Hypoxia‐sensing VGLL4 promotes LDHA‐driven lactate production to ameliorate neuronal dysfunction in a cellular model relevant to Alzheimer's disease

ACSL4 promotes microglia-mediated neuroinflammation by regulating lipid metabolism and VGLL4 expression

(2023) Xin Zhou et al.   BRAIN BEHAVIOR AND IMMUNITY

VGLL4-TEAD1 promotes vascular smooth muscle cell differentiation from human pluripotent stem cells via TET2

(2023) Zuxuan Wang et al.   JOURNAL OF MOLECULAR AND CELLULAR CARDIOLOGY

Lactate regulates cell cycle by remodelling the anaphase promoting complex

(2023) Weihai Liu et al.   NATURE

Astrocytic lactate dehydrogenase A regulates neuronal excitability and depressive-like behaviors through lactate homeostasis in mice

(2023) Shan Yao et al.   Nature Communications

Neurons require glucose uptake and glycolysis in vivo

(2023) Huihui Li et al.   Cell Reports

ULK1-mediated metabolic reprogramming regulates Vps34 lipid kinase activity by its lactylation

(2023) Mengshu Jia et al.   Science Advances

Function and therapeutic value of astrocytes in neurological diseases

(2022) Hong-Gyun Lee et al.   NATURE REVIEWS DRUG DISCOVERY

YAP: a novel target for Alzheimer's disease

(2022) Xingxing Xu et al.   Aging-US

Positive feedback regulation of microglial glucose metabolism by histone H4 lysine 12 lactylation in Alzheimer’s disease

(2022) Rui-Yuan Pan et al.   Cell Metabolism

Hypoxia Inducible Factor-1α binds and activates γ-secretase for Aβ production under hypoxia and cerebral hypoperfusion

(2022) Courtney Alexander et al.   MOLECULAR PSYCHIATRY

Astrocyte contribution to dysfunction, risk and progression in neurodegenerative disorders

(2022) Ashley N. Brandebura et al.   NATURE REVIEWS NEUROSCIENCE

Cholinergic basal forebrain degeneration due to sleep-disordered breathing exacerbates pathology in a mouse model of Alzheimer’s disease

(2022) Lei Qian et al.   Nature Communications

YAP–VGLL4 antagonism defines the major physiological function of the Hippo signaling effector YAP

(2022) Jing Cai et al.   GENES & DEVELOPMENT

Role of Hypoxia Inducible Factor-1α in Alzheimer’s Disease

(2021) Yang-Yang Wang et al.   JOURNAL OF ALZHEIMERS DISEASE

YAP prevents premature senescence of astrocytes and cognitive decline of Alzheimer's disease through regulating CDK6 signaling

(2021) Xingxing Xu et al.   AGING CELL

Upregulation of KDM6B contributes to lipopolysaccharide-induced anxiety-like behavior via modulation of VGLL4 in mice

(2021) Yangping Shentu et al.   BEHAVIOURAL BRAIN RESEARCH

Critical role of VGLL4 in the regulation of chronic normobaric hypoxia‐induced pulmonary hypertension in mice

(2021) Qiuyun Tian et al.   FASEB JOURNAL

Sulfide catabolism ameliorates hypoxic brain injury

(2021) Eizo Marutani et al.   Nature Communications

YAP-dependent necrosis occurs in early stages of Alzheimer’s disease and regulates mouse model pathology

(2020) Hikari Tanaka et al.   Nature Communications

Glucose metabolism links astroglial mitochondria to cannabinoid effects

(2020) Daniel Jimenez-Blasco et al.   NATURE

Brain energy rescue: an emerging therapeutic concept for neurodegenerative disorders of ageing

(2020) Stephen C. Cunnane et al.   NATURE REVIEWS DRUG DISCOVERY

VGLL4 plays a critical role in heart valve development and homeostasis

(2019) Wei Yu et al.   PLoS Genetics

L-Lactate Promotes Adult Hippocampal Neurogenesis

(2019) Yaeli Lev-Vachnish et al.   Frontiers in Neuroscience

Lactate: A Novel Signaling Molecule in Synaptic Plasticity and Drug Addiction

(2019) Qiuting Wang et al.   BIOESSAYS

A Breakdown in Metabolic Reprogramming Causes Microglia Dysfunction in Alzheimer's Disease

(2019) Sung Hoon Baik et al.   Cell Metabolism

VGLL4 interacts with STAT3 to function as a tumor suppressor in triple-negative breast cancer

(2019) Hongming Song et al.   EXPERIMENTAL AND MOLECULAR MEDICINE

The NOTCH1-dependent HIF1α/VGLL4/IRF2BP2 oxygen sensing pathway triggers erythropoiesis terminal differentiation

(2019) Yiqin Wang et al.   Redox Biology

The Science and Translation of Lactate Shuttle Theory

(2018) George A. Brooks   Cell Metabolism

Astrocytic glycogen metabolism in the healthy and diseased brain

(2018) Lasse K. Bak et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

CrossTalk proposal: an important astrocyte-to-neuron lactate shuttle couples neuronal activity to glucose utilisation in the brain

(2018) L. F. Barros et al.   JOURNAL OF PHYSIOLOGY-LONDON

Lactate in the brain: from metabolic end-product to signalling molecule

(2018) Pierre J. Magistretti et al.   NATURE REVIEWS NEUROSCIENCE

LPS-induced histone H3 phospho(Ser10)-acetylation(Lys14) regulates neuronal and microglial neuroinflammatory response

(2018) Giovanna Rigillo et al.   BRAIN BEHAVIOR AND IMMUNITY

Loss of VGLL4 suppresses tumor PD‐L1 expression and immune evasion

(2018) Ailing Wu et al.   EMBO JOURNAL

Lactate Deficit in an Alzheimer Disease Mouse Model: The Relationship With Neuronal Damage

(2018) Mao Zhang et al.   JOURNAL OF NEUROPATHOLOGY AND EXPERIMENTAL NEUROLOGY

Astrocyte glycogen and lactate: New insights into learning and memory mechanisms

(2017) Cristina M. Alberini et al.   GLIA

The TREM2-APOE Pathway Drives the Transcriptional Phenotype of Dysfunctional Microglia in Neurodegenerative Diseases

(2017) Susanne Krasemann et al.   IMMUNITY

Meta-analysis of genome-wide SNP- and pathway-based associations for facets of neuroticism

(2017) Song E Kim et al.   JOURNAL OF HUMAN GENETICS

Uncovering the SUMOylation and ubiquitylation crosstalk in human cells using sequential peptide immunopurification

(2017) Frédéric Lamoliatte et al.   Nature Communications

VGLL4 targets a TCF4–TEAD4 complex to coregulate Wnt and Hippo signalling in colorectal cancer

(2017) Shi Jiao et al.   Nature Communications

Emerging Roles for Glycogen in the CNS

(2017) Alice E. Waitt et al.   Frontiers in Molecular Neuroscience

PSEN1 Mutant iPSC-Derived Model Reveals Severe Astrocyte Pathology in Alzheimer's Disease

(2017) Minna Oksanen et al.   Stem Cell Reports

Chronic hypoxia facilitates Alzheimer's disease through demethylation of γ-secretase by downregulating DNA methyltransferase 3b

(2016) Hui Liu et al.   Alzheimers & Dementia

Acetylation of VGLL4 Regulates Hippo-YAP Signaling and Postnatal Cardiac Growth

(2016) Zhiqiang Lin et al.   DEVELOPMENTAL CELL

Lactate as a Metabolite and a Regulator in the Central Nervous System

(2016) Patrizia Proia et al.   INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES

A Lactate-Induced Response to Hypoxia

(2015) Dong Chul Lee et al.   CELL

Changes in lactate content and monocarboxylate transporter 2 expression in Aβ25-35-treated rat model of Alzheimer’s disease

(2015) Weitian Lu et al.   NEUROLOGICAL SCIENCES

Neuroglial Transmission

(2015) Vidar Gundersen et al.   PHYSIOLOGICAL REVIEWS

Expression analysis in a rat psychosis model identifies novel candidate genes validated in a large case–control sample of schizophrenia

(2015) A Ingason et al.   Translational Psychiatry

Hypoxia Affects Neprilysin Expression Through Caspase Activation and an APP Intracellular Domain-dependent Mechanism

(2015) Caroline Kerridge et al.   Frontiers in Neuroscience

VGLL4 functions as a new tumor suppressor in lung cancer by negatively regulating the YAP-TEAD transcriptional complex

(2014) Wenjing Zhang et al.   CELL RESEARCH

Microglia Enhance Neurogenesis and Oligodendrogenesis in the Early Postnatal Subventricular Zone

(2014) Y. Shigemoto-Mogami et al.   JOURNAL OF NEUROSCIENCE

Direct evidence for activity-dependent glucose phosphorylation in neurons with implications for the astrocyte-to-neuron lactate shuttle

(2014) A. B. Patel et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Characterization of genetic variation in the VGLL4 gene in anorexia nervosa

(2014) Toni-Kim Clarke et al.   PSYCHIATRIC GENETICS

Layer V cortical neurons require microglial support for survival during postnatal development

(2013) Masaki Ueno et al.   NATURE NEUROSCIENCE

Overexpression of Pyruvate Dehydrogenase Kinase 1 and Lactate Dehydrogenase A in Nerve Cells Confers Resistance to Amyloid β and Other Toxins by Decreasing Mitochondrial Respiration and Reactive Oxygen Species Production

(2012) Jordan T. Newington et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Astrocyte-Neuron Lactate Transport Is Required for Long-Term Memory Formation

(2011) Akinobu Suzuki et al.   CELL

Amyloid Beta Resistance in Nerve Cell Lines Is Mediated by the Warburg Effect

(2011) Jordan T. Newington et al.   PLoS One

Genome-wide association study of comorbid depressive syndrome and alcohol dependence

(2011) Alexis C. Edwards et al.   PSYCHIATRIC GENETICS

Hypoxia-mediated biological control

(2010) Jessica Cassavaugh et al.   JOURNAL OF CELLULAR BIOCHEMISTRY

Presenilin-1 regulates induction of hypoxia inducible factor-1α: altered activation by a mutation associated with familial Alzheimer's disease

(2010) Rita De Gasperi et al.   Molecular Neurodegeneration

Astroglial Metabolic Networks Sustain Hippocampal Synaptic Transmission

(2008) N. Rouach et al.   SCIENCE