YAP prevents premature senescence of astrocytes and cognitive decline of Alzheimer's disease through regulating CDK6 signaling

Sphingosine 1‐phosphate promotes the proliferation of olfactory ensheathing cells through YAP signaling and participates in the formation of olfactory nerve layer

(2020) Xiaomei Bao et al.   GLIA

Astrocytic YAP promotes the formation of glia scars and neural regeneration after spinal cord injury

(2020) Changnan Xie et al.   JOURNAL OF NEUROSCIENCE

YAP-dependent necrosis occurs in early stages of Alzheimer’s disease and regulates mouse model pathology

(2020) Hikari Tanaka et al.   Nature Communications

The MSP‐RON axis stimulates cancer cell growth in models of triple negative breast cancer

(2020) Rhona Millar et al.   Molecular Oncology

Astrocyte Senescence and Alzheimer’s Disease: A Review

(2020) Xiaojuan Han et al.   Frontiers in Aging Neuroscience

D-galactose induces senescence of glioblastoma cells through YAP-CDK6 pathway

(2020) Xingxing Xu et al.   Aging-US

Radiation-induced astrocyte senescence is rescued by Δ133p53

(2019) Casmir Turnquist et al.   NEURO-ONCOLOGY

Senolytic therapy alleviates Aβ-associated oligodendrocyte progenitor cell senescence and cognitive deficits in an Alzheimer’s disease model

(2019) Peisu Zhang et al.   NATURE NEUROSCIENCE

Up-regulation of FOXD1 by YAP alleviates senescence and osteoarthritis

(2019) Lina Fu et al.   PLOS BIOLOGY

Exploration of MST1-Mediated Secondary Brain Injury Induced by Intracerebral Hemorrhage in Rats via Hippo Signaling Pathway

(2019) Peng Zhang et al.   Translational Stroke Research

Silencing of Long Non-Coding RNA MALAT1 Prevents Inflammatory Injury after Lung Transplant Ischemia-Reperfusion by Downregulation of IL8 through Recruiting p300

(2019) Jiwei Li et al.   Molecular Therapy-Nucleic Acids

Pharmacological Inhibition of Hippo Pathway using XMU‐MP‐1 Protects The Heart Against Adverse Effects during Pressure Overload

(2019) Efta Triastuti et al.   BRITISH JOURNAL OF PHARMACOLOGY

YAP inhibition enhances the differentiation of functional stem cell-derived insulin-producing β cells

(2019) Edwin A. Rosado-Olivieri et al.   Nature Communications

YAP promotes the proliferation of neuroblastoma cells through decreasing the nuclear location of p27 Kip1 mediated by Akt

(2019) Xiya Shen et al.   CELL PROLIFERATION

Ginsenoside F1 suppresses astrocytic senescence-associated secretory phenotype

(2018) Jingang Hou et al.   CHEMICO-BIOLOGICAL INTERACTIONS

REGγ Controls Hippo Signaling and Reciprocal NF-κB–YAP Regulation to Promote Colon Cancer

(2018) Qingwei Wang et al.   CLINICAL CANCER RESEARCH

dNTP metabolism links mechanical cues and YAP/TAZ to cell growth and oncogene‐induced senescence

(2018) Giulia Santinon et al.   EMBO JOURNAL

The PHD1 oxygen sensor in health and disease

(2018) Kilian B. Kennel et al.   JOURNAL OF PHYSIOLOGY-LONDON

Senolytics improve physical function and increase lifespan in old age

(2018) Ming Xu et al.   NATURE MEDICINE

Cellular Senescence Is Induced by the Environmental Neurotoxin Paraquat and Contributes to Neuropathology Linked to Parkinson’s Disease

(2018) Shankar J. Chinta et al.   Cell Reports

Activated Yes-Associated Protein Accelerates Cell Cycle, Inhibits Apoptosis, and Delays Senescence in Human Periodontal Ligament Stem Cells

(2018) Linglu Jia et al.   International Journal of Medical Sciences

Clearance of senescent glial cells prevents tau-dependent pathology and cognitive decline

(2018) Tyler J. Bussian et al.   NATURE

YAP1-mediated CDK6 Activation Confers Radiation Resistance in Esophageal Cancer - Rationale for the combination of YAP1 and CDK4/6 inhibitors in Esophageal Cancer

(2018) Fan Li et al.   CLINICAL CANCER RESEARCH

Pax6 Lengthens G1 Phase and Decreases Oscillating Cdk6 Levels in Murine Embryonic Cortical Progenitors

(2018) Da Mi et al.   Frontiers in Cellular Neuroscience

Inhibition of YAP signaling contributes to senescence of hepatic stellate cells induced by tetramethylpyrazine

(2017) Huanhuan Jin et al.   EUROPEAN JOURNAL OF PHARMACEUTICAL SCIENCES

Cellular Senescence in Mouse Hippocampus After Irradiation and the Role of p53 and p21

(2017) Zoey Cheng et al.   JOURNAL OF NEUROPATHOLOGY AND EXPERIMENTAL NEUROLOGY

Ginsenoside Rg3 Prevents Oxidative Stress-Induced Astrocytic Senescence and Ameliorates Senescence Paracrine Effects on Glioblastoma

(2017) Jingang Hou et al.   MOLECULES

Review: Astrocytes in Alzheimer's disease and other age-associated dementias: a supporting player with a central role

(2017) C. J. Garwood et al.   NEUROPATHOLOGY AND APPLIED NEUROBIOLOGY

Parkinson’s in the oldest old: Impact on estimates of future disease burden

(2017) D.J. Myall et al.   PARKINSONISM & RELATED DISORDERS

Adiponectin protects against development of metabolic disturbances in a PCOS mouse model

(2017) Anna Benrick et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Major Shifts in Glial Regional Identity Are a Transcriptional Hallmark of Human Brain Aging

(2017) Lilach Soreq et al.   Cell Reports

YAP stabilizes SMAD1 and promotes BMP2-induced neocortical astrocytic differentiation

(2016) Zhihui Huang et al.   DEVELOPMENT

Serotonin-Exacerbated DSS-Induced Colitis Is Associated with Increase in MMP-3 and MMP-9 Expression in the Mouse Colon

(2016) Menglu Chen et al.   MEDIATORS OF INFLAMMATION

Calcium sensor regulation of the CaV2.1 Ca2+channel contributes to long-term potentiation and spatial learning

(2016) Evanthia Nanou et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Pharmacological targeting of kinases MST1 and MST2 augments tissue repair and regeneration

(2016) Fuqin Fan et al.   Science Translational Medicine

Hippo Pathway in Organ Size Control, Tissue Homeostasis, and Cancer

(2015) Fa-Xing Yu et al.   CELL

YAP Is a Critical Inducer of SOCS3, Preventing Reactive Astrogliosis

(2015) Zhihui Huang et al.   CEREBRAL CORTEX

CDK-dependent phosphorylation of PHD1 on serine 130 alters its substrate preference in cells

(2015) Brian Ortmann et al.   JOURNAL OF CELL SCIENCE

A Model for p38MAPK-Induced Astrocyte Senescence

(2015) José C. M. Mombach et al.   PLoS One

Ageing and Parkinson's disease: Why is advancing age the biggest risk factor?

(2014) Amy Reeve et al.   AGEING RESEARCH REVIEWS

Glutamine synthetase plays a role in d-galactose-induced astrocyte aging in vitro and in vivo

(2014) Yao Shen et al.   EXPERIMENTAL GERONTOLOGY

A temporal requirement for Hippo signaling in mammary gland differentiation, growth, and tumorigenesis

(2014) Q. Chen et al.   GENES & DEVELOPMENT

YAP/TEAD-Mediated Transcription Controls Cellular Senescence

(2013) Q. Xie et al.   CANCER RESEARCH

Dual CDK4/CDK6 Inhibition Induces Cell-Cycle Arrest and Senescence in Neuroblastoma

(2013) J. Rader et al.   CLINICAL CANCER RESEARCH

Yes-associated protein homolog, YAP-1, is involved in the thermotolerance and aging in the nematode Caenorhabditis elegans

(2013) Hiroaki Iwasa et al.   EXPERIMENTAL CELL RESEARCH

Protein kinase A activates the Hippo pathway to modulate cell proliferation and differentiation

(2013) F.-X. Yu et al.   GENES & DEVELOPMENT

Characterization of the APP/PS1 mouse model of Alzheimer's disease in senescence accelerated background

(2013) Kenghoe Lok et al.   NEUROSCIENCE LETTERS

Regulation of the Hippo-YAP Pathway by G-Protein-Coupled Receptor Signaling

(2012) Fa-Xing Yu et al.   CELL

Lamin B1 loss is a senescence-associated biomarker

(2012) Adam Freund et al.   MOLECULAR BIOLOGY OF THE CELL

Astrocyte Senescence as a Component of Alzheimer’s Disease

(2012) Rekha Bhat et al.   PLoS One

A Systematic Screen for CDK4/6 Substrates Links FOXM1 Phosphorylation to Senescence Suppression in Cancer Cells

(2011) Lars Anders et al.   CANCER CELL

Astrocytes in the aging brain express characteristics of senescence-associated secretory phenotype

(2011) Antero Salminen et al.   EUROPEAN JOURNAL OF NEUROSCIENCE

The role of nuclear lamin B1 in cell proliferation and senescence

(2011) T. Shimi et al.   GENES & DEVELOPMENT

Angiotensin II induces human astrocyte senescence through reactive oxygen species production

(2011) Gang Liu et al.   HYPERTENSION RESEARCH

Worldwide variation in the doubling time of Alzheimer's disease incidence rates

(2008) Kathryn Ziegler-Graham et al.   Alzheimers & Dementia

The Aging Brain

(2008) Bruce A. Yankner et al.   Annual Review of Pathology-Mechanisms of Disease