Upregulation of KDM6B contributes to lipopolysaccharide-induced anxiety-like behavior via modulation of VGLL4 in mice

Inducible nitric oxide synthase plays a role in depression- and anxiety-like behaviors chronically induced by lipopolysaccharide in rats: evidence from inflammation and oxidative stress

(2020) Farimah Beheshti et al.   BEHAVIOURAL BRAIN RESEARCH

Critical role of histone H3 lysine 27 demethylase Kdm6b in the homeostasis and function of medullary thymic epithelial cells

(2020) Zhi Liu et al.   CELL DEATH AND DIFFERENTIATION

Hydrogen Sulfide Reverses LPS-Induced Behavioral Deficits by Suppressing Microglial Activation and Promoting M2 Polarization

(2020) Mohit Kumar et al.   Journal of Neuroimmune Pharmacology

Resveratrol ameliorates lipopolysaccharide-induced anxiety-like behavior by attenuating YAP-mediated neuro-inflammation and promoting hippocampal autophagy in mice

(2020) Qiuyun Tian et al.   TOXICOLOGY AND APPLIED PHARMACOLOGY

Adolescent alcohol exposure epigenetically suppresses amygdala Arc enhancer RNA expression to confer adult anxiety susceptibility

(2019) Evan J. Kyzar et al.   BIOLOGICAL PSYCHIATRY

VGLL4 plays a critical role in heart valve development and homeostasis

(2019) Wei Yu et al.   PLoS Genetics

Altered DNA Methylation in the Developing Brains of Rats Genetically Prone to High Versus Low Anxiety

(2019) C. R. Mccoy et al.   JOURNAL OF NEUROSCIENCE

LATS2 Inhibits Malignant Behaviors of Glioma Cells via Inactivating YAP

(2019) Yi Shi et al.   JOURNAL OF MOLECULAR NEUROSCIENCE

Histone demethylase KDM6B regulates 1,25-dihydroxyvitamin D3-induced senescence in glioma cells

(2019) Aixia Sui et al.   JOURNAL OF CELLULAR PHYSIOLOGY

The Association Between Symptoms of Anxiety, Depression, and Cardiovascular Risk Factors

(2019) Giulia Rioli et al.   JOURNAL OF NERVOUS AND MENTAL DISEASE

Epigenetic Regulations in Neuropsychiatric Disorders

(2019) Janise N. Kuehner et al.   Frontiers in Genetics

Probiotic consumption during puberty mitigates LPS-induced immune responses and protects against stress-induced depression- and anxiety-like behaviors in adulthood in a sex-specific manner

(2019) Emma Murray et al.   BRAIN BEHAVIOR AND IMMUNITY

Vitamin C–dependent lysine demethylase 6 (KDM6)-mediated demethylation promotes a chromatin state that supports the endothelial-to-hematopoietic transition

(2019) Tian Zhang et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

JMJD3 regulates CD4+ T cell trafficking by targeting actin cytoskeleton regulatory gene Pdlim4

(2019) Chuntang Fu et al.   JOURNAL OF CLINICAL INVESTIGATION

Upregulation of H3K27 Demethylase KDM6 During Respiratory Syncytial Virus Infection Enhances Proinflammatory Responses and Immunopathology

(2019) Carrie-Anne Malinczak et al.   JOURNAL OF IMMUNOLOGY

DNA Methylation within the Amygdala Early in Life Increases Susceptibility for Depression and Anxiety Disorders

(2019) Ilan Vonderwalde   JOURNAL OF NEUROSCIENCE

Influence of mental stress and environmental toxins on circadian clocks: Implications for redox regulation of the heart and cardioprotection

(2019) Huige Li et al.   BRITISH JOURNAL OF PHARMACOLOGY

Histone demethylases in neuronal differentiation, plasticity, and disease

(2019) Vijay Swahari et al.   CURRENT OPINION IN NEUROBIOLOGY

Association of pre-existing depression with all-cause, cancer-related, and noncancer-related mortality among 5-year cancer survivors: a population-based cohort study

(2019) Ahryoung Ko et al.   Scientific Reports

Role of Hippo signaling in regulating immunity

(2018) Lixin Hong et al.   Cellular & Molecular Immunology

YAP Controls Endothelial Activation and Vascular Inflammation Through TRAF6Novelty and Significance

(2018) Yang Lv et al.   CIRCULATION RESEARCH

Inhibition of histone H3K27 demethylases selectively modulates inflammatory phenotypes of natural killer cells

(2018) Adam Cribbs et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

The histone demethylase Kdm6b regulates a mature gene expression program in differentiating cerebellar granule neurons

(2018) Ranjula Wijayatunge et al.   MOLECULAR AND CELLULAR NEUROSCIENCE

YAP/TAZ upstream signals and downstream responses

(2018) Antonio Totaro et al.   NATURE CELL BIOLOGY

SIRT1 Mediates Apelin-13 in Ameliorating Chronic Normobaric Hypoxia-induced Anxiety-like Behavior by Suppressing NF-κB Pathway in Mice Hippocampus

(2018) Junming Fan et al.   NEUROSCIENCE

Hearts and Minds

(2018) Alexandra L. Silverman et al.   Cardiology in Review

The histone demethylase KDM6B in the medial prefrontal cortex epigenetically regulates cocaine reward memory

(2018) Yu-Xiang Zhang et al.   NEUROPHARMACOLOGY

JMJD3 facilitates C/EBPβ-centered transcriptional program to exert oncorepressor activity in AML

(2018) Shan-He Yu et al.   Nature Communications

Loss of VGLL4 suppresses tumor PD‐L1 expression and immune evasion

(2018) Ailing Wu et al.   EMBO JOURNAL

Yes-associated protein (YAP) and transcriptional coactivator with PDZ-binding motif (TAZ) mediate cell density–dependent proinflammatory responses

(2018) Qiong Zhang et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Global, regional, and national incidence, prevalence, and years lived with disability for 354 diseases and injuries for 195 countries and territories, 1990–2017: a systematic analysis for the Global Burden of Disease Study 2017

(2018) Spencer L James et al.   LANCET

Lentivirus-mediated interleukin-1β (IL-1β) knock-down in the hippocampus alleviates lipopolysaccharide (LPS)-induced memory deficits and anxiety- and depression-like behaviors in mice

(2017) Mengmeng Li et al.   Journal of Neuroinflammation

Microglial recruitment of IL-1β-producing monocytes to brain endothelium causes stress-induced anxiety

(2017) D B McKim et al.   MOLECULAR PSYCHIATRY

VGLL4 targets a TCF4–TEAD4 complex to coregulate Wnt and Hippo signalling in colorectal cancer

(2017) Shi Jiao et al.   Nature Communications

H3K27 Demethylase JMJD3 Employs the NF- B and BMP Signaling Pathways to Modulate the Tumor Microenvironment and Promote Melanoma Progression and Metastasis

(2016) W.-Y. Park et al.   CANCER RESEARCH

miR-146b-5p within BCR-ABL1-Positive Microvesicles Promotes Leukemic Transformation of Hematopoietic Cells

(2016) H.-M. Zhang et al.   CANCER RESEARCH

Acetylation of VGLL4 Regulates Hippo-YAP Signaling and Postnatal Cardiac Growth

(2016) Zhiqiang Lin et al.   DEVELOPMENTAL CELL

Mechanisms of Hippo pathway regulation

(2016) Zhipeng Meng et al.   GENES & DEVELOPMENT

Depression and coronary heart disease

(2016) Robert M. Carney et al.   Nature Reviews Cardiology

Yes-associated protein mediates immune reprogramming in pancreatic ductal adenocarcinoma

(2016) S Murakami et al.   ONCOGENE

Hippo Pathway in Organ Size Control, Tissue Homeostasis, and Cancer

(2015) Fa-Xing Yu et al.   CELL

JMJD3 as an epigenetic regulator in development and disease

(2015) Jana S. Burchfield et al.   INTERNATIONAL JOURNAL OF BIOCHEMISTRY & CELL BIOLOGY

VGLL4 functions as a new tumor suppressor in lung cancer by negatively regulating the YAP-TEAD transcriptional complex

(2014) Wenjing Zhang et al.   CELL RESEARCH

Knockdown of Interleukin-1 Receptor Type-1 on Endothelial Cells Attenuated Stress-Induced Neuroinflammation and Prevented Anxiety-Like Behavior

(2014) E. S. Wohleb et al.   JOURNAL OF NEUROSCIENCE

The histone lysine demethylase Kdm6b is required for activity-dependent preconditioning of hippocampal neuronal survival

(2014) Ranjula Wijayatunge et al.   MOLECULAR AND CELLULAR NEUROSCIENCE

The Biology of YAP/TAZ: Hippo Signaling and Beyond

(2014) Stefano Piccolo et al.   PHYSIOLOGICAL REVIEWS

Activation of Neuronal Gene Expression by the JMJD3 Demethylase Is Required for Postnatal and Adult Brain Neurogenesis

(2014) Dae Hwi Park et al.   Cell Reports

Gestational Hypoxia Induces Sex-Differential Methylation of Crhr1 Linked to Anxiety-like Behavior

(2013) Xi Wang et al.   MOLECULAR NEUROBIOLOGY

NMDA Receptor Blockade by Ketamine Abrogates Lipopolysaccharide-Induced Depressive-Like Behavior in C57BL/6J Mice

(2013) Adam K Walker et al.   NEUROPSYCHOPHARMACOLOGY

Molecular mechanisms and potential functions of histone demethylases

(2012) Susanne Marije Kooistra et al.   NATURE REVIEWS MOLECULAR CELL BIOLOGY

Inflammation and Its Discontents: The Role of Cytokines in the Pathophysiology of Major Depression

(2009) Andrew H. Miller et al.   BIOLOGICAL PSYCHIATRY

Jmjd3 contributes to the control of gene expression in LPS-activated macrophages

(2009) Francesca De Santa et al.   EMBO JOURNAL

An operational definition of epigenetics

(2009) S. L. Berger et al.   GENES & DEVELOPMENT

The Cooperative Induction of Hypoxia-Inducible Factor-1  and STAT3 during Hypoxia Induced an Impairment of Tumor Susceptibility to CTL-Mediated Cell Lysis

(2009) M. Z. Noman et al.   JOURNAL OF IMMUNOLOGY

Gestational hypoxia alone or combined with restraint sensitizes the hypothalamic–pituitary–adrenal axis and induces anxiety-like behavior in adult male rat offspring

(2009) J.-M. Fan et al.   NEUROSCIENCE

The molecular neurobiology of depression

(2008) Vaishnav Krishnan et al.   NATURE