis A. Arroyo et al.   ANTIMICROBIAL AGENTS AND CHEMOTHERAPY