Sulfide catabolism ameliorates hypoxic brain injury

Pathogenic variants in SQOR encoding sulfide:quinone oxidoreductase are a potentially treatable cause of Leigh disease

(2020) Marisa W. Friederich et al.   JOURNAL OF INHERITED METABOLIC DISEASE

Data-Driven Identification of Hydrogen Sulfide Scavengers

(2019) Chun-tao Yang et al.   ANGEWANDTE CHEMIE-INTERNATIONAL EDITION

Preconditioning with hydrogen sulfide ameliorates cerebral ischemia/reperfusion injury in a mouse model of transient middle cerebral artery occlusion

(2019) Lei Tao et al.   CHEMICO-BIOLOGICAL INTERACTIONS

cGMP-dependent protein kinase I in vascular smooth muscle cells improves ischemic stroke outcome in mice

(2019) Maria Shvedova et al.   JOURNAL OF CEREBRAL BLOOD FLOW AND METABOLISM

Persulfide synthases that are functionally coupled with translation mediate sulfur respiration in mammalian cells

(2018) Shigemoto Fujii et al.   BRITISH JOURNAL OF PHARMACOLOGY

Development and validation of an oxygen dissociation assay, a screening platform for discovering, and characterizing hemoglobin–oxygen affinity modifiers

(2018) Mira Patel et al.   Drug Design Development and Therapy

H2S oxidation by nanodisc-embedded human sulfide quinone oxidoreductase

(2017) Aaron P. Landry et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Assessment of H2Sin vivousing the newly developed mitochondria-targeted mass spectrometry probe MitoA

(2017) Sabine Arndt et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Cysteinyl-tRNA synthetase governs cysteine polysulfidation and mitochondrial bioenergetics

(2017) Takaaki Akaike et al.   Nature Communications

Discovery and Mechanistic Characterization of Selective Inhibitors of H2S-producing Enzyme: 3-Mercaptopyruvate Sulfurtransferase (3MST) Targeting Active-site Cysteine Persulfide

(2017) Kenjiro Hanaoka et al.   Scientific Reports

Electroporation of Cas9 protein/sgRNA into early pronuclear zygotes generates non-mosaic mutants in the mouse

(2016) Masakazu Hashimoto et al.   DEVELOPMENTAL BIOLOGY

Sex-dependent mitochondrial respiratory impairment and oxidative stress in a rat model of neonatal hypoxic-ischemic encephalopathy

(2016) Tyler G. Demarest et al.   JOURNAL OF NEUROCHEMISTRY

Cystathionine β-Synthase Inhibition Is a Potential Therapeutic Approach to Treatment of Ischemic Injury

(2015) Su Jing Chan et al.   ASN Neuro

Cdk5rap1-Mediated 2-Methylthio Modification of Mitochondrial tRNAs Governs Protein Translation and Contributes to Myopathy in Mice and Humans

(2015) Fan-Yan Wei et al.   Cell Metabolism

Mitochondria-targeted hydrogen sulfide donor AP39 improves neurological outcomes after cardiac arrest in mice

(2015) Kohei Ikeda et al.   NITRIC OXIDE-BIOLOGY AND CHEMISTRY

On the chemical biology of the nitrite/sulfide interaction

(2015) Miriam M. Cortese-Krott et al.   NITRIC OXIDE-BIOLOGY AND CHEMISTRY

Sodium Thiosulfate Attenuates Acute Lung Injury in Mice

(2014) Masahiro Sakaguchi et al.   ANESTHESIOLOGY

Hydrogen Sulfide Protects the Brain Against Ischemic Reperfusion Injury in a Transient Model of Focal Cerebral Ischemia

(2014) Sevda Gheibi et al.   JOURNAL OF MOLECULAR NEUROSCIENCE

Ischaemic accumulation of succinate controls reperfusion injury through mitochondrial ROS

(2014) Edward T. Chouchani et al.   NATURE

Widespread neuron-specific transgene expression in brain and spinal cord following synapsin promoter-driven AAV9 neonatal intracerebroventricular injection

(2014) Jesse R. McLean et al.   NEUROSCIENCE LETTERS

Metabolic changes associated with the long winter fast dominate the liver proteome in 13-lined ground squirrels

(2014) Allyson G. Hindle et al.   PHYSIOLOGICAL GENOMICS

Cystathionine γ-Lyase Deficiency Protects Mice from Galactosamine/Lipopolysaccharide-Induced Acute Liver Failure

(2013) Kazuhiro Shirozu et al.   ANTIOXIDANTS & REDOX SIGNALING

Regulation of mitochondrial bioenergetic function by hydrogen sulfide. Part I. Biochemical and physiological mechanisms

(2013) Csaba Szabo et al.   BRITISH JOURNAL OF PHARMACOLOGY

Mitochondrial Regulation in Pluripotent Stem Cells

(2013) Xiuling Xu et al.   Cell Metabolism

Meclizine Inhibits Mitochondrial Respiration through Direct Targeting of Cytosolic Phosphoethanolamine Metabolism

(2013) Vishal M. Gohil et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Physiological role of hydrogen sulfide and polysulfide in the central nervous system

(2013) Hideo Kimura   NEUROCHEMISTRY INTERNATIONAL

Reductive glutamine metabolism is a function of the α-ketoglutarate to citrate ratio in cells

(2013) Sarah-Maria Fendt et al.   Nature Communications

A Novel Hydrogen Sulfide-releasingN-Methyl-d-Aspartate Receptor Antagonist Prevents Ischemic Neuronal Death

(2012) Eizo Marutani et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Hypoxic regulation of the cerebral microcirculation is mediated by a carbon monoxide-sensitive hydrogen sulfide pathway

(2012) T. Morikawa et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Hepatocyte-like cells differentiated from human induced pluripotent stem cells: Relevance to cellular therapies

(2012) Yue Yu et al.   Stem Cell Research

Ovariectomy and 17β-estradiol Replacement in Rats and Mice: A Visual Demonstration

(2012) Jakob O. Ström et al.   Jove-Journal of Visualized Experiments

Hydrogen Sulfide Inhibits Hypoxia- But Not Anoxia-Induced Hypoxia-Inducible Factor 1 Activation in a von Hippel-Lindau- and Mitochondria-Dependent Manner

(2011) Shinichi Kai et al.   ANTIOXIDANTS & REDOX SIGNALING

Sulphide quinone reductase contributes to hydrogen sulphide metabolism in murine peripheral tissues but not in the CNS

(2011) DR Linden et al.   BRITISH JOURNAL OF PHARMACOLOGY

Vitamin B12 protects against superoxide-induced cell injury in human aortic endothelial cells

(2011) Edward S. Moreira et al.   FREE RADICAL BIOLOGY AND MEDICINE

High Throughput Microplate Respiratory Measurements Using Minimal Quantities Of Isolated Mitochondria

(2011) George W. Rogers et al.   PLoS One

Inhaled Hydrogen Sulfide Prevents Neurodegeneration and Movement Disorder in a Mouse Model of Parkinson's Disease

(2010) Kotaro Kida et al.   ANTIOXIDANTS & REDOX SIGNALING

Oxidation of hydrogen sulfide remains a priority in mammalian cells and causes reverse electron transfer in colonocytes

(2010) Emilie Lagoutte et al.   BIOCHIMICA ET BIOPHYSICA ACTA-BIOENERGETICS

Hypoxia-Inducible Factor-1α Is Involved in the Pro-angiogenic Effect of Hydrogen Sulfide under Hypoxic Stress

(2010) XinHua Liu et al.   BIOLOGICAL & PHARMACEUTICAL BULLETIN

Dynamic change of hydrogen sulfide during global cerebral ischemia–reperfusion and its effect in rats

(2010) Caili Ren et al.   BRAIN RESEARCH

Genetic and Pharmacologic Hydrogen Sulfide Therapy Attenuates Ischemia-Induced Heart Failure in Mice

(2010) John W. Calvert et al.   CIRCULATION

Characterization of a 3-vessel occlusion model for the induction of complete global cerebral ischemia in mice

(2010) Serge C. Thal et al.   JOURNAL OF NEUROSCIENCE METHODS

Inhaled Hydrogen Sulfide

(2009) Gian Paolo Volpato et al.   ANESTHESIOLOGY

TTC, Fluoro-Jade B and NeuN staining confirm evolving phases of infarction induced by middle cerebral artery occlusion

(2009) Fudong Liu et al.   JOURNAL OF NEUROSCIENCE METHODS

Hydrogen Sulfide Increases Hypoxia-inducible Factor-1 Activity Independently of von Hippel–Lindau Tumor Suppressor-1 in C. elegans

(2009) Mark W. Budde et al.   MOLECULAR BIOLOGY OF THE CELL

Loss of ETHE1, a mitochondrial dioxygenase, causes fatal sulfide toxicity in ethylmalonic encephalopathy

(2009) Valeria Tiranti et al.   NATURE MEDICINE

The inhibition of mitochondrial cytochrome oxidase by the gases carbon monoxide, nitric oxide, hydrogen cyanide and hydrogen sulfide: chemical mechanism and physiological significance

(2008) Chris E. Cooper et al.   JOURNAL OF BIOENERGETICS AND BIOMEMBRANES