Genetic mechanisms of fertilization failure and early embryonic arrest: a comprehensive review

Novel variants in ACTL7A and PLCZ1 are associated with male infertility and total fertilization failure

(2023) Shuai Zhao et al.   CLINICAL GENETICS

Mitochondrial Transfer into Human Oocytes Improved Embryo Quality and Clinical Outcomes in Recurrent Pregnancy Failure Cases

(2023) Yoshiharu Morimoto et al.   INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES

A novel compound heterozygous mutation in TUBB8 causing early embryonic developmental arrest

(2023) Jing Zhang et al.   JOURNAL OF ASSISTED REPRODUCTION AND GENETICS

Testis-Specific Actin-Like 7A (ACTL7A) is an indispensable protein for subacrosomal associated F-actin formation, acrosomal anchoring, and male fertility

(2023) P Ferrer et al.   MOLECULAR HUMAN REPRODUCTION

First pilot study of maternal spindle transfer for the treatment of repeated in vitro fertilization failures in couples with idiopathic infertility

(2023) Nuno Costa-Borges et al.   FERTILITY AND STERILITY

Bi-allelic variants in ASTL cause abnormal fertilization or oocyte maturation defects

(2023) Yang Zeng et al.   HUMAN MOLECULAR GENETICS

Biallelic variants in IQCN cause sperm flagellar assembly defects and male infertility

(2023) Qi Li et al.   HUMAN REPRODUCTION

Mitochondrial DNA Deficiency and Supplementation in Sus scrofa Oocytes Influence Transcriptome Profiles in Oocytes and Blastocysts

(2023) Takashi Okada et al.   INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES

Mitochondria in Human Fertility and Infertility

(2023) Jan Tesarik et al.   INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES

Base editing-mediated one-step inactivation of the Dnmt gene family reveals critical roles of DNA methylation during mouse gastrulation

(2023) Qing Li et al.   Nature Communications

Dissecting Sperm Mitochondrial G-Quadruplex Structures Using a Fluorescent Probe Biomarker to Monitor and Regulate Fertilization Capability

(2023) Sixian Wu et al.   ACS Sensors

Novel mutations in PLCZ1 lead to early embryonic arrest as a male factor

(2023) Yunying Lin et al.   Frontiers in Cell and Developmental Biology

Novel mutations in NLRP5 and PATL2 cause female infertility characterized by primarily oocyte maturation abnormality and consequent early embryonic arrest

(2022) Lingli Huang et al.   JOURNAL OF ASSISTED REPRODUCTION AND GENETICS

Novel biallelic mutations in PADI6 in patients with early embryonic arrest

(2022) Jie Dong et al.   JOURNAL OF HUMAN GENETICS

DCZ0415, a small‐molecule inhibitor targeting TRIP13, inhibits EMT and metastasis via inactivation of the FGFR4/STAT3 axis and the Wnt/β‐catenin pathway in colorectal cancer

(2022) Sumit Agarwal et al.   Molecular Oncology

Whole-exome sequencing in patients with maturation arrest: a potential additional diagnostic tool for prevention of recurrent negative testicular sperm extraction outcomes

(2022) F Ghieh et al.   HUMAN REPRODUCTION

Bi-allelic variants in KCNU1 cause impaired acrosome reactions and male infertility

(2022) Ruyi Liu et al.   HUMAN REPRODUCTION

Fertilization, Oocyte Activation, Calcium Release and Epigenetic Remodelling: Lessons From Cancer Models

(2022) Areez Shafqat et al.   Frontiers in Cell and Developmental Biology

Novel Homozygous PADI6 Variants in Infertile Females with Early Embryonic Arrest

(2022) Yao Xu et al.   Frontiers in Cell and Developmental Biology

SPATA16 promoter hypermethylation and downregulation in male infertility

(2022) Kumar Mohanty Sujit et al.   ANDROLOGIA

Replication stress impairs chromosome segregation and preimplantation development in human embryos

(2022) Katherine L. Palmerola et al.   CELL

Mutations in OOEP and NLRP5 identified in infertile patients with early embryonic arrest

(2022) Xiaomei Tong et al.   HUMAN MUTATION

P-060 Bubble-shaped Acrosome: Novel phenotype of Teratozoospermia Caused by Mutation in Actin-like 7A

(2022) J Dai et al.   HUMAN REPRODUCTION

Biallelic variants in MOS cause large polar body in oocyte and human female infertility

(2022) Yin-Li Zhang et al.   HUMAN REPRODUCTION

Identification of Novel Variants of Thyroid Hormone Receptor Interaction Protein 13 That Cause Female Infertility Characterized by Zygotic Cleavage Failure

(2022) Huiling Hu et al.   Frontiers in Physiology

Hierarchical Accumulation of Histone Variant H2A.Z Regulates Transcriptional States and Histone Modifications in Early Mammalian Embryos

(2022) Xin Liu et al.   Advanced Science

IQCN disruption causes fertilization failure and male infertility due to manchette assembly defect

(2022) Jing Dai et al.   EMBO Molecular Medicine

Human NOP2/NSUN1 regulates ribosome biogenesis through non-catalytic complex formation with box C/D snoRNPs

(2022) Han Liao et al.   NUCLEIC ACIDS RESEARCH

Genetic screening and analysis of TUBB8 variants in the females seeking assisted reproductive technology

(2022) Tingting Lin et al.   REPRODUCTIVE BIOMEDICINE ONLINE

A novel variant in TLE6 is associated with embryonic developmental arrest (EDA) in familial female infertility

(2022) Mojdeh Akbari et al.   Scientific Reports

Genetics of Oocyte Maturation Defects and Early Embryo Development Arrest

(2022) Olga Aleksandrovna Solovova et al.   Genes

A novel homozygous C-terminal deletion in BTG4 causes zygotic cleavage failure and female infertility

(2022) Yufeng Wang et al.   JOURNAL OF ASSISTED REPRODUCTION AND GENETICS

A novel homozygous mutation in ACTL7A leads to male infertility

(2022) Xiaopei Zhou et al.   MOLECULAR GENETICS AND GENOMICS

Can successful pregnancy be achieved and predicted from patients with identified ZP mutations? A literature review

(2022) Juepu Zhou et al.   Reproductive Biology and Endocrinology

MiR-145 is upregulated in the retarded preimplantation embryos and modulates cholesterol levels in mice preimplantation embryos through targeting Abca1

(2022) Ou Jian et al.   Reproductive Biology and Endocrinology

Globozoospermia: A Case Report and Systematic Review of Literature

(2022) Andrea Crafa et al.   World Journal of Mens Health

Mutations in ZP4 are associated with abnormal zona pellucida and female infertility

(2021) Xiaoli Wei et al.   JOURNAL OF CLINICAL PATHOLOGY

Homozygous pathogenic variants in ACTL9 cause fertilization failure and male infertility in humans and mice

(2021) Jing Dai et al.   AMERICAN JOURNAL OF HUMAN GENETICS

Novel Mutations in CDC20 Are Associated with Female Infertility Due to Oocyte Maturation Abnormality and Early Embryonic Arrest

(2021) Lingli Huang et al.   Reproductive Sciences

Dominant mutations in CHK1 cause pronuclear fusion failure and zygote arrest that can be rescued by CHK1 inhibitor

(2021) Honghui Zhang et al.   CELL RESEARCH

Non-coding RNA in cancer

(2021) Huiwen Yan et al.   Essays in Biochemistry

Clinical exome sequencing identifies novel compound heterozygous mutations of the WEE2 gene in primary infertile women with fertilization failure

(2021) Ancong Wang et al.   GYNECOLOGICAL ENDOCRINOLOGY

Single-center thorough evaluation and targeted treatment of globozoospermic men

(2021) Stephanie Cheung et al.   JOURNAL OF ASSISTED REPRODUCTION AND GENETICS

Segmental duplications and monosomies are linked to in vitro developmental arrest

(2021) N. De Munck et al.   JOURNAL OF ASSISTED REPRODUCTION AND GENETICS

The comprehensive variant and phenotypic spectrum of TUBB8 in female infertility

(2021) Wei Zheng et al.   JOURNAL OF ASSISTED REPRODUCTION AND GENETICS

Genetic causes of preimplantation embryo developmental failure

(2021) Mariagrazia Paonessa et al.   MOLECULAR REPRODUCTION AND DEVELOPMENT

Maternal heterozygous mutation in CHEK1 leads to mitotic arrest in human zygotes

(2021) Beili Chen et al.   Protein & Cell

Identification of Novel Mutations in CDC20: Expanding the Mutational Spectrum for Female Infertility

(2021) Lin Zhao et al.   Frontiers in Cell and Developmental Biology

The role of protein arginine methyltransferase 7 in human developmentally arrested embryos cultured in vitro

(2021) Wuwen Zhang et al.   ACTA BIOCHIMICA ET BIOPHYSICA SINICA

A transgenic system for targeted ablation of reproductive and maternal-effect genes

(2021) Sylvain Bertho et al.   DEVELOPMENT

Novel DNAH17 mutations associated with fertilization failures after ICSI

(2021) Miaomiao Jia et al.   GYNECOLOGICAL ENDOCRINOLOGY

Reprogramming of DNA methylation is linked to successful human preimplantation development

(2021) Julia Arand et al.   HISTOCHEMISTRY AND CELL BIOLOGY

Novel biallelic mutations in MEI1: expanding the phenotypic spectrum to human embryonic arrest and recurrent implantation failure

(2021) Jie Dong et al.   HUMAN REPRODUCTION

FBXO43 variants in patients with female infertility characterized by early embryonic arrest

(2021) Weijie Wang et al.   HUMAN REPRODUCTION

Loss of SPACA1 function causes autosomal recessive globozoospermia by damaging the acrosome–acroplaxome complex

(2021) Pingping Chen et al.   HUMAN REPRODUCTION

Knockdown of Dnmt1 and Dnmt3a gene expression disrupts preimplantation embryo development through global DNA methylation

(2021) Fatma Uysal et al.   JOURNAL OF ASSISTED REPRODUCTION AND GENETICS

Two novel mutations in PADI6 and TLE6 genes cause female infertility due to arrest in embryonic development

(2021) Juan Liu et al.   JOURNAL OF ASSISTED REPRODUCTION AND GENETICS

Novel WEE2 compound heterozygous mutations identified in patients with fertilization failure or poor fertilization

(2021) Jiamin Jin et al.   JOURNAL OF ASSISTED REPRODUCTION AND GENETICS

The subcortical maternal complex: emerging roles and novel perspectives

(2021) Daniela Bebbere et al.   MOLECULAR HUMAN REPRODUCTION

Two mutations in TUBB8 cause developmental arrest in human oocytes and early embryos

(2021) Tianqi Cao et al.   REPRODUCTIVE BIOMEDICINE ONLINE

TUBB8 Mutations Cause Female Infertility with Large Polar Body Oocyte and Fertilization Failure

(2021) Zhenxing Liu et al.   Reproductive Sciences

Identification of Novel Biallelic TLE6 Variants in Female Infertility With Preimplantation Embryonic Lethality

(2021) Manyu Zhang et al.   Frontiers in Genetics

Wenshen Shengjing Decoction Improves Early Embryo Development by Maintaining Low H3K27me3 Levels in Sperm and Pronuclear Embryos of Spermatogenesis Impaired Mice

(2021) Yanmei Sun et al.   Evidence-based Complementary and Alternative Medicine

ASTL is mutated in female infertility

(2021) Sateesh Maddirevula et al.   HUMAN GENETICS

Whole-exome sequencing of a cohort of infertile men reveals novel causative genes in teratozoospermia that are chiefly related to sperm head defects

(2021) Yaqian Li et al.   HUMAN REPRODUCTION

Bi-allelic mutations in MOS cause female infertility characterized by preimplantation embryonic arrest

(2021) Yang Zeng et al.   HUMAN REPRODUCTION

Novel bi-allelic variants in ACTL7A are associated with male infertility and total fertilization failure

(2021) Jing Wang et al.   HUMAN REPRODUCTION

A novel homozygous missense variant in BTG4 causes zygotic cleavage failure and female infertility

(2021) Ruyi Liu et al.   JOURNAL OF ASSISTED REPRODUCTION AND GENETICS

Biallelic variants in ZFP36L2 cause female infertility characterised by recurrent preimplantation embryo arrest

(2021) Wei Zheng et al.   JOURNAL OF MEDICAL GENETICS

Integration and gene co-expression network analysis of scRNA-seq transcriptomes reveal heterogeneity and key functional genes in human spermatogenesis

(2021) Najmeh Salehi et al.   Scientific Reports

GGNBP1 ensures proper spermiogenesis in response to stress in mice

(2020) Tingting Han et al.   BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS

A novel homozygous mutation of phospholipase C zeta leading to defective human oocyte activation and fertilization failure

(2020) Peng Yuan et al.   HUMAN REPRODUCTION

Disturbed genomic imprinting and its relevance for human reproduction: causes and clinical consequences

(2020) Miriam Elbracht et al.   HUMAN REPRODUCTION UPDATE

Expanding the genetic and phenotypic spectrum of female infertility caused by TLE6 mutations

(2020) Jing Lin et al.   JOURNAL OF ASSISTED REPRODUCTION AND GENETICS

BTG4 is A Novel p53 Target Gene That Inhibits Cell Growth and Induces Apoptosis

(2020) Na Zhang et al.   Genes

Essential Role of Sperm-Specific PLC-Zeta in Egg Activation and Male Factor Infertility: An Update

(2020) Alaaeldin Saleh et al.   Frontiers in Cell and Developmental Biology

Bi-allelic Missense Pathogenic Variants in TRIP13Cause Female Infertility Characterized by Oocyte Maturation Arrest

(2020) Zhihua Zhang et al.   AMERICAN JOURNAL OF HUMAN GENETICS

Relationship between sperm telomere length and sperm quality in infertile men

(2020) Zahra Darmishonnejad et al.   ANDROLOGIA

A novel homozygous variant in NLRP5 is associate with human early embryonic arrest in a consanguineous Chinese family

(2020) Yao Xu et al.   CLINICAL GENETICS

Increasing associations between defects in phospholipase C zeta and conditions of male infertility: not just ICSI failure?

(2020) Junaid Kashir   JOURNAL OF ASSISTED REPRODUCTION AND GENETICS

A homozygous nonsense mutation of PLCZ1 cause male infertility with oocyte activation deficiency

(2020) Fengsong Wang et al.   JOURNAL OF ASSISTED REPRODUCTION AND GENETICS

KDM4A regulates the maternal-to-zygotic transition by protecting broad H3K4me3 domains from H3K9me3 invasion in oocytes

(2020) Aditya Sankar et al.   NATURE CELL BIOLOGY

Vital and Distinct Roles of H2A.Z Isoforms in Hepatocellular Carcinoma

(2020) Shaomei Tang et al.   OncoTargets and Therapy

Homozygous Mutations in BTG4 Cause Zygotic Cleavage Failure and Female Infertility

(2020) Wei Zheng et al.   AMERICAN JOURNAL OF HUMAN GENETICS

Zona Pellucida Proteins, Fibrils, and Matrix

(2020) Eveline S. Litscher et al.   Annual Review of Biochemistry

DNA methylation and the core pluripotency network

(2020) Siba Shanak et al.   DEVELOPMENTAL BIOLOGY

Role of PIWI ‐interacting RNAs on cell survival: Proliferation, apoptosis, and cycle

(2020) Qian Zeng et al.   IUBMB LIFE

Identification novel mutations in TUBB8 in female infertility and a novel phenotype of large polar body in oocytes with TUBB8 mutations

(2020) Lin Zhao et al.   JOURNAL OF ASSISTED REPRODUCTION AND GENETICS

Modern epigenetics methods in biological research

(2020) Yuanyuan Li   METHODS

Variation Screening of Zygote Arrest 1(ZAR1) in Women with Recurrent Zygote Arrest During IVF/ICSI Programs

(2020) Ye Tian et al.   Reproductive Sciences

The Contribution of Epigenetics to Cancer Immunotherapy

(2020) Lorea Villanueva et al.   TRENDS IN IMMUNOLOGY

Developmental potential of aneuploid human embryos cultured beyond implantation

(2020) Marta N. Shahbazi et al.   Nature Communications

Biallelic mutations in CDC20 cause female infertility characterized by abnormalities in oocyte maturation and early embryonic development

(2020) Lin Zhao et al.   Protein & Cell

Insights into epigenetic patterns in mammalian early embryos

(2020) Ruimin Xu et al.   Protein & Cell

A Single-Cell Transcriptomics CRISPR-Activation Screen Identifies Epigenetic Regulators of the Zygotic Genome Activation Program

(2020) Celia Alda-Catalinas et al.   Cell Systems

Predictive value of the sperm DNA fragmentation index for low or failed IVF fertilization in men with mild-to-moderate asthenozoospermia

(2020) Li Tang et al.   Journal of Gynecology Obstetrics and Human Reproduction

Mutation analysis of tubulin beta 8 class VIII in infertile females with oocyte or embryonic defects

(2020) Ping Yang et al.   CLINICAL GENETICS

Expanding the genetic and phenotypic spectrum of the subcortical maternal complex genes in recurrent preimplantation embryonic arrest

(2020) Wei Zheng et al.   CLINICAL GENETICS

Novel mutations in TUBB8 expand the mutational and phenotypic spectrum of patients with zygotes containing multiple pronuclei

(2020) Qianqian Sha et al.   GENE

A new NLRP5 mutation causes female infertility and total fertilization failure

(2020) Mingzhao Li et al.   GYNECOLOGICAL ENDOCRINOLOGY

Identification and rescue of a novel TUBB8 mutation that causes the first mitotic division defects and infertility

(2020) Yanping Jia et al.   JOURNAL OF ASSISTED REPRODUCTION AND GENETICS

Dynamics and clinical relevance of maternal mRNA clearance during the oocyte-to-embryo transition in humans

(2020) Qian-Qian Sha et al.   Nature Communications

Disruption in ACTL7A causes acrosomal ultrastructural defects in human and mouse sperm as a novel male factor inducing early embryonic arrest

(2020) Aijie Xin et al.   Science Advances

Novel mutations in the PLCZ1 gene associated with human low or failed fertilization

(2020) Ping Yuan et al.   Molecular Genetics & Genomic Medicine

The critical role of ZP genes in female infertility characterized by empty follicle syndrome and oocyte degeneration

(2020) Ping Yang et al.   FERTILITY AND STERILITY

Preconception genome medicine: current state and future perspectives to improve infertility diagnosis and reproductive and health outcomes based on individual genomic data

(2020) Antonio Capalbo et al.   HUMAN REPRODUCTION UPDATE

Small Noncoding RNA Signatures for Determining the Developmental Potential of an Embryo at the Morula Stage

(2020) Angelika Timofeeva et al.   INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES

Patient with CATSPER3 mutations‐related failure of sperm acrosome reaction with successful pregnancy outcome from intracytoplasmic sperm injection (ICSI)

(2020) Jiaxiong Wang et al.   Molecular Genetics & Genomic Medicine

Novel mutations in WEE2 : expanding the spectrum of mutations responsible for human fertilization failure

(2019) Zhihua Zhang et al.   CLINICAL GENETICS

The art of oocyte meiotic arrest regulation

(2019) Bo Pan et al.   Reproductive Biology and Endocrinology

DNA Methylation Reprogramming during Mammalian Development

(2019) Yang Zeng et al.   Genes

Single and Double Strand Sperm DNA Damage: Different Reproductive Effects on Male Fertility

(2019) Jordi Ribas-Maynou et al.   Genes

Mutations in NLRP2 and NLRP5 cause female infertility characterised by early embryonic arrest

(2019) Jian Mu et al.   JOURNAL OF MEDICAL GENETICS

Homozygous missense mutation Arg207Cys in the WEE2 gene causes female infertility and fertilization failure

(2019) Xiaoyu Yang et al.   JOURNAL OF ASSISTED REPRODUCTION AND GENETICS

Novel mutations in ZP1, ZP2, and ZP3 cause female infertility due to abnormal zona pellucida formation

(2019) Zhou Zhou et al.   HUMAN GENETICS

New biallelic mutations in WEE2: expanding the spectrum of mutations that cause fertilization failure or poor fertilization

(2019) Jing Dai et al.   FERTILITY AND STERILITY

Novel WEE2 gene variants identified in patients with fertilization failure and female infertility

(2019) Shuai Zhao et al.   FERTILITY AND STERILITY

A story of birth and death: mRNA translation and clearance at the onset of maternal-to-zygotic transition in mammals†

(2019) Qian-Qian Sha et al.   BIOLOGY OF REPRODUCTION

Nuclear envelope dynamics during mammalian spermatogenesis: new insights on male fertility

(2019) Cátia D. Pereira et al.   BIOLOGICAL REVIEWS

Comparison of sperm morphology and nuclear sperm quality in SPATA16‐ and DPY19L2‐ mutated globozoospermic patients

(2019) Houda Ghédir et al.   ANDROLOGIA

The impact of sperm DNA fragmentation on ICSI outcome in cases of donated oocytes

(2019) Sevastiani Antonouli et al.   ARCHIVES OF GYNECOLOGY AND OBSTETRICS

Sperm chromosomal abnormalities and their contribution to human embryo aneuploidy

(2019) Lorena Rodrigo et al.   BIOLOGY OF REPRODUCTION

The maternal-to-zygotic transition revisited

(2019) Nadine L. Vastenhouw et al.   DEVELOPMENT

Sperm DNA fragmentation is correlated with poor embryo development, lower implantation rate, and higher miscarriage rate in reproductive cycles of non–male factor infertility

(2019) Edson Borges et al.   FERTILITY AND STERILITY

Novel phospholipase C zeta 1 mutations associated with fertilization failures after ICSI

(2019) Marc Torra-Massana et al.   HUMAN REPRODUCTION

Resetting histone modifications during human parental-to-zygotic transition

(2019) Weikun Xia et al.   SCIENCE

Maternal DCAF13 Regulates Chromatin Tightness to Contribute to Embryonic Development

(2019) Yang Liu et al.   Scientific Reports

Novel homozygous variations in PLCZ1 lead to poor or failed fertilization characterized by abnormal localization patterns of PLCζ in sperm

(2019) Jing Dai et al.   CLINICAL GENETICS

Novel compound heterozygous mutations in WEE2 causes female infertility and fertilization failure

(2019) Xiaopei Zhou et al.   JOURNAL OF ASSISTED REPRODUCTION AND GENETICS

Proteomic Analysis of Dpy19l2‐Deficient Human Globozoospermia Reveals Multiple Molecular Defects

(2019) Yueshuai Guo et al.   Proteomics Clinical Applications

The Emerging Role of H3K9me3 as a Potential Therapeutic Target in Acute Myeloid Leukemia

(2019) Laura Monaghan et al.   Frontiers in Oncology

Globozoospermia syndrome: An update

(2019) Farzaneh Fesahat et al.   ANDROLOGIA

New biallelic mutations in PADI6 cause recurrent preimplantation embryonic arrest characterized by direct cleavage

(2019) Wei Zheng et al.   JOURNAL OF ASSISTED REPRODUCTION AND GENETICS

Homozygous mutations in REC114 cause female infertility characterised by multiple pronuclei formation and early embryonic arrest

(2019) Wenjing Wang et al.   JOURNAL OF MEDICAL GENETICS

Characterization of zygotic genome activation-dependent maternal mRNA clearance in mouse

(2019) Qian-Qian Sha et al.   NUCLEIC ACIDS RESEARCH

The nucleolar protein NOP2 is required for nucleolar maturation and ribosome biogenesis during preimplantation development in mammals

(2019) Huanan Wang et al.   FASEB JOURNAL

Exome sequencing reveals novel causes as well as new candidate genes for human globozoospermia

(2019) M S Oud et al.   HUMAN REPRODUCTION

Novel mutations in PLCZ1 cause male infertility due to fertilization failure or poor fertilization

(2019) Zheng Yan et al.   HUMAN REPRODUCTION

Homozygous Mutations in WEE2 Cause Fertilization Failure and Female Infertility

(2018) Qing Sang et al.   AMERICAN JOURNAL OF HUMAN GENETICS

DNAH6 is a novel candidate gene associated with sperm head anomaly

(2018) L. Li et al.   ANDROLOGIA

DNA methylation dynamics of genomic imprinting in mouse development†

(2018) Jennifer M SanMiguel et al.   BIOLOGY OF REPRODUCTION

ZP2 pathogenic variants cause in vitro fertilization failure and female infertility

(2018) Can Dai et al.   GENETICS IN MEDICINE

Tripolar chromosome segregation drives the association between maternal genotype at variants spanning PLK4 and aneuploidy in human preimplantation embryos

(2018) Rajiv C McCoy et al.   HUMAN MOLECULAR GENETICS

Sperm telomere length in donor samples is not related to ICSI outcome

(2018) Marc Torra-Massana et al.   JOURNAL OF ASSISTED REPRODUCTION AND GENETICS

The Histone Acetylation Modifications of Breast Cancer and their Therapeutic Implications

(2018) Pingping Guo et al.   PATHOLOGY & ONCOLOGY RESEARCH

Minor zygotic gene activation is essential for mouse preimplantation development

(2018) Ken-ichiro Abe et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Novel mutations in genes encoding subcortical maternal complex proteins may cause human embryonic developmental arrest

(2018) Xueqian Wang et al.   REPRODUCTIVE BIOMEDICINE ONLINE

Expression of sperm PLCζ and clinical outcomes of ICSI-AOA in men affected by globozoospermia due to DPY19L2 deletion

(2018) Marziyeh Tavalaee et al.   REPRODUCTIVE BIOMEDICINE ONLINE

Nucleolar Function in Lifespan Regulation

(2018) Varnesh Tiku et al.   TRENDS IN CELL BIOLOGY

DCAF13 promotes pluripotency by negatively regulating SUV39H1 stability during early embryonic development

(2018) Yin‐Li Zhang et al.   EMBO JOURNAL

Mammalian nucleolar protein DCAF13 is essential for ovarian follicle maintenance and oocyte growth by mediating rRNA processing

(2018) Jue Zhang et al.   CELL DEATH AND DIFFERENTIATION

The comprehensive mutational and phenotypic spectrum of TUBB8 in female infertility

(2018) Biaobang Chen et al.   EUROPEAN JOURNAL OF HUMAN GENETICS

Functions and mechanisms of epigenetic inheritance in animals

(2018) Ksenia Skvortsova et al.   NATURE REVIEWS MOLECULAR CELL BIOLOGY

Evaluation of sperm telomere length in infertile men with failed fertilization after intra-cytoplasmic sperm injection

(2018) Zahra Darmishonnejad et al.   REPRODUCTIVE BIOMEDICINE ONLINE

Dosage effects of ZP2 and ZP3 heterozygous mutations cause human infertility

(2017) Wenqiang Liu et al.   HUMAN GENETICS

Sub-fertile sperm cells exemplify telomere dysfunction

(2017) Tal Biron-Shental et al.   JOURNAL OF ASSISTED REPRODUCTION AND GENETICS

Dynamic epigenomic landscapes during early lineage specification in mouse embryos

(2017) Yu Zhang et al.   NATURE GENETICS

The overexpression and prognostic role of DCAF13 in hepatocellular carcinoma

(2017) Jianzhong Cao et al.   TUMOR BIOLOGY

Tripolar mitosis and partitioning of the genome arrests human preimplantation development in vitro

(2017) Christian S. Ottolini et al.   Scientific Reports

Mutations in PADI6 Cause Female Infertility Characterized by Early Embryonic Arrest

(2016) Yao Xu et al.   AMERICAN JOURNAL OF HUMAN GENETICS

HDAC1 and HDAC2 in mouse oocytes and preimplantation embryos: Specificity versus compensation

(2016) P Ma et al.   CELL DEATH AND DIFFERENTIATION

The human knockout phenotype ofPADI6is female sterility caused by cleavage failure of their fertilized eggs

(2016) S. Maddirevula et al.   CLINICAL GENETICS

Role of TET enzymes in DNA methylation, development, and cancer

(2016) Kasper Dindler Rasmussen et al.   GENES & DEVELOPMENT

Novel mutations and structural deletions in TUBB8 : expanding mutational and phenotypic spectrum of patients with arrest in oocyte maturation, fertilization or early embryonic development

(2016) Biaobang Chen et al.   HUMAN REPRODUCTION

Sperm telomere length as a parameter of sperm quality in normozoospermic men

(2016) M.S. Rocca et al.   HUMAN REPRODUCTION

The molecular basis of fertilization (Review)

(2016) Katerina Georgadaki et al.   INTERNATIONAL JOURNAL OF MOLECULAR MEDICINE

The subcortical maternal complex: multiple functions for one biological structure?

(2016) D. Bebbere et al.   JOURNAL OF ASSISTED REPRODUCTION AND GENETICS

Mutations inTUBB8cause a multiplicity of phenotypes in human oocytes and early embryos

(2016) Ruizhi Feng et al.   JOURNAL OF MEDICAL GENETICS

Distinct features of H3K4me3 and H3K27me3 chromatin domains in pre-implantation embryos

(2016) Xiaoyu Liu et al.   NATURE

Allelic reprogramming of the histone modification H3K4me3 in early mammalian development

(2016) Bingjie Zhang et al.   NATURE

Broad histone H3K4me3 domains in mouse oocytes modulate maternal-to-zygotic transition

(2016) John Arne Dahl et al.   NATURE

BTG4 is a meiotic cell cycle–coupled maternal-zygotic-transition licensing factor in oocytes

(2016) Chao Yu et al.   NATURE STRUCTURAL & MOLECULAR BIOLOGY

An essential role for UTX in resolution and activation of bivalent promoters

(2016) Shilpa S. Dhar et al.   NUCLEIC ACIDS RESEARCH

Oxidative stress and alterations in DNA methylation: two sides of the same coin in reproduction

(2016) Yves J.R. Menezo et al.   REPRODUCTIVE BIOMEDICINE ONLINE

BTG4 is a meiotic cell cycle–coupled maternal-zygotic-transition licensing factor in oocytes

(2016) Chao Yu et al.   NATURE STRUCTURAL & MOLECULAR BIOLOGY

Oncogenic potential of histone-variant H2A.Z.1 and its regulatory role in cell cycle and epithelial-mesenchymal transition in liver cancer

(2016) Hee Doo Yang et al.   Oncotarget

Targeted disruption of Noc4l leads to preimplantation embryonic lethality in mice

(2016) Yongli Qin et al.   Protein & Cell

Chromosomal instability in mammalian pre-implantation embryos: potential causes, detection methods, and clinical consequences

(2015) Brittany L. Daughtry et al.   CELL AND TISSUE RESEARCH

Homozygous mutation of PLCZ1 leads to defective human oocyte activation and infertility that is not rescued by the WW-binding protein PAWP

(2015) Jessica Escoffier et al.   HUMAN MOLECULAR GENETICS

DNA Methylation, Its Mediators and Genome Integrity

(2015) Huan Meng et al.   International Journal of Biological Sciences

Role of PAFAH1B1 in human spermatogenesis, fertilization and early embryonic development

(2015) Gui-Dong Yao et al.   REPRODUCTIVE BIOMEDICINE ONLINE

Chromosome microarray analysis: a case report of infertile brothers with CATSPER gene deletion

(2014) Deepika Jaiswal et al.   GENE

Localization and expression of histone H2A variants during mouse oogenesis and preimplantation embryo development

(2014) B.J. Wu et al.   GENETICS AND MOLECULAR RESEARCH

The DNA methylation landscape of human early embryos

(2014) Hongshan Guo et al.   NATURE

A Comprehensive View of the Epigenetic Landscape Part I: DNA Methylation, Passive and Active DNA Demethylation Pathways and Histone Variants

(2014) Anna Sadakierska-Chudy et al.   NEUROTOXICITY RESEARCH

Mutant ZP1 in Familial Infertility

(2014) Hua-Lin Huang et al.   NEW ENGLAND JOURNAL OF MEDICINE

The subcortical maternal complex controls symmetric division of mouse zygotes by regulating F-actin dynamics

(2014) Xing-Jiang Yu et al.   Nature Communications

Genome-Wide Analysis of DNA Methylation Dynamics during Early Human Development

(2014) Hiroaki Okae et al.   PLoS Genetics

A Homozygous Deletion of the DPY19L2 Gene is a Cause of Globozoospermia in Men From the Republic of Macedonia

(2013) P Noveski et al.   Balkan Journal of Medical Genetics

Post-translational modifications of the histone variant h2az

(2013) Ana Sevilla et al.   Stem Cell Research

Telomere length in reproduction

(2012) J. Thilagavathi et al.   ANDROLOGIA

Evolution of the Egg: New Findings and Challenges

(2012) Katrina G. Claw et al.   Annual Review of Genomics and Human Genetics

Analysis of active chromatin modifications in early mammalian embryos reveals uncoupling of H2A.Z acetylation and H3K36 trimethylation from embryonic genome activation

(2012) Ana Bošković et al.   Epigenetics

DNA Methylation and Its Basic Function

(2012) Lisa D Moore et al.   NEUROPSYCHOPHARMACOLOGY

A Recurrent Deletion of DPY19L2 Causes Infertility in Man by Blocking Sperm Head Elongation and Acrosome Formation

(2011) Radu Harbuz et al.   AMERICAN JOURNAL OF HUMAN GENETICS

DPY19L2 Deletion as a Major Cause of Globozoospermia

(2011) Isabelle Koscinski et al.   AMERICAN JOURNAL OF HUMAN GENETICS

A maternally inherited autosomal point mutation in human phospholipase C zeta (PLC ) leads to male infertility

(2011) J. Kashir et al.   HUMAN REPRODUCTION

Molecular Recognition of the Tes LIM2–3 Domains by the Actin-related Protein Arp7A

(2011) Batiste Boëda et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Protein Tyrosine Kinase Wee1B Is Essential for Metaphase II Exit in Mouse Oocytes

(2011) J. S. Oh et al.   SCIENCE

Human Sperm Binding Is Mediated by the Sialyl-Lewisx Oligosaccharide on the Zona Pellucida

(2011) P.-C. Pang et al.   SCIENCE

Fertilization failure and dysfunctions as possible causes for human idiopathic infertility

(2010) S. Y. W. Chan et al.   ANDROLOGIA

A newly discovered mutation in PICK1 in a human with globozoospermia

(2010) Gang Liu et al.   ASIAN JOURNAL OF ANDROLOGY

Sperm DNA fragmentation: mechanisms of origin, impact on reproductive outcome, and analysis

(2010) Denny Sakkas et al.   FERTILITY AND STERILITY

Lack of WDR36 leads to preimplantation embryonic lethality in mice and delays the formation of small subunit ribosomal RNA in human cells in vitro

(2010) Martin Gallenberger et al.   HUMAN MOLECULAR GENETICS

The fate of the mosaic embryo: chromosomal constitution and development of Day 4, 5 and 8 human embryos

(2010) Margarida Avo Santos et al.   HUMAN REPRODUCTION

Oocyte activation, phospholipase C zeta and human infertility

(2010) J. Kashir et al.   HUMAN REPRODUCTION UPDATE

Human Male Infertility Caused by Mutations in the CATSPER1 Channel Protein

(2009) Matthew R. Avenarius et al.   AMERICAN JOURNAL OF HUMAN GENETICS

A successful pregnancy and live birth after intracytoplasmic sperm injection with globozoospermic sperm and electrical oocyte activation

(2009) Akiyoshi Egashira et al.   FERTILITY AND STERILITY

Reduced amounts and abnormal forms of phospholipase C zeta (PLC ) in spermatozoa from infertile men

(2009) E. Heytens et al.   HUMAN REPRODUCTION

Role of Filia, a maternal effect gene, in maintaining euploidy during cleavage-stage mouse embryogenesis

(2009) P. Zheng et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Histone deacetylase 1 (HDAC1) regulates histone acetylation, development, and gene expression in preimplantation mouse embryos

(2008) Pengpeng Ma et al.   DEVELOPMENTAL BIOLOGY

A Subcortical Maternal Complex Essential for Preimplantation Mouse Embryogenesis

(2008) Lei Li et al.   DEVELOPMENTAL CELL

Zona Pellucida Glycoproteins

(2008) Paul M. Wassarman   JOURNAL OF BIOLOGICAL CHEMISTRY