Novel mutations in PLCZ1 lead to early embryonic arrest as a male factor

Novel variants in ACTL7A and PLCZ1 are associated with male infertility and total fertilization failure

(2023) Shuai Zhao et al.   CLINICAL GENETICS

Plcz1 Deficiency Decreased Fertility in Male Mice Which Is Associated with Sperm Quality Decline and Abnormal Cytoskeleton in Epididymis

(2022) Tao Wang et al.   INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES

Mutations in PLCZ1 induce male infertility associated with polyspermy and fertilization failure

(2022) Yawen Peng et al.   JOURNAL OF ASSISTED REPRODUCTION AND GENETICS

Novel bi-allelic variants in ACTL7A are associated with male infertility and total fertilization failure

(2021) Jing Wang et al.   HUMAN REPRODUCTION

A novel homozygous mutation of phospholipase C zeta leading to defective human oocyte activation and fertilization failure

(2020) Peng Yuan et al.   HUMAN REPRODUCTION

Increasing associations between defects in phospholipase C zeta and conditions of male infertility: not just ICSI failure?

(2020) Junaid Kashir   JOURNAL OF ASSISTED REPRODUCTION AND GENETICS

Preventing polyspermy in mammalian eggs-Contributions of the membrane block and other mechanisms

(2020) Janice P. Evans   MOLECULAR REPRODUCTION AND DEVELOPMENT

Phospholipase C zeta profiles are indicative of optimal sperm parameters and fertilisation success in patients undergoing fertility treatment

(2020) Junaid Kashir et al.   Andrology

Identification and treatment of men with phospholipase Cζ–defective spermatozoa

(2020) Stephanie Cheung et al.   FERTILITY AND STERILITY

The soluble sperm factor that activates the egg: PLCzeta and beyond

(2020) Karl Swann   REPRODUCTION

Disruption in ACTL7A causes acrosomal ultrastructural defects in human and mouse sperm as a novel male factor inducing early embryonic arrest

(2020) Aijie Xin et al.   Science Advances

Novel mutations in the PLCZ1 gene associated with human low or failed fertilization

(2020) Ping Yuan et al.   Molecular Genetics & Genomic Medicine

Male infertility

(2020) Ashok Agarwal et al.   LANCET

Novel phospholipase C zeta 1 mutations associated with fertilization failures after ICSI

(2019) Marc Torra-Massana et al.   HUMAN REPRODUCTION

Novel homozygous variations in PLCZ1 lead to poor or failed fertilization characterized by abnormal localization patterns of PLCζ in sperm

(2019) Jing Dai et al.   CLINICAL GENETICS

Novel mutations in PLCZ1 cause male infertility due to fertilization failure or poor fertilization

(2019) Zheng Yan et al.   HUMAN REPRODUCTION

Sperm-borne phospholipase C zeta-1 ensures monospermic fertilization in mice

(2018) Kaori Nozawa et al.   Scientific Reports

The sperm phospholipase C-  and Ca2+ signalling at fertilization in mammals

(2016) K. Swann et al.   BIOCHEMICAL SOCIETY TRANSACTIONS

Effect of two assisted oocyte activation protocols used to overcome fertilization failure on the activation potential and calcium releasing pattern

(2016) Dimitra Nikiforaki et al.   FERTILITY AND STERILITY

Antigen unmasking enhances visualization efficacy of the oocyte activation factor, phospholipase C zeta, in mammalian sperm

(2016) Junaid Kashir et al.   MOLECULAR HUMAN REPRODUCTION

Total levels, localization patterns, and proportions of sperm exhibiting phospholipase C zeta are significantly correlated with fertilization rates after intracytoplasmic sperm injection

(2015) Suseela Yelumalai et al.   FERTILITY AND STERILITY

Homozygous mutation of PLCZ1 leads to defective human oocyte activation and infertility that is not rescued by the WW-binding protein PAWP

(2015) Jessica Escoffier et al.   HUMAN MOLECULAR GENETICS

Oocyte activation deficiency: a role for an oocyte contribution?

(2015) Marc Yeste et al.   HUMAN REPRODUCTION UPDATE

Sperm-induced Ca2+ release during egg activation in mammals

(2014) Junaid Kashir et al.   BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS

Sperm PLCζ: From structure to Ca2+oscillations, egg activation and therapeutic potential

(2013) Michail Nomikos et al.   FEBS LETTERS

Variance in total levels of phospholipase C zeta (PLC-ζ) in human sperm may limit the applicability of quantitative immunofluorescent analysis as a diagnostic indicator of oocyte activation capability

(2012) Junaid Kashir et al.   FERTILITY AND STERILITY

Loss of activity mutations in phospholipase C zeta (PLC ) abolishes calcium oscillatory ability of human recombinant protein in mouse oocytes

(2011) J. Kashir et al.   HUMAN REPRODUCTION

A maternally inherited autosomal point mutation in human phospholipase C zeta (PLC ) leads to male infertility

(2011) J. Kashir et al.   HUMAN REPRODUCTION

The pattern of localization of the putative oocyte activation factor, phospholipase C , in uncapacitated, capacitated, and ionophore-treated human spermatozoa

(2008) P. Grasa et al.   HUMAN REPRODUCTION

Male age negatively impacts embryo development and reproductive outcome in donor oocyte assisted reproductive technology cycles

(2007) John L. Frattarelli et al.   FERTILITY AND STERILITY